Urolithin A nibintu bisanzwe aribintu bya metabolite byakozwe na bagiteri zo munda zihindura ellagitannine kugirango ubuzima bwiza burusheho kuba bwiza. Urolithin B yitabiriwe n’abashakashatsi ku bushobozi ifite bwo kuzamura ubuzima bwo mu nda no kugabanya uburibwe. Urolithin A na urolithin B bifite imiterere bifitanye isano, ariko bifite itandukaniro ritandukanye. Ni irihe tandukaniro ryihariye wowe, reka tubimenye!
Mu myaka yashize, abahanga mu bya siyansi bakoze ubushakashatsi ku nyungu z’ubuzima bwa urolithine, ikomatanyirizo karemano rikaba ari metabolite ikomoka ku ihinduka rya ellagitannine na bagiteri zo mu nda. Ibibanjirije ni aside ya ellagic na ellagitannine, bibaho bisanzwe mubisoko byinshi byibiribwa nka amakomamanga, guava, icyayi, pecans, imbuto, n'imbuto nka strawberry, raspberries, na blackberries. Byongeye kandi, urolithin A, polifenol karemano, irashimishije nka antioxydants ikomeye kandi irwanya inflammatory ifite ubuzima bwiza.
S.tudies iperereza the ingaruka za UA kumikorere ya selile ninzira yibinyabuzima yerekanye ko ifite uburyo bwinshi bwibikorwa. Ubushakashatsi bwerekanye kandi ko UA ikora mitochondrial autophagy, inzira ikuraho mitochondriya yangiritse mu ngirabuzimafatizo kandi ikongera umusaruro. Iki gikorwa kireba cyane cyane indwara ziterwa no gusaza, kuko mitochondriya idakora neza itera kwirundanya kwa okiside no gutwika. UA igenga kandi imiterere ya gen zigira uruhare mu gukemura ibibazo bya okiside, gusana ADN na apoptose, zikenewe mu gukomeza ubusugire bwa selile no kwirinda kanseri.
Another ikintu gishimishije cya UA niubushobozi bwayo nka senescence scavenger, bivuze ko ishobora guhitamo gutera apoptose mungirangingo ya senescent, yangiritse ingirabuzimafatizo zitagabanije ahubwo zisohora ibintu byangiza byangiza ingirabuzimafatizo hamwe nuduce. Ingirabuzimafatizo za Senescent zifitanye isano n'indwara zitandukanye ziterwa no gusaza, nka arthrite, atherosclerose na neurodegeneration. Muguhitamo gukuraho utugingo ngengabuzima, UA irashobora gutinza cyangwa gukumira indwara ziterwa no guteza imbere ubuzima muri rusange.
Urolithine ni urwego rwimvange izwi nka ellagitannin metabolite, ikorwa cyane na mikorobe yo munda. Muri byo, molekile ebyiri, urolithine A na urolithin B, zimaze kwitabwaho cyane ku nyungu zishobora kubaho ku buzima. Izi miti ziboneka mu mbuto zitandukanye nk'amakomamanga, strawberry, na raspberries. Muri iyi blog, tuzareba neza imiterere ijyanye na urolithin A na urolithin B.
Urolithin A ni molekile nyinshi mu muryango wa urolithin, kandi yakozweho ubushakashatsi ku miterere ya antioxydeant na anti-inflammatory. Byongeye kandi, ubushakashatsi bwerekanye ko UA ishobora kunoza imikorere ya mito-iyambere kandi ikarinda kwangirika kwimitsi. UA izwiho kandi kuba ishobora kurwanya kanseri. Ubushakashatsi bwerekanye ko UA ishobora kubuza ikwirakwizwa ry’uturemangingo kandi igatera urupfu mu ngirabuzimafatizo zitandukanye za kanseri, harimo kanseri ya prostate, amabere, na kanseri y'amara.
Ku rundi ruhande, urolithin B yitabiriwe n’abashakashatsi ku bushobozi ifite bwo kuzamura ubuzima bw’inda no kugabanya umuriro. Ubushakashatsi bwerekanye ko UB ishobora kongera mikorobe itandukanye kandi ikagabanya cytokine itera inflammatory, nka interleukin-6 hamwe na tumorosi necrosis factor-alpha. Byongeye kandi, UB yavumbuwe kandi ifite imitekerereze ya neuroprotective, kuko ubushakashatsi bwerekanye ko bushobora gufasha kwirinda indwara zifata ubwonko nka Parkinson na Alzheimer.
