Nigute Glycerylphosphocholine ishobora kongera imbaraga zubwonko bwawe?

Glycerylphosphocholine (GPC, izwi kandi nka L-alpha-glycerylphosphorylcholine cyangwa alphacholine)ni isoko isanzwe ya choline iboneka mubiribwa bitandukanye (harimo n'amata yonsa) no muri selile zose zabantu Harimo choline nkeya. GPC ni molekile ikabura amazi yerekanwe ko ari isoko ikomeye ya choline ivura kuruta choline cyangwa fosifatiqueylcholine (PC) iva mu mirire cyangwa inyongera.

Ubusanzwe GPC yatanzwe neza kandi yinjijwe neza muri enterocytes muri glycerol-1-fosifate na choline. Nyuma yo gufata GPC, urugero rwa choline muri plasma rwazamutse vuba kandi rukomeza kuba hejuru mumasaha 10. Igipimo kinini cya plasma yibintu bya choline itera ubwikorezi bwayo bwambukiranya inzitizi yubwonko bwamaraso. Ibi byongera ububiko bwa choline muri neuron, aho bikoreshwa muguhuza PC na acetylcholine.

Mu buryo bwubaka, α-GPC ni choline ivanze na molekile ya glycerol ikoresheje itsinda rya fosifate, kandi ni choline irimo fosifolipide. Ibigize choline ni byinshi cyane, bingana na 40%, bivuze ko mg 1000 ya α-GPC ishobora kubyara mg 400 za choline yubusa.

Choline nintungamubiri zingenzi ziboneka mubikomoka ku mata n'amagi afasha ingirabuzimafatizo kubungabunga ibibondo. Choline ubwayo irakenewe no gukora acetylcholine. Mugihe alpha-GPC hamwe na choline nka fosifatiqueylcholine na lecithine bishobora guteza imbere umusaruro wa acetylcholine, alpha-GPC mubyukuri irarenze kuko lipide itanga mubyukuri byorohereza ingirabuzimafatizo, hejuru ya 90% ya fosifatiqueylcholine yakirwa nimiyoboro ya lymphatique; , mugihe α-GPC yinjizwa cyane numuyoboro wurubuga, bityo imikorere yo kwinjirira iba myinshi, bityo igateza imbere umusaruro wa acetyloline cyane neza. Acetylcholine ni neurotransmitter igira uruhare runini mugutunganya imikorere yubwonko no kugenzura imitsi. Nubwo dushobora kurya choline dukoresheje ibiryo, ingano ya acetyloline igabanuka uko imyaka igenda ishira.

Inyungu zubushakashatsi bushingiye kuri GPC

Imikorere y'ubwonko

• Itezimbere kwibuka, kwibanda hamwe nigihe cyo kwitwara mubantu bakuze nabato
• Guteza imbere umusaruro no kurekura acetylcholine (ACh) muri neurone ndetse nizindi selile.
• Irashobora kwishyura igabanuka rya ACh iterwa no gusaza, kubura estrogene (gucura, no gukoresha uburyo bwo kuboneza urubyaro)
• Kunoza imiterere ya EEG
• Yongera umusaruro wa dopamine, serotonine na GABA18.
• Kunoza imikorere ya mitochondrial mugihe cya ischemia / stress oxydeide
• Kurwanya igabanuka rishingiye kumyaka mumyanya yubwonko numubare wa reseptor ya ACh, imikorere yimitsi no gukora imisemburo ikura
• Guteza imbere imisemburo ikura mu basore n'abakuru
• Yongera okiside yibinure, imbaraga zimitsi nigihe cyo kubyitwaramo, birashoboka kuzamura uburinganire, cyane cyane kubantu bakuze.

Gusana ubwonko hamwe na Alzheimer's / Inkunga yo guta umutwe

• Itezimbere ubwonko nyuma yubwonko, gukomeretsa ubwonko, na anesthesia (mbere na nyuma yo kubagwa).
• Gusana inzitizi y'amaraso n'ubwonko yangijwe na hypertension
• Kunoza imyumvire n'imyitwarire mbonezamubano mu ndwara ya Alzheimer, imitsi y'amaraso / guta umutwe, n'indwara ya Parkinson.
• Kugabanya ubwonko bugabanuka nkindwara ya Alzheimer
• Birashobora kuba ingirakamaro mu ndwara zisaba gusana myelin na Duchenne muscular dystrofiya Choline imikorere ya metabolism yabantu na GPC

Imiterere yihariye nkisoko ikomeye ya choline, inyubako ya acetylcholine nibintu bitera synthesis hamwe nisohoka.

• Acetylcholine ni neurotransmitter mu bwonko na transducer yerekana ibimenyetso ahandi mu mubiri, bigira uruhare runini mu kugabanuka kw'imitsi, imiterere y'uruhu, umuvuduko wa gastrointestinal, n'indi mirimo ya tissue. Bitandukanye na choline / PC itangwa binyuze mumirire cyangwa inyongeramusaruro, inyongera ya GPC yerekanwe ko igira ingaruka zikomeye zo gukurura synthesis ya ACh no kurekurwa kwa selile cholinergique.

Kwiyongera kwa GPC bivamo kongera ibimenyetso bya cholinergique muri neuron nizindi selile zishobora kubyara acetylcholine. Ibi ni ingirakamaro cyane cyane iyo umubare nigikorwa cyiza cya cholinergic neuron bigabanutse kubera gusaza bisanzwe cyangwa inzira zitandukanye. Kwiyongera hamwe na GPC bifite ubushobozi bwo kwishyura igice cyibi byangiritse kuko bitera izamuka ryihuse rya plasma choline, bigira ingaruka zikomeye kuri enzymes hamwe nabatwara muriyi nzira.

