Mwisi yintungamubiri, nicotinamide riboside chloride (NRC) yitabiriwe cyane ninyungu zishobora guteza imbere ubuzima bwimikorere no kuramba. Ariko, hamwe nisoko ryuzuyemo ibicuruzwa nibisobanuro, guhitamo ifu nziza ya NRC irashobora kuba ingorabahizi. Guhitamo nicotinamide ya riboside ya chloride ya chloride ubanza bisaba gutekereza neza kubwera, kubikora, ibitekerezo byabakiriya, nigiciro. Mugushira imbere ibi bintu, urashobora guhitamo ibicuruzwa bigenewe bifasha neza kandi neza umutekano wawe.
Nikotinamide riboside chloride nuburyo bwa chloride yumunyu wa nicotinamide riboside (NR). NR nigitabo cyitwa pyridine nucleoside ya vitamine B3 ikora nkibibanziriza nicotinamide adenine dinucleotide (NAD) cyangwa NAD +. Nikotinamide riboside chloride nuburyo bwa kristaline ya nicotinamide riboside (NR) chloride. Nikotinamide riboside chloride yongera urwego rwa NAD [+] kandi ikora SIRT1 na SIRT3, amaherezo ikazamura metabolisme ya okiside kandi ikarinda metabolike idasanzwe iterwa nimirire yuzuye amavuta. Nicotinamide riboside chloride ikoreshwa mubyokurya.
Nikotinamide riboside chloride nuburyo bukoreshwa mubyongeweho kandi ni verisiyo ihamye ya NR. Imiterere yumunyu wa chloride yongerera imbaraga na bioavailable ya NR, bigatuma inyongera zayo zikora neza. Nikotinamide Riboside Chloride ikorwa muburyo bwogukora kugirango habeho ubudahwema, ubuziranenge, nimbaraga zikomeye mubikorwa byayo n'umutekano.
NR nuburyo bwa vitamine B3 (niacin) nibibanzirizanicotinamide adenine dinucleotide (NAD +),urufunguzo rwa coenzyme ruboneka muri selile zose nzima kandi ni ngombwa mubuzima. Ni dinucleotide, bivuze ko igizwe nucleotide ebyiri zihujwe nitsinda rya fosifate. Nucleotide imwe irimo base ya adenine indi irimo nikotinamide. NAD + ni imwe muri molekile zitandukanye cyane mumubiri hamwe nigice cyingenzi cyubushakashatsi bwo gusaza.
NAD + ni lisansi kubikorwa byinshi byingenzi biologiya:
1. Hindura intungamubiri mu mbaraga
2. Gusana ibyangiritse kuri ADN
3. Shimangira sisitemu yo kwirwanaho
4. Tunganya injyana ya circadian
Kubwamahirwe, uko dusaza, urwego rwa NAD + rugabanuka, hasigara imbaraga nke mumikorere ya selile. Ibi birashobora gutera indwara zitandukanye ziterwa nimyaka nka diyabete,
Umubare wa NR uboneka mubisanzwe mubiribwa bimwe. Amata, umusemburo, nibindi biribwa birimo NR, ariko ugereranije ni bike. Kurugero, amata arimo NR, ariko ugomba gukoresha byinshi kugirango ugere kurwego rukoreshwa mubushakashatsi bwubuvuzi. Kubwibyo, nubwo NR ibaho bisanzwe, kubona NR nyinshi binyuze mumirire yonyine biragoye.
Bitewe ningorabahizi zo kubona NRC ihagije ivuye mubisanzwe, uburyo bwo guhuza NRC bwateguwe. Umusaruro wubukorikori wa NRC urimo urukurikirane rwimiti ihindura ibikoresho bitangira mubintu byifuzwa. Iyi nzira irashobora gutanga umusaruro uhagije wa NRC kubushakashatsi no kuzuza.
Nikotinamide riboside (NR) ni ubwoko bwa vitamine B3, izwi kandi nka niacin. Nibibanziriza nicotinamide adenine dinucleotide (NAD +), coenzyme igaragara mu ngirabuzimafatizo zose kandi ikagira uruhare runini mu guhinduranya ingufu no gusana ingirabuzimafatizo. uruhare rukomeye. Urwego rwa NAD + rusanzwe rugabanuka uko imyaka igenda ishira, bigatuma imikorere ya selile igabanuka ndetse nubwiyongere bwindwara ziterwa nimyaka. Nikotinamide riboside chloride nuburyo butajegajega bwa NR kandi bukunze gukoreshwa mubyokurya byongera ibiryo kugirango NAD + igabanuke mumubiri.