Nuburyo bifitanye isano, UA na UB bifite itandukaniro rigaragara. Kurugero, UA yerekanwe ko ifite imbaraga nka anti-inflammatory na antioxidant kurusha UB. Ku rundi ruhande, UB yasanze ifite akamaro kanini mu gukumira ibibazo biterwa n'umubyibuho ukabije, nko kurwanya insuline no gutandukanya adipocyte. Byongeye kandi, bitandukanye na UA, UB ntabwo yigeze yigwa cyane nkumuti urwanya kanseri.
Uburyo bwibikorwa bya UA na UB nabyo biratandukanye. UA ikora Peroxisome prolifator-ikora reseptor gamma coactivator 1-alpha (PGC-1α) inzira, igira uruhare muri biogenezi ya mitochondrial, mugihe UB itezimbere inzira ya AMP ikora protein kinase (AMPK), igira uruhare murugo homeostasis. Izi nzira zigira uruhare mu ngaruka zingirakamaro zibi bice byubuzima.
Nubwo inyungu zishimishije za UA na UB, haracyari imbogamizi kubikoresha. Kurugero, bioavailable yibi bikoresho iracyari hasi cyane, kandi imiti ya farumasi ntabwo yunvikana neza. Byongeye kandi, ingaruka z’ibi bikoresho ku bantu ntizisobanurwa neza, kubera ko ubushakashatsi bwinshi bwakorewe muri vitro cyangwa mu nyamaswa. Nubwo bimeze bityo ariko, ubushakashatsi buriho bwerekana ko UA na UB bashobora kuba bafite ikizere cyo guteza imbere ibiryo bikora cyangwa inyongera zunganira ubuzima muri rusange no kwirinda indwara.
Urolithin A. Iyi molekile ntoya iboneka mubisanzwe mu mbuto n'imbuto zimwe na zimwe irazwi cyane kubera ubushobozi bwayo buvugwa ko butezimbere ibintu byose kuva imikurire yimitsi kugeza imikorere yubwonko. Urolithin A ni metabolite, bivuze ko ari umusaruro wibindi bikoresho mu mubiri. By'umwihariko, ikorwa iyo bagiteri zo munda zimennye ellagitannine, iboneka mu biribwa bimwe na bimwe nk'amakomamanga, strawberry na walnuts. Ariko dore igice gishimishije: ntabwo buriwese afite bagiteri zo munda zikenewe kugirango zibyare urolithine A. Mubyukuri, ubushakashatsi bwerekanye ko abantu 30-50% bonyine aribo bashobora kubyara iyi molekile muburyo busanzwe. Aha niho inyongera ziza.
None, ni ikiinyungu za urolithin A? Nibyiza, kimwe mubisabwa cyane nuko bishobora gufasha kuzamura ubuzima bwimitsi. Ubushakashatsi bwasohotse mu kinyamakuru Nature Medicine bwerekanye ko iyo imbeba zahawe urolithine A, ziyongereyeho 42% mu kwihangana no kwiyongera kwa 70%. Nubwo ibi bisubizo bitangaje rwose, birakwiye ko tumenya ko iyi yari ubushakashatsi buke kandi hakenewe ubushakashatsi bwinshi kugirango hemezwe ibyo byagaragaye mubantu.
Ariko ntabwo aribyo byose urolithin A bivugwa gukora. Byerekanwe kandi kunoza imikorere ya mitochondrial. Mitochondria mubyukuri ningufu zingirabuzimafatizo, zishinzwe kubyara ingufu umubiri ushobora gukoresha. Mugihe tugenda dusaza, imikorere yacu ya mitochondial itangira kugabanuka, bishobora gutera ibibazo byinshi byubuzima. Nyamara, ubushakashatsi bwambere bwerekana ko urolithine A ishobora gufasha kugabanya iri gabanuka, bishobora kuzamura ubuzima muri rusange no kongera igihe cyo kubaho.
Nkaho ibyo bidahagije, urolithin A nayo yerekanwe ko ifite inyungu zubwenge. Ubushakashatsi bwasohotse mu kinyamakuru Scientific Reports bwerekanye ko iyo imbeba zahawe urolithin A, ubushobozi bwabo bwo kwibuka no kwiga byateye imbere. Abashakashatsi bemeza ko ibyo bishobora guterwa n'ingaruka za molekile zirwanya inflammatory, zifasha kurinda ingirangingo z'ubwonko kwangirika.
