Deazaflavins, igereranya rya riboflavin, ihinduka abakinyi bakomeye muri catalizike ya enzymatique na reaction ya redox. Imiterere yihariye hamwe na redox ituma bakora cofactors nziza ya enzymes zitandukanye kugirango ihererekanyabubasha rya electron hamwe nibikorwa bya catalitiki. ifite amasezerano akomeye mubijyanye na farumasi. Ubushobozi bwayo nka antioxydeant kandi igenga metabolism selile ifungura inzira nshya zubushakashatsi no kuvura.
Deazaflavin, inkomoko ya riboflavin hamwe na analogue ikomeye ya flavin naturel, ifite imiterere yihariye yakwegereye abashakashatsi mubushakashatsi butandukanye. Deazaflavin, izwi kandi ku izina rya 7,8-dimethyl-8-hydroxy-5-deazariboflavin, yitiriwe atome ya 7 ya azote yo mu mpeta ya isoalloxazine ya riboflavin isimburwa na atome ya karubone.
Ihinduka ryimiterere ritandukanya na riboflavin mugenzi we kandi ritanga imiti idasanzwe. Nuburyo bwihariye, deazaflavin igira uruhare runini mubikorwa byinshi byibinyabuzima.
Deazaflavin ni ibara ry'umuhondo-orange hamwe na molekile ya C16H13N3O2, irangwa nitsinda rya hydroxyl ya fenolike kumwanya wa 8.
Imwe mumikorere igaragara ya deazaflavin nukwitabira biosynthesis ya cofactor F420, iboneka muri bagiteri zimwe na zimwe, archaea na eukaryote yo hepfo. Nka moteri ikomeye ya electron, F420 igira uruhare mubitekerezo bya redox kandi ikohereza byihuse electron hagati ya enzymes. Kubaho kwa deazaflavin nibyingenzi kugirango intambwe yanyuma ya synthesis ya F420, ihindure riboflavin kuri F420 no kongera imikorere yibinyabuzima byinshi.
Inyungu zishobora gutangwa na deazaflavin:
●Kurwanya gusaza / Kurwanya gusaza
●irinde indwara
●Yongera umusaruro w'ingirabuzimafatizo
●Antioxidant na anti-inflammatory
●Guteza imbere ubuzima bwubwonko nibikorwa
●infashanyo yumubiri
1. Kurwanya gusaza / kurwanya gusaza
5-Ifu ya Desaflavin ningirakamaro ikomeye yo kurwanya gusaza igenda ikundwa cyane mubikorwa byubuzima n’ubuzima bwiza. Birazwi kuzamura umusaruro wumubiri wa NAD +, acoenzymebigira uruhare runini muguhindura ingufu no gusana selile.
2. Irinde indwara
Deazaflavins igira uruhare runini mugikorwa cya erythropoiesis. Ifasha kugumya gukora no gukora bisanzwe mumaraso atukura kandi ikarinda indwara zifitanye isano na anemia.
3. Yongera ingufu zingirabuzimafatizo
Bumwe mu buryo bw'ingenzi deazaflavin akoresha mu buzima bwayo ni ukongera ingufu z'ingirabuzimafatizo. Kimwe na riboflavin, deazaflavin ikora nka coenzyme ikomeye muri metabolism selile. Mu kwitabira urwego rwo gutwara ibintu bya elegitoronike hamwe n’ibindi bintu bitera imbaraga, deazaflavin iteza imbere umusaruro mwiza, bigatuma imikorere ya selile ikora neza. Uyu mutungo ntabwo ufasha kurwanya umunaniro gusa, ahubwo unashyigikira ubuzima muri rusange n'imibereho myiza.
4. Antioxydants na anti-inflammatory
Ubushakashatsi bwerekanye ko deazaflavin ifite antioxydants ikomeye igira uruhare runini mu kugabanya imihangayiko ya okiside no kurwanya ingaruka mbi ziterwa na radicals yubusa mu mubiri. Guhangayikishwa na Oxidative bifitanye isano rya hafi n'indwara zitandukanye zidakira, harimo n'indwara z'umutima n'imitsi, indwara zifata ubwonko, na kanseri. Ubushobozi bwa radical-scavenging ubushobozi bwa deazaflavin burashobora gufasha kurinda umubiri izo ndwara no gushyigikira kuramba muri rusange.
