Inyongera 5 Zirwanya Gusaza: Ninde uruta kuzamura ubuzima bwa mitochondial?

Mitochondria bakunze kwita "amashanyarazi" y'akagari, ijambo rishimangira uruhare rwabo mu kubyara ingufu. Utugingo ngengabuzima duto ni ingenzi cyane mu ngirabuzimafatizo zitabarika, kandi akamaro kazo karenze kure umusaruro w'ingufu. Hano hari inyongera nyinshi zishobora guteza imbere ubuzima bwa mitochondial. Reka turebe!

Imiterere ya mitochondria

Mitochondria irihariye mu ngirabuzimafatizo bitewe n'imiterere yazo ebyiri. Igice cyo hanze kiroroshye kandi gikora nk'inzitizi hagati ya cytoplazme n'ibidukikije by'imbere bya mitochondria. Ariko, intima iragoramye cyane, ikora ibice byitwa cristae. Izi cristae zongera ubuso buboneka kubisubizo byimiti, nibyingenzi mumikorere ya organelle.

Muri membrane y'imbere harimo matrix ya mitochondrial, ibintu bimeze nka gel birimo enzymes, ADN ya mitochondrial (mtDNA), na ribosomes. Bitandukanye nizindi ngirangingo nyinshi, mitochondriya ifite ibikoresho bya genetike byayo, iragwa kumurongo wababyeyi. Iyi miterere idasanzwe itera abahanga kwemeza ko mitochondriya yakomotse kuri bagiteri ya kera ya symbiotic.

Imikorere ya mitochondial

1. Umusaruro w'ingufu

Igikorwa cyibanze cya mitochondria ni ugukora adenosine triphosphate (ATP), ifaranga ryibanze ryingirabuzimafatizo. Ubu buryo bwitwa okiside fosifora, buboneka mumbere yimbere kandi burimo urukurikirane rugoye rwibinyabuzima. Urunigi rwo gutwara ibintu bya elegitoronike (ETC) na synthase ya ATP ni uruhare runini muriki gikorwa.

. Electron zihererekanwa zinyuze muri ibyo bigo, zikarekura ingufu zikoreshwa mu kuvoma proton (H +) kuva muri matrix mukibanza cya intermembrane. Ibi birema amashanyarazi ya elegitoroniki, bizwi kandi nka proton motive power.

. Mugihe proton isubira muri matrix ikoresheje synthase ya ATP, enzyme itera gushiraho ATP.

2. Inzira ya metabolike

Usibye umusaruro wa ATP, mitochondriya igira uruhare munzira zitandukanye za metabolike, harimo aside citric cycle (Krebs cycle) hamwe na okiside ya aside irike. Izi nzira zitanga molekile zo hagati zingirakamaro mubindi bikorwa bya selile, nka synthesis ya aside amine, nucleotide, na lipide.

3. Apoptose

Mitochondria nayo igira uruhare runini mu rupfu rwa porogaramu, cyangwa apoptose. Mugihe cya apoptose, mitochondria irekura cytochrome c nibindi bintu bifasha apoptotique muri cytoplazme, bikurura ibintu byinshi biganisha ku rupfu. Ubu buryo ni ingenzi mu kubungabunga homeostasis ya selile no gukuraho selile zangiritse cyangwa zirwaye.

4. Mitochondria n'ubuzima

Urebye uruhare nyamukuru rwa mitochondriya mu kubyara ingufu na metabolism selile, ntabwo bitangaje kuba imikorere mibi ya mitochondial ifitanye isano nibibazo byinshi byubuzima. Dore bimwe mubice byingenzi mitochondriya igira ku buzima bwacu:

5.Gusaza

Mitochondria batekereza ko igira uruhare runini mugusaza. Igihe kirenze, ADN ya mitochondrial ikusanya ihinduka kandi urwego rwo gutwara ibintu rwa elegitoronike ntirukora neza. Ibi biganisha ku kongera umusaruro wubwoko bwa ogisijeni ikora (ROS), yangiza ibice bigize selile kandi ikagira uruhare mugusaza. Ingamba zo kuzamura imikorere ya mitochondial no kugabanya imihangayiko ya okiside zirimo gushakishwa nkigikorwa cyo kurwanya gusaza.

6. Indwara ya metabolike

Imikorere mibi ya Mitochondrial nayo ifitanye isano n'indwara zitandukanye zo guhindagurika, harimo umubyibuho ukabije, diyabete, n'indwara z'umutima. Imikorere mibi ya mitochondial ituma umusaruro ugabanuka, kongera ibinure, hamwe no kurwanya insuline. Kunoza imikorere ya mito-iyambere binyuze mubikorwa byubuzima nkimyitozo ngororamubiri nimirire myiza bishobora gufasha kugabanya ibi bihe.

NADH, resveratrol, astaxanthin, coenzyme Q10, urolithin A, na spermidine byose ni inyongera zirimo kwitabwaho cyane mugihe cyo kuzamura ubuzima bwa mitochondial no kurwanya gusaza. Nyamara, buri nyongera ifite uburyo bwihariye ninyungu zayo.

