Mugihe dusaza, kubungabunga ubuzima bwacu muri rusange bigenda biba ngombwa. Ubushakashatsi bujyanye nabwo bwerekana ko nicotinamide riboside, ubwoko bwa vitamine B3, ishobora kurwanya gusaza kwa selile kandi igatera gusaza neza. Nikotinamide Riboside Usibye kuvugurura ingirabuzimafatizo zishaje, nicotinamide riboside irerekana kandi amasezerano yo kuzamura ubuzima muri rusange no kuramba. Ubushakashatsi bw’inyamaswa bwerekana ko inyongera za NR zishobora kongera igihe cyo kubaho no kuzamura ubuzima mu bihe bitandukanye bijyanye n’imyaka, harimo umubyibuho ukabije, indwara zifata umutima ndetse n’indwara zifata ubwonko.
Gusaza ninzira karemano ibinyabuzima byose bigenda. Nkabantu, imibiri yacu nibitekerezo byacu bigira impinduka nyinshi uko dusaza.
Impinduka zigaragara cyane ni izuruhu, hamwe n'iminkanyari, ibibara byimyaka, nibindi bigaragara. Byongeye kandi, imitsi iracika intege, amagufwa atakaza ubucucike, ingingo zikomera, kandi kugenda kwumuntu kugarukira.
Ikindi kintu cyingenzi cyo gusaza ni ibyago byiyongera byindwara zidakira nkindwara z'umutima, diyabete, na kanseri zimwe na zimwe. Byongeye kandi, kugabanuka kwubwenge nikindi kibazo gikunze kugaragara. Gutakaza kwibuka, ingorane zo kwibanda, no kugabanya imbaraga zo mumutwe birashobora kugira ingaruka mubuzima bwacu bwa buri munsi.
Benshi mu bakuze nabo bafite ibyiyumvo byo kwigunga, kwiheba, cyangwa guhangayika, cyane cyane iyo bahuye nibibazo byubuzima cyangwa babuze uwo bakundaga. Muri ibi bihe, ni ngombwa gushaka inkunga yumutima mumuryango, inshuti, ndetse nababigize umwuga.
Mugihe tudashobora guhagarika gusaza, hariho uburyo dushobora kubitindaho no gukomeza isura yubusore igihe kirekire. Kurwanya gusaza inyongera nimwe muburyo bwiza.
NAD + ni coenzyme y'ingenzi iboneka mu ngirabuzimafatizo zose. Igikorwa cyacyo nyamukuru ni uguteza imbere metabolism selile ifasha ihererekanyabubasha rya elegitoronike mubikorwa byinshi byibinyabuzima nko kubyara ingufu. Ariko, uko dusaza, urwego rwa NAD + mumibiri yacu rusanzwe rugabanuka. Ubushakashatsi bumwe bwerekana ko kugabanuka kurwego rwa NAD + bishobora kuba intandaro yo gusaza.
Kimwe mu bintu byingenzi byagaragaye mu bushakashatsi bwa NAD + ni ukuvumbura molekile ya NAD + ibanziriza nicotinamide riboside (NR). NR nuburyo bwa vitamine B3 ihinduka NAD + muri selile zacu. Ubushakashatsi bwinshi bwinyamanswa bwerekanye ibisubizo bitanga icyizere, byerekana ko inyongera ya NR ishobora kongera urwego rwa NAD + kandi bishobora guhindura imyaka igabanuka.
Indwara nyinshi zijyanye n'imyaka, nk'indwara zifata ubwonko ndetse n'imikorere mibi ya metabolike, zifitanye isano n'imikorere mibi ya mito-iyambere. Mitochondria nimbaraga zama selile yacu, ishinzwe kubyara ingufu. NAD + igira uruhare runini mugukomeza imikorere ya mito-iyambere. Mu kurinda ubuzima bwa mitochondial, NAD + ifite ubushobozi bwo kugabanya ibyago byindwara ziterwa nimyaka no kongera igihe cyo kubaho.
Mubyongeyeho, NAD + igira uruhare mubikorwa bya sirtuins, umuryango wa proteine zijyanye no kuramba. Sirtuins igenga uburyo butandukanye bwibinyabuzima, harimo gusana ADN, gusubiza ibibazo bya selile, no gutwika. NAD + ningirakamaro kumikorere ya Sirtuin, ikora nka coenzyme ikora ibikorwa byayo byimikorere. Mu kuzuza NAD + no kuzamura imikorere ya Sirtuin, dushobora gushobora gutinza gusaza no guteza imbere ubuzima no kuramba.
