Mugihe twinjiye muri 2024, umurima wongeyeho ibiryo ukomeje kwiyongera, hamwe na Alpha GPC ibaye umuyobozi mukuzamura ubwenge. Azwiho ubushobozi bwo kongera kwibuka, kwibanda, hamwe nubuzima rusange bwubwonko, iyi choline naturel ikurura abantu bakunda ubuzima nabashakashatsi. Hamwe na bioavailable yongerewe imbaraga, ibirango bisukuye, amahitamo yihariye hamwe no kwibanda kumasomo ashyigikiwe nubushakashatsi, abaguzi barashobora kwitega uburambe bunoze, bwizewe. Mugihe isoko rikomeje guhanga udushya, Alpha GPC ikomeje kuba umukinnyi wingenzi ushaka kunoza imikorere yo mumutwe.
Alpha-GPC (Choline Alfoscerate)ni choline irimo fosifolipide. Iyo ufashwe, α-GPC ihita yinjira vuba kandi byoroshye kurenga inzitizi yubwonko bwamaraso. Ihindurwamo choline na glycerol-1-fosifate. Choline ni yo ibanziriza acetylcholine, neurotransmitter igira uruhare mu kwibuka, kwitondera, no kugabanuka kw'imitsi ya skeletale. Glycerol-1-fosifate ikoreshwa mu gushyigikira uturemangingo.
Alpha GPC cyangwa Alpha Glyceryl Phosphoryl Choline ni ibintu bisanzwe kandi bitaziguye bibuka ubwonko no kwiga imiti Acetylcholine. Choline ihinduka acetylcholine, ifasha ubwonko gukora. Acetylcholine nintumwa yingenzi mubwonko kandi igira uruhare runini mukwibuka gukora hamwe nubushobozi bwo kwiga. Choline ihagije itanga urugero rukwiye rwa acetyloline, bivuze ko iyi ntumwa yubwonko ishobora kurekurwa mugihe gisaba ubwenge nko kwiga.
Choline ni intungamubiri ziboneka mu biribwa nk'amagi na soya. Twibyara intungamubiri zingenzi ubwacu, kandi birumvikana, inyongera ya alpha-GPC nayo irahari. Impamvu abantu bashaka kubona urugero rwiza rwa choline nuko ikoreshwa mugukora acetylcholine mubwonko. Acetylcholine ni neurotransmitter (ubutumwa bwimiti ikorwa numubiri) izwiho guteza imbere kwibuka no kwiga.
Umubiri ukora alpha-GPC kuva choline. Choline nintungamubiri zingenzi zisabwa numubiri wumuntu kandi ni ntangarugero kubuzima bwiza. Nubwo choline atari vitamine cyangwa imyunyu ngugu, akenshi iba ifitanye isano na vitamine B kubera gusangira inzira zisa na physiologique mu mubiri.
Choline irakenewe muburyo bwa metabolisme isanzwe, ikora nkumuterankunga wa methyl, ndetse ikagira uruhare runini mukubyara umusaruro wa neurotransmitter nka acetylcholine.
Nubwo umwijima wumuntu ukora choline, ntabwo bihagije guhaza ibyo umubiri ukeneye. Umusemburo wa choline udahagije mu mubiri bivuze ko tugomba kubona choline mu biryo. Kubura Choline birashobora kubaho mugihe utabonye choline ihagije mumirire yawe.
Ubushakashatsi bwahujije kubura choline na atherosklerose cyangwa gukomera kw'imitsi, indwara z'umwijima ndetse n'indwara zifata ubwonko. Byongeye kandi, byagereranijwe ko abantu benshi batarya choline ihagije mumirire yabo.
Nubwo choline iboneka mubisanzwe mubiribwa nk'inka, amagi, soya, cinoa, n'ibirayi bifite uruhu rutukura, urugero rwa choline mu mubiri rushobora kwiyongera byihuse hiyongereyeho alpha-GPC.
Acide ya Gamma-aminobutyric (GABA) ningingo nyamukuru ibuza neurotransmitter mu bwonko. Ifite uruhare runini muguhindura imitekerereze ya neuronal muri sisitemu yose. Muguhuza reseptors ya GABA, ifasha gutuza ubwonko, kugabanya amaganya, no guteza imbere kuruhuka. Urwego rwa GABA rutaringaniye rushobora gukurura ibibazo bitandukanye byubwonko na psychologiya, harimo guhangayika no kwiheba.
