Wigeze ushakisha uburyo bwo kuzamura ubuzima bwawe muri rusange?Kalisiyumu alpha-ketoglutarate inyongera nibyo byiza wahisemo.Kalisiyumu alpha-ketoglutarate ni uruvange rufite uruhare runini mu kubyara ingufu z'umubiri no guhindagurika.Nibyingenzi byingenzi mukubungabunga amagufwa akomeye kandi meza, bigatuma intungamubiri zingenzi kubuzima muri rusange.Mugushyiramo calcium alpha ketoglutarate inyongera mubikorwa byawe bya buri munsi, urashobora kubona inyungu zinyuranye zubuzima zongera imyumvire yawe myiza.
Ca-AKGni ihuriro rya calcium ya minerval na molekile ya alpha-ketoglutarate.Alpha-ketoglutarate ni ikintu cyingenzi mu buryo bwo gukora ingufu z'umubiri, cyane cyane mu cyerekezo cya acide tricarboxylic, aho ari ngombwa mu gukora adenosine triphosphate (ATP), isoko nyamukuru y’umubiri.
Byongeye kandi, Ca-AKG ikora nka metabolite ya Kreb kandi α-ketoglutarate ikorwa mugihe selile zimenagura molekile yibiribwa kugirango ingufu.Ihita itemba imbere no hagati ya selile, igafasha inzira nyinshi zikomeza ubuzima hamwe na sisitemu yerekana ibimenyetso.Ndetse igira uruhare mu mvugo ya gene, ikora nk'uburyo bugenga amategeko bugaragara bwo gukumira amakosa yo kwanduza ADN akenshi atera indwara nka kanseri.
Iyo umuntu ageze kumyaka runaka, urwego rusanzwe rwa α-ketoglutarate mumubiri rugabanuka, kandi uku kugabanuka gufitanye isano no gusaza.
Muri byo, α-ketoglutarate ni aside α-keto igira uruhare runini muburyo butandukanye bwibinyabuzima.Byongeye kandi, alpha-ketoglutarate nayo ni imiti ya endogenous, bivuze ko ikorwa numubiri.Ntishobora kuboneka binyuze mu biryo, ariko ubushakashatsi bumwe bwerekana ko bushobora kubikwa binyuze mu kwiyiriza no kurya ketogenique.Bigaragara ko byibuze bifite uburyo bune bwibanze bwibikorwa.Ibi birimo kubungabunga metabolisme nzima, guteza imbere kwanduza aside amine yingenzi, kurinda ADN no guhagarika umuriro udakira. Hagati aho, calcium ni minerval yingenzi igira uruhare runini mumikorere myinshi yumubiri, harimo kwikuramo imitsi, neurotransmission, nubuzima bwamagufwa
Ca-AKG inyongera ni ihuriro rya calcium na alpha-ketoglutarate itanga inyungu zitandukanye zishoboka, zirimo kunoza imikorere ya siporo, gukura kwimitsi, hamwe nubufasha muri rusange.
Alpha-ketoglutarateni molekile igira uruhare runini muri metabolism selile.Nibintu bisanzwe biboneka mumubiri kandi biranaboneka nkinyongera yimirire.
Kugira ngo usubize iki kibazo, ni ngombwa gusobanukirwa nuburyo bwibanze bwo gusaza.Gusaza ni inzira igoye irimo ibintu byinshi byibinyabuzima nibidukikije.Imwe mumashanyarazi yingenzi yo gusaza nukwirundanya kwangirika kwingirabuzimafatizo no kudakora neza mugihe.Ibi birashobora gutuma igabanuka ryimikorere yinyama ningingo zitandukanye, amaherezo biganisha ku bimenyetso biranga gusaza nkiminkanyari, kugabanuka kwingufu no kongera kwandura indwara.
Ubushakashatsi bwerekana ko alpha-ketoglutarate ishobora kuba ifite ubushobozi bwo guhindura impinduka zijyanye n'imyaka.Ubushakashatsi bwasohotse mu kinyamakuru Cell Metabolism bwerekanye ko kuzuza indyo yimbeba zishaje hamwe na alpha-ketoglutarate byatanze ingaruka zitandukanye zingirakamaro.Ibi birimo kunoza imikorere yumubiri, kongera kuramba, no kugabanya ibimenyetso byo gusaza mu mwijima no mumitsi ya skeletale.
Abashakashatsi basanze kandi inyongera ya alpha-ketoglutarate yateje impinduka mu bikorwa bya gen zigira uruhare mu kubyara ingufu na metabolism.Ibi birerekana ko alpha-ketoglutarate ishobora kuvugurura ingirabuzimafatizo zishaje zongerera ubushobozi bwo gutanga ingufu no gusana ibyangiritse.
