Dehydrozingerone ni bioactive compound iboneka muri ginger ikomoka kuri gingerol, ifumbire ya bioactive muri ginger ifite anti-inflammatory na antioxidant. Mugihe abantu bibanda kubuzima, dehydrozingerone biteganijwe ko izagira uruhare runini mugushiraho ejo hazaza h'intungamubiri ninyongera. Inyungu zinyuranye zubuzima nibishobora gukoreshwa bituma byongerwaho agaciro munganda, bigaha abaguzi inzira karemano kandi ifatika yo gushyigikira ubuzima n'imibereho myiza.
Igitoki kavukire mu turere dushyuha two mu majyepfo y’iburasirazuba bwa Aziya kandi ni kimwe mu bikoresho by’ibimera bizwi ko ari imiti kandi biribwa. Ntabwo ari ibintu byingenzi bya buri munsi kubantu, ahubwo bifite na antioxydeant, anti-inflammatory, antibacterial na antiseptic.
Zingerone nikintu cyingenzi kigize ginger kandi gishobora kubyara gingerol binyuze muburyo bwa reaction ya aldol mugihe ginger nshya ishyushye. Muri icyo gihe, zingiberone irashobora kandi kuba igice cyingenzi cya ginger, gifite ingaruka zitandukanye za farumasi, nka anti-inflammatory, antioxidant, hypolipidemic, anticancer nibikorwa bya antibacterial. Kubwibyo, usibye gukoreshwa nkibintu biryoha, zingiberone ifite kandi imiti myinshi yimiti kandi irashobora gukoreshwa muguhashya indwara zitandukanye zabantu ninyamaswa. Nubwo zingerone ishobora gukurwa mubikoresho fatizo byibimera bisanzwe cyangwa bigahuzwa nuburyo bwa chimique, synthesis ya mikorobe ninzira itanga icyizere cyo kugera kumusaruro urambye wa zingerone.
Dehydrozingerone (DHZ), kimwe mubintu byingenzi bigize ibice bya ginger, birashobora kuba umushoferi wingenzi inyuma yimicungire yuburemere bujyanye na ginger kandi bifitanye isano ya hafi na curcumin. DHZ yerekanwe gukora poroteyine ya AMP ikoreshwa na AMPK (AMPK), bityo ikagira uruhare mu ngaruka ziterwa no guhinduranya urugero nko kuzamura amaraso ya glucose mu maraso, kumva insuline, no gufata glucose.
Dehydrozingerone nimwe mubintu bishya bigera ku isoko, kandi bitandukanye na ginger cyangwa curcumin, DHZ irashobora kunoza cyane imyumvire no kumenya binyuze muri serotonergic na noradrenergic. Nibintu bisanzwe bya fenolike byakuwe muri ginger rhizome kandi mubisanzwe bizwi nkumutekano (GRAS) na FDA.
Ndetse igishimishije kurushaho, ubushakashatsi bumwe bwagereranije DHZ na curcumin kugirango hamenyekane iyari nziza mugukora AMPK. Ugereranije na curcumin, DHZ yerekana ubushobozi busa ariko birashoboka bioavailable. Curcumin ikoreshwa cyane cyane mubintu bikomeye birwanya antioxydeant, ifasha kuzamura ingaruka zo kurwanya inflammatory yibintu.
Ibintu byinshi bya dehydrozingerone bituma ikora ibintu byinshi hamwe nibishobora gukoreshwa mubice bitandukanye.Dehydrozingeroneifite ubushobozi bwo kuba ingirakamaro hamwe ningirakamaro zitandukanye zubuzima, kuva ku ntungamubiri kugeza kosmetika no kubika ibiryo. Byongeye kandi, ubushakashatsi burimo bukomeje kuvumbura uburyo bushya bushobora gukoreshwa kuri uru ruganda rushimishije, bikarushaho kwagura ingaruka zishobora kugira ku buzima bw’abantu n’imibereho myiza.