MugiheAlpha-GPC izwi cyane kubikorwa byayo mukongera urugero rwa acetyloline, ingaruka zayo kuri GABA ntizigaragara. Ubushakashatsi bumwe bwerekana ko ibibyimba bya choline, harimo na Alpha-GPC, bishobora kugira ingaruka ku buryo butaziguye ibikorwa bya GABA. Dore uko:
1. Sisitemu ya Cholinergic na GABAergic
Sisitemu ya cholinergique na GABAergic irimo acetylcholine irafitanye isano. Acetylcholine irashobora guhindura GABAergic kwanduza. Kurugero, mubice bimwe byubwonko, acetylcholine irashobora kongera irekurwa rya GABA, bityo bikongera kubuza. Kubwibyo, Alpha-GPC irashobora kugira ingaruka zitaziguye ibikorwa bya GABA mukongera urugero rwa acetyloline.
2. Ingaruka ya Neuroprotective
Alpha-GPC yerekanwe ifite imiterere ya neuroprotective. Ubushakashatsi bumwe buvuga ko bushobora gufasha kurinda neurone kwangirika no guteza imbere ubuzima bwubwonko. Ubuzima bwiza bwubwonko bushobora gushyigikira imikorere myiza ya GABA kuko neuroprotection irinda kwangirika kwa neurone ya GABAergic. Ibi birashobora gusobanura ko nubwo Alpha-GPC itongera urwego rwa GABA mu buryo butaziguye, irashobora gukora ibintu bishyigikira imikorere ya GABA.
3. Guhangayika no gusubiza ibibazo
Urebye ko GABA ari ingenzi mu kugenzura amaganya no guhangayika, ingaruka zishobora guhangayikisha (kugabanya amaganya) za Alpha-GPC ziragaragara. Bamwe mubakoresha bavuga ko bumva batuje kandi bibanze cyane nyuma yo gufata Alpha-GPC, ishobora guterwa ningaruka zayo kuri sisitemu ya cholinergique hamwe nubushobozi bwayo bwo kuzamura ibikorwa bya GABA mu buryo butaziguye. Nyamara, ubushakashatsi burakenewe kugirango hamenyekane isano itaziguye hagati yinyongera ya Alpha-GPC ninzego za GABA.
Kunoza ubushobozi bwo kumenya
α-GPC irashobora kunoza imikorere yubwenge kandi irihanganirwa neza, igira uruhare runini mugutezimbere imikorere yibitekerezo, sisitemu yimitsi nibuka. Mu byumweru 12 byateganijwe kugereranya ubushakashatsi bwakozwe ku mikorere ya alpha-GPC na oxiracetam ku kigero kimwe ku barwayi b'igitsina gabo bafite imyaka 55-65 bafite syndrome y'ubwonko kama, byombi wasangaga bihanganirwa.
Kwemerwa, nta murwayi wahagaritse kwivuza kubera ingaruka mbi. Oxiracetam ifite ibikorwa byihuse mugihe cyo kuvura, ariko imikorere yayo iragabanuka vuba kuko kuvura bihagaritswe. Nubwo α-GPC ifite buhoro buhoro ibikorwa, imikorere yayo iraramba. Ingaruka zamavuriro nyuma yibyumweru 8 zihagaritse kwivuza zihuye nizo mugihe cyibyumweru 8 byo kuvura. . Urebye imyaka myinshi ivuye mumavuriro mumahanga, α-GPC igira ingaruka nziza mukuvura ibikomere bya craniocerebral n'indwara ya Alzheimer bifite ingaruka nke. Mu Burayi, ibintu by'ingenzi bigize ibiyobyabwenge bya Alzheimer "Gliation" ni α-GPC.
Ubushakashatsi bw’inyamaswa bwerekanye ko alpha-GPC igabanya urupfu rwa neuronal kandi igashyigikira inzitizi yubwonko bwamaraso. Abashakashatsi bemeza ko inyongera ishobora gufasha kunoza imikorere yubwenge kubantu barwaye igicuri.
