Urolithin A ni metabolite karemano ikorwa mugihe umubiri winjije ibintu bimwe na bimwe mu mbuto nk'amakomamanga, strawberry, na raspberries. Iyi metabolite yerekanwe ko ifite inyungu zitandukanye mubuzima kandi ni ningingo itanga ikizere cyo kurwanya gusaza ifite ubushobozi bwo guhindura uburyo duhura nubusaza. Ubushobozi bwayo bwo gushyigikira imikorere ya mito-iyambere, ubuzima bwimitsi, nibikorwa byubwenge bituma iba inyongera yingirakamaro kubashaka gukomeza ubusore nubuzima. Mugihe ubushakashatsi kuri urolithin A bukomeje kugenda bwiyongera, birashoboka ko bizahinduka urufatiro rwibikorwa byo kurwanya gusaza. Witondere kuri iki kigo gikomeye - gishobora kuba urufunguzo rwo gufungura isoko yubuto.
Urolithin A. ni metabolite ikorwa mu mara nyuma yo kurya ibiryo bimwe na bimwe, nk'amakomamanga, imbuto zirimo ellagitannin, n'imbuto. Ubushakashatsi bwerekana ko urolithine A ifite imbaraga zo kurwanya gusaza kandi ishobora kugira uruhare runini mugutezimbere ubuzima bwimikorere no kuramba.
Urolithin A ikora inzira yitwa mitofagy. Mitophagy nuburyo busanzwe bwumubiri bwo gukuraho mitochondriya yangiritse cyangwa idakora neza, imbaraga za selile. Mugihe tugenda dusaza, mitochondriya yacu idakora neza kandi ikusanya ibyangiritse, bigatuma imikorere ya selile igabanuka ndetse nubuzima muri rusange. Mugutezimbere mitofagy, urolithin A ifasha kugarura no kuzuza inganda zingufu zingirabuzimafatizo, bishobora kudindiza gusaza
Usibye guteza imbere ubuzima bwa mitochondrial, urolithin A ifite kandi antioxydants na anti-inflammatory. Guhangayikishwa na Oxidative hamwe no gutwika karande ni ibintu bibiri byingenzi bitera gusaza n'indwara ziterwa n'imyaka. Urolithin A ifasha kurwanya izi nzira, ikingira ingirabuzimafatizo n'ingirangingo zidashaje.
Byongeye kandi, urolithin A yerekanwe kuzamura imikorere yimitsi no guteza imbere ubuzima bwimitsi, biba ngombwa cyane cyane uko dusaza. Sarcopenia, cyangwa gutakaza imitsi bijyanye nimyaka, nikibazo gikunze kugaragara kubantu bakuze kandi gishobora gutera intege nke no kugabanuka mubuzima rusange. Mugushigikira imikorere yimitsi, urolithin A irashobora gufasha gukomeza imbaraga no kugenda uko dusaza.
Ubwa mbere, reka turebe neza urolithin icyo aricyo nuburyo ikora mumubiri. Urolithine ni metabolite ikorwa mugihe mikorobe zo mu nda zisenya ellagitannine, ziboneka mu mbuto nk'amakomamanga n'imbuto. Iyi nzira ningirakamaro kuko urolithine ntishobora kuboneka muburyo bwo kurya izo mbuto. Urolithine imaze gukorwa, abantu batekereza ko ifite inyungu zitandukanye mubuzima, harimo kunoza imikorere ya mito-iyambere (ifite akamaro kanini mu gutanga ingufu za selile) no guteza imbere ubuzima bwimitsi no kuramba.
Ubushakashatsi bwasohotse mu kinyamakuru Nature Metabolism bwerekanye ko urolithin A, bumwe mu buryo bwize cyane bwa urolithine, bwateje imbere imikorere y’imitsi no kwihangana ku mbeba zishaje. Ubu bushakashatsi buratanga ikizere kuko bwerekana ko urolithine ishobora kugira inyungu zishobora kugabanuka kumitsi ijyanye no gusaza.
Usibye inyungu zishobora guteza ubuzima bwimitsi, urolithin yanakozweho ubushakashatsi ku miterere yarwo yo gusaza. Ubundi bushakashatsi bwasohotse mu kinyamakuru Nature Medicine mu 2016 bwerekanye ko urolithine A ishobora kuvugurura mitochondriya mu ngirabuzimafatizo zishaje, bityo bigatuma imikorere ya selile ikanadindiza gusaza.
