Gusaza ni inzira byanze bikunze ibinyabuzima bizima, birangwa no kugabanuka buhoro buhoro imiterere yumubiri nimirimo mugihe. Iyi nzira iragoye kandi irashobora kwibasirwa cyane ningaruka zifatika zituruka kubintu bitandukanye byo hanze nkibidukikije. Kugirango dusobanukirwe neza umuvuduko wo gusaza, abahanga baretse uburyo bwa gakondo bwo gupima imyaka cyangwa iminsi ahubwo bibanda ku gihe cyoroshye cyane, baharanira kugera kubushishozi bwihuse mubusaza.
Muri ubu bushakashatsi, abahanga bakoze urutonde rwibinyabuzima bishaje bifite ubuhanga, muri byo uburyo bwa methylation ya ADN bushimishije cyane. Nuburyo bwingenzi bwo kugenzura epigenetike, uburyo bwa methylation ya ADN burashobora gushushanya neza imiterere yumuntu ugeze mu za bukuru, ntibigaragaza gusa impinduka zikomeye zamakuru yimiterere yimiterere yubusaza, ariko kandi biba ingenzi mubushakashatsi bwa siyanse busaza. ibikoresho byuzuye. Binyuze mu isesengura ryimbitse ry’ibi binyabuzima, abahanga barashobora kubona uburyo bwimikorere ya molekile itera gusaza, bikingura inzira nshya zo gutinda gusaza no guteza imbere gusaza neza.
Mu kirere kinini cyane cya siyanse yo kurwanya gusaza, NMN (nicotinamide mononucleotide) yigeze kunyura nka meteor itangaje. Ibiranga nkibibanziriza NAD + (nicotinamide adenine dinucleotide) byashishikarije abahanga batabarika. ishyaka ry'ubushakashatsi. Ariko, uko ibihe byagiye bisimburana, indi nyenyeri yaka cyane, AKG (alpha-ketoglutarate), yagiye igaragara buhoro buhoro kandi itangira kumenyekana cyane mubijyanye no kurwanya gusaza hamwe nubwiza bwihariye kandi bushingiye kuri siyansi. .
Mu bushakashatsi bwasohotse mu kinyamakuru Nature Metabolism, abahanga basobanuye uburyo bwa AKG mu mikorere ya metabolism, imikorere ya mitochondial no kurwanya gusaza. Ubushakashatsi bwerekanye ko AKG ishobora guteza imbere aside irike ya tricarboxylic no kongera ingufu mu ngirabuzimafatizo, bityo bikazamura ubuzima rusange muri selile. Byongeye kandi, ikinyamakuru "Cell Metabolism" cyanasohoye ibyavuye mu bushakashatsi ku bushobozi bwa AKG bwo guteza imbere synthesis ya kolagen no kunoza imiterere y’uruhu, bikomeza kwemeza ubushobozi bwayo mu rwego rwo kurwanya gusaza.
Guhindura ibimenyetso byigihe
Ubushakashatsi buvuye mu Buyapani buduha urugero rwiza. Umugore ugeze mu kigero cyo hagati umaze igihe kinini yitondera kurwanya gusaza, nyuma yo gufata inyongera ya AKG mu gihe cyumwaka, ntabwo ubuzima bwuruhu rwe bwonyine bwarushijeho kuba bwiza, buba bukomeye kandi bworoshye, ariko nubuzima bwe muri rusange n'imitekerereze nayo yariyongereye cyane. Mugereranije ibipimo bya physiologique mbere na nyuma yubushakashatsi, abashakashatsi basanze imikorere ya mitochondial yumugore yazamutse cyane, ibyo bikaba bifitanye isano rya hafi nuruhare rwa AKG mugutezimbere metabolism.
Umurinzi wubuzima bwimitsi
Ubundi bushakashatsi bwakorewe muri Amerika bwibanze ku ruhare rwa neuroprotective rwa AKG. Nyuma yo kwivuza AKG, umusaza ufite ubumuga bworoheje bwubwenge yerekanye iterambere ryinshi mubushobozi bwe bwo kumenya, harimo no kwibuka neza no kwibanda. Abashakashatsi babonye binyuze mu buhanga bwo gufata amashusho mu bwonko ko imikorere ya neuron mitochondrial yumurwayi yagaruwe, itanga inkunga ikomeye kuri AKG mu gukumira no kuvura indwara zifata ubwonko.
AKG ibyiza byihariye
1. Ingaruka nyinshi zo kurwanya gusaza
Bitandukanye na NMN, irwanya gusaza mu kongera urwego rwa NAD +, AKG igira uruhare runini mu kurwanya gusaza. Ntishobora guteza imbere metabolisme yingufu gusa no kongera imikorere ya mitochondial, ariko kandi irashobora kunoza gusaza kwumubiri kuva mubice byinshi bigira ingaruka kuri metabolisme ya aside amine no guteza imbere synthesis.
2. Biocompatibilité yo hejuru n'umutekano
Nka metabolite isanzwe iboneka mumubiri wumuntu, AKG ifite biocompatibilité nziza numutekano. Irashobora kwinjizwa mu buryo butaziguye kandi igakoreshwa n'umubiri w'umuntu bitanyuze mu nzira igoye yo guhindura, bikagabanya ibyago byo guterwa n'ingaruka mbi. Ibi bituma ikoreshwa rya AKG murwego rwo kurwanya gusaza umutekano kandi wizewe.
