Mitochondriya ni ingenzi cyane nk'imbaraga z'ingirabuzimafatizo z'umubiri, zitanga imbaraga zidasanzwe zo gukomeza umutima wawe gutera, ibihaha byacu bihumeka ndetse n'umubiri ukora binyuze mu kuvugurura buri munsi. Ariko, uko ibihe bigenda bisimburana, hamwe nimyaka, imiterere yacu itanga ingufu, mitochondria, irashobora kwangirika no gutakaza ubushobozi bwo gukora neza. Imikorere ya mitochondriya ni ngombwa mubuzima bwumuntu. Nyamara, mitochondriya nayo irashobora kwibasirwa cyane n’amasoko atandukanye, harimo guhagarika umutima, gutwika, n’uburozi bw’ibidukikije. Izi ngingo zishobora kwangiza ADN ya mitochondial, bikabangamira ubushobozi bwabo bwo gukora ATP nibindi bintu byingenzi.
Ku bw'amahirwe, umubiri wacu uhitamo gukuramo mitochondriya yangiritse kandi idakora neza mu ngirabuzimafatizo zacu binyuze muri mitochondrial autophagy mu rwego rwo kubungabunga ubuzima bwiza no kwirinda ingaruka mbi ziterwa na mitochondriya yangiritse, nk'uko ubushakashatsi bwerekana ko inzira ya autofagy ya mitochondial igira uruhare mu kurwanya gusaza. Reka twumve isano iri hagati ya mitochondria na anti-gusaza!
Ni uruhe ruhare rwa mitochondriya?
Mitochondria ni ingirangingo zingenzi zitanga ingufu muri selile. Uruhare rwabo nyamukuru ni ugukora adenosine triphosphate (ATP), nifaranga ryingufu za selile. Iyo mitochondriya myinshi dufite, niko ATP dushobora kubyara umusaruro, bigatuma imbaraga ziyongera kandi umunaniro ukagabanuka. Mu nshingano nyamukuru ikina harimo:
(1)gutanga ingufu hamwe na metabolike ihuza umubiri
(2)Mitochondrial autophagy imenya mitochondriya yangiritse ikanayikuraho, kandi kuvanaho mitochondriya yangiritse bitera biosynthesis ya mitochondriya nshya.
(3)Irashobora kugira uruhare mukurinda urupfu rwa selile ikuraho mitochondria
(4)Bifitanye isano no guteza imbere ibibazo bitandukanye byubuzima, harimo indwara z'umutima, indwara zifata ubwonko ndetse na kanseri zimwe na zimwe.
Ni irihe sano riri hagati ya mitochondria no kurwanya gusaza?
Ubushakashatsi bwerekanye ko uko tugenda dusaza, gukuraho binyuze muri mitochondrial autophagy bitagengwa, bivuze ko selile mitochondial idashobora gukuraho imikorere yayo. Hatabayeho uburyo bunoze bwo kugenzura ubuziranenge nka mitochondrial autophagy, kwangirika kwa selile birashobora kwihuta.
Mu bushakashatsi bw’inyamaswa, igihe kirekire cyo kubaho cyagaragaye igihe hagaragajwe ingirabuzimafatizo zigenga imiterere ya mitochondrial autophagy, byerekana ko autophagy ya mitochondial no kuramba bifitanye isano. Byongeye kandi, autophagy yanduye mitochondrial ikunze kugaragara mu ndwara nyinshi ziterwa n’imyaka, harimo indwara ya Parkinson na Alzheimer, indwara z'umutima, na kanseri, byerekana ko ingamba zigamije kurwanya indwara ziterwa na mitochondial zishobora kugira uruhare mu gukumira no kuvura indwara. Ubwanyuma, urufunguzo rwo gusaza neza ruri mu gusobanukirwa no gushyigikira inzira igoye cyane ituma umubiri ukora. Mugukora kugirango duteze imbere ubuzima bwa mitochondrial autophagy no guhitamo imibereho ishyira imbere imibereho yacu, dushobora gufungura amabanga mubuzima burebure kandi bwiza!
