NR ni ubwoko bwa vitamine B3, igabanuka rya nicotinamide riboside, NRH, izwi cyane ku nyungu zishobora guteza ubuzima, harimo no gushyigikira ingufu za selile no guteza imbere gusaza neza. Mugihe ibyifuzo byinyongera bya NRH bikomeje kwiyongera, nibyingenzi kumva uburyo wahitamo inyongera ikubereye. Guhitamo ibyagabanijwe neza bya nicotinamide riboside kubyo ukeneye bisaba gutekereza neza kubwera, bioavailable, dosage, formulaire, ibintu byinganda nkizina ryubucuruzi nagaciro muri rusange. Mugushira imbere izi ngingo no gukora ubushakashatsi bunoze, urashobora guhitamo inyongera nziza ya NRH kugirango ushyigikire intego zubuzima nubuzima bwiza.
Nikotinamide riboside (NR) irimo kwitabwaho mu muryango w’ubuzima n’ubuzima bwiza kubera inyungu zishobora gutera mu gushyigikira ingufu z’ingirabuzimafatizo no kumererwa neza muri rusange. Nkibibanziriza nicotinamide adenine dinucleotide (NAD +), NR igira uruhare runini mubikorwa bitandukanye byibinyabuzima, harimo metabolism, gusana ADN, no kwerekana gene. Ariko, ubundi buryo bwa NR bwabaye amatsiko ninyungu: uburyo bwagabanutse.
None, ni ubuhe buryo bwagabanijwe bwa nikotinamide riboside? Bitandukaniye he nuburyo busanzwe? Reka tubishakire hamwe!
Nikotinamide riboside, izwi kandi ku izina rya NR, ni ubwoko bwa vitamine B3 yakozweho ubushakashatsi ku bushobozi ifite bwo gushyigikira ingufu z'ingirabuzimafatizo ndetse n'ubuzima bwa metabolike muri rusange. Nibibanziriza nicotinamide adenine dinucleotide (NAD +), coenzyme igira uruhare runini mubikorwa bitandukanye byibinyabuzima, harimo metabolism yingufu no gusana ADN. imvugo ya gene. Urwego rwa NAD + rugabanuka uko imyaka igenda ishira, kandi uku kugabanuka kwagiye guhura nibibazo bitandukanye byubuzima.
Kugabanuka kwa nicotinamide riboside, bakunze kwita NRH, ni inkomoko ya NR ikora inzira yo kugabanuka, bikavamo impinduka mumiterere yimiti. Iyi nzira yo kugabanya ikubiyemo kongeramo atome ya hydrogène kuri molekile ya NR, bikavamo impinduka mumiterere yayo n'ingaruka zishobora kubaho.
Imwe muntandukanyirizo nyamukuru hagati ya NR nuburyo bwagabanutse NRH iri mubishobora redox. Redox ishobora kuba ishaka kwerekana molekile yo kubona cyangwa gutakaza electron, nikintu cyibanze cyibikorwa bya biologiya. Kugabanuka kwa NR kuri NRH bihindura ubushobozi bwa redox, bishobora kugira ingaruka kubushobozi bwayo bwo kwitabira selile redox reaction no kwerekana inzira.
Ubushakashatsi bwibanze bwerekana ko NRH ishobora kwerekana antioxydeant kandi ishobora kugira uruhare mugutunganya selile redox.
Usibye ingaruka zishobora kurwanya antioxydeant, NRH irashobora no kugira ingaruka kuri metabolism yingufu za selile. Nkibikomoka kuri NR, NRH izwiho uruhare muri NAD + biosynthesis, aho ishobora gufasha kugumana urwego rwa NAD + no gushyigikira imikorere ya mito-iyambere. Mitochondria ni imbaraga zingirabuzimafatizo, ishinzwe kubyara ingufu nyinshi zingirabuzimafatizo muburyo bwa adenosine triphosphate (ATP). Mugushyigikira imikorere ya mitochondial, NRH irashobora kugira ingaruka mubikorwa rusange byingirabuzimafatizo hamwe nubuzima bwa metabolike.
Byongeye kandi, uburyo bwagabanijwe bwa nicotinamide riboside irashobora kugira ingaruka kumikorere ya selile yerekana inzira ya gene. NAD + ni coenzyme yingenzi igira uruhare mubikorwa bitandukanye byerekana ibimenyetso, harimo nibijyanye na sirtuins, umuryango wa poroteyine zijyanye no kuramba hamwe nubuzima bwa selile. Muguhindura urwego rwa NAD +, NRH irashobora guhindura ibikorwa bya sirtuin kandi igafasha kugenzura imikorere ya selile ijyanye no gusaza n'indwara ziterwa n'imyaka.