Byongeye kandi, ubushakashatsi bushya bwerekana ko Deazaflavin afite imiti igabanya ubukana. Indwara idakira ni ikintu kigira uruhare mubibazo byinshi byubuzima. Muguhindura ibisubizo byumuriro, deazaflavin irashobora gufasha kuvura no gukumira indwara nka artite, asima, nindwara ziterwa na autoimmune.
5. Guteza imbere ubuzima bwubwonko nimikorere
Ingaruka zishobora guterwa na neuroprotective de deazaflavin nazo zirashimishije abashakashatsi biga ubwenge nubuzima bwubwonko. Indwara zifata ubwonko nk'indwara ya Alzheimer n'indwara ya Parkinson zabaye ibibazo bikomeye by'ubuzima ku isi. Ubushobozi bwa deazaflavins bwo kongera ingufu zingirabuzimafatizo hamwe na antioxydeant na anti-inflammatory bituma bakora abakandida basezerana kugabanya ingaruka mbi zizi ndwara.
Byongeye kandi, ubushakashatsi bwibanze bwerekana ko Deazaflavin ashobora gushyigikira ibikorwa byo kwibuka no kumenya ubwenge, bigatuma ashobora kuba umufasha mukurwanya igabanuka ryubwenge rishingiye kumyaka no kuzamura ubuzima bwubwonko muri rusange. Nyamara, ubushakashatsi bwimbitse burakenewe kugirango twumve neza urugero ingaruka za deazaflavin zigira ku buzima bwubwonko.
6. Inkunga ya sisitemu
Ubudahangarwa bw'umubiri ni uburyo bwo kwirinda umubiri n'indwara. Uruhare rwa deazaflavin nka coenzyme yingenzi mubitekerezo bitandukanye byimisemburo nayo igera kumikorere yumubiri. Gushyigikira ubudahangarwa bw'umubiri ni ngombwa mu kubungabunga ubuzima bwiza no kwirinda indwara. Mugutezimbere ingufu nubuzima rusange muri selile, deazaflavins irashobora kugira uruhare runini mugushigikira imikorere yumubiri no kongera ubushobozi bwumubiri wo kurwanya indwara ziterwa na virusi.
Deazaflavin nintungamubiri zingenzi zigira uruhare runini mubikorwa bitandukanye byumubiri. Ibikurikira ningaruka zimwe zishobora kugaragara nibimenyetso byo kubura deazaflavin:
Ibibazo byuruhu nu mucyo: Kubura Deazaflavin birashobora gutera indwara zuruhu nka dermatite, iminwa yumye cyangwa yacagaguritse, no kubabara mu muhogo. Ibice byanduye byuruhu birashobora guhinduka byumye, bikabyimba, cyangwa bigashya.
Ibibazo by'amaso: Mugihe gikomeye, kubura deazaflavin birashobora gutera ibibazo bifitanye isano nijisho nko gufotora no kutabona neza.
Anemia: Deazaflavin ni ngombwa mu gukora selile zitukura. Kubura kwayo birashobora gutera amaraso make, arangwa numubare muto wamaraso atukura hamwe nubushobozi buke bwo gutwara ogisijeni, biganisha kumunaniro, intege nke no guhumeka neza.
Ibibazo byubuzima bwo mu kanwa no mu kanwa: Kubura Deazaflavins birashobora gutuma habaho ibibazo byubuzima bwo mu kanwa nka glossitis （gutwika ururimi）, iminwa yacitse, n'ibisebe byo mu kanwa.
Ibimenyetso bya Neurologique: Nubwo bidasanzwe, kubura deazaflavin bikabije bishobora kugira ingaruka kumitsi, bigatera ibimenyetso byubwonko nko kutamenya ubwenge, urujijo, no kwangiza imitsi.
Deazaflavin nuburyo bwahinduwe bwa chimique ya riboflavin （izwi kandi nkavitamine B2）. Ikoreshwa nka cofactor ya enzymes zitandukanye mubinyabuzima na biologiya ikoreshwa. Dore amabwiriza rusange yuburyo bwo gukoresha deazaflavin:
Menya neza ko ufite ibisubizo bishya, byujuje ubuziranenge biboneka mbere yo gukoresha deazaflavin. Ubusanzwe Desaflavin iboneka mubifu cyangwa muburyo bukomeye, kuburyo ushobora gukenera kuyishonga mumashanyarazi akwiye, nkamazi cyangwa igisubizo kibisi. Niba bihari, kurikiza amabwiriza yabakozwe kugirango yongere kwiyubaka.