Kubaka blok ya fosifatidyloline (PC)

• PC ni iyitwa fosifolipide kandi ni igice cyingenzi cyibice bigize selile na mitochondrial membrane. Ubushobozi bw'inyongera ya GPC mu gufasha gukira indwara ya stroke, kimwe no kurwanya igabanuka rishingiye ku myaka mu mubare w'abakira ACh mu ngirabuzimafatizo cyangwa mu bwonko, ni ikindi kimenyetso kigaragaza uruhare rwacyo mu kubungabunga imitsi ya neuronal binyuze muri synthesis ya PC.

Imiterere ya sphingomyelin

• Sphingomyelin ni kimwe mu bigize sheel ya myelin itwikira kandi ikingira neuron na nervice. Kubwibyo rero, inyongera ya GPC irashobora kuba ingirakamaro mubihe byose hamwe no gukenera gusanwa kwa myelin, nka neuropathie, sclerose nyinshi, nibindi bihe bijyanye na demyelination na autoimmunite ya tissue nervice. Gutwara ibinure muri selile no hanze

• PC irakenewe muguhindura no gusohora ibice bya VLDL. Triglyceride isiga umwijima mu bice bya VLDL, bisobanura impamvu kubura choline byongera ibyago byo kurwara umwijima. PC irashobora kuboneka mubisoko byibiribwa cyangwa inyongera; icyakora, PC ya fosifolipide na lipoproteine ​​ntabwo iboneka biturutse kuri PC yinjiye cyangwa yakozwe mbere. Ihinduranya kuva choline itandukanye (harimo na GPC), bityo rero gufata PC ntabwo byanze bikunze aribwo buryo bwiza bwo kongera pisine yumubiri.
Shyigikira intanga ngabo

• GPC nikintu cyingenzi muguhuza DHA (acide docosahexaenoic), gukora PC-DHA. Urusobe rwa DHA-PC rukoreshwa muburyo bwimikorere yingirabuzimafatizo nka retinal-sensing selile na sperm selile. DHA-PC yongerera membrane fluidity, ningirakamaro mumikorere yintanga nzima. Semen irimo kwibanda cyane kuri GPC; epididymal selile zihinga intanga ngabo zikurwa muri pisine ya GPC no guhuza PC-DHA. Urwego rwo hasi rwa GPC na PC-DHA mu masohoro rushobora kongera ibyago byo kugabanuka kwintanga ngabo.

Kugereranya GPC na Acetyl-L-Carnitine (ALCAR)

• Mu bushakashatsi bwakozwe ku barwayi bafite indwara ya Alzheimer yateye imbere, GPC yatumye habaho iterambere ryinshi mu bipimo byinshi by’imyororokere ugereranije na ALCAR. Mugihe ibyo bikoresho byombi bishyigikira kwiyongera kwa acetyloline, birashoboka ko hashobora kubaho ingaruka zoguhuza hagati yo kuzuza ibyo bice byombi, kuko GPC itanga choline mugihe ALCAR itanga acetyl kugirango ikomatanye acetylcholine.

Ibishobora gukorana hagati ya GPC nibiyobyabwenge. GPC inyongera ntabwo yatekerezwa kubangamira imiti iyo ari yo yose yagenewe kunoza imikorere yubwonko. Mubyukuri, kubera inyungu zayo munzira za cholinergique no kunoza imikorere ya selile ya neuronal selile, irashobora rwose kuzamura inyungu zabo. GPC irashobora kongera ingaruka za acetylcholinesterase AChE inhibitor kuko ishobora kongera urugero rwa ACh mugice cya synaptic, mugihe iyi miti itinda kwangirika kwayo.

Byongeye kandi, ukurikije ubushakashatsi bw’inyamaswa, GPC irashobora kongera umusaruro wa dopamine, serotonine, cyangwa GABA mu bwonko, kandi GPC irashobora kongera ingaruka ziterwa na reuptake inhibitor zaba neurotransmitter.

Suzhou Myland Pharm & Nutrition Inc.ni uruganda rwanditswe na FDA rutanga ifu ya Alpha GPC nziza kandi nziza.

Muri Pharm ya Suzhou Myland twiyemeje gutanga ibicuruzwa byiza cyane kubiciro byiza. Ifu yacu ya Alpha GPC irageragezwa cyane kugirango isukure nimbaraga, ikwemeza ko uzabona inyongera nziza-nziza ushobora kwizera. Waba ushaka gushyigikira ubuzima bwimikorere, kuzamura sisitemu yumubiri cyangwa kuzamura ubuzima muri rusange, ifu ya Alpha GPC niyo ihitamo neza.

Hamwe nuburambe bwimyaka 30 kandi itwarwa nubuhanga buhanitse hamwe nuburyo bunoze bwa R&D, Pharm ya Suzhou Myland Pharm yateje imbere ibicuruzwa bitandukanye byapiganiwe kandi ihinduka ubuzima bushya bwa siyanse yubuzima, synthèse progaramu na sosiyete ikora serivise.

Mubyongeyeho, Suzhou Myland Pharm nayo ikora FDA yemewe. Ibikoresho bya sosiyete R&D, ibikoresho byo kubyaza umusaruro, nibikoresho byisesengura nibigezweho kandi byinshi, kandi birashobora gukora imiti kuva kuri miligarama kugeza kuri toni mubipimo, kandi ikubahiriza ibipimo bya ISO 9001 nibisobanuro bya GMP.