Kugabanuka kurwego rwa NAD + biranga gusaza kandi bifitanye isano nindwara zitandukanye ziterwa nimyaka, harimo indwara ziterwa na metabolike, indwara zifata ubwonko, nibibazo byumutima. Mu kongera urwego rwa NAD +, NRC ifite ubushobozi bwo kunoza imikorere ya selile no guteza imbere gusaza neza. Dore bumwe mu buryo bw'ingenzi NRC ishobora kugira ingaruka ku gusaza:
1. Kuzamura ingufu zingirabuzimafatizo: NAD + ningirakamaro mumikorere ya mitochondria, imbaraga zingirabuzimafatizo zitanga ingufu. Mu kongera urwego rwa NAD +, NR itezimbere imikorere ya mito-iyambere, bityo ikongera ingufu zingufu no kuzamura ubuzima bwimikorere.
2. Gusana ADN no kuyitaho: NAD + nikintu cyingenzi mubikorwa byo gusana ADN. Ikusanyirizo ryangirika rya ADN hamwe nimyaka irashobora gutera imikorere mibi ya selile no gutera indwara ziterwa nimyaka. Inyongera ya NR irashobora gushyigikira uburyo bwo gusana ADN, bifasha kubungabunga ituze no kugabanya ibyago byindwara.
3. Gukora Sirtuin: Sirtuins ni umuryango wa poroteyine zigira uruhare runini mugutunganya ubuzima bwimikorere nubuzima. NAD + irasabwa gukora Sirtuins, bityo igateza imbere gusana selile, kurwanya stress no kugenzura metabolike. Mugukomeza urwego rwa NAD +, NR irashobora kongera ibikorwa bya sirtuin no gushyigikira gusaza neza.
Ubushakashatsi bwibanze mubyitegererezo byinyamanswa byerekana ko inyongera ya NR ishobora kongera igihe cyo kubaho, kuzamura ubuzima bwimikorere, no kongera imikorere yubwenge. Ibigeragezo byamavuriro byabantu byerekanye ibisubizo bitanga icyizere, hamwe ninyongera ya NR yongera urwego rwa NAD +, kuzamura ibimenyetso byubuzima bwa metabolike, no kuzamura imikorere yumubiri.
Ubushakashatsi buzwi cyane bwasohotse mu kinyamakuru Cell Metabolism bwerekanye ko inyongera ya NR ku bantu bakuze yongereye cyane urwego rwa NAD + kandi inoza imikorere y'imitsi no kwihangana. Ubundi bushakashatsi bwasohotse muri Nature Communications bwatangaje ko inyongera ya NR yatezimbere imikorere yubwenge kandi igabanya ibimenyetso bya neuroinflammatory muburyo bwimbeba yindwara ya Alzheimer.
1. Guteza imbere ingufu zingirabuzimafatizo
Intandaro ya selile zacu ni mitochondriya, bakunze kwita "imbaraga" za selile. Izi ngirabuzimafatizo zifite inshingano zo gukora adenosine triphosphate (ATP), ifaranga ryibanze ryingirabuzimafatizo. Nikotinamide riboside chloride igira uruhare runini muriki gikorwa hongerwa urugero rwa nicotinamide adenine dinucleotide (NAD +), coenzyme ikenewe mumikorere ya mito-iyambere.
NAD +urwego rusanzwe rugabanuka uko dusaza, biganisha ku kugabanya ingufu zingirabuzimafatizo no kongera umunaniro. Kwiyongera hamwe na NRC bifasha kugarura urwego rwa NAD +, bityo bikazamura imikorere ya mitochondial no kuzamura umusaruro rusange muri rusange. Ibi bitezimbere imikorere yumubiri, bigabanya umunaniro kandi byongera ingufu.