Dehydrozingerone, izwi kandi ku izina rya DZ, ikomoka kuri gingerol, ikomatanya bioaktike mu ginger ifite anti-inflammatory na antioxidant. Dehydrozingerone yagiye ikorerwa ubushakashatsi bwinshi ku nyungu zishobora kugira ku buzima, harimo kurwanya anti-inflammatory, antioxidant, na anti-kanseri.
Iyo ugereranije dehydrozingerone nibindi byongeweho, kimwe mubitandukaniro nyamukuru nuburyo bwihariye bwibikorwa. Bitandukanye nibindi byinshi byiyongera bigamije inzira cyangwa imikorere yihariye mumubiri, dehydrozingerone ikora ingaruka zayo binyuze munzira nyinshi, bigatuma iba inyongera kandi yuzuye kubuzima rusange nubuzima bwiza. Ubushobozi bwayo bwo guhindura inzira zitandukanye zerekana ibimenyetso no gukoresha antioxydeant itandukanya nibindi byongeweho bishobora kuba byibasiwe cyane.
Ikindi kintu cyingenzi tugomba gusuzuma ni bioavailable yayo. Bioavailability bivuga urugero nigipimo ikintu cyinjira mumaraso kandi kigakoreshwa ningingo zigenewe. Kubijyanye na dehydrozingerone, ubushakashatsi bwerekana ko ifite bioavailable nziza, bivuze ko ishobora kwinjizwa neza no gukoreshwa numubiri. Ibi biratandukanya nibindi byongeweho bifite bioavailable mbi, bigabanya imikorere yabyo.
Dehydrozingerone nayo igaragara iyo ugereranije nibindi byiyongera mugihe cyumutekano. Dehydrozingerone muri rusange yihanganirwa kandi ifite ibyago bike byingaruka mbi iyo ifashwe kumupanga.
Byongeye kandi, antioxydants ya dehydrozingerone ituma iba inshuti ikomeye mukurwanya stress ya okiside, ifitanye isano no gusaza n'indwara zitandukanye. Ubushobozi bwayo bwo gusibanganya radicals yubusa no kurinda selile kwangirika kwa okiside itandukanya nibindi byongeweho bishobora kuba bifite ubushobozi buke bwa antioxydeant. Mugukemura ikibazo cyo gutwika no guhagarika umutima, dehydrozingerone itanga uburyo bwuzuye bwo gushyigikira ubuzima rusange nubuzima bwiza.
1. Gucunga ibiro
Ubushakashatsi bwerekana ko igitoki gishobora kwihutisha igogorwa, kugabanya isesemi, no kongera kalori. Inyinshi murizo ngaruka ziterwa na ginger ya 6-gingerol.
6-Gingerol ikora PPAR (reseptor ya peroxisome prolifator-ikora), inzira ya metabolike yongerera imbaraga za caloric mugutezimbere ibara ryumubiri wa adipose yera (kubika amavuta).
Dehydrozingerone ifite ingaruka zikomeye zo kurwanya inflammatory (bisa na curcumin) ariko irashobora no gukumira ikwirakwizwa rya tissue ya adipose (ibinure)
Ubushakashatsi bwerekana ko ingaruka nziza za dehydrozingerone ziterwa ahanini nubushobozi bwayo bwo gukora adenosine monophosphate kinase (AMPK). AMPK ni enzyme igira uruhare runini muburyo bwo guhinduranya ingufu, cyane cyane karubone ndetse na lipide metabolism. Iyo AMPK ikora, itera ATP (adenosine triphosphate) -ibyara umusaruro, harimo okiside ya aside irike hamwe no gufata glucose, mugihe igabanya ibikorwa "kubika" ingufu nka lipide na synthesis.
Ntabwo ari ibanga ko kugirango ugabanye ibiro kandi ubirinde, imyitozo isanzwe, gusinzira bihagije, kurya indyo yuzuye kandi yuzuza indyo idafite ibiryo bitunganijwe, no gucunga amaganya nibintu byingenzi biganisha ku ntsinzi. Ariko, iyo ibyo bintu byose bimaze kuba, inyongera zirashobora kugufasha kwihutisha imbaraga zawe. Kuberako itera AMPK idakeneye imyitozo, irashobora kugabanya ibiro.
