Spermidine, imbaraga zikomeye zo kuvugurura ingirabuzimafatizo, ifatwa nk "isoko yubuto." Iyi micronutrient ni chimique polyamine kandi ikorwa cyane cyane na bagiteri zo munda mumibiri yacu. Byongeye kandi, spermidine irashobora kandi kwinjizwa numubiri binyuze mu gufata ibiryo. Ubushakashatsi bwerekana ko spermidine, yaba itangwa hanze cyangwa yakozwe na mikorobe yumubiri ubwayo, ikora muburyo bwuzuzanya.
Ihuriro rya spermidine endogenous irashobora kugabanuka uko imyaka igenda ishira, kandi hashobora kubaho isano iri hagati yibi no kwangirika kwimyaka mumikorere yumubiri. Spermidine iboneka mu biribwa byinshi, hamwe n'imizabibu ni kimwe mu biribwa bikungahaye kuri spermidine. Ubushakashatsi bumwe bwerekanye ko spermidine idadindiza gusaza gusa ahubwo ishobora no guteza imbere ubuzima no kuramba. Ibyavuye mu bushakashatsi bituma spermidine imwe mu ngingo zishyushye zubushakashatsi bugezweho.
Mu binyabuzima bizima, ingirabuzimafatizo zaspermidinekugabanuka muburyo bushingiye ku myaka; icyakora, ubuzima bwiza 90- na centenarians bafite urugero rwa spermidine hafi yurubyiruko (hagati yimyaka). Ubushakashatsi bw’ibyorezo bwerekanye isano iri hagati yo gufata intanga ngabo n’ubuzima bwabantu. 829 bitabiriye imyaka 45-84 bakurikiranwe imyaka 15. Intungamubiri za spermidine zagereranijwe buri myaka 5 zishingiye kubibazo byinshyi. Ubushakashatsi bwerekanye ko abantu bafite intanga nyinshi za spermidine bagabanije umuvuduko wa kanseri n'indwara z'umutima-damura kandi bifitanye isano no kubaho neza muri rusange.
Mechanism Uburyo bwo kurwanya gusaza
Mu 2023, "Akagari" yasohoye ingingo ivuga ko hari ibintu 12 biranga gusaza, harimo guhungabana kwa genome, kwinjiza telomere, guhindura epigenetike, gutakaza protein homeostasis, kutagira macroautophagy, kutumva neza intungamubiri, imikorere mibi ya mitochondial, na senescence ya selile. Kunanirwa kwingirangingo, guhindura itumanaho hagati yimitsi, gutwika karande, na dysbiose.
Kwinjiza autophagy
Kugeza ubu, kwinjiza autophagy bifatwa nkuburyo nyamukuru uburyo spermidine itinda gusaza. Ubushakashatsi bwerekanye ko spermidine itera dephosifora ya poroteyine kinase B, bigatuma habaho gutwara ibintu byandikirwa mu gasanduku ka O (FoxO) kwandikirwa kuri nucleus, bigatuma habaho kwandukura kwa FoxO intego ya gene autophagy microtubule ifitanye isano na poroteyine yumucyo wa 3 (LC3) ). Teza imbere autophagy.
Byongeye kandi, spermidine yasanze ifasha gutinda gusaza kwingirabuzimafatizo zumugore ziterwa no guhagarika umutima no kurinda uburumbuke bwumugore. Ubushakashatsi bwakozwe mu mwaka wose bwerekanye ko intanga ngabo zongerewe imbaraga mu bushake bw’abagabo bafite ubuzima bwiza igihe bagaburwaga intanga ngabo; mu bushakashatsi bwakozwe mu 2022, ubushakashatsi bwarebye abarwayi 377 bakaze ba myocardial infarction (AMI). basanze abantu bafite spermidine nyinshi mu maraso yabo bafite amahirwe menshi yo kubaho kurusha abarwayi b'indwara z'umutima bafite spermidine nkeya; ikinyamakuru 2021 cyerekanye ko gufata intungamubiri nyinshi za spermidine Hariho isano iri hagati ya dosiye no kugabanya ibyago byo kutagira ubwenge bwabantu, bigirira akamaro cyane ubwonko mugutezimbere ubumenyi no gukumira indwara zisanzwe ziterwa nubwonko.