2. Shigikira gusaza neza
Ubushakashatsi bwerekana ko gukomeza urwego rwiza rwa NAD + ari ingenzi kuramba nubuzima muri rusange. NAD + igira uruhare mubikorwa bitandukanye bya selile, harimo gusana ADN, imvugo ya gene, hamwe nibisubizo bya selile.
Mu kongera urwego rwa NAD +, NRC irashobora gufasha kurinda ingirangingo kwangirika, guteza imbere gusana ADN, no gushyigikira uburyo bwo kwirwanaho bwumubiri kugirango birinde kugabanuka kwimyaka. Ibi birashobora guteza imbere ubuzima bwuruhu, kugabanya ibimenyetso byubusaza, no kugabanya ibyago byindwara ziterwa nimyaka nkindwara ya Alzheimer na Parkinson.
3. Kongera imikorere yubwenge
Kugabanuka kwubwenge nikibazo gisanzwe uko dusaza, ariko nicotinamide riboside chloride irashobora gutanga igisubizo. NAD + ningirakamaro kubuzima bwubwonko kuko ishyigikira imikorere ya neuron, irinda neurodegeneration, kandi iteza imbere umusaruro wa neurotransmitter. Kwiyongera hamwe na NRC birashobora kunoza imikorere yubwenge, kongera kwibuka, no kwirinda kugabanuka kwimyaka. Mu kongera urwego rwa NAD +, NRC ifasha kubungabunga ubuzima n'imikorere y'utugingo ngengabuzima two mu bwonko, bityo bikazamura ubwonko bwo mu mutwe, kwibanda, hamwe n'imikorere rusange yo kumenya.
4. Guteza imbere ubuzima bwimikorere
Ubuzima bwa metabolike ni ikintu cyingenzi cyubuzima muri rusange, kandi nicotinamide riboside chloride byagaragaye ko igira ingaruka nziza kuri metabolism. NAD + igira uruhare muburyo butandukanye bwo guhinduranya, harimo glucose na lipide metabolism, sensulitivite ya insuline, hamwe nogukoresha ingufu. Kuzuza hamwe na NRC birashobora guteza imbere ubuzima bwa metabolike mukongera urwego rwa NAD +, bityo bikazamura imikorere yinzira nyamukuru ya metabolike. Ibi birashobora kunoza isukari mu maraso, kugabanya ibyago byindwara ziterwa na diyabete, kandi bigafasha gucunga neza ibiro.
5. Shigikira ubuzima bwumutima
Ubuzima bwumutima nimiyoboro nubundi buryo bwibanze kuri nicotinamide riboside chloride. NAD + igira uruhare runini mukubungabunga ubuzima nimikorere ya sisitemu yumutima nimiyoboro, harimo umutima nimiyoboro yamaraso. Kuzuza NRC birashobora guteza imbere ubuzima bwimitsi yumutima no kongera urwego rwa NAD +, rufasha kwirinda guhagarika umutima, gutwika, no kudakora neza kwa endoteliyale. Ibi bizamura amaraso, bigabanya ibyago byindwara zifata umutima, kandi bizamura ubuzima bwumutima muri rusange.
NRC ihindurwamo NAD + binyuze murukurikirane rwibinyabuzima. Iyi nzira irakora neza ugereranije nabandi NAD + ibanziriza nka niacin na nicotinamide. Ubushakashatsi bwerekana ko inyongera ya NRC ishobora kongera urwego rwa NAD +, bigatuma imikorere ya mito-iyambere itera imbere, kongera ingufu zingufu hamwe nuburyo bwiza bwo gusana selile.
Uburyo NR igereranya nibindi byiyongera
1. NR na Vitamine B3 Yinyongera
Imiti gakondo ya vitamine B3 nka niacin na niacinamide yakoreshejwe mu myaka ibarirwa muri za mirongo kugira ngo ifashe ubuzima bw'umutima n'imitsi ndetse na cholesterol nkeya. Ariko, bafite kandi ibibi bimwe. Kurugero, niacin irashobora gutera guhindagurika, ingaruka zisanzwe zirangwa no gutukura nubushyuhe bwuruhu. Ku rundi ruhande, Niacinamide, ntabwo itera guhindagurika, ariko ntigikora neza mukuzamura urwego rwa NAD + kurusha NRC.
