Urolithin A ni ibintu karemano bigizwe n'ibinyabutabire bivangwa na bagiteri zo mu mara zihindura ellagitannins kugira ngo zirusheho kugira ubuzima bwiza ku rwego rw'uturemangingo. Urolithin B yakunzwe n'abashakashatsi kubera ubushobozi bwayo bwo kunoza ubuzima bw'amara no kugabanya ububyimbirwe. Urolithin A na urolithin B bifite imiterere ijyanye, ariko bifite itandukaniro ritandukanye. Ni izihe tandukaniro ryihariye, reka tubirebe!
Mu myaka ya vuba aha, abahanga bagiye biga ku byiza by’ubuzima bya urolithin, ikintu karemano gikomoka ku mikorobe ikomoka ku ihinduka rya ellagitannins na bagiteri zo mu mara. Ibintu byayo bya mbere ni aside ellagique na ellagitannins, biboneka mu buryo busanzwe mu biribwa bitandukanye nka pomegranate, guava, icyayi, pecans, imbuto, n’imbuto nka sitroberi, raspberries z’umukara, n’imbuto z’umukara. Byongeye kandi, urolithin A, polyphenol karemano, ni ingenzi cyane nk’umuti ukomeye wo kurwanya ubushyuhe n’ububyimbirwe, ukaba n’inyungu nziza ku buzima.
Subushakashatsi bukora iperereza kuriIngaruka za UA ku mikorere y'uturemangingo n'inzira z'ibinyabuzima zagaragaje ko ifite uburyo bwinshi bwo gukora. Ubushakashatsi bwagaragaje kandi ko UA ikora autophagy ya mitochondrial, inzira ikuraho mitochondria yangiritse mu turemangingo kandi ikongera umusaruro w'ingufu. Iki gikorwa kireba cyane cyane indwara ziterwa no gusaza, kuko mitochondria idakora neza ituma habaho kwiyongera kwa oxidative stress no kubyimba. UA inagenzura igaragara rya za gene zigize uruhare mu gusubiza oxidative stress, gusana ADN no kuzura kwa apoptosis, ibyo bikaba ari ingenzi mu kubungabunga ubusugire bw'uturemangingo no gukumira kanseri.
IkindiIkintu gishimishije cya UA niubushobozi bwayo nk'umuti wo gusahura imyaka y'ubukure, bivuze ko ishobora gutera apoptosis mu turemangingo tw'ubukure, ari two turemangingo twangiritse tutakigabanyamo ibice ahubwo tugatanga ibintu byangiza uturemangingo n'ingingo bituranye. Uturemangingo tw'ubukure dufitanye isano n'indwara zitandukanye ziterwa no gusaza, nka rubagimpande, atherosclerosis na neKugabanya uturemangingo tw’amaraso. Mu gukuraho uturemangingo mu buryo bwihariye, UA ishobora gutinza cyangwa gukumira itangira ry’izi ndwara no kunoza ubuzima muri rusange.
Urolithine ni ubwoko bw'ibintu bizwi nka metabolites za ellagitannin, bikorerwa ahanini na microbiota yo mu nda. Muri byo, molekile ebyiri, urolithine A na urolithine B, byakunzwe cyane kubera akamaro kabyo ku buzima. Ibi bintu biboneka mu mbuto zitandukanye nka pomegranate, strawberries, na raspberries. Muri iyi blog, tuzareba neza imiterere ifitanye isano ya urolithine A na urolithin B.
Urolithin A ni molekile iboneka cyane mu muryango wa urolithin, kandi yakozweho ubushakashatsi burambuye ku miterere yayo irwanya ubushyuhe n'ububyimbirwe. Byongeye kandi, ubushakashatsi bwagaragaje ko UA ishobora kunoza imikorere ya mitochondrial no gukumira kwangirika kw'imitsi. UA izwi kandi kubera ubushobozi bwayo bwo kurwanya kanseri. Ubushakashatsi bwagaragaje ko UA ishobora kubuza ikwirakwira ry'uturemangingo no gutera urupfu rw'uturemangingo mu turemangingo dutandukanye twa kanseri, harimo uturemangingo twa prostate, ibere, n'amara.
Ku rundi ruhande, urolithin B yakuruye ibitekerezo by'abashakashatsi ku bushobozi bwayo bwo kunoza ubuzima bw'amara no kugabanya ububyimbirwe. Ubushakashatsi bwagaragaje ko UB ishobora kongera ubudasa bw'udukoko two mu mara no kugabanya cytokines zitera ububyimbirwe, nka interleukin-6 na tumor necrosis factor-alpha. Byongeye kandi, UB nayo yavumbuwe ko ishobora kurinda ubwonko, kuko ubushakashatsi bwagaragaje ko ishobora gufasha mu gukumira indwara zitera ububyimbirwe nka Parkinson na Alzheimer.
