Palmitoylethanolamide ni endogenous fatty acide amide iri murwego rwibintu bya kirimbuzi agoniste. Nibimwe mubintu byingenzi bya endogenous analgesic na anti-inflammatory byagaragaye ko bifite akamaro atari mububabare bukabije ariko no kubabara karande. Nkigabanya ububabare busanzwe, nuburyo bwiza bwimiti gakondo ishobora gutera ingaruka.
PEA yerekanwe ko ifite anti-inflammatory, antinociceptive, neuroprotective, na anticonvulsant. PEA yagiye ikora ubushakashatsi kubantu bafite ububabare butandukanye, inflammation na syndromes yububabare mubigeragezo bitandukanye byamavuriro. Gushyira mu bikorwa: Palmitoylethanolamide ni synthesis organique hagati na farumasi hagati, ishobora gukoreshwa mubushakashatsi bwa laboratoire no mubikorwa byiterambere ndetse nubushakashatsi bwimiti na farumasi nibikorwa byiterambere.
Muri iki gihe ubushakashatsi bwa siyansi n’inganda, Palmitoylethanolamide, nk’ibikoresho by’ibanze by’imiti, byitabiriwe cyane n’imiterere yihariye y’imiti ndetse n’uburyo bukoreshwa.
1. Gutegura Palmitoylethanolamide
Gutegura Palmitoylethanolamide mubisanzwe bikubiyemo esterification reaction. Mugihe cyo gutegura, aside palmitadecanoic na Ethanol bigira reaction ya esterification ikorwa na catalizator kugirango itange palmitadecanamide Ethanol. Mugihe cyo kwitegura, ibintu nkubushyuhe bwa reaction, ubwoko bwa catalizator na dosiye, nigihe cyo kubyitwaramo bigira ingaruka zikomeye kumiterere numusaruro wibicuruzwa. Kubwibyo, guhitamo inzira yo kwitegura nurufunguzo rwo kuzamura ubuziranenge bwibicuruzwa no kugabanya ibiciro.
2. Ibyiza bya Palmitoylethanolamide
Palmitoylethanolamide ni umweru kugeza umuhondo muto cyane hamwe no gukomera neza no gutuza. Irakomeye mubushyuhe bwicyumba, ariko irashonga mumashanyarazi atandukanye yumutungo runaka mubushyuhe runaka, nka Ethanol, acetone, nibindi. Byongeye kandi, Palmitoylethanolamide nayo ifite ubushyuhe bwiza nubushyuhe bwa chimique, butuma ikomeza imiterere n'imiterere yabyo munsi ubushyuhe bwinshi nibidukikije bigoye.
3. Gukoresha Palmitoylethanolamide
1. Ubushakashatsi bwa farumasi na laboratoire niterambere:
● PEA ni intera yingenzi yimiti, ikoreshwa mubushakashatsi bwa laboratoire no mubikorwa byiterambere hamwe nubushakashatsi bwimiti yimiti nibikorwa byiterambere.
Byagaragaye ko bifite anti-inflammatory, analgesic, neuroprotective na anticonvulsant kandi birakwiriye kuvura ububabare budakira, igicuri, ischemia yubwonko na stroke.
Inganda zo kwisiga:
● PEA ifite imirimo yihuta ya surfactant na furo yihuta kandi ikoreshwa mugukora amavuta yo kwisiga nka moisturizers na shampo.
● Irashobora kongera ubudahwema no gutuza kw'ibicuruzwa, mugihe bitezimbere ingaruka zogutanga amazi nubushuhe bwibicuruzwa.
3. Inganda z’imyenda:
● PEA ikoreshwa nk'ibyoroshya, imiti igabanya ubukana hamwe n'amavuta kugirango yongere ubworoherane n'uburabyo bw'imyenda kandi bigabanye coefficient de fraisse na electrostatike.
4. Inganda za plastiki:
● Nka plasitike, amavuta kandi akwirakwiza, PEA itezimbere ubworoherane nubukomezi bwa plastiki kandi igabanya ubushyuhe bwo gutunganya no gukoresha ingufu.
5. Kurwanya inflammatory no gusesengura:
● PEA igabanya ibimenyetso byerekana umuriro uhindura imvugo ya gene, ifite anti-inflammatory na analgesic, kandi ikwiriye kuvura indwara zitandukanye nuburwayi.
6. Ibindi bishoboka:
● Mu rwego rwingufu nshya, PEA irashobora gukoreshwa mugukora ibikoresho bishya byingufu nka selile yizuba na batiri ya lithium-ion.
● Mu rwego rwo kurengera ibidukikije, irashobora gukoreshwa mu gukora plastiki ibora, ibinyabuzima byangiza ibidukikije nibindi bicuruzwa bitangiza ibidukikije.