NRC igaragara nkubundi buryo busumba ubundi bitewe nubushobozi bwayo bwo kuzamura neza urwego rwa NAD + bidateye ingaruka mbi zidahwitse zijyanye na niacin. Ibi bituma NRC ihitamo neza kubashaka inyungu za vitamine B3 nta nkomyi.
2. NR na Coenzyme Q10 (CoQ10)
Coenzyme Q10 (CoQ10) niyindi nyongera ikunzwe izwiho uruhare mukubyara ingufu hamwe na antioxydeant. Coenzyme Q10 ningirakamaro kumikorere ya mitochondria, imbaraga za selile. Mugihe inyongera ya CoQ10 ishobora gushyigikira ubuzima bwa mitochondial no kurwanya stress ya okiside, ntabwo bigira ingaruka muburyo bwa NAD +.
Ku rundi ruhande, NRC, yongera mu buryo butaziguye urwego rwa NAD +, bityo ikazamura imikorere ya mito-iyambere ndetse n’umusaruro w'ingufu. Mu kongera urwego rwa NAD +, NRC itanga uburyo bwuzuye kubuzima bwimikorere ningirabuzimafatizo kuruta CoQ10 yonyine.
3. NRC na Resveratrol
Resveratrol ni polifenol iboneka muri vino itukura, inzabibu n'imbuto zimwe. Azwiho kurwanya antioxydants na anti-inflammatory. Resveratrol irazwi cyane kubushobozi bwayo bwo gukora sirtuins, umuryango wa poroteyine zijyanye n'ubuzima bwa selile no kuramba. Nyamara, resveratrol ifite bioavailable nkeya ugereranije, bivuze ko agace gato gusa k’ibintu byinjiye byinjira kandi bigakoreshwa numubiri.
Mu kongera urwego rwa NAD +, NRC nayo ikora sirtuins, bityo igateza imbere inyungu zisa na resveratrol. Byongeye kandi, bioavailability ya NR iremeza ko igice kinini cyinyongera gikoreshwa neza numubiri, bigatuma kiba uburyo bwiza bwo gushyigikira ubuzima bwimikorere no kuramba.
4. NRC ninyongera ya Antioxydeant
Antioxidant inyongera nka vitamine C, vitamine E, na glutathione, ikoreshwa cyane mu kurwanya imihangayiko ya okiside no kurinda selile kwangirika. Nubwo iyi antioxydants igira uruhare runini muguhindura radicals yubuntu, ntabwo ikemura igabanuka ryibanze ryurwego rwa NAD + rujyanye no gusaza.
NRC ifite inyungu zidasanzwe zo kudashyigikira gusa kwirinda antioxydeant, ahubwo inongera urwego rwa NAD +, rukenewe mu gusana no kubungabunga. Mugukemura ibibazo bya okiside na NAD + kugabanuka,NRC itanga uburyo bwuzuye bwo guteza imbere ubuzima muri rusange no kuramba.
Impamvu ubuziranenge ari ngombwa
Imikorere yinyongera ya NRC biterwa ahanini nubwiza bwayo. Ibicuruzwa byujuje ubuziranenge birashobora kuba birimo umwanda, ntibigabanuke, cyangwa bifite imiti idahwitse igabanya inyungu zabo cyangwa bikangiza. Kubwibyo, gushora imari nziza ya nicotinamide riboside ya chloride ya chloride ni ngombwa kugirango ugere ku buzima bwiza wifuza.
Ibintu by'ingenzi ugomba gusuzuma
1. Ubuziranenge nubushobozi
Isuku ya Nikotinamide Riboside Ifu ya Chloride irakomeye. Shakisha ibicuruzwa bitanga laboratoire ya gatatu Icyemezo cyo gusesengura (CoA). Iyi nyandiko igenzura ubuziranenge nimbaraga zibicuruzwa, ikemeza ko irimo ingano ya NR kandi idafite umwanda wangiza. Byiza, ibikubiye muri NR bigomba kuba byibuze 98%.
2. Inkomoko nuburyo bwo gukora
Inkomoko y'ibikoresho fatizo hamwe nuburyo bwo gukora bukoreshwa burashobora kugira ingaruka zikomeye kumiterere ya nicotinamide riboside ya chloride. Hitamo ibicuruzwa biva mubatanga isoko bazwi kandi bikorerwa mubikoresho byubahiriza uburyo bwiza bwo gukora (GMP). Ibipimo ngenderwaho byemeza ko ibicuruzwa bikorerwa ahantu hasukuye, hagenzurwa bigabanya ibyago byo kwanduza.