Gutinda gusaza kwa telomere
Gusaza bitera kwangirika kwinshi kwa molekile, selile, na physiologique, harimo kunanirwa k'umutima, neurodegeneration, maladaptation metabolike, kwinjiza telomere, no guta umusatsi. Igishimishije, kurwego rwa molekile, ubushobozi bwo gutera autofagy (uburyo bukuru bwibikorwa bya spermidine) bigabanuka uko imyaka igenda ishira, ibintu bigaragara mubyitegererezo byinshi byibinyabuzima kandi bikekwa ko bifitanye isano cyane no gusaza. .
Effects Ingaruka za Antioxydeant na anti-inflammatory
Guhangayikishwa na Oxidative ni ikintu cyingenzi kiganisha ku gusaza no kwangirika. Spermidine ifite antioxydeant. Abashakashatsi bagaburiye imbeba exogenous spermidine amezi atatu kandi bareba impinduka zintanga ngore. Nyuma yo kuvura intanga ngabo, itsinda, umubare wa atropique follicles (degenerated follicles) wagabanutse ku buryo bugaragara, ibikorwa bya enzyme ya antioxydeant byiyongera, kandi urugero rwa malondialdehyde (MDA) rwaragabanutse, ibyo bikaba bishobora kugabanya ubwoko bwa ogisijeni ikora (ROS), bikagabanya imbaraga za okiside muri spermidine. -itsinda ryakozwe.
Indurwe idakira isa nkaho byanze bikunze uko dusaza. Kwiyongera kwa spermidine bifasha kuzamura umusaruro wa cytokine anti-inflammatory mugihe ugabanya umusaruro wa cytokine itera inflammatory. Ubushakashatsi buherutse gukorwa bwerekana ko spermidine nayo yongera imbaraga zo kurwanya inflammatory macrophage.
Kubuza gusaza ingirabuzimafatizo
Spermidine iteza imbere imikorere ya mitochondial na keratine mu ngirabuzimafatizo ya epiteliyale, bikarushaho gutuma imitsi n'imisatsi bivuka.
Spermidineni polyamine ivanze mubisanzwe ibinyabuzima. Kubera ko ari uruganda rwa polyamine, rufite amatsinda menshi ya amino (-NH2). Aya matsinda nayo ayiha umwihariko kandi wingenzi Uburyohe bwizina.
Nukuri kuberako ayo matsinda ya amino ashobora gukorana na biomolecules zitandukanye kandi agakora imirimo yayo ya physiologique muri selile. Kurugero, igira uruhare runini mu mikurire yimikorere, gutandukanya, kugenzura gene, no kurwanya gusaza.
Kurwanya gusaza
Urwego rwa spermidine nikimenyetso cyerekana urugero rwo gusaza kwumubiri. Mugihe umubiri usaza, intanga ngabo nazo zigabanuka. Ubushakashatsi bwerekanye ko spermidine ishobora gutinza gusaza kwingirabuzimafatizo nka selile yimisemburo n’inyamabere z’inyamabere, kandi ikongerera igihe cy’ibinyabuzima by’intangarugero nka Drosophila melanogaster na Caenorhabditis elegans n'imbeba.
Kugeza ubu, kwinjiza autophagy byagaragaye ko ari bumwe mu buryo bw'ingenzi intanga ngabo zitinda gusaza kandi bikongerera igihe cyo kubaho. Ubushakashatsi bwerekanye ko nyuma yo gukuramo ingirabuzimafatizo zikenewe kuri autofagy mu musemburo ushaje, Drosophila hamwe n’ingirabuzimafatizo z’inyamabere z’inyamabere, izo nyamaswa ntangarugero ntizigeze zimara igihe kinini nyuma yo kuvurwa na spermidine. Byongeye kandi, spermidine ikora kandi muburyo bwo kugabanya acetylation ya histone.
Antioxidant
Spermidine ifite imikorere ikomeye ya antioxydeant, kandi irashobora kugira ingaruka zikomeye zo kurwanya gusaza binyuze mumiterere ya antioxydeant. Ubushakashatsi bwerekanye ko spermidine ishobora kugabanya cyane urugero rwa okiside malondialdehyde kandi ikongera urugero rwa antioxydeant igabanya glutathione mu bwonko bwimbeba.
