Muri iyi si yihuta cyane, gukomeza ubuzima buzira umuze birashobora kugorana. Hamwe nibindi byinshi bitandukanye hamwe na vitamine kumasoko, birashobora kuba birenze kumenya ibyingenzi mubuzima bwiza. Ariko, inyongera imwe irimo kwitabwaho kubishobora guteza ubuzima bwiza ni Deazaflavin. Inyongera ya Deazaflavin ifite inyungu nyinshi zubuzima, uhereye ku gushyigikira umusaruro w’ingufu no kwirinda antioxydeant kugeza guteza imbere gusaza neza no kumererwa neza muri rusange. Niba ushaka guhindura ubuzima bwawe no gushyigikira imikorere yumubiri wawe, tekereza kongeramo deazaflavin mubyo ukora bya buri munsi.
Wigeze wumva 5-deazaflavin? Niba atari byo, ntabwo uri wenyine. Iyi molekile izwi cyane igira uruhare runini mubikorwa byibinyabuzima mubinyabuzima bitandukanye, ariko abantu benshi ntibazi kubaho kwayo nakamaro kayo.
None, mubyukuri 5-desazoflavin ni iki? 5-deazaflavin nuburyo bwahinduwe bwa molekile izwi cyane ya flavin, ikunze kuboneka muri kamere kandi ikagira uruhare mubikorwa bitandukanye byibinyabuzima. By'umwihariko, 5-deazaflavin ibura atome ya azote kumwanya wa 5 wimiterere yimpeta, bigatuma itandukanye na mugenzi wayo usanzwe. Itandukaniro ryihishe ritanga 5-deazaflavin imiterere yihariye nimirimo yihariye, ukayitandukanya nizindi molekile za flavin.
Flavine nicyiciro cyibintu kama bigira uruhare runini mubikorwa bitandukanye byibinyabuzima. Nibintu byingenzi bigize flavoproteine, enzymes zigira uruhare runini muburyo bwo guhinduranya ibinyabuzima. Flavine izwi cyane kubera uruhare nka coenzymes muri redox reaction, aho byorohereza ihererekanyabubasha.
5-Deazaflavin ni verisiyo yahinduwe ya riboflavine isanzwe (vitamine B2). Yitwa 5-deazaflavin kuko ibura atome ya azote kumwanya wa 5 wimpeta ya isoalloxazine, iranga riboflavin. Ihinduka ritanga 5-deazaflavin imiterere yihariye.
Usibye uruhare rwayo muri biosynthesis ya quinoline, 5-deazaflavin agira uruhare mubindi bikorwa byibinyabuzima, nka metabolism ya purine no kwangiza ibintu byangiza. 5-Guhindura byinshi kwa Deazaflavin nakamaro kayo mumikorere ya selile bituma iba molekile ishimishije cyane kubashaka gusobanukirwa n'inzira zoroshye za biohimiki.
Usibye kuba bisanzwe, 5-deazaflavin ishishikajwe nibishobora gukoreshwa mubuvuzi na biotechnologiya. Imiterere n'imikorere idasanzwe bituma iba intego ishimishije yo guteza imbere ibiyobyabwenge, cyane cyane mu kuvura indwara ziterwa na bagiteri zitera indwara zishingiye kuri biosintezez ya quinoside kugirango ibeho.
Byongeye kandi, ubushobozi bwa 5-deazaflavin bwo kwitabira reaction ya redox na catalizike enzymatique ituma iba igikoresho cyingirakamaro mubikorwa bya tekinoloji, nko gukora ibicanwa na farumasi.
Ifumbire ya deazaflavin izwiho ibara ryumuhondo ryerurutse, bigatuma byoroshye gutandukanya muri laboratoire. Byongeye kandi, deazaflavin ifite aho ishonga cyane kandi irashobora gushonga byoroshye mumashanyarazi. Iyi miterere yumubiri ituma flavin ya deconjugated igizwe nibintu byinshi bishobora gukoreshwa byoroshye kandi bigakoreshwa muburyo butandukanye bwimiti.
Ikigaragara, iyi compound ifite ibikorwa bya redox. Ibi bivuze ko ishobora gukora kugabanya-okiside reaction, ikagira igice cyingenzi mubikorwa byo kohereza electron. Mubyongeyeho, deazaflavin irashobora gukora inganda zihamye hamwe nicyuma gitandukanye. Uyu mutungo utanga amahirwe yo gukoresha deazaflavins muri chimie ihuza ibyuma kandi nkibisubizo byibyuma byahujwe.
