Mu rwego rwa biohimiki na farumasi, Spermine (polyamine), nka biomolecule ikomeye, yitabiriwe n'abantu benshi kubera uruhare runini rwayo mu mikurire y’ingirabuzimafatizo, ikwirakwizwa ry’ibinyabuzima bitandukanye. Mugihe ubushakashatsi mubuzima, gusaza nimikorere ya selile bikomeje gutera imbere, icyifuzo cya Spermine gikomeje kwiyongera. Nyamara, hari isoko ryinshi rya Spermine ku isoko, nuburyo bwo kubona uruganda rwizewe rwa Spermine rwabaye umurimo wingenzi kubashakashatsi ninganda. Mugihe ushakisha uruganda rwizewe rwa Spermine, ni ngombwa guhitamo utanga isoko uzwi.Suzhou Mylandibaye ihitamo ryambere ryabashakashatsi benshi mubumenyi ninganda hamwe nibicuruzwa byayo bifite isuku nyinshi, inkunga ya tekiniki yumwuga nibiciro byapiganwa. Waba ukora ubushakashatsi bwibanze cyangwa iterambere ryiterambere, Suzhou Mailun Biotechnology irashobora kuguha Spermine nziza cyane kugirango igufashe mubushakashatsi bwawe bwa siyansi nurugendo rwo guhanga udushya. Iyo uhisemo Suzhou Myland, ntuzabona ibicuruzwa gusa, ahubwo uzabona umufatanyabikorwa wizewe.
Intanga ishyirwa mubikorwa nka polyamine, itsinda ryibintu kama birangwa no kuba hari amine menshi. Polyamine, harimo putrescine, spermidine, na spermine, ni ngombwa mu mikurire no mu mikorere. Bagira uruhare mubikorwa bitandukanye byibinyabuzima nko gukwirakwiza selile, gutandukanya, na apoptose. By'umwihariko, intanga ngabo ni umusaruro wo guhinduranya imisemburo ya spermidine, indi polyamine.
Spermine ni polyamine irimo amatsinda abiri ya amino hamwe nitsinda rya imino, rifite umurimo wingenzi wo guteza imbere ikwirakwizwa rya selile. Intanga ngabo, nk'urugingo ngengabuzima rufite uruhare runini mu binyabuzima, ibisobanuro byayo n'ibiranga ni ingingo y'ingenzi mu bijyanye na biyolojiya na shimi.
Iyi ngingo ntabwo yihariye mumiterere gusa, irimo amatsinda menshi ya amino na imino, ariko kandi igira uruhare runini mubikorwa byimiterere yibinyabuzima. Intanga ngabo ni kirisiti itagira ibara.
Ihonga byoroshye mumazi mubushyuhe busanzwe bwibidukikije, kandi iyo ihujwe, ikora igisubizo kiranga alkaline. Mu buryo bwa shimi, intanga ngabo zirekura oxyde ya azote iyo itwitswe, bisaba kwitabwaho cyane mugihe ikora no kubika intanga.
Muri vivo, inzira ya synthesis yinzira yintanga ikubiyemo inzira igoye yo guhindura enzymatique hagati ya putrescine (compound diamine yoroshye) na S-adenosylmethionine. Iyi nzira ikubiyemo ibinyabuzima bigoye cyane, byerekana itandukaniro nakamaro ka enzymes mubinyabuzima.
Intanga ngabo na spermidine biboneka hamwe muri bagiteri no mu ngirabuzimafatizo nyinshi, kandi byombi ni ibintu by'ingenzi mu buryo bwo gukwirakwiza ingirabuzimafatizo. Imwe mumikorere nyamukuru yibinyabuzima ya spermine ni uguteza imbere ingirabuzimafatizo. Intanga ngabo igira uruhare runini mugikorwa cyo kugabana ingirabuzimafatizo no gukura, cyane cyane muri ADN itajegajega hamwe na proteyine.
Irashobora kandi kwerekana imiterere ya polycationic mubihe bya acide, ituma intanga ngabo zihuza ADN, RNA nizindi molekile, bityo bikagira ingaruka kumikorere n'imiterere ya selile.
Duhereye ku miterere, intanga ngabo zishobora gufatwa nkibindi bikomoka kuri aside amine. Imiterere yacyo igoye ya tetraamine itanga ibikorwa byihariye byibinyabuzima nibikorwa byumubiri.