Urolithin B, ifumbire iboneka mu mbuto zitandukanye n'amakomamanga, izwiho inyungu zishobora guteza imbere ubuzima bwa metabolike no kongera ubuzima. Ubushakashatsi buherutse gukorwa bwerekanye ko urolithin B ifite imiti igabanya ubukana na antioxydeant ishobora gufasha kwirinda indwara zidakira no kuzamura ubuzima muri rusange.
1. Ibintu birwanya inflammatory
Indwara idakira ni yo mpamvu nyamukuru itera indwara nyinshi, zirimo indwara z'umutima, diyabete na kanseri. Urolithin B ifite imiti igabanya ubukana ifasha kugabanya uburibwe mu mubiri, bityo bikagabanya ibyago byindwara zidakira. Ubushakashatsi bumwe bwerekanye ko urolithin B yagabanije cyane gutwika imbeba n’indwara zifata amara, byerekana ko ishobora kugira akamaro mu kuvura abantu bafite indwara zisa.
2. Imiti igabanya ubukana
Urolithin B ni antioxydants ikomeye, bivuze ko ishobora gufasha kurinda umubiri imbaraga za okiside, inzira yangiza selile kandi igatera imbere gusaza. Urolithin B ifasha kwirinda kwangirika kwa okiside muguhindura radicals yubusa, ishobora kwangiza selile kandi igatera indwara zidakira. Ubushakashatsi bumwe bwerekanye ko urolithin B yagabanije imbaraga za okiside mu nzoka, bikomeza gushyigikira ubushobozi bwayo nk'inyongera yo gusaza.
3. Guteza imbere ubuzima bwimitsi
Urolithin B yerekanwe kubyutsa mitochondrial autophagy, inzira ya selile ifasha kurandura mitochondriya yangiritse muri selile. Iyi nzira ifasha kuzamura ubuzima bwimitsi nimikorere muri rusange, bigatuma ishobora kuba inyongera kubashaka kunoza imikorere yumubiri. Ubushakashatsi bumwe bwerekanye ko urolithin B yatezimbere imikorere yimitsi nimbaraga mumbeba nabantu.
4. Gushyigikira ubuzima bwubwenge
Urolithin B yerekanwe gushyigikira ubuzima bwubwenge iteza imbere neuroplastique, inzira ifasha ubwonko kumenyera amakuru mashya kandi bushobora kunoza imikorere yubwenge. Ubushakashatsi bumwe bwerekanye ko urolithin B yatezimbere imikorere yubwenge no kongera ububiko bwimbeba.
5. Inyungu zishobora kuramba
Ubushakashatsi buherutse gukorwa bwerekanye ko urolithine B ifite ubushobozi bwo kuramba mu kuzamura ubuzima bwa metabolike, kugabanya umuriro, no kwirinda impagarara za okiside. Ubushakashatsi bumwe bwerekanye ko urolithin B yongereye igihe muri C. elegans, ubwoko bwinzoka ya nematode, ishyigikira inyungu zishobora guteza kuramba.
1. Amakomamanga
Amakomamanga ni imwe mu masoko meza ya urolithine. Abashakashatsi basanze umutobe w'amakomamanga ushobora kongera urugero rw'amaraso ya urolithine A na B. Byongeye kandi, amakomamanga afite izindi nyungu z'ubuzima, harimo na anti-inflammatory na antioxidant.
2. Imbuto
Imbuto nka strawberry, raspberries na blackberries nazo ni isoko nziza ya urolithin. Ubushakashatsi bwerekanye ko kurya imbuto bishobora kongera amaraso ya urolithine A na B.
3. Imbuto
Walnuts na pecans nibindi biti nabyo ni isoko nziza ya urolithin. Ubushakashatsi bwerekanye ko kurya ibinyomoro bizongera urugero rwa urolithine A na B mu maraso.
Urolithin A na B nibintu bisanzwe biboneka mubiribwa bimwe na bimwe, bifite inyungu nyinshi mubuzima. Izi mvange zifite imiti irwanya inflammatory, itezimbere ubuzima bwa mitochondial n imitsi, kandi iteza imbere ubuzima bwubwenge. Amakomamanga, imbuto, imbuto hamwe n'inyongera za ellagitannin ni zimwe mu masoko meza y'ibiribwa ashobora gutanga urolithine. Gushyira ibyo biryo mumirire yawe birashobora kugufasha gufungura ibyiza bya urolithine A na B no guteza imbere gusaza neza.
Igihe cyo kohereza: Jun-05-2023