Undi mutungo ushimishije wa deazaflavin nubushobozi bwawo bwo gukora nka fotosensizer. Ibi bivuze ko ishobora gukuramo ingufu z'umucyo no kuyijyana mu zindi molekile, bigatera reaction ya fotokome. Uyu mutungo watumye abantu bashishikazwa no gukoresha deazaflavin mu buvuzi bwa Photodynamic, ubuvuzi bukoresha imiti ikoresha urumuri mu kurwanya no gusenya selile.
Muri rusange, imiterere yumubiri na chimique ya deazaflavin bituma iba uruganda rushimishije hamwe nuburyo bwinshi bushobora gukoreshwa. Ibara ryacyo ridasanzwe, solubile, ibikorwa bya redox, ibyuma bya ion bigoye, ubushobozi bwo gufotora, hamwe na fluorescence bituma iba igikoresho cyagaciro mubushakashatsi bwimiti ninganda.
Deazaflavin, izwi kandi nk'ibigereranyo bya riboflavin, ni icyiciro cya molekile zifite imiterere isa na riboflavine (vitamine B2). Izi nteruro zakozweho ubushakashatsi kugirango zishobore kuzamura imikorere ya mito-iyambere no gushyigikira ubuzima rusange bwimikorere. Ku rundi ruhande, NMN ni inkomoko ya niacine (vitamine B3) kandi ibanziriza nicotinamide adenine dinucleotide (NAD +), coenzyme y'ingenzi igira uruhare mu ngirabuzimafatizo zitandukanye, harimo kubyara ingufu no gusana ADN. .
Kimwe mubitandukaniro nyamukuru betweendeazaflavin na NMN nuburyo bwabo bwibikorwa. Byizerwa ko deazaflavin ishyigikira imikorere ya mitochondial ikora nka cofactor ya enzymes zigira uruhare mungufu. Ibi birashobora gufasha kuzamura ingufu za selile nubuzima bwa mito-iyambere. Ibinyuranye, NMN ihindurwa NAD + mu mubiri kandi igira uruhare runini mu kubyara ingufu za selile no gusana ADN. Mu kongera urwego rwa NAD +, NMN irashobora gufasha gushyigikira inzira zitandukanye za selile no guteza imbere ubuzima rusange.
Kubijyanye ninyungu zishobora kubaho, zombideazaflavin na NMN bemeza ko bafite imiti irwanya gusaza. Mugushyigikira imikorere ya mitochondial no kongera urwego rwa NAD +, ibyo bikoresho bishobora gufasha kurwanya ingaruka zo gusaza no guteza imbere ubuzima rusange bwimikorere. Byongeye kandi, NMN yizwe kubushobozi bwayo bwo kunoza imikorere ya metabolike, kuzamura imikorere ya siporo, no gushyigikira ubuzima bwumutima.
Kubijyanye numutekano no kwihanganira, deazaflavin na NMN mubisanzwe bifatwa nkumutekano kubantu benshi iyo bikoreshejwe nkuko byateganijwe. Nubwo bimeze bityo ariko, ni ngombwa buri gihe kubaza inzobere mu buvuzi mbere yo gutangira gahunda nshya y’inyongera, cyane cyane niba ufite ubuzima bw’ibanze cyangwa ukaba ufata imiti.
Deazaflavin ni uruvange rukomoka kuri riboflavin, ruzwi kandi nka vitamine B2. Yakozweho ubushakashatsi kubishobora kurwanya anti-gusaza, cyane cyane ubushobozi bwayo bwo kurwanya indwara ziterwa nimyaka. Zimwe mu nyungu zishobora guterwa na defazoflavin nk'inyongera yo kurwanya gusaza harimo kuzamura ubuzima bw'uruhu, kugabanya isura y'iminkanyari, no guteza imbere ubuzima muri rusange.
Imwe mumpamvu nyamukuru zituma deazaflavin atekereza ko ifite akamaro mukurwanya ibimenyetso byubusaza nubushobozi bwayo bwo kongera imikorere ya mito-iyambere. Mitochondria ni imbaraga zingirabuzimafatizo, ishinzwe kubyara ingufu. Mugihe tugenda dusaza, imikorere ya mitochondial iragabanuka, bigatuma umusaruro ugabanuka no kwangirika kwa okiside. deazaflavin yerekanwe gushyigikira imikorere ya mito-iyambere, nayo ishobora gufasha kugabanya umuvuduko wo gusaza.