Nubwo bifite isano, UA na UB bifite itandukaniro rigaragara. Urugero, UA byagaragaye ko ifite imbaraga zo kurwanya ububyimbirwe no kurwanya antioxydants kurusha UB. Ku rundi ruhande, UB byagaragaye ko igira akamaro kanini mu gukumira ibibazo bifitanye isano n'umubyibuho ukabije, nko kudakora neza kwa insuline no gutandukanya amafuta. Byongeye kandi, bitandukanye na UA, UB ntabwo yigwaho cyane nk'umuti urwanya kanseri.
Uburyo UA na UB bikora nabwo buratandukanye. UA ikora inzira ya Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α), igira uruhare mu mitochondria biogenesis, mu gihe UB yongera inzira ya AMP-activated protein kinase (AMPK), igira uruhare mu kongera ingufu. Izi nzira zigira uruhare mu ngaruka nziza z'izi mvange ku buzima.
Nubwo hari ibyiza bishimishije bya UA na UB, haracyari imbogamizi ku ikoreshwa ryabyo. Urugero, ubushobozi bw'ibi bintu buracyari hasi cyane, kandi imiterere yabyo mu bijyanye n'imiti ntabwo irasobanuka neza. Byongeye kandi, ingaruka z'ibi bintu ku bantu ntizirasobanuka neza, kuko ubushakashatsi bwinshi bwakozwe mu buryo bwa vitro cyangwa mu nyamaswa. Nyamara, ubushakashatsi buriho bwerekana ko UA na UB zishobora kuba abakandida beza bo guteza imbere ibiryo bikora cyangwa inyongeramusaruro kugira ngo bifashe ubuzima rusange no gukumira indwara.
Urolithin A. Aka kanyamuryango gato kaboneka mu mbuto zimwe na zimwe n'imbuto z'ibinyampeke kazwi cyane kubera ubushobozi bwako bwo kunoza ibintu byose kuva ku mikurire y'imitsi kugeza ku mikorere y'ubwonko. Urolithin A ni metabolite, bivuze ko ari umusaruro w'ibindi bintu biri mu mubiri. By'umwihariko, kakorwa iyo bagiteri zo mu mara zisenya ellagitannins, ziboneka mu biribwa bimwe na bimwe nk'amakomamanga, inkeri n'imbuto z'ibihwagari. Ariko dore igice gishimishije: si buri wese ufite bagiteri zikenewe mu mara kugira ngo zikore urolithin A. Mu by'ukuri, ubushakashatsi bwagaragaje ko abantu bagera kuri 30-50% gusa ari bo bashobora gukora iyi molekile mu buryo busanzwe. Aha niho inyongeramusaruro ziba ingirakamaro.
None se, ni ikiAkamaro ka urolithin A? Kimwe mu bintu bikomeye bivugwa ni uko ishobora gufasha kunoza ubuzima bw'imitsi. Ubushakashatsi bwasohotse mu kinyamakuru Nature Medicine bwagaragaje ko igihe imbeba zahabwaga urolithin A, zari zifite ubwiyongere bwa 42% mu kwihangana no kwiyongera kwa 70%. Nubwo ibi bisubizo bitangaje rwose, ni ngombwa kumenya ko ubu bwari ubushakashatsi buto kandi hakenewe ubushakashatsi bwinshi kugira ngo hemezwe ibi byavumbuwe ku bantu.
Ariko ibyo si byo byonyine bivugwa ko urolithine A ikora. Byagaragaye kandi ko yongera imikorere ya mitochondria. Mitochondria ni inkingi z'ingufu z'uturemangingo, zishinzwe gutanga ingufu umubiri ushobora gukoresha. Uko tugenda dusaza, imikorere yacu ya mitochondria itangira kugabanuka, ibi bikaba bishobora gutera ibibazo byinshi by'ubuzima. Ariko, ubushakashatsi bwa mbere bwerekana ko urolithine A ishobora gufasha kugabanya uku kugabanuka, bigashobora kunoza ubuzima muri rusange no kongera igihe cyo kubaho.
Nk’aho ibyo bidahagije, urolithin A nayo byagaragaye ko ifite akamaro mu bwenge. Ubushakashatsi bwasohotse mu kinyamakuru Scientific Reports bwagaragaje ko iyo imbeba zahabwaga urolithin A, ubushobozi bwazo bwo kwibuka no kwiga bwarushijeho kwiyongera. Abashakashatsi bemeza ko ibi bishobora kuba biterwa n’ingaruka z’uyu mubumbe zo kurwanya ububyimbirwe, zifasha kurinda uturemangingo tw’ubwonko kwangirika.
Urolithin B, ikinyabutabire kiboneka mu mbuto zitandukanye n'amakomamanga, kizwiho akamaro kacyo mu kunoza ubuzima bw'umubiri no kongera igihe cyo kubaho. Ubushakashatsi buherutse bwerekanye ko urolithin B ifite ubushobozi bwo kurwanya ububyimbirwe n'ubudahangarwa bw'umubiri bushobora gufasha mu gukumira indwara zidakira no kunoza ubuzima muri rusange.
