Taurine ni micronutrient ya ngombwa na aside aminosulfonike nyinshi. Ikwirakwizwa cyane mubice bitandukanye no mumubiri. Bibaho cyane cyane muburyo bwubuntu mumazi yimbere hamwe namazi yo mu nda. Kuberako yabayeho bwa mbere Kwitwa Nyuma yo kuboneka muri ox bile. Taurine yongewe mubinyobwa bisanzwe bikora kugirango yuzuze ingufu kandi itezimbere umunaniro.
Vuba aha, ubushakashatsi kuri taurine bwasohotse mubinyamakuru bitatu byingenzi Science, Cell, na Kamere. Ubu bushakashatsi bwerekanye imikorere mishya ya taurine - kurwanya gusaza, kunoza ingaruka zo kuvura kanseri, no kurwanya umubyibuho ukabije.
Muri Kamena 2023, abashakashatsi bo mu kigo cy’igihugu gishinzwe ubudahangarwa mu Buhinde, kaminuza ya Columbiya muri Amerika, ndetse n’ibindi bigo basohoye impapuro mu kinyamakuru mpuzamahanga cy’ubumenyi cyitwa Science. Ubushakashatsi bwerekana ko kubura taurine ari umushoferi wo gusaza. Kuzuza taurine birashobora kugabanya gusaza kwa nematode, imbeba, ninguge, ndetse birashobora no kongera ubuzima bwiza bwimbeba zimaze imyaka hagati 12%. Ibisobanuro: Siyanse: Imbaraga zirenze ibitekerezo byawe! Taurine irashobora kandi guhindura gusaza no kongera igihe cyo kubaho?
Muri Mata 2024, Porofeseri Zhao Xiaodi, Umwarimu wungirije Lu Yuanyuan, Porofeseri Nie Yongzhan, na Porofeseri Wang Xin wo mu bitaro bya Xijing byo muri kaminuza ya kane y’ubuvuzi ya Gisirikare basohoye impapuro mu kinyamakuru mpuzamahanga cy’ubumenyi mpuzamahanga Cell. Ubu bushakashatsi bwerekanye ko uturemangingo tw’ibibyimba duhanganye na selile CD8 + T ya taurine mu gukabya gukabije gutwara transport ya taurine SLC6A6, itera urupfu rwa T na selile umunaniro, bigatuma habaho ubudahangarwa bw’umubiri w’ibibyimba, bityo bigatuma ibibyimba bitera imbere kandi bikongera kubaho, mu gihe kuzuza Taurine bishobora kongera gukora CD8 + T. no kunoza imikorere yo kuvura kanseri.
Ku ya 7 Kanama 2024, itsinda rya Jonathan Z. Long wo muri kaminuza ya Stanford (Dr. Wei Wei ni we mwanditsi wa mbere) ryasohoye urupapuro rw’ubushakashatsi rwiswe: PTER ni hydrolase ya N-acetyl taurine igenga kugaburira n'umubyibuho ukabije mu masomo mpuzamahanga akomeye. ikinyamakuru Kamere.
Ubu bushakashatsi bwavumbuye hydrolase ya mbere ya N-acetyl taurine y’inyamabere, PTER, kandi yemeza uruhare rukomeye rwa N-acetyl taurine mu kugabanya gufata ibiryo no kurwanya umubyibuho ukabije. Mugihe kizaza, birashoboka guteza imbere imbaraga za PTER inhibitor zo kuvura umubyibuho ukabije.
Taurine iboneka cyane mu nyama z’inyamabere no mu biribwa byinshi kandi iboneka cyane cyane mu myanya ishimishije nk'umutima, amaso, ubwonko, n'imitsi. Taurine yasobanuwe ko ifite imikorere ya selile na physiologique ya pleiotropique, cyane cyane mubijyanye na metabost homeostasis. Kugabanuka kwa genetike kurwego rwa taurine biganisha ku mitsi itagabanuka, ubushobozi bwimyitozo ngororamubiri, hamwe no gukora nabi kwa mitochondial mubice byinshi. Inyongera ya Taurine igabanya imitekerereze ya mitochondrial redox, yongerera ubushobozi imyitozo, kandi igabanya uburemere bwumubiri.