Ubundi bushakashatsi bwakorewe abakorerabushake bafite ubuzima bwiza bwerekanye ko inyongera ya alpha-GPC yatezimbere kwibuka no kwibanda. Abitabiriye gufata alpha-GPC berekanye amakuru meza yibutsa no kongera ibitekerezo no kuba maso.
Kongera ubushobozi bwa siporo
Ubushakashatsi bwerekana ko kuzuza na alpha-GPC bishobora gufasha kunoza imikorere ya siporo n'imbaraga. Mu bushakashatsi bwakozwe mu 2016, abagabo bo muri kaminuza bafashe mg 600 za alpha-GPC cyangwa umwanya wa buri munsi iminsi 6. Imikorere yabo kumurongo wo hagati yibibero byageragejwe mbere yo kunywa no icyumweru 1 nyuma yigihe cyiminsi 6. Ubushakashatsi bwerekana alpha-GPC irashobora kongera gukurura hagati yibibero, bigashyigikira igitekerezo cyuko iyi ngingo ifasha kuzamura umusaruro muke wumubiri. Ubundi bushakashatsi buhumye-buhumyi, butemewe, bugenzurwa na placebo bwarimo abakinnyi 14 b'umupira w'amaguru bo muri kaminuza bafite imyaka 20 kugeza 21. Abitabiriye amahugurwa bafashe inyongera ya alpha-GPC isaha 1 mbere yo gukora urukurikirane rwimyitozo, harimo gusimbuka guhagaritse, imyitozo ya isometric, no kwikuramo imitsi. Ubushakashatsi bwerekanye ko kuzuza alpha-GPC mbere yimyitozo ngororamubiri bishobora gufasha kuzamura umuvuduko amasomo aterura ibiro, kandi ko kuzuza alpha-GPC bishobora gufasha kugabanya umunaniro ujyanye nimyitozo ngororamubiri. Kuberako alpha-GPC ifitanye isano nimbaraga zimitsi no kwihangana, ubushakashatsi bwinshi bwerekanye ko bushobora gutanga ibisasu biturika, imbaraga, nubwihuta.
Gukura imisemburo ya hormone
Ubushakashatsi bwerekana ko alpha-GPC ishobora kongera urugero rwa neurotransmitter acetylcholine, bityo bikongera imisemburo ya hormone yo gukura kwabantu (HGH). HGH irakenewe kubuzima muri rusange haba mubana ndetse nabakuze. Mu bana, HGH ishinzwe kongera uburebure iteza imbere gukura kw'amagufwa na karitsiye. Ku bantu bakuru, HGH irashobora gufasha guteza imbere ubuzima bwamagufwa mukongera ubwinshi bwamagufwa no gushyigikira imitsi nzima mukuzamura imitsi. HGH izwiho kandi kunoza imikorere ya siporo, ariko gukoresha HGH mu buryo butaziguye hakoreshejwe inshinge byarabujijwe muri siporo nyinshi.
Mu mwaka wa 2008, ubushakashatsi bwatewe inkunga n'inganda bwasesenguye ingaruka za alpha-GPC ku bijyanye n'amahugurwa yo guhangana. Ukoresheje uburyo butemewe, buhumye-buhumyi, abasore barindwi bafite uburambe mu myitozo yuburemere bafashe mg 600 za α-GPC cyangwa umwanya wa minota 90 mbere yimyitozo. Nyuma yo gukora imashini ya Smith, ibipimo byabo byo kuruhuka (RMR) hamwe n’ikigereranyo cyo guhana ubuhumekero (RER). Buri somo noneho ryakoze ibice 3 byintebe yo gukanda kugirango bapime imbaraga nimbaraga zabo. Abashakashatsi bapimye ubwiyongere bukabije bw’imisemburo yo gukura no kwiyongera kwa 14%.