Nigute ushobora kongera mitochondrial autophagy
(1)Tekereza kwiyiriza ubusa icyiciro no kubuza kalori
Ubushakashatsi bwerekanye ko autophagy mitochondrial ishobora guterwa nuburyo butandukanye bwo kubaho. Kurugero, imyitozo yerekanwe kugirango yongere mitochondrial autophagy, bityo itezimbere imikorere ya mito-iyambere. Byongeye kandi, gufata ibyokurya nko kwiyiriza ubusa rimwe na rimwe cyangwa kugabanya kalori birashobora no gutera mitochondrial autophagy, bigatuma mitochondriya yiyongera.
(2)Imyitozo idasanzwe
Imyitozo ngororangingo niyo yoroshye kandi yoroshye gukurikiza. Irashobora guteza imbere ubuzima no kuramba kimwe no kunoza imikorere ya mito-iyambere ndetse no gutera mito-iyambere ya mito-iyambere, bityo imyitozo irashobora gutegurwa muburyo bukwiye hamwe nimbaraga, imyitozo yindege no kwihangana kugirango yongere autophagy ya mito-iyambere.
(3)Urolithin A ni molekile itera autophagy ya mitochondrial
Urolithin A ni metabolite ivangwa no guhindura tannine ellagic na bagiteri zo munda. Ibibanziriza ni aside ya ellagic na ellagitannin, ishobora kuboneka mu bimera byinshi biribwa, nk'amakomamanga, strawberry, raspberries, walnuts, n'ibindi, ariko ntabwo bivuze ko iboneka mu biryo, kuko bagiteri zimwe gusa zishobora guhindura ellagitannin kuri urolithine. Kandi urolithin A, ifumbire mvaruganda ikomoka kubabanjirije ibiryo, ni ibintu byagaragaye ko bitera mitochondrial autophagy.
Akamaro ka mitochondrial autophagy
Mitochondrial autophagy ni inzira karemano kandi y'ingenzi ifasha kubungabunga mitochondriya nzima mu ngirabuzimafatizo zacu. Ubu buryo bukubiyemo kumenya mitochondriya yangiritse cyangwa idakora neza no guhitamo kuyikura mu kagari kugirango habeho mitochondriya nshya, ishobora kubaho yo kuyisimbuza. Muri icyo gihe, inzira ya autophagy ya mitochondrial ifasha kwemeza ko imbaraga z'umubiri wacu ziguma zihamye kandi ko ingirabuzimafatizo hamwe ningirangingo bikomeza kuba byiza kandi bikora.
Mu gusoza, kubungabunga mitochondriya nzima ningirakamaro mubuzima bwacu muri rusange no kumererwa neza muri rusange, kandi selile zacu zahinduye inzira yitwa mitochondrial autophagy kugirango tumenye ko dukomeza gutanga mitochondriya nzima. Nyamara, ibikorwa byubuzima (nkimyitozo ngororamubiri) hamwe nubufasha bwimirire (nkimirire ya ketogenique) no gukoresha inyongeramusaruro birashobora gushyigikira imikorere ya mito-iyambere kandi bigafasha kwirinda indwara ziterwa nimyaka. Mu kwita kuri mitochondriya yacu, turashobora kwemeza ko dufite imbaraga nubuzima dukeneye kugirango tubeho ubuzima bwuzuye.
Byongeye kandi, dushobora kumenya neza isano iri hagati ya mitochondria na anti-gusaza, uko tugenda dusaza, inzira ya mitochondrial autophagy irabangamiwe, ni ukuvuga ko itera kwirundanya kwa mitochondriya mu ngirabuzimafatizo, kubera kwiyiriza ubusa, kubuza kalori, urolithine A. , etc. icyakora, urolithin A ifite ikindi gikorwa cyingenzi. Ihindura inzira yitwa mitochondrial autophagy, aho mitochondriya yangiritse ikurwaho kandi ikongera gukoreshwa muri mitochondriya nshya. Abantu benshi mubuzima bwacu ntibashobora gukomeza imyitozo mugihe kirekire, ariko ibicuruzwa byihariye dutanga, Urolithin A, birashobora gutanga ubuzima bwiza.
Ikibazo: Hari ibiryo byihariye mubuzima bwawe bishobora gufasha kwirinda gusaza imburagihe?
Igisubizo: Yego, ibiryo bimwe na bimwe bikungahaye kuri antioxydants, vitamine n'imyunyu ngugu birashobora gufasha guteza imbere uruhu rwiza no gutinda gusaza. Ingero zirimo imbuto, imboga, proteyine zidafite amavuta hamwe namavuta meza.
Igihe cyo kohereza: Jun-01-2023