Nibyo, ibi ntibisobanura ko utagikeneye gukora ikaride cyangwa guterura ibiro, ariko wongeyeho urugero rwiza rwa dehydrozingerone birashobora gutuma umubiri wawe utwika amavuta menshi mugihe cyumunsi aho kuba utwitse amavuta menshi muri umwanya umara muri siporo.
2. Kunoza insuline
DHZ wasangaga ikora cyane ya fosifora ya AMPK kandi ikongerera glucose gufata ingirabuzimafatizo ya skeletale binyuze muri GLUT4. Mu bushakashatsi bumwe, imbeba zagaburiwe na DHZ zagize glucose nziza kandi zifata glucose iterwa na insuline, byerekana ko DHZ ishobora guteza imbere insuline - ikintu cyingenzi kigize metabolism ikora neza.
Kurwanya insuline bikunze kugaragara ku bantu bafite ibiro byinshi, umubyibuho ukabije cyangwa bafite ubuvuzi mbere. Ibi bivuze ko selile zawe zitagisubiza insuline, imisemburo irekurwa na pancreas ifasha kugabanya isukari mu maraso mu gutwara glucose mu ngirabuzimafatizo zawe. Muri ubu buryo, imitsi n'ibinure byuzuye "byuzuye" kandi banga kwakira imbaraga nyinshi.
Bumwe mu buryo bwiza bwo kunoza insuline ni imyitozo ikomeye, kurya indyo yuzuye proteine mu gihombo cya caloric (kugabanya karbone no kongera poroteyine ni bwo buryo bwiza), no gusinzira bihagije. Ariko ubu insuline yumutima irashobora kunozwa hiyongereyeho urugero rwa dehydrozingerone.
3. Impamvu zishobora kurwanya gusaza
Dehydrozingerone (DHZ) yerekana radicals yubusa kuruta ibicuruzwa bisa, kandi DHZ yerekana ibikorwa byingenzi bya hydroxyl radical scavenging. Hydroxyl radicals irakora cyane, cyane cyane kubijyanye n’umwanda uhumanya ikirere, kandi birasabwa kugenzura ibyo bintu byangiza cyane. Ubushakashatsi bumwe kandi bwerekanye ko kubuza lipide peroxidisation, yangiza uturemangingo (cyangwa "ibishishwa birinda") kandi bifitanye isano cyane n'indwara z'umutima-damura, akenshi ziterwa na acide ya omega-6 mu mafunguro meza ya kijyambere.
Umwuka umwe wa ogisijeni urashobora kwangiza ibinyabuzima byinshi kuko urira ADN, uburozi mu ngirabuzimafatizo, kandi bifitanye isano n'indwara zitandukanye. Dehydrozingerone irashobora gukuramo ogisijeni imwe rukumbi neza cyane cyane mugihe bioavailable ya DHZ ishobora gutanga imbaraga nyinshi. Byongeye kandi, ibikomoka kuri DHZ bifite antioxydeant, kandi ubundi bushakashatsi bwinshi bwabonye intsinzi mubushobozi bwayo bwo kurwanya radicals yubuntu. ROS gushakisha, kugabanya umuriro, kongera imbaraga za metabolike, no kongera imikorere ya mito-iyambere - “kurwanya gusaza.” Igice kinini cy "gusaza" gituruka kuri glycation nibicuruzwa byanyuma - cyane cyane ibyangijwe nisukari yamaraso.
4. Gushyigikira ubuzima bwamarangamutima no mumutwe
By'umwihariko, icyitonderwa ni sisitemu ya serotonergique na noradrenergique, byombi bifasha kubyara amine inganda zifasha kugenzura umubiri.
