Evodiamine ni uruganda rusanzwe ruboneka mu mbuto z’igihingwa cya Evodiamine, kavukire mu Bushinwa no mu bindi bihugu bya Aziya. Yakoreshejwe mubuvuzi gakondo bwabashinwa kubera ibinyejana byinshi. Muri byo, evodiamine ifite imbaraga nyinshi mu kurwanya umuriro no gufasha kugabanya ibiro. Imiti irwanya inflammatory ituma iba umukandida w'ingirakamaro mu kuvura indwara zitandukanye zanduza, mu gihe ubushobozi bwayo bwo kongera thermogenez no guteza imbere lipolysis bishobora gufasha mu gucunga ibiro.
Wigeze uhura nijambo "evodiamine" ukibaza icyo bivuze mubyukuri? Evodiamine, ikomoka ku gihingwa Evodiamine, ni uruganda rusanzwe rukomoka mu Bushinwa no mu bindi bihugu bya Aziya. Evodiamine ni mu cyiciro cya alkaloide izwi ku izina rya "quinazole alkaloide," ibivangwa mu mbuto zidahiye z'igihingwa kandi bizwiho imiti. Mu binyejana byashize, ubuvuzi gakondo bwabashinwa bwakoresheje imbaraga za evodiamine kugirango igabanye indwara zitandukanye.
Evodiamine izwiho imiterere ya thermogeneque, uburyo umubiri ubyara ubushyuhe, bushobora kongera umuvuduko wa metabolike no guteza imbere gutwika karori. Mu kongera thermogenezi, evodiamine irashobora gufasha gutwika amavuta no kugenzura ibiro.
Gutwika nigisubizo gisanzwe cyumubiri kubikomere cyangwa kwandura. Nyamara, gutwika karande bishobora gutera indwara zitandukanye. Mugabanya gucana, evodiamine irashobora gufasha kuzamura ubuzima muri rusange no kugabanya ibyago byindwara zimwe.
Evodiamine izwiho imiterere ya thermogenic. Thermogenezes bivuga inzira yo kubyara ubushyuhe mumubiri. Nigute evodiamine itanga ubushyuhe bwihariye?
Bumwe mu buryo evodiamine ikoresha ingaruka zayo ziterwa nubushyuhe ni ugukora proteine yitwa transient reseptor potential vanilloid subtype 1 (TRPV1). TRPV1 ni reseptor iboneka cyane cyane muri sisitemu y'imitsi kandi igira uruhare mukugenzura ubushyuhe bwumubiri na metabolism. Iyo evodiamine ihujwe na TRPV1, itera urukurikirane rwibisubizo byumubiri, harimo kongera ingufu hamwe na thermogenez.
Evodiamine yabonetse itera glande ya adrenal kurekura catecholamine nka epinephrine na norepinephrine. Catecholamine igira uruhare runini mu kongera lipolysis, kugabanuka kw'amavuta yabitswe muri aside irike yubusa ishobora gukoreshwa nkisoko yingufu. Ubu buryo buteza imbere ingaruka ziterwa na thermogenic ya evodiamine.
Byongeye kandi, evodiamine yerekanwe kubuza ibikorwa bya enzymes zimwe na zimwe zigira uruhare mu gukora no kubika ingirabuzimafatizo. Kurugero, irabuza imvugo ya peroxisome prolifator-ikora reseptor gamma (PPARγ), ikintu cyandikirwa gitera kwiyongera kwamavuta muri adipocytes. Muguhagarika ibikorwa bya PPARγ, evodiamine irashobora gufasha kwirinda gukora ingirabuzimafatizo nshya no kugabanya ububiko bwamavuta.
1. Gucunga ibiro
Imwe mu nyungu zizwi cyane za evodiamine nubushobozi bwayo nkimfashanyo yo gucunga ibiro bisanzwe. Ubushakashatsi bwerekana ko evodiamine ishobora gukurura "ubushyuhe" mu mibiri yacu, izwi nka reseptor transient reseptor vanilloid 1 (TRPV1). Mugukoresha ibyo byakira, evodiamine irashobora gufasha kongera thermogenezesi hamwe na okiside yibinure, bityo bigatuma metabolisme ishobora kugabanuka. Byongeye kandi, irabuza gukura kwama selile mashya, ikomeza gushyigikira imicungire yuburemere bwayo.
2. Kurwanya inflammatory
Indwara idakira ifitanye isano nibibazo bitandukanye byubuzima, harimo indwara zifata umutima, diabete, nibindi byinshi. Evodiamine ifatwa nkibishobora kurwanya anti-inflammatory bitewe nubushobozi bwayo bwo kubuza umusaruro wa molekile ziterwa na inflammatory. Ubushakashatsi bwinshi bwerekanye ko evodiamine ishobora guhagarika ibikorwa bya kirimbuzi-κB (NF-κB), ikintu cyingenzi cyo kwandukura kigenga imvugo ya gene itera. Muguhagarika NF-κB, evodiamine igabanya gucana mukugabanya umusaruro wa cytokine ikongora nka interleukin-1β (IL-1β) hamwe nikibyimba cya niyose-α (TNF-α).
3. Ibintu byo gusesengura no gusesengura
Ububabare, akenshi bujyana no gutwika, ni ikindi kimenyetso cyingenzi gishobora kugira ingaruka nziza mubuzima. Imiterere ya analgesic ya evodiamine yarizwe cyane, hamwe nibisubizo bishimishije. Ubushakashatsi bwerekana ko evodiamine ishobora gukora umuyoboro wigihe gito wa vanilloid 1 (TRPV1), igira uruhare mugukwirakwiza ibimenyetso byububabare. Mugukoresha iyo miyoboro, evodiamine irashobora guhagarika ububabare kandi igatanga ihumure kubantu bafite ububabare bwubwoko bwose, harimo ububabare bwa neuropathique nububabare.