Ubu bushakashatsi bwerekana ko igipimo kimwe cya α-GPC gishobora kongera ururenda rwa HGH mu buryo busanzwe hamwe na okiside y’ibinure ku rubyiruko rukuze. HGH ikorwa cyane mugihe cyo gusinzira kwabantu kandi ishyigikira gusana no kuvugurura umubiri, bityo ikagira uruhare mubwiza bwumugore.
ikindi
Alpha-GPC isa niyongera imbaraga zo kwinjiza fer itari heme ivuye mu biribwa, bisa ningaruka za vitamine C ku kigereranyo cya 2: 1 na fer, bityo alpha-GPC ikekwa kuba, cyangwa byibuze ikagira uruhare, itari heme kuzamura ibicuruzwa byinyama Ikintu cyo kwinjiza fer. Byongeye kandi, kuzuza alpha-GPC birashobora kandi gufasha uburyo bwo gutwika amavuta no gushyigikira metabolism ya lipide. Ibi biterwa n'uruhare rwa choline nk'intungamubiri za lipofilique. Urwego rwiza rwintungamubiri rwemeza ko aside irike iboneka kuri mitochondria ya selile, ishobora guhindura ayo mavuta muri ATP cyangwa ingufu.
Muri Amerika, alpha-GPC ikoreshwa nk'inyongera y'ibiryo; mu Muryango w’ubumwe bw’ibihugu by’Uburayi, ishyirwa mu rwego rwo kongera ibiryo; muri Kanada, ishyirwa mubicuruzwa byubuzima bisanzwe kandi bigengwa nubuzima bwa Canada; no muri Ositaraliya, ni Byashyizwe mu buvuzi bwuzuzanya; Ubuyapani bwemeje kandi α-GPC nk'ibikoresho bishya by'ibiribwa. Byizerwa ko α-GPC izahinduka umunyamuryango wibikoresho bishya byibiribwa mugihe cya vuba.
1. Cafeine
Cafeine nimwe mu nyongeramusaruro zikoreshwa cyane kugirango zongere ubwenge no kwibanda. Nubwo ishobora kongera imbaraga nimbaraga zubwenge, ingaruka zayo akenshi zimara igihe gito kandi zishobora gutera impanuka. Ibinyuranye, Alpha GPC itanga ubumenyi burambye bwo kongera ubwenge nta jitter ijyanye na cafine. Byongeye kandi, Alpha GPC ishyigikira umusaruro wa neurotransmitter, cafeyine ntabwo.
2. Kurema
Creatine izwi cyane kubwinyungu zayo kumikorere yumubiri, cyane cyane mugihe cyamahugurwa akomeye. Nubwo ishobora kongera imbaraga zimitsi no gukira, ntabwo ifite inyungu zubwenge zijyanye na Alpha GPC. Kubashaka kunoza imikorere yo mumutwe no mumubiri, guhuza Alpha GPC na creine birashobora gutanga ingaruka zifatika.
3. Bacopa monnieri
Bacopa monnieri ninyongera yibimera izwiho ubushobozi bwo kuzamura imikorere yubwenge, cyane cyane kubika kwibuka. Nubwo Bacopa na Alpha GPC zombi zishyigikira imikorere yubwenge, babikora binyuze muburyo butandukanye. Bacopa yatekereje kuzamura itumanaho no kugabanya amaganya, mugihe Alpha GPC yongerera urwego rwa acetyloline. Abakoresha barashobora gusanga guhuza byombi bitezimbere imikorere yubwenge.
4. Rhodiola rose
Rhodiola rosea ni adaptogen ifasha umubiri kumenyera umunaniro n'umunaniro. Nubwo ishobora kunoza imyumvire no kugabanya umunaniro, ntabwo igamije cyane cyane imikorere yubwenge nka Alpha GPC. Kubantu bafite ibibazo byo kugabanuka kwubwenge, gukoresha Rhodiola Rosea hamwe na Alpha GPC birashobora gutanga inkunga yuzuye.
5. Omega-3 amavuta acide
Omega-3 fatty acide, cyane cyane EPA na DHA, nibyingenzi mubuzima bwubwonko kandi byagaragaye ko bishyigikira imikorere yubwenge hamwe numutima. Nubwo ari ngombwa kubuzima rusange bwubwonko, ntabwo byongera urugero rwa acetyloline nka Alpha GPC. Kubuzima bwiza bwubwonko, guhuza Omega-3 na Alpha GPC birashobora kuba ingirakamaro.
abantu bafite ubuvuzi bwihariye
1. Abagore batwite n'abonsa: Abagore batwite n'abonsa bagomba kwirinda gukoresha Alpha-GPC kubera kubura ubushakashatsi buhagije ku mutekano wacyo mugihe batwite ndetse no konsa. Ingaruka ku mikurire y’inda n’abana bonsa ntizwi kandi nibyiza kwibeshya kuruhande rwo kwitonda.