Ubushakashatsi bwahujije kugabanya imikorere ya sisitemu nibibazo byubuzima bwo mu mutwe nko kwiheba no guhangayika, bishobora guterwa no kubura serotonine ihagije na norepinephrine. Izi catecholamine zombi ziri mubintu byingenzi byangiza umubiri kandi bikoreshwa mugufasha kuringaniza imiti mubwonko. Iyo ubwonko budashobora kubyara bihagije ibyo bintu, ibintu biva muburyo bumwe kandi ubuzima bwo mumutwe burababara.
Ubushakashatsi bwerekanye ko DHZ ari ingirakamaro muri urwo rwego, bishoboka mu gukangurira sisitemu itanga catecholamine.
5. Irashobora kunoza uburyo bwo kwirinda indwara zitandukanye
Radikal yubusa ni molekile idahindagurika itera guhagarika umutima no kwangirika kwingirabuzimafatizo, biganisha ku gusaza n'indwara zitandukanye. Dehydrozingerone ni antioxydants ikomeye ikuraho radicals yubusa kandi ikarinda umubiri kwangirika kwa okiside.
Byongeye kandi, antioxydants yangiza ubwoko bwa ogisijeni ikora kandi igakomeza ubusugire bwa selile. [90] Uburyo bwinshi bwo kuvura kanseri nabwo bushingira ku mikurire yihuse ya selile kugira ngo bugire akamaro, ibyo bikaba bibujijwe no guhangayika cyane - gukoresha intwaro zabo bwite kubarwanya!
Ubundi bushakashatsi bwerekanye ko dehydrozingerone yagize ibikorwa bya antimutagenic mugihe selile E. coli yahuye nimirasire yangiza ya UV, hamwe ningaruka zikomeye zituruka kuri metabolite yacyo.
Hanyuma, dehydrozingerone yerekanwe ko ari ikintu gikomeye kibuza ibintu gukura / H2O2-iterwa na VSMC (imitsi itwara imitsi itwara imitsi), igira uruhare mu mikurire ya ateriyose.
Kuberako radicals yubusa ikusanyiriza hamwe muburyo bwa exogenous na endogenous, byangiza ubuzima bwingirabuzimafatizo. Iyo itagenzuwe, irashobora guteza akaduruvayo kandi ikangiza byinshi. Mu kurwanya imbaraga za okiside, dehydrozingerone irashobora kugira uruhare mubuzima rusange bwimikorere ya selile kandi igafasha uburyo bwo kwirinda umubiri.
Sarah numusore wimyaka 35 ukunda imyitozo ngororamubiri umaze imyaka myinshi ahanganye nububabare budakira. Amaze kwinjiza inyongera ya dehydrozingerone muri gahunda ye ya buri munsi, yabonye igabanuka rikabije ry’umuriro no kutamererwa neza. Yabisangiye agira ati: "Najyaga nishingikiriza ku kugabanya ububabare burenze urugero, ariko kuva natangira gufata dehydrozingerone, ubuzima bwanjye buhuriweho bwateye imbere ku buryo bugaragara. Ubu nshobora kwishimira imyitozo ntabangamiwe n'ububabare."
Mu buryo nk'ubwo, John ni umunyamwuga w'imyaka 40 umaze igihe kinini akemura ibibazo byigifu. Amaze kumenya inyungu zishobora guterwa na zingiberone kubuzima bwo munda, yahisemo kubigerageza. Agira ati: "Natangajwe cyane n'ingaruka nziza zagize ku igogora ryanjye. Sinkigira umubyimba no kutamererwa neza nyuma yo kurya, kandi ubuzima bwanjye bwo mu nda muri rusange bwateye imbere ku buryo bugaragara".
Izi nkuru zifatika zigaragaza inyungu nyinshi zo kuzuza dehydrozingerone. Kuva kugabanya ububabare bufatika kugeza gushyigikira ubuzima bwigifu, ibyabaye kuri Sarah na John byerekana ubushobozi bwuru ruganda rusanzwe rwo guteza imbere ubuzima bwiza nubuzima bwiza.
