Trigonelline ni alkaloide isanzwe iboneka mu bimera nka fenugreek na kawa. Trigonelline HCl, hydrochloride ya trigonelline, ni urugingo rushimishije rugira uruhare mu gushyigikira isukari mu maraso, uruhare rwa lipide mu mikorere ya metabolism no mumikorere yubwenge. Mugihe ubushakashatsi bukomeje kuriyi nteruro, ni ngombwa gukomeza kugezwaho amakuru agezweho. Waba ushishikajwe nubuvuzi bwa naturopathique, guhanga imiti, cyangwa ushaka kwagura ubumenyi bwawe, trigonelline HCL rwose ni ingingo yo kureba muri 2024.
Izina ry'ubumenyi rya trigonelline ni trimethylxanthine. Ni azote irimo alkaline ivanze kandi ni iya alkaloide ya pyridine. Trigonelline ikomoka cyane cyane ku bimera bya fenugreek. Fenugreek nigiterwa cya leguminine. Ni igihingwa ngarukamwaka kiva muri Afurika y'Iburengerazuba none kikaba gikwirakwizwa cyane muri Afurika, Uburayi, Aziya n'utundi turere. Byongeye kandi, iboneka no mu bishyimbo bya kawa, alfalfa, amababi ya tuteri, radis, soya n'ibindi bimera, ndetse na molluscs, amafi yo mu nyanja ndetse n’inyamabere. Ikawa ibishyimbo nisoko nyamukuru ya trigonelline nyuma ya fenugreek. Kugeza ubu, hari uburyo bwinshi bwo gupima trigonelline mu bishyimbo bya kawa, harimo chromatografiya ikora cyane, spekitifotometometrie, nibindi.
Trigonelline nikintu kibanziriza gutanga uburyohe mugihe cyo gutwika ikawa. Nimwe mumasoko yuburakari muri kawa. Nibindi bibanziriza ibice byinshi bya aromatic. Muri iki gihe, ni ibikoresho bishya bishobora guteza imbere ibiryo bikora birwanya gusaza.
Trigonelline ifite imirimo itandukanye ya physiologique, harimo antioxydeant, kugabanya isukari mu maraso, kwikuramo radicals yubusa, kunoza imikorere ya mito-iyambere, kongera imbaraga zimitsi, kugabanya kwangirika kwingirabuzimafatizo, kunoza imikorere yubwenge, nibindi. Hashingiwe kuri ibyo, trigonelline ikoreshwa cyane mubuvuzi, kwisiga, n'imirire. Inyongera, ibicuruzwa byubuzima nizindi nzego zerekanye ibyiza byo gusaba. Kugeza ubu, trigonelline yaracururizwaga, ariko hari ibicuruzwa bike kandi isoko rifite umwanya mugari witerambere. Hamwe nubushakashatsi bwimbitse mugihe kizaza, ibicuruzwa byinshi hamwe na trigonelline nkibice byingenzi bizatezwa imbere mugihe kizaza.
Akenshi byitwa imbaraga zingirabuzimafatizo, mitochondriya igira uruhare runini mukubyara ingufu mumikorere ya selile. Trigonelline hydrochloride ni alkaloide isanzwe iboneka mu bimera nka fenugreek kandi yitabiriwe n'ingaruka zishobora kugira ku mikorere ya mito-iyambere.
Mitochondria ishinzwe kubyara adenosine triphosphate (ATP), isoko nyamukuru yingufu za selile. Imikorere mibi ya mitochondrial irashobora gukurura ibibazo byinshi byubuzima, harimo indwara ziterwa na metabolike, indwara zifata ubwonko, nindwara ziterwa no gusaza. Kubwibyo, gusobanukirwa nibintu bigira ingaruka kumikorere ya mito-iyambere ningirakamaro cyane mubijyanye na biologiya selile nubuvuzi.
Imikorere mibi ya mitochondrial no kugabanya urwego rwa NAD + bigira uruhare runini mugikorwa cyo gutakaza imitsi. Mitochondria ni ibigo bitanga ingufu mu ngirabuzimafatizo, bishinzwe kubyara molekile yingufu ATP isabwa na selile. Iyo imikorere ya mitochondial yangiritse cyangwa idahungabanye, bizaganisha ku gutanga ingufu zidahagije mu ngirabuzimafatizo, bigira ingaruka ku mikorere isanzwe no guhindura imikorere ya selile yimitsi, bityo byihutishe kubaho gutakaza imitsi.