3. Ibyiza byinshi byubuzima
Usibye kurwanya gusaza, AKG inagaragaza inyungu nyinshi zubuzima mu guteza imbere ubuzima bw’imitsi no kongera ubudahangarwa. Izi nyungu zinyongera zubuzima zituma AKG irushaho gukurura porogaramu zo kurwanya gusaza.
Hamwe nogukomeza ubushakashatsi bwubumenyi no gukomeza gutera imbere kwikoranabuhanga, ibyifuzo bya AKG mubijyanye no kurwanya gusaza bizaba binini. Dutegerezanyije amatsiko ubushakashatsi buhanitse mu bihe biri imbere kugira ngo tumenye andi mayobera ya AKG, kandi tunategereje ubushobozi bwayo bwo guhuzwa n’izindi ngamba zo kurwanya gusaza nka NMN kugira ngo dufatanye gutanga ubwenge n’imbaraga nyinshi mu buzima bw’abantu no kuramba. . Muri iri siganwa rirwanya igihe, AKG nta gushidikanya ko yerekanye imbaraga zikomeye zo guhangana kandi bishoboka.
Ibikorwa by'ingenzi ni:
Kurwanya gusaza: Irashobora gutinza cyane gahunda yo gusaza kwa selile muguhuza inzira ya signal ya mTOR, guteza imbere autofagy, kunoza metabolisme ya protein idasanzwe, no kugenzura epigenetique. Byongeye kandi, irashobora guteza imbere synthesis ya kolagen, igafasha kwangiza selile, ifasha kugarura urugero rwa calcium yibisanzwe mumaraso, kwihutisha gukira ibikomere, guteza imbere gusana imitsi, nibindi.
Kunoza indwara zidakira: Ubushakashatsi bwa Clinical bwerekanye ko bugira ingaruka zikomeye ku ndwara zitandukanye zidakira, harimo ariko ntizigarukira gusa kuri osteoporose, indwara zifata ubwonko (nk'indwara ya Parkinson), indwara z'umutima n'imitsi, diyabete, na kanseri. Ikemura byimazeyo intandaro yindwara zidakira ikora poroteyine ndende mu mubiri no gusana ADN yangiritse.
Kunoza ubudahangarwa: Irashobora kongera ibikorwa nubwinshi bwingirangingo z'umubiri, kuzamura ubudahangarwa bw'umubiri muri rusange, bityo bigafasha umubiri kurwanya neza indwara n'indwara.
Guteza imbere ubuzima: Iki gicuruzwa nacyo gifite inyungu nko guteza imbere metabolisme yisukari yamaraso hamwe namavuta mumubiri no gushyigikira imikorere myiza yubwonko bwubwenge, bifasha kubungabunga ubuzima rusange bwumubiri wumuntu.
Ingaruka zo kurwanya gusaza zishyigikiwe nubushakashatsi bwa siyansi. Kurugero, muri 2014, ikinyamakuru cyo hejuru "Kamere" cyatangaje bwa mbere ko gusaza bishobora gutinda kubuza ibikorwa bya mTOR; ubushakashatsi kuri selile osteosarcoma yabantu nabwo bwerekanye ko bushobora guteza autofagy; hiyongereyeho, irashobora kandi kugira uruhare muri synthesis ya aminide acide no kugabanya protein metabolism. Ibidasanzwe bibaho kandi bigira uruhare mubikorwa byo kugenzura epigenetike nka ADN demethylation.
Igeragezwa rya Clinical ryongeye gushimangira umutekano waryo. Kurugero, raporo yikigereranyo cyubuvuzi bwa mbere cyabantu yashinzwe n’ibitaro bya NewMed muri Californiya yerekana ko igira ingaruka zikomeye zo kuvura ku bimenyetso bitandukanye by’indwara zidakira nko kudasinzira, kubura kwibuka, kunanirwa kw'impyiko, indwara ya stroke, kandi birashobora no kuvura igihe gito guhumeka, umunaniro, nibindi bimenyetso biterwa na coronavirus nshya. Ifite kandi uburyo bwiza bwo gutondekanya ibintu bikurikirana nka inkorora.
Nuburyo bukomeye n'umutekano byacyo, byitabiriwe n'abantu benshi ku isoko. Abakoresha benshi bavuze ko hari byinshi byahinduye mu mibereho yabo nyuma yo kuyifata, nk'ingufu nyinshi, uruhu rukomeye ndetse n’uruhu rworoshye cyane, n'ibindi. Muri icyo gihe, iki gicuruzwa nacyo cyaramenyekanye kandi gishyigikirwa n’ibigo byinshi n’inzobere byemewe.
Muri make, Kalisiyumu Alpha ketoglutarate nibicuruzwa bya siyansi, umutekano kandi byiza birwanya gusaza. Igera ku ngaruka zo kurwanya gusaza kandi itezimbere ibimenyetso byindwara zidakira zinyuze muburyo bwinshi. Ni amahitamo meza kubantu bakurikirana ubuzima no kuramba.
Igihe cyo kohereza: Nyakanga-08-2024