Usibye inyungu zumubiri, dehydrozingerone yanashimiwe ingaruka zishobora guterwa. Umunyeshuri Emily, 28, asangira ubunararibonye bwe akoresheje dehydrozingerone kugirango agumane umutwe kandi yibanze. "Nkumunyeshuri urangije, akenshi narwanaga no guhangayikishwa cyane n'umunaniro wo mu mutwe. Kuva natangira gufata dehydrozingerone, nabonye ko hari byinshi byahinduye mu mikorere yanjye yo kumenya. Ndumva ndushijeho kuba maso kandi nibanda cyane, ibyo bikaba byangiriye akamaro cyane mu myigire yanjye." ati.
Isuzuma ryabakoresha nyabo ryerekana ingaruka zinyuranye za dehydrozingerone kubuzima bwumubiri nubwenge. Byaba byongera umuvuduko uhuriweho, gushyigikira ubuzima bwigifu cyangwa guteza imbere imitekerereze, uburambe bwabantu nka Sarah, John na Emily butanga ubumenyi bwingenzi mubushobozi bwuru ruganda.
Ni ngombwa kumenya ko uburambe bwa buri muntu hamwe ninyongeramusaruro ya dehydrozingerone bushobora gutandukana kandi birasabwa kubaza inzobere mubuzima mbere yo kwinjiza ikindi kintu gishya mubikorwa byawe bya buri munsi. Nyamara, inkuru zingirakamaro zisangiwe nabakoresha nyabo zitanga urujijo ku nyungu zishobora guterwa na dehydrozingerone nubushobozi bwayo kugirango bigire ingaruka nziza mubuzima rusange no kumererwa neza.
1. Ubwishingizi bufite ireme
Kimwe mu bintu byingenzi bigomba kwitabwaho muguhitamo uruganda rwa dehydrozingerone ni ubwitange bwabo kubwiza no gutanga ibyemezo. Shakisha ababikora bubahiriza ingamba zikomeye zo kugenzura ubuziranenge kandi bafite ibyemezo bifatika nka ISO, GMP cyangwa HACCP. Izi mpamyabumenyi zerekana ko abayikora bakurikiza umusaruro mpuzamahanga nubuyobozi bufite ireme kugirango barebe ko dehydrozingerone bakora yujuje ibyangombwa bisabwa n’inganda.
2. Ubushakashatsi nubushobozi bwiterambere
Abakora bafite ubushobozi bukomeye bwa R&D barashobora gukora ubushakashatsi niterambere (R&D) kugirango batange ibisubizo bishya, uburyo bwihariye, hamwe niterambere ryibicuruzwa. Ibi nibyiza cyane cyane niba ufite ibisabwa byihariye cyangwa ukeneye uburyo bwihariye bwa dehydrozingerone kubicuruzwa byawe. Byongeye kandi, abakora bafite ubushobozi bwa R&D birashoboka cyane ko baza ku isonga ryiterambere ryinganda niterambere ryikoranabuhanga, bakwemeza kubona ibicuruzwa bigezweho, byiza cyane bya dehydrozingerone.
3. Ubushobozi bwumusaruro nubunini
Reba ubushobozi bwo gukora nubunini bwumushinga urimo gusuzuma. Ni ngombwa guhitamo uruganda rushobora guhuza ibyo ukeneye muri dehydrozingerone mugihe ushobora no kwagura umusaruro niba ibyo ukeneye byiyongera mugihe kizaza. Abahinguzi bafite ubushobozi bworoshye kandi bunini bwo gukora barashobora kwakira iterambere ryawe kandi bakemeza ko Dehydrozingerone itangwa, bikarinda guhungabanya ibikorwa byawe.
4. Kubahiriza amabwiriza ninyandiko
Iyo gushakisha dehydrozingerone, kubahiriza ibisabwa byubuyobozi ntabwo biganirwaho. Menya neza ko uwabikoze utekereza yubahiriza amabwiriza n'amabwiriza yose bijyanye no gukora no gukwirakwiza dehydrozingerone. Ibi birimo inyandiko ziboneye nkicyemezo cyisesengura, impapuro zumutekano wibikoresho hamwe ninyandiko zigenga. Gukorana nu ruganda rushyira imbere kubahiriza bizagufasha kwirinda ibibazo bishobora kuba byemewe namategeko.