Byongeye kandi, NAD + (nicotinamide adenine dinucleotide) ni coenzyme y'ingenzi mu ngirabuzimafatizo, igira uruhare mu kugenzura ingufu za metabolisme n'ingaruka za redox mu ngirabuzimafatizo. Mugihe dusaza, urwego rwa NAD + muri selile ruzagabanuka. Kugabanuka kurwego rwa NAD + bishobora kugira ingaruka kumubiri wa redoxulaire, bikongera imbaraga za okiside ya selile hamwe nibisubizo byokongoka, bityo bikagira ingaruka kumikorere no kubaho kwingirangingo.
Ingaruka ya trigonelline mugutezimbere imikorere ya mito-iyambere igaragara cyane mubice bikurikira:
1. Kunoza ibikorwa bya mitochondial
Ubushakashatsi bwerekana ko Trigonelline HCl ishobora kugenga ibikorwa bya mitochondial bigira ingaruka kumurongo wa transport ya electron, urukurikirane rwa poroteyine zitanga ATP. Mu kongera imikorere yurwego rwo gutwara ibintu bya elegitoronike, trigonelline HCl irashobora guteza imbere umusaruro wa ATP, bityo igashyigikira ingufu za selile.
Byongeye kandi, trigonelline irashobora kongera urwego rwa NAD +, kandi NAD + ni coenzyme yingenzi ya fosifori ya okiside muri mitochondria. Mu kongera urwego rwa NAD +, trigonelline irashobora gukora urunigi rw'ubuhumekero rwa mitochondrial kandi igateza imbere synthesis ya ATP, bityo ibikorwa bya mitochondial bikiyongera. Ibi bifasha selile gukomeza gutanga ingufu zihagije mugusubiza ibibazo byo hanze no gukomeza imikorere isanzwe.
2. Kurinda mitochondriya kwangirika
Trigonelline ifite antioxydants na anti-inflammatory, irashobora gukuraho radicals yubusa nibintu bitera ingirabuzimafatizo, kandi bikagabanya imihangayiko ya okiside ndetse no kwangirika kwa mitochondria. Muri icyo gihe, trigonelline irashobora kandi guhagarika imiterere ya mitochondrial membrane, ikagabanya kugabanuka kwimyanya mito mito no gufungura imyenge yinzibacyuho ya mitochondrial, bityo ikarinda mitochondriya kwangirika.
3. Guteza imbere ibinyabuzima bya mitochondrial
Trigonelline irashobora gukangura no kwandukura ADN ya mitochondial kandi igateza imbere intungamubiri za poroteyine za mitochondrial, bityo bikongera ubwinshi nubwiza bwa mitochondriya. Ibi bifasha selile kongera vuba umubare wa mitochondriya no kunoza imikorere yingufu mugihe hasubijwe ingufu zikenewe.
4. Guteza imbere insuline
Ubushakashatsi bwerekana ko hydrochloride ya trigonelline ishobora kugira ingaruka kuri glucose metabolism hamwe no kumva insuline, bifitanye isano rya bugufi n'imikorere ya mito-iyambere. Trigonelline HCl irashobora gushyigikira mu buryo butaziguye ubuzima bwa mitochondial hamwe n’uburinganire rusange bw’ingirabuzimafatizo binyuze mu guteza imbere ikoreshwa rya glucose no gutangaza insuline.
Trigonelline, izwi kandi nka N-methylnicotinic aside, ni alkaloide isanzwe iboneka mu bimera bitandukanye, birimo fenugreek, ibishyimbo bya kawa, hamwe n’ibindi bikomoka ku bimera.
Trigonelline HCl,kurundi ruhande, nuburyo bwa hydrochloride umunyu wa trigonelline. Ibi bivuze ko hydrochloride ya trigonelline ikomoka kuri trigonelline yahujwe na aside hydrochloric ikora umunyu. Ihinduka rihindura imiterere yimiti ya trigonelline, bivamo itandukaniro mumiterere yayo nibishobora gukoreshwa.
Imwe muntandukanyirizo nyamukuru hagati ya trigonelline na hydrochloride ya trigonelline nubushobozi bwabo. Trigonelline irashobora gushonga gato mumazi, mugihe trigonelline hydrochloride ibora cyane mumazi. Ubwiyongere bukabije bwa hydrochloride ya trigonelline butuma bikenerwa cyane mubikorwa bimwe na bimwe, nko gukora ibiryo byongera ibiryo cyangwa imiti ikenera amazi.