Mu byiciro bya biohimiki, intanga, putrescine, spermidine, nibindi byose bigize umuryango wa polyamine nyinshi ziboneka mubinyabuzima. Izi molekile zigira uruhare mukugenzura imiterere ya gene, kugenzura ingirabuzimafatizo, no kwitabira inzira zitandukanye zerekana ibimenyetso. uruhare rw'ingenzi.
Kubwibyo, intanga ntabwo ari molekile yoroshye gusa, ahubwo ni ikintu cyingenzi muburyo bwiza bwo kugenzura ubuzima. Ubushakashatsi bwabwo bukubiyemo ibintu byinshi bitandukanye nka biologiya ya biologiya, genetiki, na farumasi.
Autophagy ni iki?
Autophagy ni uburyo bwingenzi mu ngirabuzimafatizo zigumana imikorere isanzwe ya selile mu gutesha agaciro no gutunganya poroteyine na selile. Autophagy irashobora gukuraho ibintu byangiza muri selile, ifasha selile kurokoka ingorane, guteza imbere ubuzima bwakagari no kongera igihe cyo kubaho.
Uruhare rwa autophagy mukurwanya gusaza
Kuraho imyanda ya selile: Mugihe tugenda dusaza, proteine nyinshi na selile zangiritse birundanya muri selile. Ibi bintu byangiza birashobora kugira ingaruka kumikorere ya selile kandi biganisha ku gusaza n'indwara. Autophagy irashobora gutesha agaciro iyi myanda, kubungabunga ubuzima bwingirabuzimafatizo, no gutinda gusaza.
Komeza ubuzima bwa mitochondrial: Mitochondria ninganda zingufu zingirabuzimafatizo, kandi kugabanuka kwimikorere yabyo nimwe mumpamvu zingenzi zitera gusaza. Autophagy idindiza gusaza kwa selile muguhitamo guhitamo mitochondriya yangiritse, gukomeza imikorere ya mito-iyambere, no kugabanya umusaruro wubwoko bwa ogisijeni yangiza (ROS).
Guteza imbere ingirabuzimafatizo: Autophagy irashobora gutanga imbaraga zifasha selile kubaho mugihe intungamubiri ari nke. Byongeye kandi, autophagy iteza imbere no kwiyubaka kwingirangingo fatizo no kuvugurura ingirabuzimafatizo, bikomeza ubuzima bwumubiri.
Intanga: inducer naturel ya autophagy
Intanga ni polyamine ivanze mubisanzwe ibinyabuzima byose bitera autophagy. Ubushakashatsi bwerekanye ko intanga ngabo ziyongera zishobora kongera igihe mu binyabuzima bitandukanye, birimo umusemburo, nematode, isazi z'imbuto, n'imbeba.
Duteze imbere autophagy: Spermine itera autofagy muguhagarika acetyltransferase (nka EP300), bityo igahanagura ibintu byangiza ingirabuzimafatizo no kwirinda indwara ziterwa no gusaza.
Anti-inflammatory na antioxidant: Spermine ifite imiti irwanya inflammatory na antioxydeant, yongera imikorere ya metabolike ya mitochondriya, itera poroteyine homeostasis, kandi ikingira ubuzima bwa selile.
Kunoza imikorere yubudahangarwa: Intanga ngabo zirashobora gutuma habaho ingirabuzimafatizo T yibuka, ikarinda gusaza kwimikorere yumubiri, kandi ikongera indwara yumubiri.
ibyavuye mu bushakashatsi
Kongera igihe cyo kubaho: Kwiyongera kwintanga ngabo birashobora kwongerera cyane ubuzima bwibinyabuzima bitandukanye. Kurugero, kugaburira imbeba intanga zongereye igihe cyazo kandi byerekana ingaruka z'umutima na neuroprotective.
Kurinda Anticancer no kurinda umutima: Spermine yongerera imbaraga immunite igenzura hamwe ningaruka z'umutima utera autophagy. Imbeba, izi ngaruka ziratakara mugihe autophagy yabujijwe.
Kugabanya gucana no kunoza ubudahangarwa: Ubushakashatsi bwerekana ko intanga ngabo zishobora kugabanya ibisubizo byumuriro no kunoza imikorere yubudahangarwa bw'umubiri mu gutera imbaraga za selile T.
Nuburyo bukomeye bwo kurinda ingirabuzimafatizo, autophagy igira uruhare runini murwego rwo kurwanya gusaza. Intanga ngabo, nkibisanzwe bitera autofagy, igira ingaruka zikomeye mugutinda gusaza no kwirinda indwara zifitanye isano no guteza imbere autofagy, anti-inflammatory na antioxidant. Kongera intanga ngabo binyuze mumirire cyangwa kuzuza birashobora kuba ingamba zifatika zo gusaza neza.