Desoflavin ni uruganda rwerekanwe ko rufite antioxydants, bivuze ko rushobora gufasha kurinda selile zacu kwangirika kwatewe na radicals yubuntu. Radical radicals yubusa ni molekile idahindagurika itera kwangirika kwingirabuzimafatizo zacu, igira uruhare mugusaza no kongera ibyago byindwara nka kanseri n'indwara z'umutima. Mugutesha agaciro radicals yubuntu, deazaflavin irashobora gufasha gutinda gusaza no kugabanya ibyago byindwara ziterwa nimyaka.
Usibye imiterere ya antioxydeant, deazaflavin yanagaragaye ko ifite ingaruka zo kurwanya inflammatory. Indurwe idakira ifitanye isano n'indwara nyinshi ziterwa n'imyaka, bityo kugabanya umuriro mu mubiri birashobora gufasha ubuzima bwiza muri rusange kandi bishobora kudindiza gusaza.
1.Indwara ya Antioxydants: Antioxydants ningirakamaro mukurwanya radicals yubusa mumubiri, ishobora kwangiza selile kandi igatera ibibazo bitandukanye byubuzima. Ukoresheje ifu ya deazaflavin, urashobora gufasha kurinda umubiri wawe guhagarika umutima no kugabanya ibyago byindwara zidakira nkindwara z'umutima, kanseri, na diyabete.
2.Usibye imiterere ya antioxydeant, ifu ya deazaflavin izwiho kandi ingaruka zo kugabanya umuriro. Gutwika nigisubizo gisanzwe cyumubiri kubikomere cyangwa kwandura, ariko gutwika karande bishobora gutera ibibazo bitandukanye byubuzima. Ubushakashatsi bwerekana ko ifu ya deazaflavin ishobora gufasha kugabanya uburibwe no kugabanya indwara nka artite, asima, nindwara zifata umura.
3.deazaflavin nayo ni ngombwa mumikorere isanzwe ya sisitemu yumubiri. Zifasha gukora ingirabuzimafatizo kandi zifasha kurwanya indwara n'indwara. Ufashe inyongera ya deazaflavin, urashobora gushimangira ubudahangarwa bw'umubiri wawe kugirango birusheho kurinda umubiri wawe indwara ziterwa na virusi. Wongeyeho ifu ya deazaflavin mumirire yawe, urashobora kwemeza ko umubiri wawe ubona intungamubiri zikenewe kugirango ukore neza.
4.ifu ya deazaflavin ifitanye isano no kunoza imikorere yubwenge no kumvikana neza. Antioxydants hamwe nintungamubiri ziri mu ifu ya deazaflavin birashobora gufasha kurinda ubwonko guhangayika kandi bigashyigikira ubuzima bwubwonko muri rusange. Ubushakashatsi bumwe bwerekana kandi ko ifu ya deazaflavin ishobora kuba ifite ubushobozi bwo kwirinda indwara zifata ubwonko nka Alzheimer na Parkinson.
5.Kurwanya gusaza: deazaflavin ni antioxydants ikomeye ishobora gufasha kurwanya radicals yubusa mumubiri. Radikal yubusa ni molekile idahindagurika ishobora kwangiza selile kandi igatera ibibazo bijyanye no gusaza. Ufashe inyongera ya deazaflavin, urashobora gufasha kugabanya ingaruka zo gusaza kuruhu rwawe, ingingo, hamwe nubuzima muri rusange.
6.Yongera ingufu: deazaflavin igira uruhare runini mukubyara ingufu mumubiri ikora nka coenzyme. Ufashe inyongera ya deazaflavin, urashobora gufasha umubiri wawe kubyara ingufu neza. Ibi byongera kwihangana kandi bigabanya umunaniro, bikwemerera gukora neza haba kumubiri no mubitekerezo.
Mugihe ushakisha inyongera ya 5-deazaflavin, ni ngombwa gushyira imbere ubuziranenge. Shakisha ibirango bizwi hamwe nibisobanuro byerekana umusaruro wujuje ubuziranenge. Gusoma ibyasuzumwe byabakiriya no kugisha inama inzobere mu buvuzi birashobora kandi gutanga ubumenyi bwingenzi kubirango byawe.
Usibye ubuziranenge, imiterere ya 5-deazaflavin ikoreshwa mu nyongera igomba no gusuzumwa. Inyongera zimwe zishobora gukoresha uburyo bwa syntetique ya 5-deazaflavin, mugihe izindi zikoresha amasoko karemano. Imiterere ya sintetike ikunzwe cyane kuberako itekereza ko ifite bioavailable yo hejuru kandi igahita yinjizwa kandi igakoreshwa numubiri.
Kandi, tekereza kubindi bikoresho byinyongera. Shakisha inyongera zidafite ibyuzuzo bitari ngombwa, inyongeramusaruro, na allergens. Byiza cyane, inyongera zigomba gutegurwa nibintu byuzuzanya byongera kwinjiza no gukoresha 5-deazaflavin mumubiri.