Deazaflavins yumva urumuri, ubushyuhe na okiside. Kubwibyo, ni ngombwa kubika igisubizo ahantu hijimye, hakonje kandi ukirinda kumara igihe kinini uhura nikirere. Tekereza gukuraho igisubizo cyibicuruzwa mu bice bito bikoreshwa kugirango ugabanye kwangirika.
Ubwiyongere bwihariye bwa deazaflavin busabwa burashobora gutandukana bitewe na enzyme cyangwa reaction irimo kwigwa. Birasabwa kugisha inama ibitabo cyangwa kugisha inama impuguke mubisabwa kugirango umenye intera ikwiye.
Deazaflavins ikoreshwa muburyo bwo kuyongerera kuvanga reaction cyangwa sisitemu yo kwisuzumisha. Ibihe byubushakashatsi birashobora gutandukana bitewe na protocole yihariye yubushakashatsi. Kurikiza amabwiriza yabakozwe cyangwa ubaze ibitabo bijyanye nibihe byiza byubushakashatsi.
Ni ngombwa gushyiramo ibisubizo bikwiye byo kugenzura cyangwa kugenzura amatsinda adafite deazaflavin mugushushanya. Igenzura rizagufasha gutandukanya ingaruka zatewe na deazaflavin nibindi bintu biri muri sisitemu.
Inyandiko zigeragezwa, kwitegereza, nibisubizo muburyo bwanditse neza. Witondere witonze kandi usobanure amakuru yakuwe mubushakashatsi, ugereranya ibisubizo nubugenzuzi bukwiye.
Menya ko aya ari umurongo ngenderwaho rusange hamwe nikoreshwa ryihariye hamwe na protocole birashobora gutandukana bitewe nuburyo bwihariye bwo kugerageza hamwe nibisabwa. Witondere kubaza ibitabo bijyanye cyangwa ushake inama zinzobere mubikorwa byawe kugirango ubone amabwiriza yukuri kubushakashatsi runaka.
Umutekano wa deazaflavin
Iyo usuzumye umutekano wa deazaflavin, ni ngombwa kumenya ko uruganda rwakorewe ibizamini by’ibanze n’inyamaswa kugira ngo hamenyekane uburozi bwabyo n'ingaruka mbi zabyo. Ubu bushakashatsi bwatangaje ko nta burozi bukabije cyangwa uburozi buhoraho, bugaragaza imiterere rusange y’umutekano. Ariko, ni ngombwa gukora ibindi bigeragezo byo kwa muganga kugirango dusuzume umutekano wacyo mu bantu.
ingaruka mbi za deazaflavin:
Mugihe ubushakashatsi bwibanze butigeze bugaragaza ingaruka mbi za deazaflavin, ni ngombwa kwitonda kubikoresha. Kimwe n’ibindi byose, hakenewe ubundi bushakashatsi bw’amavuriro kugira ngo hamenyekane umutekano wabwo mu bantu no kumenya ingaruka zose zishobora guterwa cyangwa ibiyobyabwenge. Kunywa neza, kuyobora no gukurikirana abarwayi bizaba urufunguzo rwo gukoresha neza umutekano.
Q: Bifata igihe kingana iki kugirango deazaflavin ikore?
A: Ingaruka za Kalisiyumu deazaflavin zirashobora gutandukana bitewe numuntu kugiti cye, dosiye, nuburyo bwo kuyobora. Ariko, mubisanzwe, byizerwa ko deazaflavin ashobora gufata ahantu hose kuva muminota mike kugeza kumasaha make kugirango utangire gukora. Birasabwa kugisha inama inzobere mu by'ubuzima cyangwa gukurikiza amabwiriza yatanzwe n’uruganda kugira ngo umenye amakuru arambuye ku gihe bifata kugira ngo iki kigo gitangire gukurikizwa.
Inshingano: Iyi ngingo igamije amakuru gusa kandi ntigomba gufatwa nkinama zubuvuzi. Buri gihe ujye ubaza inzobere mu by'ubuzima mbere yo gukoresha inyongera cyangwa guhindura gahunda z'ubuzima.
Igihe cyo kohereza: Nyakanga-10-2023