5. Icyubahiro no gukurikirana inyandiko
Hanyuma, tekereza izina kandi ukurikirane inyandiko ya dehydrozingerone. Shakisha ababikora bafite amateka maremare yo gutanga ibicuruzwa byiza-byiza na serivisi nziza zabakiriya. Urashobora gukora ubushakashatsi ku izina ryabo usoma abakiriya, usaba ibyifuzo, kandi usuzume uburambe bwinganda. Abahinguzi bafite izina ryiza kandi banditse kwizerwa birashoboka cyane kuba umufatanyabikorwa wizewe kandi ufite agaciro kubyo kugura Dehydrozingerone.
Suzhou Myland Pharm & Nutrition Inc.Yatangiye gukora ubucuruzi bwongera imirire kuva mu 1992. Nisosiyete ya mbere mu Bushinwa yateje imbere kandi igacuruza imbuto zinzabibu.
Hamwe nuburambe bwimyaka 30 kandi itwarwa nubuhanga buhanitse hamwe ningamba zinoze cyane R&D, isosiyete yateje imbere ibicuruzwa bitandukanye byapiganwa kandi ihinduka ubumenyi bwa siyanse yubuzima bushya, synthesis gakondo hamwe na serivise zikora inganda.
Mubyongeyeho, Suzhou Myland Pharm & Nutrition Inc nayo ikora FDA yemewe. Ibikoresho bya sosiyete R&D, ibikoresho byububiko, nibikoresho byisesengura nibigezweho kandi bikora kandi birashobora gukora imiti kuva kuri miligarama kugeza kuri toni mubipimo, kandi ikubahiriza ibipimo bya ISO 9001 nibisobanuro byakozwe na GMP.
Ikibazo: Dehydrozingerone ni iki
Igisubizo: Dehydrozingerone igira uruhare mubikorwa byintungamubiri ninyongera mugukora nkibintu bisanzwe bioaktique ishobora gufasha mubikorwa bitandukanye byumubiri, harimo ubuzima bwumubiri ndetse no kurinda selile.
Ikibazo: Ni izihe nyungu zishobora kubaho mu gushyiramo dehydrozingerone mu nyongera?
Igisubizo: Harimo dehydrozingerone mubyongeweho birashobora gutanga inyungu zubuzima nko kugabanya imihangayiko ya okiside, gushyigikira ubuzima bufatanije, no guteza imbere ubuzima bwumutima. Irashobora kandi gufasha mugucunga umuriro no kunoza imiterere ya antioxydeant.
Ikibazo: Nigute abaguzi bashobora kwemeza ubuziranenge nubushobozi bwa dehydrozingerone irimo intungamubiri ninyongera?
Igisubizo: Abaguzi barashobora kwemeza ubuziranenge nubushobozi bwa dehydrozingerone irimo intungamubiri n’inyongera bahitamo ibicuruzwa biva mu nganda zizwi zubahiriza amahame akomeye yo kugenzura ubuziranenge kandi bigatanga amakuru mu mucyo yerekeye isoko n’umusaruro wabyo. Byongeye kandi, gushaka ibicuruzwa byakorewe ibizamini byabandi kugirango bigire isuku nimbaraga birashobora gufasha gukora neza.
Inshingano: Iyi ngingo ni iyamakuru rusange gusa kandi ntigomba gusobanurwa nkinama zose zubuvuzi. Amwe mumakuru yohereza amakuru aturuka kuri enterineti kandi ntabwo ari umwuga. Uru rubuga rufite inshingano zo gutondeka, gutunganya no guhindura ingingo. Intego yo gutanga amakuru menshi ntabwo bivuze ko wemera ibitekerezo byayo cyangwa kwemeza ukuri kwibirimo. Buri gihe ujye ubaza inzobere mu buzima mbere yo gukoresha inyongera cyangwa guhindura ibintu byubuzima bwawe.
Igihe cyo kohereza: Kanama-02-2024