Ubushakashatsi bwinshi bwerekanye ko inyongera ya NAD + igira ingaruka nziza mubyitegererezo by'inyamaswa. Kurugero, ubushakashatsi bumwe bwimbeba bwerekanye ko kuzuza NR kunoza imikorere yimitsi no kwihangana. Ubundi bushakashatsi bwerekanye ko inyongera ya NR ishobora kongera imikorere ya metabolike mu mbeba zashaje, bigatuma isa niy'imbeba zikiri nto. Ubu bushakashatsi bwerekana ko inyongera ya NAD + ishobora kugira ingaruka nkizo mu bantu, nubwo hakenewe ubundi bushakashatsi.
Nikotinamide riboside. Irashobora guhindukaNAD + muri selile. Nkibibanziriza, NR yakirwa byoroshye kandi ikajyanwa mu ngirabuzimafatizo, aho ihinduka NAD + binyuze mu ruhererekane rw'imisemburo.
Ubushakashatsi bwiyongera bwa NR mubushakashatsi bwinyamaswa n’abantu bwerekanye ibisubizo bitanga icyizere. Imbeba, inyongera ya NR wasangaga yongera urwego rwa NAD + mubice bitandukanye no kunoza imikorere ya metabolike na mitochondrial.
NAD + igira uruhare mubikorwa bitandukanye bya selile bigabanuka uko imyaka igenda ishira, harimo gusana ADN, kubyara ingufu, no kugenzura imiterere ya gene. Biravugwa ko kuzuza urwego rwa NAD + hamwe na NR bishobora kugarura imikorere ya selile, bityo ubuzima bugatera imbere no kuramba.
Byongeye kandi, mu bushakashatsi bwakozwe ku bagabo bafite umubyibuho ukabije n'umubyibuho ukabije, inyongera ya NR yongereye urwego rwa NAD +, bityo bigatuma insuline ikomeza ndetse n'imikorere ya mito-iyambere. Ubu bushakashatsi bwerekana ko inyongera ya NR ishobora kuba ishobora gukoreshwa mu gukemura indwara ziterwa na diyabete yo mu bwoko bwa 2 n'umubyibuho ukabije.
1. Ibiribwa bisanzwe bya nicotinamide riboside
Imwe mu nkomoko ya NR ni ibikomoka ku mata. Ubushakashatsi bumwe bwerekanye ko ibikomoka ku mata birimo urugero rwa NR, cyane cyane amata akomezwa na NR. Nyamara, ibikubiye muri NR muri ibyo bicuruzwa ni bike kandi kubona amafaranga ahagije binyuze mu gufata indyo yonyine birashobora kugorana.
Usibye inkomoko yimirire, inyongera za NR ziraboneka muri capsule cyangwa ifu yifu. Izi nyongera akenshi zikomoka kumasoko karemano nkumusemburo cyangwa fermentation ya bagiteri. NR ikomoka ku musemburo muri rusange ifatwa nkisoko yizewe kandi irambye kuko ishobora kubyara umusaruro mwinshi udashingiye kumasoko yinyamaswa. Indwara ya bacteri NR nubundi buryo, akenshi buboneka muburyo bwihariye bwa bagiteri zisanzwe zitanga NR.
2. Ongeraho nicotinamide riboside
Isoko isanzwe kandi yizewe ya nicotinamide riboside ni inyongera yimirire. Inyongera za NR zitanga uburyo bworoshye kandi bunoze bwo kwemeza neza gufata neza uru ruganda. Muguhitamo inyongera nziza ya NR, ni ngombwa gusuzuma ibintu bikurikira:
a) Ubwishingizi Bwiza: Shakisha inyongera zakozwe namasosiyete azwi kandi ukurikiza amahame akomeye yo kugenzura ubuziranenge. Ibi bizagufasha kubona ibicuruzwa byujuje ubuziranenge bitarimo umwanda cyangwa umwanda.
b) Bioavailability: inyongera ya NR ikoresha sisitemu yo gutanga ibintu bigezweho nka encapsulation cyangwa tekinoroji ya liposome kugirango yongere bioavailable ya NR kugirango ishobore kwinjizwa neza no gukoreshwa numubiri. Hitamo ubu bwoko bwinyongera kugirango wongere inyungu ukura muri NR.
c) Isuku: Menya neza ko inyongera ya NR wahisemo ari nziza kandi nta nyongeramusaruro idakenewe, yuzuza cyangwa ibizigama. Gusoma ibirango no gusobanukirwa ibiyigize birashobora kugufasha gufata icyemezo cyuzuye.
1. Kongera ingufu zingirabuzimafatizo
NR igira uruhare runini mukubyara molekile ya nikotinamide ya adenine dinucleotide (NAD +). NAD + igira uruhare mubikorwa bitandukanye bya selile, harimo imbaraga za metabolism. Mugihe tugenda dusaza, urwego rwa NAD + mumibiri yacu rugabanuka, bigatuma umusaruro ugabanuka. Mugutezimbere synthesis ya NAD +, NR ifasha kuvugurura ingirabuzimafatizo no gukora ingufu nziza. Izi mbaraga zingirabuzimafatizo zongera ingufu, zitezimbere imikorere yumubiri, kandi zigabanya umunaniro.
