Mu myaka yashize, hagiye hagaragara ubushake bwibintu bisanzwe bishobora kuzamura ubuzima muri rusange. Urolithin A na urolithin B nibintu bibiri bisanzwe biva muri ellagitannine biboneka mu mbuto zimwe na zimwe. Ibintu birwanya inflammatory, antioxydeant, hamwe nubwubatsi bwimitsi bituma bakora ibintu bishimishije mugutezimbere ubuzima rusange. Nubwo urolithin A na urolithin B bifite imiterere bifitanye isano, bifite kandi itandukaniro rikomeye.
Urolithin A na B ni metabolite isanzwe ikorwa mu mubiri w'umuntu biturutse ku igogorwa ry'ibigize bimwe na bimwe, cyane cyane ellagitannine. Ellagitannine iboneka mu mbuto n'imbuto zitandukanye, harimo amakomamanga, strawberry, raspberries, blackberries, na walnuts. Nyamara, ijanisha rito ryabaturage bafite bagiteri zo munda zishobora guhindura ellagitannine muri urolithine, bigatuma urwego rwa urolithine mubantu ruhinduka cyane.
Kubafite ikibazo cyo guhaza magnesium bakeneye binyuze mumirire yonyine, inyongera ya magnesium irashobora kugirira akamaro ubuzima muburyo butandukanye kandi ikaza muburyo nka oxyde ya magnesium, magnesium threonate, magnesium taurate, na glycine ya magnesium. Ariko, birasabwa kugisha inama inzobere mubuzima mbere yo gutangira gahunda yinyongera kugirango wirinde imikoranire cyangwa ingorane.
Urolithin A ni molekile nyinshi mu muryango wa urolithin, kandi antioxydeant na anti-inflammatory byakozwe neza. Ubushakashatsi bwerekanye ko urolithine A ishobora kunoza imikorere ya mito-iyambere kandi ikarinda kwangirika kwimitsi. Byongeye kandi, ubushakashatsi bwerekanye ko urolithine A ishobora kubuza ikwirakwizwa ry’uturemangingo no gutera urupfu mu ngirabuzimafatizo zitandukanye za kanseri.
Urolithin B yakwegereye abashakashatsi kubushobozi bwayo bwo kuzamura amara no kugabanya uburibwe. Ubushakashatsi bwerekana ko urolithine B ishobora kongera mikorobe itandukanye kandi ikagabanya cytokine itera inflammatory nka interleukin-6 hamwe na tumorosi na nosrosis alpha. Byongeye kandi, urolithin B yasanze ifite imitekerereze ya neuroprotective, hamwe n’ubushakashatsi bwerekana ko ishobora gufasha kwirinda indwara zifata ubwonko nka Parkinson na Alzheimer.
Nubwo urolithin A na urolithin B bifite imiterere bifitanye isano, bifite itandukaniro rikomeye. Kurugero, urolithine A byagaragaye ko ikora neza nka anti-inflammatory na antioxidant kurusha urolithin B. Urolithin B, wasangaga ifite akamaro kanini mu gukumira ibibazo biterwa n’umubyibuho ukabije, nko kurwanya insuline na adipocyte gutandukana.
Uburyo bwibikorwa bya urolithin A na urolithin B nabyo biratandukanye. Urolithin A ikora peroxisome prolifator-ikora reseptor gamma coactivator 1-alpha (PGC-1α) inzira, igira uruhare muri mitochondrial biogenezi, mugihe urolithin B yongerera imbaraga AMP ikora protein kinase (AMPK), igira uruhare mumbaraga homeostasis. Izi nzira zigira uruhare mu ngaruka zubuzima bwibi bintu.
●Kurwanya inflammatory
Indwara idakira izwiho kugira uruhare mu ndwara nyinshi. Urolithin A yerekanwe ifite imbaraga zikomeye zo kurwanya inflammatory, kugabanya umusaruro wa molekile zitera. Muguhagarika umuriro, birashobora gufasha mugukemura ibibazo bitandukanye bidakira nka artite, indwara z'umutima, na kanseri zimwe na zimwe.
●Ubuzima bwimitsi nimbaraga
Mugihe tugenda dusaza, gutakaza imitsi ya skeletale bihangayikishije cyane. Urolithin A yabonetse itera imikurire yimitsi no kongera imikorere yimitsi, iteza imbere imitsi nimbaraga. Ibi bitanga amasezerano kubantu bashaka kubungabunga imitsi no kurwanya kugabanuka kwimitsi.
●Ubuzima bwa Mitochondrial no kuramba
Urolithin A yerekana ingaruka zikomeye kuri mitochondria, bakunze kwita imbaraga zingirabuzimafatizo zacu. Bitera inzira yitwa mitofagy, ikubiyemo kuvanaho guhitamo mitochondriya yangiritse. Mugutezimbere imikorere myiza ya mitochondrial, urolithin A irashobora kugira uruhare mu kuramba no kurinda indwara ziterwa nimyaka nkindwara zifata ubwonko.
●Igikorwa cya Antioxydeant
Urolithin B ni antioxydants ikomeye ifasha gutesha agaciro radicals yangiza umubiri. Radikal yubusa ni molekile ikora cyane ishobora kugira uruhare mu kwangirika kwa selile no guhagarika umutima, bigira uruhare mu ndwara zitandukanye. Ibikorwa bya antioxydeant ya Urolithin B bifasha kurinda ingirabuzimafatizo zacu kwangirika kandi bishobora kugabanya ibyago byindwara zidakira.