1. NADH

Igikorwa nyamukuru: NADH irashobora kubyara neza NAD + mumubiri, kandi NAD + ni molekile yingenzi mugikorwa cyo guhinduranya metabolisiyumu ningirabuzimafatizo ya mitochondial.

Uburyo bwo kurwanya gusaza: Mugukomeza urwego rwa NAD +, NADH irashobora gukora poroteyine ndende SIRT1, igahindura isaha yibinyabuzima, igakora neurotransmitter, ikanagena uburyo bwo gusinzira. Byongeye kandi, NADH irashobora gusana ADN yangiritse, kurwanya okiside, no kunoza metabolisme yabantu, bityo bikagera ku ngaruka zuzuye zo gutinda gusaza.

Ibyiza: NASA izi kandi irasaba NADH kubanyenyeri kugenga amasaha y’ibinyabuzima, ikerekana imikorere yayo mubikorwa bifatika.

2. Astaxanthin

Ibikorwa byingenzi: Astaxanthin numutuku β-ionone impeta karotenoide ifite ibikorwa bya antioxydeant cyane.

Uburyo bwo kurwanya gusaza: Astaxanthin irashobora kuzimya ogisijeni imwe rukumbi, gusiba radicals yubusa, no gukomeza imikorere ya mito-iyambere ikingira uburimbane bwa mito-iyambere. Byongeye kandi, byongera ibikorwa bya superoxide disutase na glutathione peroxidase.

Ibyiza: Ubushobozi bwa antioxydeant ya astaxantine bwikubye inshuro 6000 za vitamine C na 550 za vitamine E, byerekana imbaraga za antioxydeant.

3. Coenzyme Q10 (CoQ10)

Igikorwa nyamukuru: Coenzyme Q10 nigikoresho cyo guhindura ingufu za mitochondria ya selile kandi nintungamubiri za kera zo kurwanya gusaza muri rusange zizwi nabashakashatsi.

Uburyo bwo kurwanya gusaza: Coenzyme Q10 ifite ubushobozi bukomeye bwa antioxydeant, ishobora gusiba radicals yubusa kandi igafasha kugarura ibikorwa bya antioxydeant ya vitamine C na vitamine E byatewe na okiside. Byongeye kandi, irashobora gutanga ogisijeni ningufu zihagije kumitsi yumutima hamwe ningirangingo zubwonko.

Ibyiza: Coenzyme Q10 ni ingenzi cyane mubuzima bwumutima kandi igira ingaruka zikomeye mugutezimbere ibimenyetso byumutima no kugabanya impfu nigipimo cyibitaro kubarwayi bananirwa kumutima.

4. Urolithin A (UA)

Uruhare nyamukuru: Urolithin A ni metabolite ya kabiri ikorwa na bagiteri yo munda metabolizing polifenol.

Uburyo bwo kurwanya gusaza: Urolithin A irashobora gukora sirtuine, kongera NAD + ningufu zingirabuzimafatizo, no gukuraho mitochondriya yangiritse mumitsi yabantu. Byongeye kandi, ifite n'ingaruka zo kurwanya inflammatory no kurwanya indwara.

Ibyiza: Urolithin A irashobora kurenga inzitizi yubwonko bwamaraso kandi ifite ubushobozi bwo kunoza indwara ziterwa no kurwanya gusaza.

5. Spermidine

Inyungu zingenzi: Spermidine ni molekile isanzwe ibaho ikorwa na bagiteri zo munda.

Uburyo bwo kurwanya gusaza: Spermidine irashobora gukurura mitofagy no gukuraho mitochondriya itari nziza kandi yangiritse. Byongeye kandi, ifite ubushobozi bwo kwirinda indwara z'umutima no gusaza kw'imyororokere y'abagore.

Ibyiza: Spermidine yimirire iboneka mubiribwa bitandukanye, nka soya n'ibinyampeke, kandi birashoboka kuboneka.

Suzhou Myland Pharm & Nutrition Inc ni uruganda rwanditswe na FDA rutanga ifu yuzuye kandi yujuje ubuziranenge irwanya gusaza.

Muri Pharm ya Suzhou Myland twiyemeje gutanga ibicuruzwa byiza cyane kubiciro byiza. Ifu yacu irwanya gusaza yipimishije cyane kugirango isukure nimbaraga, ibe ihitamo ryiza waba ushaka gushyigikira ubuzima bwimikorere, kongera ubudahangarwa bw'umubiri cyangwa kuzamura ubuzima muri rusange.

Hamwe nuburambe bwimyaka 30 kandi itwarwa nubuhanga buhanitse hamwe nuburyo bunoze bwa R&D, Pharm ya Suzhou Myland Pharm yateje imbere ibicuruzwa bitandukanye byapiganiwe kandi ihinduka ubuzima bushya bwa siyanse yubuzima, synthèse progaramu na sosiyete ikora serivise.

Mubyongeyeho, Suzhou Myland Pharm nayo ikora FDA yemewe. Ibikoresho bya sosiyete R&D, ibikoresho byububiko, nibikoresho byisesengura nibigezweho kandi bikora byinshi, kandi birashobora gukora imiti kuva kuri miligarama kugeza kuri toni mubipimo, kandi ikubahiriza ibipimo bya ISO 9001 nibisobanuro byakozwe na GMP.