● Mu rwego rwa farumasi, irashobora gukoreshwa mugukora ibikoresho bya farumasi nkabatwara ibiyobyabwenge hamwe nubushakashatsi burambye.
Iyi mikoreshereze yerekana ikoreshwa ryagutse nagaciro ka palmitamide Ethanol munganda nyinshi.
4. Iterambere ryigihe kizaza cya Palmitoylethanolamide
Hamwe niterambere ryiterambere rya siyanse nikoranabuhanga hamwe niterambere ryihuse ryinganda, imirima ikoreshwa ya Palmitoylethanolamide izakomeza kwaguka. Mu bihe biri imbere, ikoreshwa rya Palmitoylethanolamide mu mbaraga nshya, kurengera ibidukikije, ubuvuzi n’izindi nzego biziyongera buhoro buhoro. Kurugero, mubijyanye ningufu nshya, Palmitoylethanolamide irashobora gukoreshwa mugukora ibikoresho bishya byingufu nka selile izuba na batiri ya lithium-ion; mu rwego rwo kurengera ibidukikije, irashobora gukoreshwa mu gukora ibidukikije bitangiza ibidukikije nka plastiki y’ibinyabuzima ishobora kwangirika ndetse n’ibidukikije byangiza ibidukikije; mubijyanye nubuvuzi, irashobora gukoreshwa Gukora ibikoresho bya farumasi nkabatwara ibiyobyabwenge hamwe nubushakashatsi burambye.
Byongeye kandi, uko abantu bamenya ubuzima no kurengera ibidukikije bikomeje kwiyongera, ubuziranenge n’ibisabwa kuri Palmitoylethanolamide nabyo bizagenda byiyongera. Kubwibyo, ubushakashatsi niterambere hamwe nibikorwa bya Palmitoylethanolamide bizita cyane kubidukikije, umutekano no kuramba. Muri icyo gihe, kugira ngo duhuze ibikenewe mu nzego zitandukanye, ubushakashatsi n’iterambere ry’ibikomoka kuri Palmitoylethanolamide nabyo bizahinduka icyerekezo cyingenzi mu bihe biri imbere.
PEA ni aside irike ya endogenous amide iri mubyiciro bya nucleaire ya agoniste. PEA yerekanwe guhuza reseptors muri nucleus (reseptor nucleaire) kandi ikora imirimo myinshi itandukanye yibinyabuzima bijyanye n'ububabare budakira no gutwika. Intego nyamukuru yatekereje kuba peroxisome prolifator-ikora reseptor alpha (PPAR-alpha).
Suzhou Myland Pharm & Nutrition Inc. ni uruganda rwanditswe na FDA rutanga ifu nziza kandi nziza-nziza ya Oleoylethanolamide (OEA).
Muri Pharm ya Suzhou Myland twiyemeje gutanga ibicuruzwa byiza cyane kubiciro byiza. Ifu ya Oleoylethanolamide (OEA) irageragezwa cyane kugirango isukure nimbaraga, ikwemeza ko uzabona inyongeramusaruro nziza ushobora kwizera. Waba ushaka gushyigikira ubuzima bwa selile, kongera imbaraga z'umubiri wawe cyangwa kuzamura ubuzima muri rusange, ifu ya Oleoylethanolamide (OEA) niyo ihitamo neza.
Hamwe nuburambe bwimyaka 30 kandi itwarwa nubuhanga buhanitse hamwe nuburyo bunoze bwa R&D, Pharm ya Suzhou Myland Pharm yateje imbere ibicuruzwa bitandukanye byapiganiwe kandi ihinduka ubuzima bushya bwa siyanse yubuzima, synthèse progaramu na sosiyete ikora serivise.
Mubyongeyeho, Suzhou Myland Pharm nayo ikora FDA yemewe. Ibikoresho bya sosiyete R&D, ibikoresho byo kubyaza umusaruro, nibikoresho byisesengura nibigezweho kandi byinshi, kandi birashobora gukora imiti kuva kuri miligarama kugeza kuri toni mubipimo, kandi ikubahiriza ibipimo bya ISO 9001 nibisobanuro bya GMP.
Inshingano: Iyi ngingo ni iyamakuru rusange gusa kandi ntigomba gusobanurwa nkinama zose zubuvuzi. Amwe mumakuru yohereza amakuru aturuka kuri enterineti kandi ntabwo ari umwuga. Uru rubuga rufite inshingano zo gutondeka, gutunganya no guhindura ingingo. Intego yo gutanga amakuru menshi ntabwo bivuze ko wemera ibitekerezo byayo cyangwa kwemeza ukuri kwibirimo. Buri gihe ujye ubaza inzobere mu buzima mbere yo gukoresha inyongera cyangwa guhindura ibintu byubuzima bwawe.
Igihe cyo kohereza: Nzeri-27-2024