3. Bioavailable
Bioavailability bivuga urugero nigipimo ibintu bifatika byinjizwa kandi bigakoreshwa numubiri. Nicotinamide riboside ya chloride ya chloride yagenewe kongera bioavailable, bigatuma ikora neza. Shakisha ibicuruzwa bikoresha sisitemu zo gutanga zigezweho, nka liposome encapsulation cyangwa tekinoroji irekura-kurekura, kugirango winjire cyane.
4. Ibyongeweho hamwe nuwuzuza
Inyongera nyinshi zirimo inyongeramusaruro nizuzuza zishobora kugabanya ibintu bikora cyangwa bigatera ingaruka mbi. Hitamo nicotinamide riboside ya chloride ifu ifite bike cyangwa nta nyongeramusaruro kugirango ubone ibicuruzwa byiza kandi byiza. Niba inyongeramusaruro zihari, zigomba gutondekwa neza kandi zifite umutekano zo kurya.
5. Kwamamaza ibirango no gusubiramo
Ikirangantego kirashobora gutanga ubushishozi bwubwiza bwibicuruzwa byacyo. Shakisha amateka yikimenyetso, isuzuma ryabakiriya, nimpamyabumenyi cyangwa ibihembo yakiriye. Ibitekerezo byiza kandi byemejwe ninzobere mu buzima zizewe nazo zerekana ko ibicuruzwa byizewe.
6. Igiciro n'agaciro
Mugihe igiciro kitagomba kuba ikintu cyonyine gifata umwanzuro, birashobora kuba ikimenyetso cyubwiza. Igiciro gito cyane cyifu ya reberi irashobora guhungabanya ubuziranenge nimbaraga. Gereranya ibiciro biva mubirango bizwi, urebye ikiguzi kuri serivisi hamwe nagaciro muri rusange. Gushora imari mu bicuruzwa bihenze cyane, byujuje ubuziranenge birashobora gutanga umusaruro mwiza mugihe kirekire.
Intambwe zifatika zo guhitamo ubuziranenge bwa Nikotinamide Riboside ya Chloride Ifu
Intambwe ya 1: Ubushakashatsi na Urutonde rugufi
Tangira ukora ubushakashatsi ku bicuruzwa bitandukanye bya NRC byifu. Kora urutonde rugufi rwibicuruzwa byujuje ibintu byingenzi byavuzwe haruguru. Koresha ibikoresho kumurongo nkihuriro ryubuzima, imbuga zisubiramo, ninama zinzobere kugirango ukusanye amakuru.
Intambwe ya 2: Kugenzura Ubuziranenge nubushobozi
Reba niba ibicuruzwa byatoranijwe bitanga CoA kuva muri laboratoire ya gatatu. Kugenzura ibiri muri NRC hanyuma urebe ko byujuje ubuziranenge bwa 98%. Irinde ibicuruzwa bidatangaza aya makuru.
Intambwe ya 3: Suzuma bioavailable
Shakisha ibicuruzwa bivuga bioavailability-yongera ibintu biranga. Iperereza kuri sisitemu yo gutanga ikoreshwa ningirakamaro. Niba bishoboka, hitamo formulaire zapimwe mubuvuzi kugirango zinjizwe neza.
Intambwe ya 4: Reba inyongeramusaruro
Reba urutonde rwibintu byose byongeweho bitari ngombwa cyangwa byuzuza. Menya neza ko ibicuruzwa birimo inyongeramusaruro nkeya cyangwa ntizongerewe kandi ko ibintu byose birimo bifite umutekano kandi byerekanwe neza.
Intambwe ya 5: Gereranya Ibiciro
Gereranya ibiciro kubicuruzwa byashyizwe ku rutonde, urebye ikiguzi kuri serivisi hamwe nagaciro muri rusange. Irinde amahitamo ahendutse cyane ashobora guhungabanya ubuziranenge. Hitamo ibicuruzwa byerekana uburinganire bwiza hagati yubuziranenge kandi buhendutse.