Uburyo bwagabanutse bwa nicotinamide riboside, bakunze kwita NRH, ni inkomoko ya NR kandi ni intangiriro ikomeye (NAD +), aho NRH iganisha kuri NAD + synthesis binyuze munzira nshya, yigenga ya NR. Iyi molekile igira uruhare runini muburyo butandukanye bwibinyabuzima, harimo ingufu za metabolism no gusana ADN. Mu myaka yashize, ubushakashatsi bwerekanye ko inyongera za NRH zishobora gutanga inyungu zitandukanye mubuzima.
NRH irashobora gushyigikira ingufu zingirabuzimafatizo. NAD + ningirakamaro muguhindura intungamubiri muri adenosine triphosphate (ATP), ifaranga ryibanze ryingirabuzimafatizo. Mugihe tugenda dusaza, urwego rwa NAD + rukunda kugabanuka, bigira ingaruka kumusaruro wingirabuzimafatizo no mumikorere rusange. Mu kuzuza NRH, abantu barashobora gushyigikira urwego rwa NAD + no guteza imbere imbaraga za metabolisme nziza, bishobora kuzamura ubuzima nubuzima muri rusange.
Usibye uruhare rwayo muri metabolism yingufu, NRH yakozweho ubushakashatsi ku ngaruka zishobora gutera ku gusaza no kugabanuka bijyanye n'imyaka. Ubushakashatsi bwerekana ko urwego rwa NAD + rugabanuka uko imyaka igenda ishira, kandi uku kugabanuka gufitanye isano nuburyo butandukanye bwo gusaza, harimo imikorere mibi ya mitochondrial na senescence. Mugushyigikira urwego rwa NAD +, inyongera za NRH zirashobora gufasha kugabanya zimwe mu ngaruka ziterwa no gusaza, bishobora guteza imbere gusaza neza no kuramba.
Byongeye kandi, NRH yakozweho ubushakashatsi ku ruhare rushoboka mu gushyigikira ubuzima bwumutima. NAD + igira uruhare runini mugukomeza imikorere yimitsi yamaraso no gushyigikira gutembera neza. Mugukomeza urwego rwa NAD +, NRH irashobora gufasha gushyigikira imikorere yumutima nimiyoboro yumutima kandi ikagira uruhare mubuzima rusange bwumutima.
Usibye uruhare rwayo muri metabolism yingufu no gusaza, NRH yanigishijwe ingaruka zishobora kugira kumikorere yubwenge. NAD + igira uruhare mubikorwa bitandukanye bijyanye n'ubuzima bw'ubwonko, harimo ibimenyetso bya neuronal no gusana ADN. Mugushigikira urwego rwa NAD +, inyongera ya NRH irashobora gufasha guteza imbere imikorere yubwenge no gushyigikira ubuzima bwubwonko muri rusange. Ibi byakuruye inyungu muri NRH nkinyongera ishobora kugabanuka kugabanya imyaka ijyanye no kugabanuka kwubwenge.
Kugabanya nicotinamide riboside (NRH)
NRH, uburyo bwa nikotinamide riboside yagabanutse, byagaragaye ko byongera urugero rwa NAD + mumubiri. Bifatwa nkibibanziriza NAD +, bivuze ko ihinduka NAD + iyo yinjiye mumubiri. NRH yitabiriwe ningaruka zishobora kurwanya kurwanya gusaza hamwe nubushobozi bwo gufasha gusaza neza. Ubushakashatsi bwerekana ko inyongera za NRh zishobora guteza imbere imikorere ya mitochondial, kongera kwihangana, no gushyigikira ubuzima rusange.
Ibisanzwe NAD +
Ibisanzwe NAD + inyongera, kurundi ruhande, itanga coenzyme kumubiri. Ubu buryo bwa NAD + bwizwe kubushobozi bwabwo bwo kunoza imikorere yubwenge, gushyigikira ubuzima bwimitsi yumutima, no guteza imbere gusaza neza. NAD + igira uruhare mubikorwa bitandukanye bya selile, kandi inyongera ya NAD + irashobora gufasha kugumana urwego rwiza mumubiri.
Ninde uruta ubuzima bwawe?