Usibye ingaruka zabyo kuri metabolism, alpha-ketoglutarate yerekanwe ko ifite izindi nyungu zitandukanye.Kurugero, nibibanziriza kubyara kolagen, igice cyingenzi cyuruhu nizindi ngingo zihuza.Ibi bivuze ko alpha-ketoglutarate ishobora gufasha kubungabunga imiterere nimikorere yuruhu, bifasha kuzamura isura yubusore.
Kalisiyumu ni minerval yingenzi igira uruhare runini mubikorwa byinshi byibinyabuzima mumubiri.Imwe mumikorere yayo itazwi cyane ni ingaruka zayo kuri alpha-ketoglutarate, igice cyingenzi cyinzira ya citricike.
Ubwa mbere, ni ngombwa kumva icyo alpha-ketoglutarate ikora mumubiri.Alpha-ketoglutarate ni uruvange ruri hagati ya acide citricike (izwi kandi nka Krebs cycle) kandi ishinzwe kubyara ingufu muburyo bwa adenosine triphosphate (ATP).Uku kuzunguruka kugaragara muri mitochondria ya selile kandi ni ingenzi cyane mu guhinduranya metabolisiyumu ya karubone, amavuta, na proteyine.Alpha-ketoglutarate igira uruhare mubikorwa byinshi bya biohimiki mumyanya ya acide citric, harimo no guhindura isocitrate kuri succinyl-CoA.
Ubushakashatsi bwerekana ko ion ion ya calcium igira uruhare runini mugutunganya ibikorwa byimisemburo igira uruhare mukuzunguruka aside citricike, harimo niyikorana na alpha-ketoglutarate.By'umwihariko, calcium ion igenga ibikorwa bya alpha-ketoglutarate dehydrogenase, itera ihinduka rya alpha-ketoglutarate na succinyl-CoA.Ibi bivuze ko kuba calcium igira ingaruka ku gipimo cya metabolism ya α-ketoglutarate muri cycle citric.
Byongeye kandi, calcium yasanze igira ingaruka kuri alpha-ketoglutarate mu mubiri.Ubushakashatsi bwerekanye ko kwiyongera kwa calcium yo mu nda itera kugabanuka kwa alfa-ketoglutarate, mugihe kugabanuka kurwego rwa calcium bigira ingaruka zinyuranye.Ibi birerekana isano iri hagati ya calcium na alpha-ketoglutarate, nuburyo ihindagurika ryurwego rwa calcium rigira ingaruka kuri metabolism yuru ruganda rukomeye.
Ingaruka za calcium kuri alpha-ketoglutarate irenze kure ya citric aside.Alpha-ketoglutarate nayo ibanziriza synthesis ya glutamate, ingirakamaro ya neurotransmitter muri sisitemu yo hagati.Ikimenyetso cya calcium cyabonetse kugirango kigenzure ibikorwa bya enzymes zigira uruhare mu gukora glutamate kuva alpha-ketoglutarate.Ibi birerekana ingaruka zimbitse za calcium kuriα-ketoglutarate metabolism, harimo uruhare rwayo muri neurotransmission.
1.Gusaza
Ca-AKG yerekanwe ko ifite ingaruka zo kurwanya gusaza kurwego rwa selire.Ubushakashatsi bumwe bwerekanye ko kuzuza Ca-AKG byatumye ibikorwa bya mitochondriya byiyongera, imbaraga za selile, bigabanuka uko imyaka igenda ishira.Mugushyigikira imikorere ya mitochondrial, Ca-AKG irashobora gufasha guteza imbere ubuzima bwimikorere no gukira, bishobora kugira ingaruka zikomeye mubuzima rusange hamwe nindwara ziterwa no gusaza.
Byongeye kandi, impapuro zo mu mwaka wa 2019 zasohotse mu kinyamakuru urungano rwasuzumwe n’urungano rwerekanye ko alpha-ketoglutarate ishobora kongera igihe cya nematode (izwi kandi ku nzoka) kandi ko uruganda rushobora kugabanya ibikorwa by’inzira ya mTOR.Kubuza mTOR bifitanye isano ninyungu nyinshi zubuzima. By'umwihariko, kubuza mTOR bigaragara ko biteza imbere kuramba no kugabanya ibyago byindwara ziterwa nimyaka byongera autofagy
2.Gutegeka Ingufu na Metabolism
Bumwe mu buryo bw'ingenzi Ca-AKG igira ku mbaraga no guhindagurika ni binyuze mu ruhare rwayo mu kuzunguruka aside aside.Uru ruzinduko rufite inshingano zo guhindura intungamubiri mu biribwa, nka karubone, amavuta, na poroteyine, muri adenosine triphosphate (ATP), isoko y'ibanze y'ingufu z'umubiri.Alpha-ketoglutarate nigice cyingenzi cyuru ruzinduko kuko igira uruhare runini muburyo bwo guhinduranya ibintu.Muguha umubiri isoko ya alpha-ketoglutarate muburyo bwa Ca-AKG, abantu batekereza ko abantu bashobora gushyigikira ibikorwa byabo bitanga ingufu, bikaba byazamura ingufu muri rusange hamwe na metabolism.