1. Ubuzima bwakagari niterambere
Imwe mu nyungu nyamukuru zintanga ni uruhare rwayo mugutezimbere ubuzima bwimikorere no gukura. Intanga ngirakamaro mu gukwirakwiza selile no gutandukanya kandi ni ngombwa mu gusana ingirabuzima fatizo. Ihindura imiterere ya ADN na RNA kandi ikanakora imikorere isanzwe ya selile. Ibi ni ingenzi cyane murwego rwo gukira ibikomere no gukira ibikomere, aho bikenewe kugabana byihuse.
Byongeye kandi, intanga ngabo zerekanwe kurinda selile imbaraga za okiside, zishobora kwangiza ingirabuzimafatizo no gusaza. Mugutesha agaciro radicals yubuntu, intanga zifasha kugumana ubusugire bwimikorere nimikorere, bigira uruhare mubuzima rusange no kuramba.
2. Kurwanya gusaza
Mugihe tugenda dusaza, imibiri yacu igira impinduka zitandukanye, harimo kugabanuka kwa polyamine nka spermine. Ubushakashatsi bwerekana ko intanga ngabo zishobora kugira imiti irwanya gusaza, bigatuma yongerwaho agaciro mukuvura uruhu nibicuruzwa byiza. Ubushobozi bwayo bwo guteza imbere ingirabuzimafatizo no gusana birashobora gufasha kurwanya ibimenyetso bigaragara byo gusaza, nk'iminkanyari hamwe n'uruhu runyeganyega.
Byongeye kandi, antioxydants ya spermine igira uruhare runini mukugabanya stress ya okiside, igira uruhare runini mugusaza. Iyo winjije intanga muri gahunda yawe yo kwita ku ruhu, ntutezimbere gusa uruhu rwawe, ahubwo unashyigikira ubuzima bwarwo murwego rwa selile.
3. Inkunga ya sisitemu
Sisitemu ikomeye yubudahangarwa ningirakamaro kubuzima muri rusange, kandi intanga ngabo zishobora kugira uruhare mukuzamura imikorere yumubiri. Ubushakashatsi bwerekana ko intanga ngabo zishobora guhindura ubudahangarwa bw'umubiri kandi bigafasha umubiri kurushaho kwirinda indwara n'indwara. Byagaragaye ko bitera imbaraga ingirabuzimafatizo z'umubiri, nka lymphocytes, zifite uruhare runini mu kurwanya indwara ziterwa na virusi.
Byongeye kandi, intanga ngabo zirwanya inflammatory zirashobora gufasha kugabanya uburibwe budakira, bujyanye nibibazo bitandukanye byubuzima, harimo indwara ziterwa na autoimmune n'indwara zidakira. Mugushyigikira ubuzima bwumubiri, intanga zirashobora gufasha gushimangira ubushobozi bwumubiri bwo kurwanya indwara.
4. Ingaruka ya Neuroprotective
Ubwonko ni rumwe mu ngingo zigoye cyane mu mubiri w'umuntu, kandi kugira ubuzima bwiza ni ngombwa. Intanga ngabo zimaze kwitabwaho ningaruka za neuroprotective, zishobora gufasha kwirinda indwara zifata ubwonko. Ubushakashatsi bwerekana ko intanga ngabo zishobora kurinda neurone kwangirika kwatewe na stress ya okiside ndetse n’umuriro, byombi bikaba bifitanye isano n'indwara nka Alzheimer's na Parkinson.
Byongeye kandi, intanga ngabo zigira uruhare mu kwanduza imitsi, bigira ingaruka ku irekurwa rya neurotransmitter, zikenewe mu itumanaho hagati ya selile. Mugushyigikira ubuzima bwimikorere nimikorere, intanga zirashobora gufasha kunoza imikorere yubwenge no kugabanya ibyago byindwara zifata ubwonko.
Kubyerekeranye ninganda zikoreshwa mubikorwa, spermine ifite uburyo bwinshi bwo gusaba. Mbere na mbere, intanga ngabo ni intera ikomeye mu rwego rwa farumasi kandi ikoreshwa cyane mu miti irwanya kanseri ndetse n’imiti yumutima. Ingaruka nziza, umutekano n’umutekano birashimwa ninganda zimiti.