Kwiyongera kwa spermidine kandi byongereye imbaraga ibikorwa byogutwara imiyoboro ya electron muri mitochondriya yubwonko busaza, byerekana ubushobozi bwa antioxydeant kurwego rwa mito-iyambere. Spermidine igabanya kwangirika kwimitsi iterwa no gusaza iterwa no gusaza kwa okiside igabanya ubukana bwa autophagy, antioxydeant no kugabanya neuroinflammation.
Ubushakashatsi bwerekanye ko intanga ngabo zirinda H2O2 kwangirika kw ingirabuzimafatizo zibuza kwiyongera kwa Ca2 + mu ngirabuzimafatizo ya epithelia.
Kurwanya inflammatory
Spermidine igira ingaruka nziza zo kurwanya inflammatory, kandi uburyo bwayo bujyanye no guhagarika umusaruro w’ibintu bitera indwara, guteza imbere umusaruro w’ibintu birwanya inflammatory, no kugira ingaruka kuri polarike ya macrophage.
Ubushakashatsi bwerekanye ko spermidine ishobora kugabanya urwego rwibintu bitera indwara nka interleukin 6 hamwe n’ibibyimba bya necrosis muri serumu yimbeba hamwe na arthrite iterwa na kolagen, byongera urwego rwa IL-10, bikabuza polarisiyasi ya M1 macrophage muri tissue synovial , no kugabanya ibyago byo kurwara rubagimpande. Imbeba synovial selile yagwiriye kandi ingirabuzimafatizo zinjira, zerekana ingaruka nziza zo kurwanya inflammatory.
Kunoza ubumenyi
Uko abaturage basaza, ubumuga bwo mu mutwe bujyanye n’imyaka buragenda biba ikibazo gikomeye. Spermidine, nka autophagy inducer, byagaragaye ko igira ingaruka nziza zo kugabanuka kwubwenge.
Ubushakashatsi bwerekana ko mu isazi yimbuto zishaje, urugero rwa spermidine rugabanuka, ruherekejwe no kugabanuka kwubushobozi bwo kwibuka. Kwiyongera kwa spermidine kugaburira isazi bigabanya ubumuga bwo kwibuka mu isazi zishaje hirindwa ihinduka ryimiterere nimirimo mumikorere ya presinaptic iterwa nurwego rwo hejuru rwa poroteyine synaptic na proteine zihuza.
Spermidine mu ndyo irashobora kunyura mu maraso y’ubwonko bw’imbeba, ikongerera umwuka wa mitochondial mu mitsi ya neuron, kandi igateza imbere imikorere yimbeba. Hashingiwe ku bushakashatsi bw’inyamaswa, ubushakashatsi bwakozwe n’abantu nabwo bwerekanye ko spermidine ifitanye isano rya bugufi no kumenya.
Rinda umutima
Spermidine irashobora kurinda ubuzima bwumutima nimiyoboro y'amaraso kandi ifite ingaruka nyinshi nko kwirinda gusaza k'umutima, kugabanya umuvuduko ukabije w'amaraso no gutinda kunanirwa k'umutima. Ubushakashatsi bwerekanye ko inyongera ya spermidine ishobora kongera umutima wa autophagy na mitofagy mu mbeba, bikagira ingaruka z'umutima kandi bigatinda gusaza k'umutima.
Imbeba zishaje, intungamubiri za spermidine zongera imitekerereze ya elastique na metabolike ya cardiomyocytes, bityo ikongerera igihe cyo kubaho kandi ikarinda hypertrophyi yumutima iterwa nimyaka. Ubushakashatsi bwa Epidemiologiya mu bantu bwerekana ko spermidine igira ingaruka nkizo ku buzima bw'umutima n'imitsi. Intungamubiri za spermidine mumirire yumuntu zifitanye isano nindwara zifata umutima. Iyi miterere ya spermidine ifungura inzira nshya zo kuvura indwara zifata umutima.
Imiterere yubu yiterambere no gukoresha spermidine
Spermidine ni polyamine isanzwe ibaho. Imiterere ya physiologique ya spermidine ni karemano, ikora neza, umutekano kandi idafite uburozi. Hamwe nubushakashatsi bwimbitse bwingaruka ziterwa na spermidine, bwerekanye agaciro gakoreshwa mubice byinshi nkubuvuzi, ibiryo byubuzima, ubuhinzi, kwisiga nibindi.
