Uratekereza kongeramo acetyl zingerone mubyo wongeyeho buri munsi? Hamwe namahitamo menshi kumasoko, birashobora kuba byinshi guhitamo imwe ijyanye nibyo ukeneye. Acetyl zingerone ni antioxydants ikomeye kandi irwanya inflammatory hamwe nibyiza byinshi byubuzima, harimo gucunga ibiro, kurwanya gusaza ndetse nubuzima muri rusange. Kugufasha gufata icyemezo kibimenyeshejwe, dore ibintu byingenzi ugomba gusuzuma mugihe uhisemo inyongera ya acetyl zingerone.
Acetyl zingerone, izwi kandi nka 4- (acetoxy) -3-mikorerexybenzaldehyde, ni inkomoko ya zingerone karemano ya gingerone muri ginger. Azwiho kurwanya antioxydeant, anti-inflammatory, na anti-kanseri, acetyl zingerone nuburyo bwahinduwe bwa zingiberone. Hamwe nimiterere yihariye ya chimique hamwe nimbaraga zikomeye, acetyl zingerone ikurura ibitekerezo kubishobora guteza ubuzima bwiza.
Muri byo, zingerone ni kimwe mu bigize antioxydeant ya ginger kandi yakozweho ubushakashatsi ku miterere itandukanye y’imbeba n’abantu. Igishimishije, ginger nshya yasanze irimo ibintu byinshi bivangwa na zingerone, bihinduka zingerone iyo byumye cyangwa bitetse. Gingerone ifite imiterere imwe na curcumin, ibaha ingaruka zimiti. Acetyl zingerone ifite itsinda rya acetyl ryiyongereye, ritanga acetyl zingerone yongeyeho gushakisha, gushonga, no gutuza ubushobozi. Acetyl zingerone ikozwe muburyo bwo gutesha agaciro ubwoko bwa UVR buterwa nubwoko bwa ogisijeni yubusa (ROS), ubwoko bwa ogisijeni idafite radical, na nucleophile ikomeye.
Acetyl zingerone ifite ibintu bikurikira:
● Nka antioxyde-intego nyinshi
Kugabanya ibyangiritse bya lipide, proteyine, na ADN
Kugabanya igisubizo kibabaza
Kuzamura matrix idasanzwe kandi wirinde kwangirika kwa kolagen
Byerekanwe mubuvuzi kunoza ibimenyetso byo gufotora
Acetyl zingeroneni bioactive compound iboneka muri ginger. Azwiho kurwanya antioxydants na anti-inflammatory, bigatuma iba ikintu gikunzwe cyane mubuvuzi gakondo hamwe ninyongera zubuzima bugezweho.
Acetyl zingerone nibisanzwe cyangwa sintetike? Igisubizo kiri muburyo bwo kugikora. Acetyl zingerone irashobora kuboneka haba mubisanzwe no muburyo bumwe.
Kamere ya acetyl zingerone iboneka mumuzi ya ginger binyuze mugukuramo no kweza. Ibi bikubiyemo gutandukanya ibimera nigiterwa cya ginger no kuyinonosora kugirango ubone uburyo bwiza bwa acetyl zingerone. Ubu buryo bwo kuvoma bisanzwe byemeza ko ibimera bigumana imiterere yumwimerere kandi bitarimo inyongeramusaruro cyangwa ihinduka.
Ku rundi ruhande, syntetique acetyl zingerone, irashobora gukorwa na synthesis ya chimique muri laboratoire. Ibi bikubiyemo gukoresha imiti nuburyo bwo gukora ibibyara udashingiye kumasoko karemano nka ginger. Sintezitike ya acetyl zingerone irashobora kuba nkigiciro cyinshi gishobora kuvamo ibicuruzwa biva mu mahanga bikoreshwa mu nganda zimiti n’ibiribwa.
1. Imiti igabanya ubukana
Mitochondria izwiho kuba imbaraga za selile kuko zitanga ingufu zikenewe mubikorwa bitandukanye. Rero, ADN ya mitochondrial ikubiyemo ibintu byinshi bikomeye bya biohimiki mu ruhu. Nubwo ifite ADN yangiritse nka ADN ya kirimbuzi, ntabwo ifite uburyo bwuzuye bwo gusana ADN ikorera muri nucleus. Abashakashatsi bamwe basabye isaha ya mitochondial yo gusaza ishingiye ku kwegeranya buhoro buhoro kwangirika kwa okiside, cyane cyane guterwa na ROS.