Ibinyabuzima na enzymologiya ya metabolism ya taurine byakuruye ubushakashatsi. Mu nzira ya endogenous taurine biosynthetic yinzira, cysteine ihindurwa na sisitemu ya dioxydejene (CDO) na sisitemu ya sulfinate decarboxylase (CSAD) kugirango itange hypotaurine, hanyuma Oxidation ikorwa na flavin monooxygenase 1 (FMO1) itanga taurine. Byongeye kandi, sisitemu irashobora kubyara hypotaurine ikoresheje ubundi buryo bwa sisitemu na dioxyde de cysteamine (ADO). Hasi ya taurine ubwayo ni metabolite ya kabiri ya taurine, harimo taurocholate, tauramidine, na N-acetyl taurine. Enzyme yonyine izwiho guhagarika izi nzira zo hepfo ni BAAT, ihuza taurine na bile acyl-CoA kugirango itange taurocholate nindi myunyu ngugu. Usibye BAAT, imiterere ya molekuline yindi misemburo ihuza metabolism ya kabiri ya taurine ntikiramenyekana.
N-acetyltaurine (N-acetyl taurine) nigishimishije cyane ariko cyize nabi metabolite ya kabiri ya taurine. Urwego rwa N-acetyl taurine mumazi yibinyabuzima bigengwa ningaruka ziterwa na physiologique nyinshi zongera taurine na / cyangwa acetate flux, harimo imyitozo yo kwihangana, kunywa inzoga, hamwe ninyongera ya taurine. Byongeye kandi, N-acetyltaurine ifite imiterere ihuriweho na marekile yerekana ibimenyetso birimo neurotransmitter acetylcholine hamwe na N-fatty acyltaurine yumunyururu muremure ugenga isukari yamaraso, byerekana ko ishobora no gukora nka metabolite yerekana ibimenyetso Igicuruzwa gikora. Nyamara, biosynthesis, gutesha agaciro, nibikorwa bishobora kuba bya N-acetyl taurine ntibisobanutse neza.
Muri ubu bushakashatsi buheruka, itsinda ry’ubushakashatsi ryerekanye PTER, enzyme yimfubyi yimirimo itazwi, nka hydrolase nini y’inyamabere N-acetyl taurine. Muri vitro, recombinant PTER yerekanye intera ntoya kandi ntarengwa. Muri N-acetyl taurine, iba hydrolyz muri taurine na acetate.
Kurandura gene ya Pter mu mbeba bivamo gutakaza burundu ibikorwa bya hydrolytike ya N-acetyl taurine muri tissue no kwiyongera kwa sisitemu ya N-acetyl taurine mubice bitandukanye.
Inzige ya PTER yumuntu ifitanye isano numubiri rusange (BMI). Itsinda ry’ubushakashatsi ryagaragaje kandi ko nyuma yo gukangurwa no kwiyongera kwa taurine, imbeba za Pter knockout zerekanye ko ibiryo byagabanutse kandi bikarwanya umubyibuho ukabije uterwa n’imirire. no kunoza glucose homeostasis. Kwiyongera kwa N-acetyl taurine ku mbeba zifite ubwoko bw’inyamanswa zifite umubyibuho ukabije nazo zagabanije gufata ibiryo nuburemere bwumubiri muburyo bushingiye kuri GFRAL.
Aya makuru ashyira PTER kumurongo wibanze wa enzyme ya taurine ya metabolism ya kabiri kandi ikagaragaza uruhare rwa PTER na N-acetyl taurine mukugenzura ibiro no kuringaniza ingufu.
Muri rusange, ubu bushakashatsi bwavumbuye hydrolase ya mbere ya acetyl taurine y’inyamabere, PTER, kandi yemeza uruhare rukomeye rwa acetyl taurine mu kugabanya ibiryo no kurwanya umubyibuho ukabije. Mu bihe biri imbere, biteganijwe ko hazashyirwaho ingufu za PTER inhibitor zikomeye kandi zihitamo kuvura umubyibuho ukabije.
Inshingano: Iyi ngingo ni iyamakuru rusange gusa kandi ntigomba gusobanurwa nkinama zose zubuvuzi. Amwe muma poste yamakuru aturuka kuri enterineti kandi ntabwo ari umwuga. Uru rubuga rufite inshingano zo gutondeka, gutunganya no guhindura ingingo. Intego yo gutanga amakuru menshi ntabwo bivuze ko wemera ibitekerezo byayo cyangwa kwemeza ukuri kwibirimo. Buri gihe ujye ubaza inzobere mu buzima mbere yo gukoresha inyongeramusaruro cyangwa guhindura ibintu byubuzima bwawe.
Igihe cyo kohereza: Kanama-12-2024