Mugihe cyo kumenya ubwoko bwa NAD + inyongera nibyiza kubuzima bwawe, bioavailability hamwe nibikorwa bya buri cyiciro bigomba kwitabwaho. NRH izwiho kuba bioavailable nyinshi, bivuze ko yakirwa byoroshye kandi igakoreshwa numubiri. Ubu ni amahitamo ashimishije kubantu bashaka kuzamura neza urwego rwa NAD +.
Ibisanzwe NAD + inyongera, kurundi ruhande, itanga coenzyme itaziguye, ikuraho ibikenewe guhinduka. Ibi birashobora guhinduka muburyo bworoshye kandi bunoze kubantu bashaka ubufasha kubibazo byihariye byubuzima, nkibikorwa byubwenge cyangwa ubuzima bwumutima.
Ni ngombwa kumenya ko buri muntu ashobora gusubiza mu buryo butandukanye inyongera za NAD +, kandi icyakora cyiza kumuntu umwe ntigishobora kuba kimwe kubandi. Ibintu nkimyaka, ubuzima muri rusange, nubuzima bwimibereho birashobora kugira ingaruka kumikorere yinyongera ya NAD +.
Inyungu Zishobora NAD + Inyongera
Byombi NRH hamwe ninyongera ya NAD + ifite inyungu zitandukanye mubuzima. Ibi bishobora kubamo:
●Shigikira gusaza neza
●Kongera imikorere ya mitochondrial
●Shyigikira ubuzima bwumutima
●Kunoza kwihangana nurwego rwingufu
●Guteza imbere ubuzima rusange
1. Ubuziranenge nubuziranenge
Iyo uhisemo ibicuruzwa, ni ngombwa gushyira imbere ubuziranenge nubuziranenge. Shakisha ibicuruzwa byagatatu byageragejwe kubwera nimbaraga. Ibi byemeza ko ibicuruzwa birimo urugero rwa NRH kandi bitarimo umwanda. Byongeye kandi, tekereza guhitamo ibicuruzwa bikozwe mu nganda zikurikiza uburyo bwiza bwo gukora (GMP) kugirango ubone ubuziranenge n'umutekano.
Ifishi ya NRH
NRH ije muburyo bwinshi, harimo capsules, ifu, namazi. Mugihe uhisemo imiterere yoroshye, tekereza kubyo ukunda hamwe nubuzima bwawe. Capsules iroroshye kujyana nawe, mugihe ifu namazi bishobora kuvangwa byoroshye mubinyobwa cyangwa ibiryo. Abantu bamwe bashobora kandi kugira ibyo bakunda bishingiye ku koroshya igogorwa cyangwa kugogorwa, tekereza rero muburyo bukwiranye nibyo ukeneye.
3. Ingano hamwe nibitekerezo
Ingano ya NRH hamwe nibitekerezo biratandukanye kubicuruzwa. Mugihe uhisemo igicuruzwa nikigero cyiza kuri wewe, ni ngombwa gusuzuma intego zubuzima bwawe bwite hamwe nibyifuzo byihariye byatanzwe ninzobere mubuzima bwawe. Abantu bamwe barashobora kungukirwa nubushakashatsi bwinshi bwa NRH, mugihe abandi bashobora guhitamo dosiye yo kubitaho. Witondere gukurikiza dosiye isabwa kurutonde rwibicuruzwa hanyuma uvugane nushinzwe ubuzima niba ufite ikibazo.
4. Bioavailable
Bioavailability bivuga ubushobozi bwumubiri bwo kwinjiza no gukoresha ikintu. Mugihe uhisemo ibicuruzwa bya NRH, tekereza kuri bioavailable ya form ya NRH irimo. Ibicuruzwa bimwe bishobora kuba birimo uburyo bwa NRH bwagenewe kunoza uburyo bwo kwinjiza. Shakisha ibicuruzwa bikoresha sisitemu yo gutanga ibikoresho cyangwa ibikoresho kugirango wongere bioavailability, ishobora kugwiza inyungu ziyongera kuri NRH.
5. Ibikoresho byongeweho
Ibicuruzwa bimwe bya NRH birashobora kuba birimo ibintu byongeweho kugirango byuzuze ingaruka za NRH cyangwa bitange inyungu zinyongera. Kurugero, ibicuruzwa bimwe bishobora kuba birimo izindi vitamine B cyangwa antioxydants kugirango zunganire ingufu nubuzima bwa selile. Ukurikije ubuzima bwawe bwite hamwe nintego zawe, tekereza niba wahitamo wenyine wenyine ibicuruzwa bya NRH cyangwa ibicuruzwa birimo ibintu byiyongera.