Ku bijyanye n’inyungu zishobora kubaho ku buzima, trigonelline na trigonelline HCl byakozweho ubushakashatsi ku ngaruka zabyo ku bice bitandukanye byubuzima. Trigonelline yakozweho ubushakashatsi ku ruhare rushobora kugira mu gushyigikira amategeko agenga glucose, metabolism ya lipide, n'imikorere yo kumenya. Ubushakashatsi bumwe bwerekana kandi ko trigonelline ishobora kuba ifite antioxydeant na anti-inflammatory, ishobora kugira uruhare mu ngaruka zitera ubuzima.
Mu buryo nk'ubwo, kwiyongera kwa hydrochloride ya trigonelline irashobora gutuma irushaho kuba bioavailable kandi igahita yinjira mu mubiri, bikaba byongera imbaraga zayo mubikorwa bimwe. Ibi ni ingenzi cyane mugutezimbere inyongeramusaruro cyangwa imiti yimiti, aho trigonelline bioavailable ari ikintu cyingenzi.
Mwisi yuzuye ibiryo, trigonelline na trigonelline HCl birashobora gushyirwamo nkibigize mubisobanuro bigamije gutera inkunga metabolike, imikorere yubwenge, cyangwa izindi ntego zijyanye nubuzima. Icyemezo cyo gukoresha trigonelline cyangwa trigonelline HCl muburyo bwinyongera gishobora guterwa nimpamvu nkifishi ya dosiye yifuzwa, ibisabwa kugirango bikemuke, ninyungu zubuzima zigamije.
Trigonelline HCl nuburyo bwa hydrochloride yumunyu wa trigonelline. Ibi bivuze ko hydrochloride ya trigonelline ikomoka kuri trigonelline yahujwe na aside hydrochloric ikora umunyu.
Kubijyanye ninyungu zubuzima, kwiyongera kwa hydrochloride ya trigonelline irashobora gutuma irushaho kuba bioavailable kandi igahita yinjizwa numubiri, bikaba byongera imbaraga mubikorwa byayo.
1. Kurwanya gusaza
Ingingo yo gusaza burigihe izenguruka kuri molekile yingenzi-NAD +, nicotinamide adenine dinucleotide. Iyi coenzyme yingirakamaro yingirakamaro igira uruhare runini mugutunganya ingufu za metabolism na redox reaction. Ifite izina rya "factor factor" na "umukire igihe cya banki".
NAD + ni cofactor yingenzi yingufu za selile metabolism. Mugihe tugenda dusaza, urwego rwa NAD + muri selile rugabanuka.
Ubushakashatsi bumwe bwibanze bwerekanye ko kugerageza kongera urwego rwa NAD + byakoreshwa nkingamba zo kugabanya ubusaza. Hariho ibintu byinshi mumirire ifasha kongera NAD +, nka NR (nicotinamide ribose), Trp (tryptophan) na Nam (nicotinamide), hamwe na vitamine B3 (nanone yitwa niacin), ikora nka molekile ya NAD + Precursor ishobora kubyara NAD + nyuma yo kujyanwa mu mubiri.
Ubushakashatsi buheruka kwerekana ko trigonelline nayo ari molekile ya NAD + ibanziriza. Trigonelline irashobora kongera urwego rwa NAD + hafi 50% ugereranije na NMN, ishobora kongera urwego rwa NAD + inshuro ebyiri. Nyamara, trigonelline irashobora gukomeza kwibanda cyane muri serumu nyuma yamasaha 72 yongerewe, mugihe NMN ibura vuba nyuma yo guhinduka muri NAM.
Inyongera Trigonelline HCl irashobora kongera urwego rwa NAD +, kongera ibikorwa bya mitochondial, no gufasha kunoza gusaza.
2. Ongera urwego rwa NAD + kandi utezimbere imitsi
Sarcopenia, izwi kandi nka sarcopenia, ni indwara yo kugabanuka kwingirangingo yimitsi yimitsi hamwe na misa, mubisanzwe bifitanye isano no gusaza kandi bikarangwa no kugabanuka kwimitsi ya skeletale n'imbaraga zayo. Kugaragara kwa clinique harimo cyane cyane kugabanya ibiro, gutakaza imitsi, kugabanya imbaraga zo gufata, kugenda bidahindutse, nibindi. Mubihe bikomeye, ibibazo nkikibazo cyo guhagarara, kugwa byoroshye, kuvunika, no gukora nabi moteri.