2. Abantu bafite hypotension: Alpha-GPC irashobora kugabanya umuvuduko wamaraso, ishobora kuba ikibazo kubantu basanzwe bafite hypotension cyangwa bafata imiti igabanya ubukana. Ibimenyetso nko kuzunguruka, gucika intege, cyangwa umunaniro birashobora kubaho, bityo abo bantu bagomba kubaza abashinzwe ubuzima mbere yo gutekereza gufata iyi nyongera.
3. Abantu allergic kuri soya cyangwa ibindi bikoresho: Bimwe mubinyongera bya Alpha-GPC bikomoka kuri soya. Abantu bafite allergie ya soya bagomba kwirinda ibyo bicuruzwa kugirango birinde allergie. Buri gihe ugenzure ibirango byibikoresho hanyuma ubaze inzobere mubuzima niba udashidikanya.
4. Abantu bafite umwijima cyangwa impyiko: Abantu bafite umwijima cyangwa impyiko bagomba kwitonda mugihe batekereza gukoresha Alpha-GPC. Umwijima nimpyiko bigira uruhare runini muri metabolisme yinyongera, kandi gutesha agaciro imikorere yabyo bishobora gutera ingaruka mbi. Nibyingenzi kubantu bafite ibi bibazo kugisha inama abashinzwe ubuzima.
1. Ubuziranenge nubuziranenge
Ikintu cya mbere ugomba gusuzuma ni ubuziranenge nubuziranenge bwifu ya Alpha GPC. Shakisha ibicuruzwa birimo byibuze 99% bya Alpha GPC. Aya makuru arashobora kuboneka kumurongo wibicuruzwa cyangwa kurubuga rwabakora. Alpha GPC yujuje ubuziranenge igomba kuba idafite umwanda, uwuzuza ninyongeramusaruro zishobora kugira ingaruka kumikorere.
2. Inkomoko nuburyo bwo gukora
Ni ngombwa kumva aho ifu ya Alpha GPC ituruka nuburyo ikorwa. Inganda zizwi akenshi zitanga umucyo mubikorwa byazo no kubyaza umusaruro. Shakisha inganda zubahiriza Ibikorwa byiza byo gukora (GMP) kandi byemejwe nishyirahamwe ryemewe. Ibi byemeza ko ibicuruzwa bikorerwa ahantu hagenzuwe, bikagabanya ibyago byo kwanduza.
3. Ikizamini cyabandi
Kwipimisha kubandi-ni ikintu cyingenzi cyo kwemeza ubwiza n'umutekano by'inyongera y'ibiryo. Hitamo ifu ya Alpha GPC yageragejwe na laboratoire yigenga. Ibi bizamini bigenzura ubuziranenge, imbaraga n'umutekano byibicuruzwa, bitanga ibyiringiro byinyongera. Shakisha ibicuruzwa bitanga icyemezo cyisesengura (COA) muri laboratoire izwi cyane.
4. Icyamamare mu ruganda
Kora ubushakashatsi ku izina ryuruganda rutanga ifu ya Alpha GPC. Shakisha ibisobanuro, ibyifuzo hamwe nu amanota yabandi baguzi. Inganda zizwi cyane zishobora gutanga ibicuruzwa byiza. Reba nanone igihe uruganda rumaze igihe rukora ubucuruzi; ibigo byashinzwe mubisanzwe bifite amateka yerekana kwizerwa nubuziranenge.
5. Igiciro n'agaciro
Mugihe igiciro ari ikintu cyingenzi, ntigomba kuba ikintu cyonyine cyo gufata ibyemezo mugikorwa cyawe cyo gufata ibyemezo. Ibicuruzwa bihendutse birashobora guhungabanya ubuziranenge, mugihe ibicuruzwa bihenze ntibishobora guhora byemeza ubuziranenge. Suzuma agaciro k'ibicuruzwa ukurikije ubuziranenge bwacyo, amasoko, ibikorwa byo gukora, hamwe no kugerageza abandi. Rimwe na rimwe, gushora bike mubindi bicuruzwa byujuje ubuziranenge birashobora kuganisha ku bisubizo byiza mugihe kirekire.