Ubuvuzi
Spermidine igira ingaruka zitandukanye zifatika nko kurwanya gusaza, kurwanya inflammatory, kurwanya kanseri, no kunoza ubumenyi. Irashobora gukoreshwa mukurinda no kuvura osteoarthritis, kwangirika kwingirangingo, indwara zifata umutima nizindi ndwara. Spermidine ikoreshwa mubikorwa byubuvuzi. Kuvura indwara bifite iterambere ryiza.
Ibiryo byubuzima
Ukoresheje "spermidine" na "ibikoresho fatizo byibiribwa bikora" nkijambo ryibanze kugirango ukore ubushakashatsi bwamakuru mububiko bwinshi, ibisubizo byerekana ko "spermidine" cyangwa "spermine" bisobanurwa nkibikoresho fatizo byibiribwa bikora, kandi spermidine yagurishijwe ku isoko hamwe na spermidine. . Ibiryo byubuzima hamwe na amine nkibikoresho nyamukuru.
Ibicuruzwa byubuzima bijyanye na spermidine bifite imikorere itandukanye kandi bikoreshwa cyane muburyo butandukanye, harimo ibinini, ifu nubundi buryo bwa dosiye. Ifite imirimo yo kurwanya gusaza, kunoza ibitotsi, no kongera ubudahangarwa; ifu y'ibiribwa isanzwe ya spermidine yakuwe muri mikorobe y'ingano ituma isuku nini nigikorwa kinini cya spermidine.
Ubuhinzi
Nkumuyobozi ushinzwe imikurire yikimera, gukoresha exermogenine spermidine birashobora kugabanya neza kwangirika kwibihingwa biterwa nihungabana nka okiside yubushyuhe bwo hejuru, ubushyuhe buke nubukonje, hypoxia, umunyu mwinshi, amapfa, imyuzure nubucengezi, kandi bigira uruhare runini mukuzamura ibimera. . Uruhare rwarwo mu buhinzi rwagiye rukurura abantu buhoro buhoro. Spermidine Exogenous irashobora kugabanya ingaruka zo guhagarika amapfa kumikurire yamasaka meza kandi bikongerera amapfa ingemwe zamasaka meza. Ukurikije uruhare rukomeye rwa spermidine mukuzamura ibimera, ifite patenti nyinshi zo guhanga mubuhinzi. Ubushakashatsi no guteza imbere ibikomoka ku buhinzi bwa spermidine no guteza imbere ikoreshwa rya spermidine mu murima w’ubuhinzi bifite akamaro kanini mu iterambere ry’ubuhinzi.
Amavuta yo kwisiga
Spermidine ifite antioxydants, irwanya gusaza, no kuzamura ingaruka za autophagy, kandi nibikoresho byiza byo kwisiga. Kugeza ubu, hari ibicuruzwa byita ku ruhu nka spermidine anti-garing cream na spermidine essence amata ku isoko. Byongeye kandi, spermidine ifite patenti nyinshi zubushakashatsi mubijyanye no kwisiga kwisi yose, birimo kwera, gusaza kurwanya uruhu, no kunoza iminkanyari zo mumaso. Ubushakashatsi bwimbitse ku buryo bwibikorwa bya spermidine, gutunganyiriza imiterere yabyo, no gusuzuma umutekano n'ingaruka ziteganijwe guha abaguzi uburyo bwiza bwo kuvura uruhu.
Mu bantu, urwego ruzenguruka rwaspermidine mubisanzwe murwego rwa micromolar nkeya, birashoboka cyane cyane kubera ingaruka zimirire yibitekerezo bya spermidine muri rusange. Nubwo bagaragaza itandukaniro rikomeye hagati yabantu. Ariko, uko tugenda dusaza, urugero rwa spermidine mu ngirabuzimafatizo z'umubiri rugabanuka. Exogenous spermidine inyongera ihindura impinduka zijyanye n'imyaka kandi itinda gusaza.
● Prescine / spermine metabolism
Mu ngirangingo z’inyamabere, spermidine ikorwa muri precresor putrescine (ubwayo ikomoka kuri ornithine) cyangwa no kwangirika kwa okiside ya spermine.