Kugabanuka kwimitsi yimitsi ya skeletale hamwe nubucucike bwamagufwa byongera ibyago byo kuvunika nyuma yo kugwa, mugihe imitsi yimitsi ishobora gutera imikorere idasanzwe ya moteri kandi ikagira ingaruka mubuzima busanzwe bwumurwayi nakazi. Uko imyaka igenda yiyongera, nyuma yimyaka 30, imitsi igabanuka ku gipimo cya 3% kugeza 8% kumwaka; nyuma yimyaka 65, igipimo cyo kwiyongera kwimitsi cyihuta kugera kuri 6% kugeza 15%. Abantu bamwe barashobora no kurwara sarcopenia, itera kugabanuka kwimitsi nimikorere, bityo bikagira ingaruka kumigendere. Mubihe bikomeye, birashobora gutuma umuntu atakaza ubwigenge bwumubiri nubumuga.
Hano haribintu bibiri byingenzi bibaho mugihe habaye sarcopenie: imwe ni imikorere mibi ya mitochondrial selile, ishobora kumvikana gusa nkumusaruro udahagije wuruganda rushinzwe kubyara ingufu mumyanya myakura; ikindi ni nicotinamide adenine dinucleus mu ngirabuzimafatizo Kugabanuka kurwego rwa molekile ya coenzyme NAD +, igira uruhare runini mu guhinduranya ingufu kandi bigira ingaruka ku buryo butaziguye kandi butaziguye ku mikorere myinshi ya selile.
Urwego rwa Trigonelline ruri hasi kubarwayi barwaye sarcopenie, kandi uko gutakaza imitsi bibaho, serumu trigonelline irushaho kugabanuka. Trigonelline ifitanye isano neza nimbaraga zimitsi hamwe ningufu za mitochondial zitanga imitsi ya skeletale, kandi serumu ya trigonelline nayo ifitanye isano nurwego rwa NAD + mumitsi ya skeletale.
Ubushakashatsi bwerekana ko trigonelline ishobora kunganirwa binyuze munzira eshatu: gufata indyo yuzuye, synthesis ya mikorobe, no kugenzura inzira ya metabolike.
1) Kurya ibiryo
Kurya ibiryo bikungahaye kuri trigonelline nuburyo butaziguye bwo kongera urugero rwa trigonelline mumubiri. Kurugero, ibishyimbo bya kawa n'imbuto za fenugreek nibimera bizwi ko bikungahaye kuri trigonelline muri kamere. Ariko, kwishingikiriza gusa ku kongera ikawa kugirango utezimbere ibibazo byubuzima bijyanye no gusaza ntibishobora kuba byoroshye nkuko wabitekerezaga.
Byongeye kandi, ibanziriza trigonelline ni niacin, bityo urugero rwa trigonelline mu mubiri rushobora kwiyongera mu buryo butaziguye no kurya ibiryo bikungahaye kuri niacine cyangwa ukongeraho niacine.
2) Synthesis ya mikorobe
Abashakashatsi basanze gufata indyo yuzuye ifitanye isano na trigonelline mu mubiri, bishoboka ko trigonelline ishobora no gukorwa na metabolism yo mu mara. Kubwibyo, mugukomeza gufata fibre yibiryo, probiotique nibindi bintu, turashobora guhindura mikorobe yo mu mara no guteza imbere imikurire mikorobe ihuza trigonelline, bityo tukongera urwego rwa trigonelline mumubiri. Ariko birakwiye ko tumenya ko hariho umubano utoroshye hagati yimirire, microbiota yo munda nubuzima bwimitsi bisaba ubundi bushakashatsi kugirango bisobanuke.
3) Kugenzura inzira ya metabolike
Enzyme ya NAPRT ni enzyme yingenzi ihindura trigonelline muri NAD + ibanziriza. Kubwibyo, mukongera imvugo ya enzyme ya NAPRT, imikorere yo guhindura trigonelline muri NAD + ibanziriza irashobora kunozwa, bityo bikongera urwego rwa trigonelline mumubiri. Byongeye kandi, ubushakashatsi bwerekanye ko trigonelline ifitanye isano na S-adenosylmethionine iterwa na methyltransferase. Kubwibyo, mukongera ibikorwa byubu bwoko bwa methyltransferase, synthesis ya trigonelline mumubiri irashobora gutezwa imbere.