Suzhou Myland Pharm & Nutrition Inc ni uruganda rwanditswe na FDA rutanga ubuziranenge bwa nicotinamide riboside ya chloride ya chloride.
Muri Pharm ya Suzhou Myland twiyemeje gutanga ibicuruzwa byiza cyane kubiciro byiza. Igeragezwa cyane kugirango isukure nimbaraga, ifu ya Nicotinamide Riboside Chloride Powder niyo ihitamo neza waba ushaka gushyigikira ubuzima bwimikorere ya selile, kuzamura umubiri wawe, cyangwa kuzamura ubuzima muri rusange.
Hamwe nuburambe bwimyaka 30 kandi itwarwa nubuhanga buhanitse hamwe nuburyo bunoze bwa R&D, Pharm ya Suzhou Myland Pharm yateje imbere ibicuruzwa bitandukanye byapiganiwe kandi ihinduka ubuzima bushya bwa siyanse yubuzima, synthèse progaramu na sosiyete ikora serivise.
Mubyongeyeho, Suzhou Myland Pharm nayo ikora FDA yemewe. Ibikoresho bya sosiyete R&D, ibikoresho byububiko, nibikoresho byisesengura nibigezweho kandi bikora byinshi, kandi birashobora gukora imiti kuva kuri miligarama kugeza kuri toni mubipimo, kandi ikubahiriza ibipimo bya ISO 9001 nibisobanuro byakozwe na GMP.
Ikibazo: Ifu ya Nikotinamide Riboside Chloride ni iki?
Igisubizo: Nicotinamide riboside chloride (NRC) ni ubwoko bwa vitamine B3 imaze kumenyekana kubera inyungu zishobora guteza ubuzima, cyane cyane mu gushyigikira ingufu za selile na metabolism. NRC ikunze kugurishwa muburyo bwifu, bigatuma byoroha kubantu bakunda guhitamo dosiye zabo.
Ikibazo; Ni izihe nyungu za Nikotinamide Riboside Ifu ya Chloride?
Igisubizo: NRC yizwe kubushobozi bwayo bwo gushyigikira gusaza neza, kunoza imikorere ya mito-iyambere, no kongera kwihangana no gukora. Byizera kandi ko biteza imbere ubuzima bwumutima nimiyoboro yimikorere. Abakoresha benshi bavuga ko ingufu ziyongereye kandi muri rusange ubuzima bwiza nyuma yo kwinjiza NRC mubikorwa byabo bya buri munsi.
Ikibazo ； Nahitamo nte ifu nziza ya Nikotinamide Riboside ya Chloride Ifu?
Igisubizo: Iyo ugura ifu ya NRC, ni ngombwa gushyira imbere ubuziranenge nubuziranenge. Shakisha isoko ryiza ritanga ibizamini byabandi kugirango umenye neza ko ibicuruzwa bitanduye kandi byujuje ubuziranenge. Byongeye kandi, tekereza ku bintu nko gushakisha, inzira zo gukora, no gusuzuma abakiriya kugirango umenye ubuziranenge bwibicuruzwa.
Ikibazo: Ni he nshobora kugura ifu ya Nikotinamide Riboside ya Chloride?
Igisubizo: Ifu ya NRC iraboneka byoroshye kubacuruzi batandukanye kumurongo, mububiko bwibiryo byubuzima, no mumaduka yinyongera yihariye. Mugihe ugura NRC, shyira imbere abatanga isoko bazwi batanga amakuru yumucyo kubicuruzwa byabo, harimo gushakisha, kugerageza, no gufasha abakiriya.
Inshingano: Iyi ngingo ni iyamakuru rusange gusa kandi ntigomba gusobanurwa nkinama zose zubuvuzi. Amwe muma poste yamakuru aturuka kuri enterineti kandi ntabwo ari umwuga. Uru rubuga rufite inshingano zo gutondeka, gutunganya no guhindura ingingo. Intego yo gutanga amakuru menshi ntabwo bivuze ko wemera ibitekerezo byayo cyangwa kwemeza ukuri kwibirimo. Buri gihe ujye ubaza inzobere mu buzima mbere yo gukoresha inyongeramusaruro cyangwa guhindura ibintu byubuzima bwawe.
Igihe cyo kohereza: Nzeri-18-2024