Gut Gut microbiota
Microbiota yo munda nisoko yingenzi ya synthesis ya spermidine. Imbeba, intanga za spermidine mumyanya yo munda byagaragaye ko biterwa na mikorobe ya colonike.
Source Inkomoko y'ibiryo
Spermidine yinjiye mu biryo irashobora kwinjizwa vuba mu mara hanyuma igakwirakwizwa mu mubiri, bityo kurya ibiryo byinshi muri spermidine birashobora gufasha kongera urugero rwa spermidine mu mubiri.
● Inyongera za spermidine
Ibicuruzwa byubuzima bijyanye na spermidine bifite imikorere itandukanye kandi bikoreshwa cyane muburyo butandukanye, harimo ibinini, ifu nubundi buryo bwa dosiye. Ifite imirimo yo kurwanya gusaza, kunoza ibitotsi, no kongera ubudahangarwa; ifu y'ibiribwa isanzwe ya spermidine yakuwe muri mikorobe y'ingano ituma isuku nini nigikorwa kinini cya spermidine.
Ubuziranenge n'Ubuziranenge
Iyo uguze ifu ya spermidine, ni ngombwa gushyira imbere ubuziranenge nubwiza. Shakisha ibicuruzwa bikozwe mubintu byujuje ubuziranenge kandi bipimishije cyane kugirango ube mwiza kandi neza. Byiza, hitamo ibicuruzwa bikozwe mu nganda zikurikiza uburyo bwiza bwo gukora (GMP) kugirango ubone umutekano n'umutekano.
Bioavailability
Bioavailability bivuga ubushobozi bwumubiri bwo kwinjiza no gukoresha ikintu. Mugihe uhisemo ifu ya spermidine, tekereza bioavailable yibicuruzwa. Shakisha formulaire yagenewe kwinjizwa neza, kuko ibi bizatuma umubiri wawe ushobora gukoresha spermidine neza kugirango utange inyungu zubuzima.
Gukorera mu mucyo no kugerageza abandi
Isoko nigikorwa cyo gukora ifu ya spermidine izwi igomba kuba mucyo. Shakisha ibirango bitanga amakuru arambuye kubyerekeye isoko yibyo bakora no gukora ibicuruzwa byabo. Byongeye kandi, igeragezwa ry-igice cya laboratoire yigenga ryemeza ubuziranenge bwibicuruzwa. Shakisha ibicuruzwa byageragejwe nimiryango yabandi kugirango umenye imikorere yabyo n'umutekano.
Ingano na Serivisi Ingano
Mugihe ugura ifu ya spermidine, tekereza kuri dosiye nubunini bujyanye nibyo ukeneye. Ibicuruzwa bimwe bishobora gutanga urugero rwinshi rwa spermidine kuri buri serivisi, mugihe ibindi bicuruzwa bishobora gutanga urugero ruto. Ni ngombwa kumenya urugero rukwiye rushingiye ku ntego zawe z'ubuzima no kugisha inama inzobere mu by'ubuzima igihe bikenewe.
Ibiryo hamwe nibindi byongeweho
Ifu ya spermidine iraboneka muburyo butandukanye bwa dosiye, harimo capsule, ifu cyangwa uburyo bwamazi. Reba imiterere ijyanye n'imibereho yawe nibyo ukunda. Byongeye kandi, ibicuruzwa bimwe bishobora kuba birimo ibintu byongeweho kugirango byongere ingaruka za spermidine cyangwa kunoza uburyohe bwayo. Witondere ibintu byose byongeweho kandi urebe neza ko byujuje ibyo ukunda kurya.
Isubiramo ryabakiriya nicyubahiro
Mbere yo kugura, fata umwanya wo gukora ubushakashatsi ku cyamamare no gusoma ibyo abakiriya basubiramo. Shakisha ibitekerezo kubantu bakoresheje ibicuruzwa kugirango bamenye neza imikorere yabyo n'ingaruka zose zishobora kubaho. Ibicuruzwa bifite izina ryiza nibisobanuro byiza byabakiriya birashoboka cyane gutanga ifu ya spermidine yizewe kandi yujuje ubuziranenge.