Serum kynurenine / vitamine B metabolome urwego rwanakozwe mubarwayi barwaye sarcopenie no kugenzura neza. Nta mpinduka zagaragaye muri metabolite nyinshi mugihe cya sarcopenia. Harimo vitamine B3 ishobora gukora nka NAD + ibanziriza. Nyamara, abarwayi ba sarcopenia bafite umuvuduko muke wa trigonelline. Ubushakashatsi bwagaragaje kandi ko trigonelline yongerera selile NAD + urwego.
3. Kugabanya isukari yo mu maraso hamwe na lipide yamaraso
Ubushakashatsi bwerekanye ko mu mbeba ya diyabete yo mu bwoko bwa 2, trigonelline ishobora kugabanya isukari yo mu maraso hamwe n’urwego rwa insuline kandi ikongera ibimenyetso byerekana insuline. Byongeye kandi, trigonelline yongereye ibiro bya pancreas, igipimo cy’uburemere bwa pancreas-ku mubiri, hamwe na insuline, byerekana ko trigonelline ishobora kugabanya urugero rwa glucose mu maraso iteza imbere ingirabuzimafatizo ya beta no kunoza insuline.
Imbeba ya diyabete yo mu bwoko bwa GK ya 2, trigonelline yagabanije serumu na hepatike triglyceride, igabanya ibikorwa bya synthase ya hepatike ya hepatike, kandi byongera ibikorwa bya hepatike karnitine palmitoyltransferase nibikorwa bya glucokinase
Byongeye kandi, trigonelline HCL irashobora gufasha kugabanya urugero rwisukari yamaraso no kunoza insuline. Izi ngaruka zishobora kugirira akamaro abantu barwaye diyabete cyangwa abafite ibyago byo kurwara diyabete. Byongeye kandi, trigonelline HCL irashobora gushyigikira urugero rwa cholesterol nziza, ifite akamaro kubuzima bwumutima
4. Imiti igabanya ubukana
Ubwoko bwa ogisijeni ikora neza (ROS) nicyo kimenyetso nyamukuru cyerekana imbaraga za okiside, zishobora kwangiza ingirabuzimafatizo no kubaho kwindwara zitandukanye. Ubushakashatsi bwerekanye ko trigonelline idashobora kugabanya cyane urwego rwa ROS rudasanzwe, ariko kandi igabanya na pancreatic malondialdehyde na aside nitide. , kongera superoxide disutase, catalase, glutathione nibikorwa bya synthase ya nitric oxyde.
Ibi bivuze ko ishobora gufasha kurinda selile kwangirika biterwa na stress ya okiside na radicals yubusa. Antioxydants igira uruhare runini mukubungabunga ubuzima muri rusange kandi irashobora gufasha kugabanya ibyago byindwara zidakira. Mugukuraho radicals yubuntu, trigonelline HCL irashobora kugira uruhare mubuzima rusange no kuramba.
5. Kunoza imikorere yubwenge
Ubushakashatsi bwerekana ko trigonelline iteza imbere transcriptomics yo kwiga no kugabanuka kwibukwa muburyo bwimasaza bwihuta bwimbeba ya 8 (SAMP8) muguhagarika cytokine itera inflammatory no kongera irekurwa rya neurotransmitter. Byongeye kandi, trigonelline irashobora gutera imikurire yimikorere ya selile ya neuroblastoma yumuntu SK-N-SH, ifitanye isano nuburyo bukora mugutezimbere kwibuka.
Isuku n'ubuziranenge
Isuku nubuziranenge bigomba kuba ibitekerezo byawe byambere muguhitamo inyongera ya trigonelline HCl. Shakisha ibicuruzwa bikozwe mubikoresho byubahiriza amahame akomeye yo kugenzura ubuziranenge kandi bifite icyemezo cya gatatu cyerekana ubuziranenge nimbaraga. Byongeye kandi, tekereza guhitamo inyongeramusaruro zidafite inyongeramusaruro, ibyuzuza, na allergens kugirango urebe ko ubona ibicuruzwa byiza.
Igipimo no kwibanda
Ingano nubunini bwa trigonelline HCl birashobora gutandukana hagati yinyongera. Ibyifuzo byawe byihariye n'intego z'ubuzima bigomba gusuzumwa mugihe uhisemo igipimo gikwiye cyibicuruzwa. Kurugero, niba wifuza gushyigikira imikorere yubwenge, urashobora guhitamo kwibanda cyane kuri trigonelline HCL, mugihe ikinini cyo hasi gishobora kuba gikwiye kubuzima rusange. Buri gihe ujye ubaza inzobere mu by'ubuzima kugirango umenye dosiye ikwiye kubyo ukeneye kugiti cyawe.