6. Kwamamaza ibicuruzwa no gukorera mu mucyo
Mugihe uhisemo ibicuruzwa bya NRH, suzuma ikirango cyamamare no gukorera mu mucyo. Shakisha ibigo bisobanutse kubyerekeye amasoko yabyo, uburyo bwo gukora, nuburyo bwo kugerageza. Byongeye kandi, tekereza gusoma ibyasuzumwe byabakiriya no gushaka inama kumasoko yizewe kugirango umenye izina ryikirango nibikorwa byibicuruzwa.
7. Igiciro n'agaciro
Mugihe igiciro kitagomba kuba ikintu cyonyine gifata umwanzuro, ni ngombwa gusuzuma agaciro rusange k'ibicuruzwa bya NRH. Gereranya ikiguzi kuri serivisi zitandukanye kugirango umenye amahitamo ahuye na bije yawe. Wibuke ko ibicuruzwa byiza bishobora gutanga ibintu byongeweho cyangwa byinshi bya NRH, bityo rero tekereza agaciro muri rusange ukurikije ibyo ukeneye nibyo ukunda.
Myland Pharm & Nutrition Inc. yatangiye gukora ubucuruzi bwongera imirire kuva mu 1992. Nisosiyete ya mbere mu Bushinwa yateje imbere kandi igacuruza imbuto zinzabibu.
Hamwe nuburambe bwimyaka 30 kandi itwarwa nubuhanga buhanitse hamwe ningamba zinoze cyane R&D, isosiyete yateje imbere ibicuruzwa bitandukanye byapiganwa kandi ihinduka ubumenyi bwa siyanse yubuzima bushya, synthesis gakondo hamwe na serivise zikora inganda.
Mubyongeyeho, Myland Pharm & Nutrition Inc nayo ikora FDA yanditswe. Ibikoresho bya R&D byikigo, ibikoresho byububiko, nibikoresho byisesengura nibigezweho kandi nibikorwa byinshi, kandi birashobora gukora imiti kuva kuri miligarama kugeza kuri toni mubipimo kandi ikubahiriza ibipimo bya ISO 9001 nibisobanuro bya GMP.
Ikibazo: Ni izihe nyungu zishobora guterwa no gufatanya n’uruganda rwifu rwa Palmitoylethanolamide (PEA)?
Igisubizo: Gufatanya n uruganda rwifu rwa PEA rwizewe rushobora gutanga inyungu nkibicuruzwa byujuje ubuziranenge, kubahiriza amabwiriza, gukora neza, hamwe na serivisi zizewe zabakiriya.
Ikibazo: Nigute izina ryuruganda rwifu rwa PEA rugira ingaruka kumyanzuro yo gufatanya nabo?
Igisubizo: Uruganda ruzwi rugaragaza kwizerwa, ubuziranenge bwibicuruzwa, no kunyurwa kwabakiriya, bigatuma biba ikintu cyingenzi mugikorwa cyo gufata ibyemezo.
Ikibazo: Nigute ubufatanye nuruganda rwa PEA rushobora kugira uruhare mubicuruzwa no kwizerwa?
Igisubizo: Gufatanya nuruganda ruzwi birashobora kwemeza ubuziranenge bwibicuruzwa byizewe kandi byizewe, byujuje ubuziranenge busabwa kugirango bikore neza n'umutekano.
Ikibazo: Ni ubuhe buryo bwo kubahiriza amabwiriza ugomba gusuzuma mugihe ukorana nuruganda rwa PEA?
Igisubizo: Kubahiriza ibipimo ngenderwaho, nko kwemeza FDA, kubahiriza amahame mpuzamahanga ya farumasi, hamwe nimpamyabumenyi zibishinzwe, ni ngombwa kugirango ibicuruzwa nibyemewe n’umutekano.
Inshingano: Iyi ngingo ni iyamakuru rusange gusa kandi ntigomba gusobanurwa nkinama zose zubuvuzi. Amwe muma poste yamakuru aturuka kuri enterineti kandi ntabwo ari umwuga. Uru rubuga rufite inshingano zo gutondeka, gutunganya no guhindura ingingo. Intego yo gutanga amakuru menshi ntabwo bivuze ko wemera ibitekerezo byayo cyangwa kwemeza ukuri kwibirimo. Buri gihe ujye ubaza inzobere mu buzima mbere yo gukoresha inyongeramusaruro cyangwa guhindura ibintu byubuzima bwawe.
Igihe cyo kohereza: Apr-22-2024