Igiciro vs agaciro
Mugihe igiciro kitagomba kuba ikintu cyonyine gifata umwanzuro, ni ngombwa gusuzuma agaciro k'ibicuruzwa bijyanye nigiciro cyacyo. Gereranya igiciro cyifu ya spermidine itandukanye hanyuma urebe ubwiza, ubuziranenge, ninyungu zinyongera za buri gicuruzwa. Gushora imari ya spermidine nziza cyane birashobora gutanga inyungu nyinshi mubuzima.
Ifu ya Spermidine ya Suzhou Myland Pharm - Ibyokurya byujuje ubuziranenge
Muri Pharm ya Suzhou Myland, twiyemeje gutanga ibicuruzwa byiza cyane kubiciro byiza. Ifu ya spermidine yacu irageragezwa cyane kugirango isukure nimbaraga, ikwemeza kubona inyongeramusaruro nziza ushobora kwizera. Waba ushaka gushyigikira ubuzima bwimikorere, kongera imbaraga mumubiri cyangwa kuzamura ubuzima muri rusange, ifu ya spermidine niyo ihitamo neza.
Hamwe nuburambe bwimyaka 30 kandi itwarwa nubuhanga buhanitse hamwe nuburyo bunoze bwa R&D, Pharm ya Suzhou Myland Pharm yateje imbere ibicuruzwa bitandukanye byapiganiwe kandi ihinduka ubuzima bushya bwa siyanse yubuzima, synthèse progaramu na sosiyete ikora serivise.
Mubyongeyeho, Suzhou Myland Pharm nayo ikora FDA yemewe. Ibikoresho bya sosiyete R&D, ibikoresho byububiko, nibikoresho byisesengura nibigezweho kandi bikora byinshi, kandi birashobora gukora imiti kuva kuri miligarama kugeza kuri toni mubipimo, kandi ikubahiriza ibipimo bya ISO 9001 nibisobanuro byakozwe na GMP.
Ikibazo: Ifu ya spermidine niki kandi ihuriye he no gusaza?
Igisubizo: Spermidine nikintu gisanzwe cya polyamine kiboneka mubiribwa bitandukanye numubiri wumuntu. Ubushakashatsi bwerekana ko intanga ngabo zishobora kugira ingaruka zo kurwanya gusaza mu guteza imbere ubuzima bwa selile no kuramba.
Ikibazo: Nigute ifu ya spermidine ikora kugirango irwanye gusaza?
Igisubizo: Spermidine yizera ko ikora inzira ya selile yitwa autophagy, ifasha gukuraho selile zangiritse no guteza imbere ingirabuzimafatizo nziza. Iyi nzira yatekereje kugira uruhare runini mugutinda gusaza.
Ikibazo: Ni izihe nyungu zishobora guterwa no gufata ifu ya spermidine yo gusaza?
Igisubizo: Ubushakashatsi bumwe bwerekanye ko inyongera ya spermidine ishobora gufasha kuzamura ubuzima bwimitsi yumutima, imikorere yubwonko, no kuramba muri rusange. Irashobora kandi kugira inyungu zishobora kubaho kubuzima bwuruhu no mumikorere yumubiri.
Ikibazo: Nigute nshobora kwemeza ubwiza bwifu ya spermidine mugihe uyigura kumurongo?
Igisubizo: Shakisha isoko ryiza kandi ryashizweho hamwe numurongo wogutanga ibyokurya byujuje ubuziranenge. Reba kubisobanuro byabakiriya nu amanota kugirango umenye uwatanze isoko.
Inshingano: Iyi ngingo ni iyamakuru rusange gusa kandi ntigomba gusobanurwa nkinama zose zubuvuzi. Amwe mumakuru yohereza amakuru aturuka kuri enterineti kandi ntabwo ari umwuga. Uru rubuga rufite inshingano zo gutondeka, gutunganya no guhindura ingingo. Intego yo gutanga amakuru menshi ntabwo bivuze ko wemera ibitekerezo byayo cyangwa kwemeza ukuri kwibirimo. Buri gihe ujye ubaza inzobere mu buzima mbere yo gukoresha inyongera cyangwa guhindura ibintu byubuzima bwawe.
Igihe cyo kohereza: Kanama-28-2024