Gukorera mu mucyo no kugerageza
Hitamo inyongera ya trigonelline HCL muri sosiyete izwi ishyira imbere gukorera mu mucyo no kugerageza bikomeye. Shakisha ibirango bitanga amakuru arambuye kubyerekeye isoko, umusaruro, no kugerageza ibicuruzwa byabo. Kwipimisha mugice cya gatatu kubisuku, imbaraga, nibihumanya byemeza ubwiza numutekano. Byongeye kandi, suzuma ibicuruzwa byizwe mubuvuzi cyangwa bifite amateka yerekana neza ibyifuzo byabakiriya.
Ibikoresho bya synergiste
Inyongera zimwe za trigonelline HCl zishobora kuba zirimo ibindi bintu byuzuza ingaruka zabyo kandi bigatanga inyungu zinyongera. Kurugero, urashobora kubona ibicuruzwa bihuza trigonelline HCl nibindi bintu bisanzwe bizwiho gushigikira ubwenge cyangwa imitekerereze ya metabolism. Reba niba ukunda inyongera ya trigonelline HCl cyangwa formula ikubiyemo ibintu bihuza kugirango ukemure ibintu byinshi byubuzima bwawe no kumererwa neza.
Ibitekerezo byubuzima
Mugihe uhisemo inyongera ya trigonelline HCl, ni ngombwa gusuzuma ibintu byose byubuzima bwumuntu cyangwa ubuvuzi buriho. Niba ufite ubuzima bwiza cyangwa ukaba ufata imiti, banza ubaze inzobere mu buvuzi mbere yo kongeramo inyongera kuri gahunda zawe za buri munsi. Barashobora gutanga ubuyobozi bwihariye kandi bagufasha kumenya niba trigonelline HCl ibereye kubyo ukeneye kugiti cyawe.
Suzhou Myland Pharm & Nutrition Inc yatangiye gukora ubucuruzi bwongera imirire kuva mu 1992. Nisosiyete ya mbere mu Bushinwa yateje imbere kandi igacuruza imbuto zinzabibu.
Hamwe nuburambe bwimyaka 30 kandi itwarwa nubuhanga buhanitse hamwe ningamba zinoze cyane R&D, isosiyete yateje imbere ibicuruzwa bitandukanye byapiganwa kandi ihinduka ubumenyi bwa siyanse yubuzima bushya, synthesis gakondo hamwe na serivise zikora inganda.
Mubyongeyeho, Suzhou Myland Pharm & Nutrition Inc nayo ikora FDA yemewe. Ibikoresho bya sosiyete R&D, ibikoresho byububiko, nibikoresho byisesengura nibigezweho kandi bikora kandi birashobora gukora imiti kuva kuri miligarama kugeza kuri toni mubipimo, kandi ikubahiriza ibipimo bya ISO 9001 nibisobanuro byakozwe na GMP.
Ikibazo: Niki trigonelline HCl ikoreshwa?
Igisubizo: Trigonelline HCl isanzwe ikoreshwa nkinyongera yimirire kugirango ifashe ubuzima bwiza nubuzima bwiza. Azwiho ubushobozi bwo kuzamura isukari nziza mu maraso no gushyigikira imikorere ya metabolike.
Ikibazo: Nigute trigonelline HCl ikoreshwa mubyokurya?
Igisubizo: Trigonelline HCl ikunze gushyirwa mubyokurya muburyo bwa capsules, ibinini, cyangwa ifu. Bikunze guhuzwa nibindi bikoresho kugirango habeho formulaire zunganira ubuzima bwa metabolike, urwego rwingufu, hamwe nubuzima bwiza muri rusange.
Ikibazo: Ese trigonelline HCl ifite umutekano mukoresha?
Igisubizo: Trigonelline HCl muri rusange ifatwa nkumutekano,
Inshingano: Iyi ngingo ni iyamakuru rusange gusa kandi ntigomba gusobanurwa nkinama zose zubuvuzi. Amwe mumakuru yohereza amakuru aturuka kuri enterineti kandi ntabwo ari umwuga. Uru rubuga rufite inshingano zo gutondeka, gutunganya no guhindura ingingo. Intego yo gutanga amakuru menshi ntabwo bivuze ko wemera ibitekerezo byayo cyangwa kwemeza ukuri kwibirimo. Buri gihe ujye ubaza inzobere mu buzima mbere yo gukoresha inyongera cyangwa guhindura ibintu byubuzima bwawe.
Igihe cyo kohereza: Kanama-12-2024