Byongeye kandi, ubushakashatsi bwerekana ko Ca-AKG ishobora kandi kugira antioxydeant, ishobora kurushaho gushyigikira uruhare rwayo mu kugenzura ingufu na metabolism.Guhangayikishwa na Oxidative bibaho mugihe habaye ubusumbane hagati yumusemburo wa radicals yubuntu nubushobozi bwumubiri bwo kurwanya ingaruka mbi zabo, kandi bifitanye isano nibibazo byinshi byubuzima, harimo nindwara ziterwa na metabolike.Mugukora nka antioxydeant, Ca-AKG irashobora gufasha kugabanya imihangayiko ya okiside, bityo igateza imbere ingufu zingirakamaro hamwe na metabolism.
3.Gutakaza ibiro byiza hamwe nubuyobozi
Ca-AKG nuburyo bwumunyu wa alpha-ketoglutarate, urufunguzo rwingenzi hagati ya acide citricike (izwi kandi nka cycle ya Krebs).Uru ruzinduko ni ingenzi cyane mu gukora adenosine triphosphate (ATP), inkomoko y'ingirabuzimafatizo zacu.Usibye uruhare rwayo mu gutanga ingufu, alpha-ketoglutarate inagira uruhare runini muri metabolism ya aside amine.
Ubushakashatsi bumwe bwerekana ko Ca-AKG ishobora no kugira ingaruka nziza ku myumvire ya insuline.Insuline ni imisemburo igira uruhare runini mu kugenzura isukari mu maraso no kubika ingufu mu mubiri.Mugushigikira insuline, Ca-AKG irashobora gufasha abantu gucunga neza isukari yamaraso no kugabanya ibyago byo kongera ibiro.
Ubushakashatsi bw’inyamaswa bwasohotse mu kinyamakuru Aging Cell bwerekana ko alpha-ketoglutarate ishobora kugabanya ibiro kandi igatera umubyibuho ukabije n’indwara.Ibyingenzi byingenzi birimo:
Ibinure birimo ibinure
Kunoza kwihanganira glucose
Kongera inyama zijimye zijimye (ibinure)
4.Gutegeka ingufu na metabolism
Kalisiyumu alpha-ketoglutarate yongerera ingufu ingufu murwego rwa selire.Mugushigikira inzinguzingu ya Krebs, Ca-AKG ifasha muguhindura intungamubiri muri ATP, selile yambere yingufu.
Byongeye kandi, calcium alpha ketoglutarate yerekanwe gushyigikira metabolism nziza.Metabolism bivuga inzira yimiti ikomeza ubuzima iba mumibiri yacu, kandi metabolism ikora neza ningirakamaro mugukora ingufu, gukura, no gusana.Ca-AKG ifasha kugenzura metabolisme iteza imbere gukoresha neza karubone, amavuta, na poroteyine, inkomoko y'ingirabuzimafatizo.
Usibye uruhare rwayo mukubyara ingufu no kugenzura metabolike, calcium alpha-ketoglutarate nayo ifite antioxydeant.Nka antioxydeant, Ca-AKG ifasha gutesha agaciro radicals yangiza yubusa, ishobora kwangiza selile kandi ikagira uruhare mubintu bitandukanye birimo guhagarika umutima, gutwika, no gusaza.Mugabanye kwangiza okiside, calcium alpha-ketoglutarate ishyigikira ubuzima bwimikorere muri rusange.
Kimwe mu bintu byingenzi ugomba gusuzuma muguhitamo inyongera ya Ca-AKG nubwiza bwibicuruzwa.Shakisha inyongera zakozwe nu ruganda ruzwi rukurikiza imikorere myiza yo gukora (GMP) kandi ni igice cya gatatu cyageragejwe kubwera nimbaraga.Ibi bizagufasha kubona ibicuruzwa byujuje ubuziranenge bitarimo umwanda kandi byujuje ibisabwa.
Ikindi gitekerezo cyingenzi muguhitamo inyongera ya Ca-AKG nuburyo bwinyongera.Ca-AKG iraboneka muburyo bwa powder na capsule, buriwese ufite ibyiza n'ibibi.Ifu yinyongera muri rusange byoroshye kwinjizwa numubiri kandi irashobora kuvangwa mubinyobwa cyangwa ibinyobwa byoroshye kugirango uyikoreshe neza.Kurundi ruhande, biroroshye kandi byoroshye gutwara.Mugihe uhisemo ifishi yinyongera ikubereye nziza, tekereza kubuzima bwawe nibyo ukunda.