Byongeye kandi, iyo uruhu rwacu rwerekanwe nimirasire ya UV, hakorwa ubwoko bwa ogisijeni yubusa bwangiza (ROS). Izi radicals zubuntu zirashobora kwangiza poroteyine, ADN, nizindi ngirabuzimafatizo mu ruhu. Uku kwiyongera kwa ROS kuganisha ku kwiyongera kwa enzyme ya MMP-1, itesha agaciro kolagen, biganisha ku kugaragara kw'iminkanyari.
Antioxydants ifasha kurinda umubiri guhangayika, bishobora kwangiza selile kandi bigatera ibibazo bitandukanye byubuzima. Acetyl zingerone yerekanwe gukuraho radicals yubusa no kugabanya kwangirika kwa okiside, bigatuma yongerwaho agaciro mubuzima bwiza.
2. Ingaruka zo kurwanya inflammatory
Gutwika ni igisubizo gisanzwe cy'umubiri ku gukomeretsa cyangwa kwandura, ariko gutwika karande bishobora gutera indwara zidakira nk'indwara z'umutima, diyabete, na kanseri. Ubushakashatsi bwerekanye ko acetyl zingerone ifite imiti igabanya ubukana kandi ishobora gufasha kugabanya uburibwe no gushyigikira ubuzima muri rusange. Acetyl zingerone nayo igenga Notch na ERK1 / 2 byerekana ibimenyetso (bigenga ibisubizo bya bagiteri) kandi bikagabanya ibimenyetso bya TGF-B (inflammation). Kugabanya imvugo ya genes yerekanwe mugihe cyo gutandukanya KC. Ingaruka zishobora kuba zijyanye no kubuza kwanduza AP-1 gene. Acetyl zingerone nayo yatumye habaho ibisubizo byinshi bya retinoide kandi ibuza gutandukanya KC kugirango yongere fenotipike ya KC.
3. Inkunga ishobora gucunga ibiro
Ubushakashatsi bumwe bwerekana ko acetyl zingerone ishobora kugira inyungu zo gucunga ibiro. Byagaragaye ko bigenga metabolisme ya lipide na lipogenezi, bishobora kugira ingaruka zo gushyigikira gucunga neza ibiro. Mugihe hakenewe ubushakashatsi bwinshi muriki gice, ibisubizo byambere biratanga ikizere.
4. Ingaruka zo kurwanya gusaza
Acetyl zingeronewasangaga bigira ingaruka kuri matrise idasanzwe (ECM) homeostasis, iteza imbere reaction ya de novo synthesis ya matrix. Matrix ni ikusanyirizo rya poroteyine nizindi nzego ziteza imbere, zigenga, kandi zigize EMC. Bashinzwe kurinda uruhu neza kandi rutagira inkeke. Acetyl zingerone ikora nkibintu birwanya gusaza muburyo bukurikira:
Ongera matrix (kolagen, proteoglycan, na ECM) kugirango utange uruhu rwubusore
Kugabanya matrix metalloproteinase (MMP) no gutesha agaciro kolagen
Kugabanya gusaza kwa fibroblast gusaza, kongera gukora umusaruro wa kolagen no koroshya uruhu
Kurwanya biomarkers pro-inflammatory bigira ingaruka kumusaruro wa kolagen, ubunyangamugayo bwa ECM, hamwe nuruhu rwuruhu
Guteza imbere synthesis
5. Lipid peroxidation
Uruhu rumaze guhura n’umucyo ultraviolet, umusaruro wa ROS utera kwangirika kwa okiside ya glycerophospholipide, sphingolipide (nka ceramide), aside irike idahagije, na cholesterol. Ibi bivuze ko lipide intercellular internaire ya barrière yubushuhe yangijwe na UV. Ibikomoka kuri lipide peroxidation bizwi ko ari uburozi, mutagenic, ndetse na kanseri. Lipid peroxidation irashobora kwirindwa ukoresheje antioxydants zimwe na zimwe zibuza iki gikorwa. Acetyl zingerone yerekanwe kubuza lipide peroxidation kandi igereranywa na resveratrol mubushobozi bwayo bwo kubuza lipide peroxidation.
6. Irinde ROS iterwa numucyo wubururu numwanda
Ubushakashatsi bwerekanye ko imirasire ya UV igizwe na 50% gusa yumutwaro wose wa ROS kuruhu, mugihe izindi 50% ziterwa numucyo ugaragara. Ndetse izuba ryinshi ririnda gusa kimwe cya kabiri cyibyangijwe nizuba. Usibye kwangizwa n'izuba, ibintu bituruka ku ihumana ry’imijyi bifitanye isano na hyperpigmentation hamwe n’imitsi. Acetyl zingerone yerekanwe kugabanya urumuri rwubururu- no mu mijyi iterwa no kwiyongera kwa ROS muburyo bwa dose.