4. Ubuzima bwumutima
Kubungabunga sisitemu nzima yumutima nimiyoboro ningirakamaro mubuzima rusange. Evodiamine yerekanwe ko ifite ingaruka nziza z'umutima-damura, nko kugabanya umuvuduko ukabije w'amaraso no kubuza guteranya platine. Mu koroshya imiyoboro yamaraso no kwirinda ko amaraso atabaho, evodiamine irashobora gufasha kunoza umuvuduko no kugabanya ibyago byindwara zifata umutima, harimo n'indwara z'umutima ndetse na stroke.
5. Gutera Ubuzima
Evodiamine irashobora kugira ingaruka nziza kubuzima bwo mu nda iteza imbere igogora no kugabanya indwara zifata igifu. Ubushakashatsi bwerekana ko evodiamine ishobora gutera ururenda rwimisemburo yimyunyungugu kandi igateza imbere amara, amaherezo igafasha igogora kandi ikagabanya uburibwe bwigifu. Byongeye kandi, evodiamine ishobora kuba ishobora kurwanya mikorobe irashobora gufasha kurwanya bagiteri zangiza no guteza mikorobe nziza.
Evodiamine yitiriwe imwe mu nkomoko nyamukuru y’ibimera, Evodia rutaecarpa, bakunze kwita imbuto za Evodiya cyangwa Evodia rutaecarpa. Iki kimera kavukire muri Aziya y Uburasirazuba kandi kimaze ibinyejana byinshi gikoreshwa mubuvuzi gakondo bwabashinwa. Imbuto zidahiye ku gihingwa cya Evodia karota nisoko nyamukuru ya evodiamine. Iki gitangaza cyibimera kirimo alkaloide nyinshi, harimo na evodiamine, yerekanye ingaruka nziza kubuzima.
Andi masoko y'ibimera
Usibye Evodiamine, evodiamine iboneka muyandi masoko menshi y'ibimera. Harimo macrophylla ya Alstonia, Evodia lepta na Euodia lepta, nibindi. Ibimera bikomoka mu bice bitandukanye bya Aziya, harimo Ubushinwa, Ubuyapani, na Tayilande.
Igishimishije, ayo masoko y'ibimera ntagarukira gusa kubice bimwe byigihingwa. Mu gihe imbuto zidahiye ari isoko y'ibanze, evodiamine irashobora kandi gukurwa mu mababi, ku giti, no mu mizi y'ibi bimera. Ubu buryo butandukanye butanga abashakashatsi naba siyanse amahirwe menshi yo gucukumbura inyungu zitandukanye zubuzima hamwe nogukoresha evodiamine.
●Igipimo cyiza: Igipimo gikwiye cya evodiamine biterwa nimpamvu nyinshi nkimyaka yumukoresha, ubuzima, nibindi bihe byinshi. Wibuke ko ibicuruzwa bisanzwe bidahorana umutekano, nibibazo bya dosiye. Ni ngombwa gusoma ibirango byibicuruzwa witonze kandi ukabaza umuganga wubuzima kugirango umenye dosiye ijyanye nibyo ukeneye kugiti cyawe.
●Ibitekerezo byubuzima bwite: Mugihe uhisemo gukoresha inyongeramusaruro zose, harimo na evodiamine, ni ngombwa gusuzuma ubuzima bwumuntu muri rusange, amateka yubuvuzi, no kwihanganira umuntu. Byongeye kandi, menya imikoranire ishoboka yibiyobyabwenge kandi uzirikane kubintu byubuzima bwawe kugirango ugabanye inyungu za evodiamine mugihe ugabanya ingaruka zose ziterwa nayo.
Ikibazo: Nigute evodiamine icunga umuriro?
Igisubizo: Evodiamine yasanze ifite imiti igabanya ubukana. Irabuza ibikorwa bya molekile zimwe na zimwe zitwika, nka nucleaire-kappa B (NF-kB) na cyclooxygenase-2 (COX-2), bigira uruhare runini mugutwika. Mugabanye umusaruro wa molekile, evodiamine ifasha kugabanya uburibwe mumubiri.
Ikibazo: Ese evodiamine irashobora gukoreshwa mugutakaza ibiro?
Igisubizo: Evodiamine yakozweho ubushakashatsi ku ngaruka zishobora guterwa no kugabanya ibiro. Byizerwa gukora inzira yitwa thermogenezesi, byongera ubushyuhe bwibanze bwumubiri nigipimo cya metabolike. Ibi na byo, bishobora kongera amafaranga ya calorie hamwe nugufasha kugabanya ibiro. Nyamara, ubushakashatsi burakenewe kugirango hamenyekane imikorere n'umutekano bya evodiamine kugirango ugabanye ibiro.
Inshingano: Iyi ngingo ni iyamakuru rusange gusa kandi ntigomba gusobanurwa nkinama zose zubuvuzi. Amwe muma poste yamakuru aturuka kuri enterineti kandi ntabwo ari umwuga. Uru rubuga rufite inshingano zo gutondeka, gutunganya no guhindura ingingo. Intego yo gutanga amakuru menshi ntabwo bivuze ko wemera ibitekerezo byayo cyangwa kwemeza ukuri kwibirimo. Buri gihe ujye ubaza inzobere mu buzima mbere yo gukoresha inyongeramusaruro cyangwa guhindura ibintu byubuzima bwawe.
Igihe cyo kohereza: Nzeri-26-2023