Icya kabiri, intanga ngabo ni anionic surfactant ifite emulisile nziza, kwinjira no kwanduza. Kubwibyo, ikoreshwa cyane munganda zikora imiti, imiti yica udukoko, fibre, gutunganya amabuye y'agaciro, amashanyarazi hamwe nizindi nzego, cyane cyane mu kwisiga, amenyo, amenyo, shampoo nibindi bicuruzwa. igira uruhare runini mu gukora.
Byongeye kandi, intanga ngabo zirashobora kandi gukoreshwa nkigihe cyo hagati y’imiti yica udukoko twangiza umubiri, bikarushaho kwaguka gukoreshwa mu nganda zica udukoko. Hanyuma, intanga, nkibintu byingenzi biteza imbere ingirabuzimafatizo, bikoreshwa no mubuhinzi. Irashobora kunoza kwinjiza no gukoresha neza intungamubiri kubihingwa, kandi byongera umusaruro nubwiza.
Mugihe ikoranabuhanga ryibinyabuzima, ubuzima bwubuvuzi, n’amasoko yita ku bantu bikomeje kwaguka, ibyifuzo byo gukoresha intanga ngabo nkibintu byingenzi ni byiza cyane. By'umwihariko mu bijyanye n'ubuvuzi, ubushobozi bwabwo mu bushakashatsi no kurwanya ibiyobyabwenge birwanya ibibyimba, kuvura ingirabuzimafatizo no kuvura indwara zikomoka ku ngirabuzima fatizo bikurura abashoramari benshi mu bushakashatsi mu bya siyansi n'ibikorwa byo guhanga udushya, byerekana ko bishobora kuba imbaraga zikomeye zo kuzamura inganda mu ahazaza.
Muri icyo gihe, intanga ngabo ziragenda zikoreshwa nk'ibikoresho byiza cyane byo gutunganya no gusana uruhu mu nganda zo kwisiga, bikagaragaza ko abakiriya bagenda bakunda ibicuruzwa byita ku ruhu karemano kandi bifite akamaro kanini, bigatuma intanga ngabo zikenerwa ku isoko ry’ibicuruzwa byiza byo mu rwego rwo hejuru.
Byongeye kandi, mu rwego rw’ubuhinzi, nubwo igabanuka ry’amasoko gakondo nka acephate, ubushakashatsi bw’intanga nk’umushinga mushya uteza imbere ibihingwa byangiza ibidukikije biteganijwe ko hazafungura inzira nshya y’ibikorwa by’ubuhinzi bw’icyatsi kandi bigasubiza isi ikenewe ku isi. ubuhinzi burambye. ibisubizo birakenewe byihutirwa.
Duhereye ku guhanga udushya mu ikoranabuhanga, iterambere rikomeje ry’ikoranabuhanga rya synthèse spermine hamwe no kugenzura ibiciro bizamura umusaruro no guhangana n’ibicuruzwa, kandi bizana iterambere ryagutse mu nganda. Hamwe n’inkunga yo mu rwego rwa politiki n’ubuyobozi ngenderwaho mu bijyanye n’ibinyabuzima n’ubuhinzi bw’icyatsi, hubatswe ibidukikije byiza byo hanze kugira ngo iterambere ry’inganda zitezimbere.
Mu rwego rwa biohimiki na farumasi, Spermine (polyamine), nka biomolecule ikomeye, yitabiriwe n'abantu benshi kubera uruhare runini rwayo mu mikurire y’ingirabuzimafatizo, ikwirakwizwa ry’ibinyabuzima bitandukanye. Mugihe ubushakashatsi mubuzima, gusaza nimikorere ya selile bikomeje gutera imbere, icyifuzo cya Spermine gikomeje kwiyongera. Nyamara, hari isoko ryinshi rya Spermine ku isoko, nuburyo bwo kubona uruganda rwizewe rwa Spermine rwabaye umurimo wingenzi kubashakashatsi ninganda.
Mu bakora Spermine benshi, Suzhou Myland igaragara neza kubera ibicuruzwa byiza na serivisi zumwuga. Spermine yatanzwe na Suzhou Myland ifite aCAS nimero ya 71-44-3 hamwe nubuziranenge burenga 98%.Ibicuruzwa bifite isuku nyinshi ntabwo byujuje ubuziranenge mpuzamahanga gusa, ahubwo binakorerwa ibizamini byujuje ubuziranenge kugirango buri cyiciro cyibicuruzwa bishobore gukenera ubushakashatsi bwa siyansi no gukoresha inganda.