●Gutera Ubuzima hamwe na Microbiome Modulation
Inda yacu igira uruhare runini mubuzima bwacu muri rusange, kandi urolithin B yagaragaye nkumukino wingenzi mukubungabunga mikorobe nziza. Itera imbere gukura kwa benefibacteri cial kandi ikabuza gukura kwa bagiteri zangiza, bityo bigatuma habaho ibidukikije bya mikorobe. Microbiome nziza yo mu nda ifitanye isano no kunoza igogorwa, imikorere yumubiri, no kumererwa neza mumutwe.
●Guteza imbere ubuzima bwimitsi
Urolithin B yerekanwe kubyutsa mitochondrial autophagy, inzira ya selile ifasha kurandura mitochondriya yangiritse muri selile. Iyi nzira ifasha kuzamura ubuzima bwimitsi nimikorere muri rusange, bigatuma ishobora kuba inyongera kubashaka kunoza imikorere yumubiri. Ubushakashatsi bumwe bwerekanye ko urolithin B yatezimbere imikorere yimitsi nimbaraga mumbeba nabantu.
Urolithine ikorwa mumibiri yacu nyuma yo kurya ibiryo bimwe na bimwe birimo ellagitannine. Inkomoko yimirire ya ellagitannine irimo ：
a) Amakomamanga
Amakomamanga ni imwe mu nkunga zikungahaye ku mirire ya ellagitannine, ihinduka urolithine A na urolithin B na bagiteri zo mu nda. Kurya imbuto z'ikomamanga, umutobe, cyangwa ibiyikuramo birashobora kongera imbaraga zo gufata ibyo bintu bikomeye, byongera ubuzima bwa selile kandi bigira ingaruka zo kurwanya inflammatory.
b) Imbuto
Imbuto zitandukanye nka strawberry, raspberries, na blackberries zirimo urugero rwa ellagitannine. Ubushakashatsi bwerekanye ko kurya izo mbuto zikomeye biteza imbere umusaruro wa urolithine A na urolithine B mu mara. Ongeramo imbuto mumirire yawe ntabwo byongera uburyohe gusa ahubwo binatanga inyungu zigihe kirekire mubuzima.
c) Imbuto
Imbuto, cyane cyane ياڭ u na pecans, ni isoko ikungahaye kuri ellagitannins. Byongeye kandi, bapakiye amavuta meza, fibre, nintungamubiri zingenzi. Harimo ibinyomoro mumirire yawe ya buri munsi ntabwo bitanga urolithine A na B gusa ahubwo binatanga inyungu zitandukanye mubuzima kumutima, ubwonko, no kumererwa neza muri rusange.
d) Divayi imaze imyaka
Nubwo bishobora gutungurana, kunywa mu buryo butagereranywa kunywa divayi itukura yashaje nabyo bishobora kugira uruhare mu gukora urolithine. Imvange ziboneka muri barrale ya oak zikoreshwa mugusaza vino zirashobora gukururwa mugihe cyo gusaza, gushiramo vino na ellagitannine. Nyamara, ni ngombwa kwibuka ko kunywa inzoga nyinshi bigira ingaruka mbi ku buzima, bityo gushyira mu gaciro ni ngombwa.
e) Ibimera bikungahaye kuri Ellagitannin
Kuruhande rw'amakomamanga, ibimera bimwe na bimwe nk'igishishwa cya oak, strawberry, n'amababi y'ibiti bisanzwe ni byinshi muri ellagitannine. Kwinjiza ibi bimera mumirire yawe birashobora kugufasha kongera urugero rwa urolithine A na urolithine B mumubiri wawe, bigashyigikira ubuzima bwimikorere kandi bigahindura imibereho myiza muri rusange.
Kwinjizaurolithin A. na B mubuzima bwawe, uburyo bumwe bworoshye nukurya ibiryo bikungahaye kuri ellagitannine. Amakomamanga, strawberry, raspberries, na ياڭ u ni isoko nziza.
Ariko, ni ngombwa kumenya ko ibirimo ellagitannin bitandukana muri buri mbuto, kandi ntabwo buriwese afite microbiota imwe yo munda ishobora guhindura ellagitannine muri urolithine. Kubwibyo, abantu bamwe ntibashobora gukora neza urolithine ziva mumirire. inyongera nubundi buryo bwo kwemeza gufata urolithin A na B.
Ikibazo: Nigute Urolithin A na Urolithin B biteza imbere ubuzima bwa mitochondial?
Igisubizo: Urolithin A na Urolithin B bakora inzira ya selile yitwa mitophagy, ishinzwe gukuraho mitochondriya yangiritse muri selile. Mugutezimbere mitofagy, ibyo bikoresho bifasha kubungabunga ubuzima bwiza bwa mito-iyambere, bifite akamaro kanini kubyara ingufu nimikorere rusange ya selile.
Ikibazo: Ese Urolithin A na Urolithin B zishobora kuboneka hifashishijwe inyongera?
Igisubizo: Yego, Urolithin A na Urolithin B inyongera ziraboneka kumasoko. Ariko, ni ngombwa kumenya ko imikorere n'umutekano by'ibi byongeweho bishobora gutandukana. Birasabwa kugisha inama inzobere mu buvuzi mbere yo gutangira inyongeramusaruro nshya.
Inshingano: Iyi ngingo igamije amakuru gusa kandi ntigomba gufatwa nkinama zubuvuzi. Buri gihe ujye ubaza inzobere mu by'ubuzima mbere yo gukoresha inyongera cyangwa guhindura gahunda z'ubuzima.
Igihe cyo kohereza: Nzeri-13-2023