Isuku n'ubuziranenge
Isuku nubuziranenge bigomba kuba ibitekerezo byawe byambere muguhitamo inyongera ya acetyl zingerone. Reba ibicuruzwa bikozwe hamwe nubwiza buhanitse, bwuzuye amavuta ya acetyl ginger. Ni ngombwa guhitamo inyongeramusaruro zapimwe na laboratoire yundi muntu kugirango isukure nimbaraga kugirango urebe ko ubona ibicuruzwa byujuje ubuziranenge bitarimo umwanda cyangwa ibyuzuza.
Bioavailability
Bioavailability bivuga ubushobozi bwumubiri bwo kwinjiza no gukoresha ikintu. Mugihe uhisemo inyongera ya acetyl zingerone, hitamo ifishi ifite bioavailable nyinshi kugirango umenye neza ko umubiri wawe ushobora kwinjirira neza no kungukirwa nuruvange. Kurugero, amavuta ya ginger ya liposomal yerekanwe kuba afite bioavailability irenze ugereranije nuburyo gakondo bwinyongera, bigatuma ihitamo neza kugirango yunguke byinshi.
Igipimo no kwibanda
Ingano hamwe nubunini bwinyongera ya acetyl zingerone irashobora gutandukana cyane mubicuruzwa bitandukanye. Ni ngombwa gusuzuma imbaraga zinyongera hamwe nibisabwa kugirango umenye neza ko ubona urugero rwiza rwa acetyl zingerone. Shakisha inyongera itanga amavuriro ajyanye na acetyl zingerone kugirango ubone inyungu zayo zose.
Ibiryo hamwe nibindi byongeweho
Usibye acetyl zingerone, inyongera zimwe zishobora kuba zirimo ibindi bintu byongera ingaruka cyangwa bigatanga inyungu zinyongera. Kurugero, amata amwe arashobora gushiramo izindi antioxydants cyangwa intungamubiri zikorana hamwe na acetyl zingerone kugirango zunganire ubuzima muri rusange. Mugihe uhisemo inyongeramusaruro hamwe nibindi bikoresho, suzuma intego zawe zubuzima hamwe nibyo ukunda.
Icyubahiro no Gusubiramo
Mbere yo kugura, fata umwanya wo gukora ubushakashatsi ku cyamamare no gusoma ibyo abakiriya basubiramo. Shakisha isosiyete izwi ifite amateka yerekana ibicuruzwa byujuje ubuziranenge nibitekerezo byiza byabakiriya. Gusoma ibyasubiwemo birashobora gutanga ubushishozi mubikorwa nuburambe muri rusange bwo gukoresha inyongera ya acetyl zingerone.
Igiciro vs agaciro
Mugihe igiciro kitagomba kuba ikintu cyonyine gifata umwanzuro, ni ngombwa gusuzuma agaciro rusange kinyongera. Gereranya igiciro kuri buri serivisi hamwe nubunini bwa acetyl zingerone kugirango umenye igiciro-cyibicuruzwa. Wibuke ko igiciro kiri hejuru gishobora kwerekana ubwiza ninyongera, bityo rero shyira imbere agaciro kubiciro biri hasi.
Ubwishingizi bufite ireme
Ubwiza bugomba kuba umwanya wambere mugihe uguze ifu ya acetyl zingerone. Shakisha ababikora bubahiriza ingamba zikomeye zo kugenzura ubuziranenge kandi bafite ibyemezo bishyigikira ubuziranenge nimbaraga zibicuruzwa byabo. Inganda zizewe zizasobanuka mubikorwa byazo kandi zitange ibyangombwa kugirango hamenyekane ubwiza bwifu ya acetyl zingerone.
Icyubahiro n'uburambe
Kora ubushakashatsi nuburambe bwabashobora gukora inganda. Abahinguzi bafite ibimenyetso byerekana neza hamwe nuburambe bwimyaka barashobora gutanga ibicuruzwa bihamye kandi byizewe. Reba ibyasuzumwe byabakiriya, ubuhamya, hamwe nimpamyabushobozi yinganda kugirango umenye izina ryakozwe nuwizerwa.
Ubushobozi bw'umusaruro
Reba ubushobozi bwumusaruro kugirango umenye neza ibyo ukeneye. Uruganda rwizewe rugomba kugira ubushobozi bwo kongera umusaruro ukurikije ibyo usabwa utabangamiye ubuziranenge. Baza ibijyanye nibikorwa byabo, ibikoresho, nubushobozi bwo gusuzuma ubushobozi bwabo bwo kuzuza ibyo wateguye mugihe gikwiye.