1. Ubwishingizi bufite ireme
Suzhou Myland azi neza ko ubuziranenge bwibicuruzwa aribwo shingiro ryimishinga yo kubaho no kwiteza imbere. Isosiyete ifite ibikoresho bigezweho byo kubyaza umusaruro hamwe na sisitemu ihamye yo gucunga neza kugirango ibicuruzwa byose bya Spermine bigeragezwa kandi bigenzurwe. Yaba amasoko y'ibikoresho fatizo cyangwa buri kintu cyose cyakozwe, Suzhou Myland yihatira kugera ku ntera nziza kugira ngo ibicuruzwa byayo bisukure kandi byiza.
2. Inkunga yumwuga
Usibye gutanga Spermine yo mu rwego rwo hejuru, Suzhou Myland inaha abakiriya inkunga yubuhanga. Yaba ikoreshwa ryibicuruzwa, imiterere yububiko, cyangwa igishushanyo mbonera kijyanye nubushakashatsi, itsinda rya tekinike ryisosiyete irashobora guha abakiriya ubuyobozi nibisobanuro birambuye. Iyi serivisi yitonze ntabwo itezimbere abakiriya gusa, ahubwo inongerera abakiriya ikizere kubicuruzwa.
3. Igiciro cyo guhatanira
Mu rwego rwo kwemeza ubuziranenge bwibicuruzwa, Suzhou Myland yiyemeje kandi guha abakiriya ibiciro byapiganwa. Muguhindura uburyo bwo gukora no gucunga amasoko, isosiyete irashobora kugabanya neza ibiciro, bityo igasubiza ibiciro byoroheje kubakiriya. Ibi bifasha ibigo byinshi byubushakashatsi nubucuruzi kubona Spermine yujuje ubuziranenge ku giciro cyiza kandi biteza imbere ubushakashatsi bujyanye.
Kugura
Niba ushaka uruganda rwizewe rwa Spermine, Suzhou Myland ntagushidikanya ni amahitamo yizewe. Urashobora kubona amakuru menshi ukoresheje urubuga rwemewe rwisosiyete cyangwa ukabaza itsinda ryabacuruzi mu buryo butaziguye. Yaba ari ntoya yubushakashatsi bukenewe cyangwa ninganda nini zinganda, Suzhou Myland irashobora gutanga ibisubizo byoroshye ukurikije ibyo abakiriya bakeneye.
Ikibazo: Intanga ngabo ni iki, kandi iboneka he?
Igisubizo: Intanga ngabo ni ibinyabuzima bisanzwe biboneka muri selile zose. Iraboneka cyane cyane mubice byinshi mumyanya nkubwonko, umwijima, na prostate. Intanga ngabo zigira uruhare mubikorwa bitandukanye byibinyabuzima, harimo gukura kwa selile, gutandukanya, no guhagarika ADN.
Ikibazo: Nigute intanga ngabo zishobora kwinjizwa mumirire yanjye?
Igisubizo: Intanga zishobora kuboneka mubiribwa bitandukanye, cyane cyane muri:
Products Ibicuruzwa bisembuye (nka foromaje na soya)
Me Inyama zimwe (nk'inkoko n'inka)
Ifi
Ains Ibinyampeke byuzuye
Ibinyamisogwe
Byongeye kandi, inyongera zintanga ziraboneka kubashaka kongera ibyo bafata.
Ikibazo: Intanga ngabo zishobora kugirira akamaro ubuzima bwuruhu?
Igisubizo: Yego, intanga izwiho akamaro k'uruhu. Irashobora gufasha kunoza imiterere yuruhu, kugabanya isura yumurongo mwiza ninkinko, no guteza imbere uruhu rwuzuye. Imiterere ya antioxydeant nayo ifasha kurinda uruhu kwangirika kw ibidukikije, bigatuma iba ikintu gikunzwe mubicuruzwa byuruhu.
Inshingano: Iyi ngingo ni iyamakuru rusange gusa kandi ntigomba gusobanurwa nkinama zose zubuvuzi. Amwe muma poste yamakuru aturuka kuri enterineti kandi ntabwo ari umwuga. Uru rubuga rufite inshingano zo gutondeka, gutunganya no guhindura ingingo. Intego yo gutanga amakuru menshi ntabwo bivuze ko wemera ibitekerezo byayo cyangwa kwemeza ukuri kwibirimo. Buri gihe ujye ubaza inzobere mu buzima mbere yo gukoresha inyongeramusaruro cyangwa guhindura ibintu byubuzima bwawe.
Igihe cyo kohereza: Ukwakira-18-2024