2. Kurwanya gusaza no gusana ADN
Kugabanuka kurwego rwa NAD + bifitanye isano no gusaza n'indwara ziterwa n'imyaka. NR irashobora kongera urwego rwa NAD + mumubiri, bigatuma ishobora kurwanya anti-gusaza. NAD + igira uruhare muburyo bwo gusana ADN, igenzura ubusugire bwibintu byacu. Mugutezimbere gusana ADN, NR irashobora gufasha kwirinda kwangirika kwimyaka ADN no gushyigikira gusaza neza. Byongeye kandi, uruhare rwa NR mugukora sirtuins, icyiciro cya poroteyine zizwiho kugenga ubuzima bwimikorere nigihe cyimibereho, byongera imbaraga zo kurwanya gusaza.
3. Ubuzima bwumutima
Kubungabunga sisitemu nzima yumutima nimiyoboro ningirakamaro mubuzima rusange. Nikotinamide riboside yerekanye ingaruka zitanga ubuzima bwiza bwumutima. Ifasha imikorere ya selile endothelia selile, itera umuvuduko wamaraso kandi igabanya gucana. NR kandi itezimbere imikorere ya mitochondial mungirangingo z'umutima, ikarinda okiside itera imbaraga kandi ikanatanga umusaruro. Izi ngaruka zishobora gufasha kugabanya ibyago byindwara z'umutima-dameri nka aterosklerose no kunanirwa k'umutima.
4. Neuroprotection hamwe nibikorwa byubwenge
NR yerekanwe ko ifite imiterere ya neuroprotective, bigatuma ishobora kuba umufasha mukubungabunga ubuzima bwubwonko. Irashobora kugira ingaruka nziza kumikorere ya neuronal kandi ikarinda kugabanuka kumyaka. Mu kongera urwego rwa NAD +, NR ishyigikira imikorere ya mitochondial mungingo zubwonko, ikongerera ingufu ingufu kandi igatera gusana ingirabuzimafatizo. Gutezimbere imikorere ya mito-iyambere irashobora kongera ubushobozi bwubwenge nko kwibuka, kwibanda, hamwe no mumitekerereze rusange.
5. Gucunga ibiro hamwe nubuzima bwa metabolike
Kugumana uburemere bwiza nuburinganire bwa metabolike ningirakamaro kubuzima bwacu muri rusange. NR yahujwe ningaruka zingirakamaro kuri metabolism, bituma iba imfashanyo ishobora gucunga ibiro. NR ikora poroteyine yitwa Sirtuin 1 (SIRT1), igenga imikorere ya metabolike nka glucose metabolism no kubika amavuta. Mugukoresha SIRT1, NR irashobora gufasha kugabanya ibiro no kuzamura ubuzima bwa metabolike, bityo bikagabanya ibyago byindwara nkumubyibuho ukabije na diyabete yo mu bwoko bwa 2.
Ikibazo: Nikotinamide Riboside (NR) ni iki?
Igisubizo: Nikotinamide Riboside (NR) ibanziriza Nicotinamide Adenine Dinucleotide (NAD +), coenzyme igira uruhare runini mubikorwa bitandukanye byibinyabuzima, harimo kubyara ingufu no kugenzura imikorere ya metabolike na selile.
Ikibazo: Ese Nikotinamide Riboside (NR) ishobora kugirira akamaro metabolism?
Igisubizo: Yego, Nikotinamide Riboside (NR) yasanze yunguka metabolism. Mu kongera urwego rwa NAD +, NR irashobora gukora enzymes zimwe na zimwe zigira uruhare muri metabolism, nka sirtuins. Uku gukora gushobora kuzamura imikorere ya metabolike, kunoza insuline, no gushyigikira gucunga neza ibiro.
Inshingano: Iyi ngingo ni iyamakuru rusange gusa kandi ntigomba gusobanurwa nkinama zose zubuvuzi. Amwe muma poste yamakuru aturuka kuri enterineti kandi ntabwo ari umwuga. Uru rubuga rufite inshingano zo gutondeka, gutunganya no guhindura ingingo. Intego yo gutanga amakuru menshi ntabwo bivuze ko wemera ibitekerezo byayo cyangwa kwemeza ukuri kwibirimo. Buri gihe ujye ubaza inzobere mu buzima mbere yo gukoresha inyongeramusaruro cyangwa guhindura ibintu byubuzima bwawe.
Igihe cyo kohereza: Ugushyingo-13-2023