Birasabwa kandi gusuzuma dosiye nimbaraga zinyongera. Ubwinshi bwa 5-deazaflavin bushobora gutandukana hagati yibicuruzwa, bityo rero ni ngombwa guhitamo inyongera ijyanye nibyo ukeneye n'intego z'ubuzima. Kugisha inama inzobere mu buzima zirashobora kugufasha kumenya igipimo gikwiye ku bihe byihariye.
Mugihe ugura inyongera 5-deazaflavin, witondere aho ubigura. Nibyiza kugura kumugurisha wizewe, haba mububiko cyangwa kumurongo, kugirango ubone ibicuruzwa byukuri. Witondere kugabanurwa cyane cyangwa kugiciro cyinyongera cyongeweho, kuko ibyo ntibishobora kuba byiza.
Suzhou Myland Pharm & Nutrition Inc yatangiye gukora ubucuruzi bwongera imirire kuva mu 1992. Nisosiyete ya mbere mu Bushinwa yateje imbere kandi igacuruza imbuto zinzabibu.
Hamwe nuburambe bwimyaka 30 kandi itwarwa nubuhanga buhanitse hamwe ningamba zinoze cyane R&D, isosiyete yateje imbere ibicuruzwa bitandukanye byapiganwa kandi ihinduka ubumenyi bwa siyanse yubuzima bushya, synthesis gakondo hamwe na serivise zikora inganda.
Byongeye kandi, isosiyete kandi ni uruganda rwanditswe na FDA, rwemeza ubuzima bwabantu bafite ireme rihamye kandi ryiterambere rirambye. Isosiyete R&D umutungo n'ibikoresho byo kubyaza umusaruro nibikoresho byisesengura nibigezweho kandi byinshi, kandi birashobora gukora imiti kuri miligarama kugeza kuri toni yubahiriza ibipimo bya ISO 9001 hamwe nuburyo bwo gukora GMP.
Ikibazo: Inyongera ya deazaflavin niyihe kandi nigute ishobora kugirira akamaro intego zubuzima bwanjye?
Igisubizo: Deazaflavin nuruvange rushyigikira imirimo itandukanye ya metabolike mumubiri, harimo kubyara ingufu nubuzima bwimikorere. Irashobora gushyigikira imibereho myiza muri rusange kandi igafasha intego zubuzima zihariye nko kuzamura ingufu zingirakamaro hamwe na antioxydeant.
Ikibazo: Nigute nahitamo neza inyongera ya deazaflavin kubyo nkeneye?
Igisubizo: Mugihe uhisemo inyongera ya deazaflavin, ni ngombwa gusuzuma ibintu nkubwiza, ubuziranenge, nimbaraga. Shakisha ikirango kizwi gikoresha ibikoresho byujuje ubuziranenge kandi gifite ibizamini byabandi kugirango umenye imbaraga nubuziranenge. Byongeye kandi, tekereza ku ntego zawe zihariye z'ubuzima hanyuma ushakishe inyongera yashyizweho kugirango ishyigikire izo ntego.
Ikibazo: Bifata igihe kingana iki kugirango ubone ibisubizo bivuye mu gufata inyongera ya deazaflavin?
Igisubizo: Igihe bifata kugirango ubone ibisubizo bivuye mu gufata inyongera ya deazaflavin irashobora gutandukana bitewe nibintu bitandukanye nkubuzima rusange, imirire, nubuzima. Abantu bamwe bashobora kubona iterambere ryurwego rwingufu hamwe nubuzima bwiza muri rusange byihuse, mugihe abandi bashobora gufata igihe kirekire kugirango babone inyungu zuzuye. Ni ngombwa guhuza no gufata inyongera nkuko byateganijwe no kuyiha umwanya wo gukora.
Inshingano: Iyi ngingo ni iyamakuru rusange gusa kandi ntigomba gusobanurwa nkinama zose zubuvuzi. Amwe muma poste yamakuru aturuka kuri enterineti kandi ntabwo ari umwuga. Uru rubuga rufite inshingano zo gutondeka, gutunganya no guhindura ingingo. Intego yo gutanga amakuru menshi ntabwo bivuze ko wemera ibitekerezo byayo cyangwa kwemeza ukuri kwibirimo. Buri gihe ujye ubaza inzobere mu buzima mbere yo gukoresha inyongeramusaruro cyangwa guhindura ibintu byubuzima bwawe.
Igihe cyo kohereza: Mutarama-19-2024