1. Imiterere irwanya ububyimbirwe
Kubyimba guhoraho ni intandaro nyamukuru y’indwara nyinshi, harimo indwara z’umutima, diyabete na kanseri. Urolithin B ifite ubushobozi bwo kurwanya ububyimbirwe bufasha kugabanya ububyimbirwe mu mubiri, bityo ikagabanya ibyago byo kurwara indwara zidakira. Ubushakashatsi bumwe bwagaragaje ko urolithin B igabanya cyane ububyimbirwe mu mbeba zifite indwara yo kubyimbirwa mu mara, bigaragaza ko ishobora kugira akamaro mu kuvura abantu bafite indwara nk’izo.
2. Imiterere ya antioxydants
Urolithin B ni antioxydant ikomeye, bivuze ko ishobora gufasha kurinda umubiri stress ya oxidative, inzira yangiza uturemangingo kandi igateza imbere gahunda yo gusaza. Urolithin B ifasha mu gukumira kwangirika kwa oxidative binyuze mu kugabanya uturemangingo tw’umubiri, dushobora kwangiza uturemangingo ndetse bigatera indwara zidakira. Ubushakashatsi bumwe bwagaragaje ko urolithin B igabanya stress ya oxidative mu mbeba, irushaho gushyigikira ubushobozi bwayo nk'inyongera mu kurwanya gusaza.
3. Guteza imbere ubuzima bw'imitsi
Urolithin B yagaragaye ko itera imbaraga mu mitochondria, inzira y’uturemangingo ifasha mu gukuraho mitochondria yangiritse mu turemangingo. Iyi nzira ifasha mu kunoza ubuzima bw’imitsi muri rusange n’imikorere yayo, bigatuma iba inyongera ku bashaka kunoza imikorere y’umubiri. Ubushakashatsi bumwe bwagaragaje ko urolithin B yongera imikorere n’imbaraga z’imitsi mu mbeba no mu bantu.
4. Ifasha ubuzima bwo mu mutwe
Urolithin B yagaragaye ko ishyigikira ubuzima bw'ubwonko binyuze mu guteza imbere uburyo bwo kongerera ubushobozi bwo gutekereza, inzira ifasha ubwonko kumenyera amakuru mashya kandi ishobora kunoza imikorere y'ubwonko. Ubushakashatsi bumwe bwagaragaje ko urolithin B yongera imikorere y'ubwonko kandi ikongera kwibuka mu mbeba.
5. Inyungu zishobora kubaho igihe kirekire
Ubushakashatsi buherutse bwerekanye ko urolithine B ifite ubushobozi bwo gutuma umuntu aramba binyuze mu kunoza ubuzima bw'umubiri, kugabanya ububyimbirwe, no kurinda stress ya oxidative. Ubushakashatsi bumwe bwagaragaje ko urolithine B yongera igihe cyo kubaho mu bwoko bwa C. elegans, ubwoko bw'inzoka zo mu bwoko bwa nematode, bushyigikira inyungu zishobora guterwa no gutuma umuntu aramba.
1. Ingano
Amakomamanga ni imwe mu masoko meza ya urolithine. Abashakashatsi bavumbuye ko umutobe w'amakomamanga ushobora kongera urugero rwa urolithine A na B mu maraso. Byongeye kandi, amakomamanga afite izindi nyungu ku buzima, harimo no kurwanya ububyimbirwe no kurwanya okisidasiyo.
2. Imbuto
Imbuto nka sitroberi, raspberries na blackberries nazo ni isoko nziza ya urolithine. Ubushakashatsi bwagaragaje ko kurya imbuto bishobora kongera urugero rwa urolithine A na B mu maraso.
3. Imbuto
Imbuto za Walnuts na pecans n'izindi mbuto nazo ni isoko nziza ya urolithine. Ubushakashatsi bwagaragaje ko kurya imbuto bizatuma urugero rwa urolithine A na B mu maraso ruzamuka.
Urolithine A na B ni ibintu karemano biboneka mu biribwa bimwe na bimwe, bifite akamaro kenshi ku buzima. Ibi bintu bifite ubushobozi bwo kurwanya ububyimbirwe, binoza ubuzima bwa mitochondrial n'imitsi, kandi bikanateza imbere ubuzima bwo mu mutwe. Amakomamanga, imbuto, imbuto n'inyongeramusaruro za ellagitannin ni bimwe mu biribwa byiza bishobora gutanga urolithine. Gushyira ibi biribwa mu mirire yawe bishobora kugufasha kubona ibyiza bya urolithine A na B no guteza imbere gusaza neza.
Igihe cyo kohereza: Kamena-05-2023