Kurikiza amabwiriza
Nibyingenzi gukorana nababikora bubahiriza amabwiriza ninganda. Menya neza ko abayikora bakurikiza uburyo bwiza bwo gukora (GMP) nandi mabwiriza ajyanye no kurinda umutekano nubwiza bwibicuruzwa byabo. Kubahiriza ibisabwa byamabwiriza byerekana uruganda rwiyemeje gukora ifu ya acetylsingerone yujuje ubuziranenge bwinganda.
Gukorera mu mucyo no gutumanaho
Gufungura itumanaho no gukorera mu mucyo nibyo bipimo byingenzi byerekana uruganda rwizewe. Shakisha ababikora bitabira ibibazo byawe, batange amakuru arambuye kubicuruzwa byabo, kandi bafite ubushake bwo gukemura ibibazo ushobora kuba ufite. Inganda zizewe zizasobanuka mubikorwa byabo, ibikoresho biva mu mahanga, hamwe nikizamini cya gatatu cyakorewe kubicuruzwa byabo.
Myland Pharm & Nutrition Inc yatangiye gukora ubucuruzi bwongera imirire kuva mu 1992. Nisosiyete ya mbere mu Bushinwa yateje imbere kandi igacuruza imbuto zinzabibu.
Hamwe nuburambe bwimyaka 30 kandi itwarwa nubuhanga buhanitse hamwe ningamba zinoze cyane R&D, isosiyete yateje imbere ibicuruzwa bitandukanye byapiganwa kandi ihinduka ubumenyi bwa siyanse yubuzima bushya, synthesis gakondo hamwe na serivise zikora inganda.
Mubyongeyeho, Myland Pharm & Nutrition Inc nayo ikora FDA yemewe. Ibikoresho bya sosiyete R&D, ibikoresho byo kubyaza umusaruro, nibikoresho byisesengura nibigezweho kandi byinshi, kandi birashobora gukora imiti kuva kuri miligarama kugeza kuri toni mubipimo, kandi ikubahiriza ibipimo bya ISO 9001 nibisobanuro bya GMP.
Ikibazo: Ni ibihe bintu by'ingenzi ugomba gusuzuma muguhitamo ifu ya Acetyl Zingerone?
Igisubizo: Mugihe uhisemo uruganda rukora ifu ya Acetyl Zingerone, tekereza kubintu nkicyubahiro cyisosiyete, kubahiriza ibipimo byubuziranenge, ibyemezo, ubuziranenge bwibicuruzwa, no kwiyemeza gukora ubushakashatsi niterambere.
Ikibazo: Nigute nshobora gusuzuma izina ryumushinga wa Acetyl Zingerone?
Igisubizo: Suzuma izina ryuwabikoze usuzuma ubuhamya bwabakiriya, kugenzura ibyemezo byinganda, no gusuzuma amateka yabo mugutanga ifu ya Acetyl Zingerone yujuje ubuziranenge, itekanye, kandi yujuje ibisabwa mubindi bucuruzi.
Ikibazo: Ni ibihe byemezo cyangwa ibipimo ngenderwaho nkwiye gushakisha mubakora ifu ya Acetyl Zingerone?
Igisubizo: Reba ababikora bubahiriza uburyo bwiza bwo gukora (GMP), bafite ibyemezo byubuziranenge nimbaraga, kandi ukurikize amabwiriza agenga umusaruro wifu ya Acetyl Zingerone.
Ikibazo: Ni ubuhe bwoko bw'ibicuruzwa uruganda rukomeye rwa Acetyl Zingerone rugomba gutanga?
Igisubizo: Uruganda rukora ifu ya Acetyl Zingerone rugomba gutanga ubwoko butandukanye bwifu ya Acetyl Zingerone yujuje ubuziranenge, bwera, kandi bushyigikiwe na siyansi, byemeza ko bikenewe mu nganda zitandukanye no mu bikorwa.
Inshingano: Iyi ngingo ni iyamakuru rusange gusa kandi ntigomba gusobanurwa nkinama zose zubuvuzi. Amwe mumakuru yohereza amakuru aturuka kuri enterineti kandi ntabwo ari umwuga. Uru rubuga rufite inshingano zo gutondeka, gutunganya no guhindura ingingo. Intego yo gutanga amakuru menshi ntabwo bivuze ko wemera ibitekerezo byayo cyangwa kwemeza ukuri kwibirimo. Buri gihe ujye ubaza inzobere mu buzima mbere yo gukoresha inyongera cyangwa guhindura ibintu byubuzima bwawe.
Igihe cyo kohereza: Gicurasi-29-2024