6. Gutegura hamwe nibindi bikoresho
Mugihe Pure Alpha GPC ikora neza yonyine, ibicuruzwa bimwe bishobora kuba birimo ibintu byongeweho kugirango byongere imikorere yayo. Shakisha formulaire ihuza Alpha GPC nibindi byongera ubwenge nka L-theanine cyangwa Bacopa monnieri. Ariko rero, witondere ibicuruzwa birimo ibintu byuzuza birenze urugero cyangwa ibihimbano kuko bishobora kugabanya ubuziranenge muri rusange.
Suzhou Myland Pharm & Nutrition Inc.ni uruganda rwanditswe na FDA rutanga ifu ya Alpha GPC nziza kandi nziza.
Muri Pharm ya Suzhou Myland twiyemeje gutanga ibicuruzwa byiza cyane kubiciro byiza. Ifu yacu ya Alpha GPC irageragezwa cyane kugirango isukure nimbaraga, ikwemeza ko uzabona inyongera nziza-nziza ushobora kwizera. Waba ushaka gushyigikira ubuzima bwimikorere, kuzamura sisitemu yumubiri cyangwa kuzamura ubuzima muri rusange, ifu ya Alpha GPC niyo ihitamo neza.
Hamwe nuburambe bwimyaka 30 kandi itwarwa nubuhanga buhanitse hamwe nuburyo bunoze bwa R&D, Pharm ya Suzhou Myland Pharm yateje imbere ibicuruzwa bitandukanye byapiganiwe kandi ihinduka ubuzima bushya bwa siyanse yubuzima, synthèse progaramu na sosiyete ikora serivise.
Mubyongeyeho, Suzhou Myland Pharm nayo ikora FDA yemewe. Ibikoresho bya sosiyete R&D, ibikoresho byo kubyaza umusaruro, nibikoresho byisesengura nibigezweho kandi byinshi, kandi birashobora gukora imiti kuva kuri miligarama kugeza kuri toni mubipimo, kandi ikubahiriza ibipimo bya ISO 9001 nibisobanuro bya GMP.
Ikibazo: Alpha-GPC ni iki?
Igisubizo: Alpha-GPC (L-Alpha glycerylphosphorylcholine) ni uruganda rwa choline rusanzwe ruboneka mu bwonko. Iraboneka kandi nk'inyongera y'ibiryo kandi izwiho ubushobozi bwo kongera ubwenge. Alpha-GPC ikoreshwa kenshi mugushigikira ubuzima bwubwonko, kunoza kwibuka, no kunoza imitekerereze.
Ikibazo: Nigute Alpha-GPC ikora?
Igisubizo: Alpha-GPC ikora mukongera urugero rwa acetyloline mubwonko. Acetylcholine ni neurotransmitter igira uruhare runini mugushinga kwibuka, kwiga, hamwe nibikorwa rusange byubwenge. Mu kuzamura urwego rwa acetylcholine, Alpha-GPC irashobora gufasha kunoza imikorere yubwenge no gushyigikira ubuzima bwubwonko.
Ikibazo: 3. Ni izihe nyungu zo gufata Alpha-GPC?
Igisubizo: Inyungu zibanze zo gufata Alpha-GPC zirimo:
- Kongera ubushobozi bwo kwibuka no kwiga
- Kunoza imitekerereze no kwibanda
- Inkunga yubuzima bwubwonko muri rusange
- Ingaruka zishobora kuba neuroprotective, zishobora gufasha mukurinda kugabanuka kwubwenge
- Kongera imikorere yumubiri, cyane cyane mubakinnyi, kubera uruhare rwayo mugutezimbere imisemburo ikura
Inshingano: Iyi ngingo ni iyamakuru rusange gusa kandi ntigomba gusobanurwa nkinama zose zubuvuzi. Amwe muma poste yamakuru aturuka kuri enterineti kandi ntabwo ari umwuga. Uru rubuga rufite inshingano zo gutondeka, gutunganya no guhindura ingingo. Intego yo gutanga amakuru menshi ntabwo bivuze ko wemera ibitekerezo byayo cyangwa kwemeza ukuri kwibirimo. Buri gihe ujye ubaza inzobere mu buzima mbere yo gukoresha inyongeramusaruro cyangwa guhindura ibintu byubuzima bwawe.
Igihe cyo kohereza: Nzeri-25-2024