Usibye ubuziranenge n'imiterere, ni ngombwa nanone gusuzuma igipimo n'ubunini bwa Ca-AKG mu nyongera.Shakisha ibicuruzwa bitanga urugero ruhagije rwa Ca-AKG kugirango uhuze ibyo ukeneye kugiti cyawe.Ni ngombwa kandi gutekereza ku kwibumbira hamwe kwa Ca-AKG mu nyongera - kwibanda cyane birashobora gusaba dosiye ntoya, bishobora korohereza abantu bamwe.
Byongeye kandi, ni ngombwa gusuzuma ibindi bintu byose byongeweho Ca-AKG.Inyongera zimwe zishobora kuba zuzuyemo ibyuzuza, ibintu birinda, cyangwa allergens ushobora kwirinda.Niba ufite allergie cyangwa imbogamizi zimirire, shakisha inyongera hamwe nibintu byongeweho bike kandi nta allergens isanzwe.
Hanyuma, tekereza ikiguzi nagaciro ka Ca-AKG.Mugihe bishobora kuba byoroshye guhitamo amahitamo ahendutse, ni ngombwa gusuzuma agaciro rusange kinyongera.Shakisha igicuruzwa gitanga ubuziranenge bwiza, bukomeye ku giciro cyiza.Reba ikiguzi kuri buri serivisi hamwe nagaciro rusange kinyongera ukurikije ubwiza, imiterere, dosiye, nibindi bikoresho.
Suzhou Myland Pharm & Nutrition Inc.yatangiye gukora ubucuruzi bwongera imirire kuva mu 1992. Nisosiyete ya mbere mu Bushinwa yateje imbere kandi igacuruza imbuto zinzabibu.
Hamwe nuburambe bwimyaka 30 kandi itwarwa nubuhanga buhanitse hamwe ningamba zinoze cyane R&D, isosiyete yateje imbere ibicuruzwa bitandukanye byapiganwa kandi ihinduka ubumenyi bwa siyanse yubuzima bushya, synthesis gakondo hamwe na serivise zikora inganda.
Byongeye kandi, isosiyete kandi ni uruganda rwanditswe na FDA, rwemeza ubuzima bwabantu bafite ireme rihamye kandi ryiterambere rirambye.Isosiyete R&D umutungo n'ibikoresho byo kubyaza umusaruro nibikoresho byisesengura nibigezweho kandi byinshi, kandi birashobora gukora imiti kuri miligarama kugeza kuri toni yubahiriza ibipimo bya ISO 9001 hamwe nuburyo bwo gukora GMP.
Ikibazo: Kalisiyumu Alpha Ketoglutarate ni iki?
Igisubizo: Kalisiyumu Alpha Ketoglutarate ninyongera ihuza calcium na acide alpha ketoglutaric, ikaba ari uruvange rufite uruhare runini mukubyara ingufu no guhinduranya intungamubiri mumubiri.
Ikibazo: Ni izihe nyungu zo gufata Kalisiyumu Alpha Ketoglutarate inyongera?
Igisubizo: Kalisiyumu Alpha Ketoglutarate inyongera zerekanwe zifasha ubuzima bwamagufwa, kuzamura imikorere yimitsi, kunoza imyitozo ngororamubiri, no guteza imbere ubuzima rusange nubuzima bwiza.
Ikibazo: Ese inyongera ya Kalisiyumu Alpha Ketoglutarate yagirira akamaro abakinnyi nabakunda imyitozo ngororamubiri?
Igisubizo: Yego, Kalisiyumu Alpha Ketoglutarate inyongera irashobora kunoza imikorere yimyitozo no kwihangana mukongera ingufu zingufu hamwe nintungamubiri zintungamubiri mumubiri.
Inshingano: Iyi ngingo ni iyamakuru rusange gusa kandi ntigomba gusobanurwa nkinama zose zubuvuzi.Amwe mumakuru yohereza amakuru aturuka kuri enterineti kandi ntabwo ari umwuga.Uru rubuga rufite inshingano zo gutondeka, gutunganya no guhindura ingingo.Intego yo gutanga amakuru menshi ntabwo bivuze ko wemera ibitekerezo byayo cyangwa kwemeza ukuri kwibirimo.Buri gihe ujye ubaza inzobere mu buzima mbere yo gukoresha inyongera cyangwa guhindura ibintu byubuzima bwawe.
Igihe cyo kohereza: Gashyantare-22-2024