Bumwe mu buryo bukunze kugaragara bwa urolithine A ni nk'inyongera y'ibiryo. Ibi byiyongera mubisanzwe biva mubikomamanga by'amakomamanga cyangwa aside ellagic kandi bifatwa muburyo bwa capsule. Nyamara, bioavailable ya urolithin A muburyo bwinyongera irashobora gutandukana, kandi ubushakashatsi bumwe bwerekana ko bushobora kuba bwiza kuruta ubundi buryo.
Ubundi buryo bwa urolithine A ni nkibigize ibiryo bikora. Ibigo bimwe byatangiye kongeramo urolithin A mubiribwa n'ibinyobwa bitandukanye, nk'utubari twa poroteyine, ibinyobwa n'ifu. Ibicuruzwa bitanga uburyo bworoshye kandi buryoshye bwo kurya urolithin A.
Bumwe mu buryo butanga ikizere cya urolithin A ni nk'inyongera ya farumasi. Ibicuruzwa bikorerwa igeragezwa rikomeye no kugenzura ubuziranenge kugirango habeho isuku nimbaraga. Urwego rwa farumasi urolithin A itanga bioavailable kandi ikora neza, bigatuma iba uburyo bwiza bwo kubona inyungu zubuzima bwuru ruganda.
Usibye ubu buryo, ubushakashatsi nabwo burakomeje mugutezimbere urolithine Ikigereranyo, kikaba ari synthique synthique yagenewe kwigana ingaruka za urolithine naturel A. Izi ngero zishobora gutanga inyungu zidasanzwe mubijyanye na bioavailable, stabilite, and power.
1. Kurwanya gusaza
Mitochondriya ni imbaraga zingirabuzimafatizo zacu, ishinzwe kubyara ingufu no kugenzura imikorere ya selile. Mugihe tugenda dusaza, mitochondriya yacu idakora neza, bigatuma imikorere ya selile igabanuka muri rusange. Urolithin A yerekanwe kuvugurura mitochondriya ishaje, bityo bigatuma umusaruro w’ingufu n’ubuzima rusange bwa selile. Usibye inyungu zayo kuri mitochondria, urolithin A yabonetse kugirango ikore inzira yitwa autophagy. Autophagy nuburyo busanzwe bwumubiri bwo gukuraho ingirabuzimafatizo zangiritse cyangwa zidakora neza, bityo bigateza imbere ingirabuzimafatizo nubuzima muri rusange. Mugutezimbere autofagy, Urolithin A ifasha gukuramo ingirabuzimafatizo zishaje, zashaje mumubiri no kuzisimbuza selile nshya, zifite ubuzima bwiza, bityo zitezimbere imikorere yumubiri nubuzima rusange.
2. Kurwanya inflammatory
Indurwe zidakira hamwe na okiside itera ni zo mpamvu nyamukuru zitera gusaza, biganisha ku ndwara ziterwa n'imyaka. Mugabanye gucana no guhagarika umutima, urolithine A irashobora kubuza umusaruro wa molekile ikongora kandi igafasha kwirinda izo ndwara ziterwa nimyaka. indwara, kandi iteza imbere ubuzima muri rusange no kuramba.
3. Ubuzima bwimitsi
Urolithin A nayo yabonetse kugirango iteze imbere imitsi n'imikorere. Mugihe tugenda dusaza, imitsi n'imbaraga zacu mubisanzwe bigabanuka. Nyamara, urolithine A irashobora kongera imitsi yingirabuzimafatizo no kunoza imikorere yimitsi, ishobora gufasha gutinda kwangirika kwimitsi.
4. Gutunga ubuzima
Ubushakashatsi bushya bwerekana ko urolithine A ishobora kugira uruhare mu kuzamura ubuzima bwo mu mara. Byagaragaye ko bifite ingaruka za prebiotic, bivuze ko ishyigikira imikurire ya bagiteri nziza munda. Microbiome nziza yinda ningirakamaro kubuzima muri rusange, kuko ishobora guhindura ibintu byose kuva igogorwa kugeza kumikorere yumubiri.
5. Ubuzima bwo kumenya
Hariho kandi ibimenyetso byerekana ko urolithin A ishobora kugira ingaruka nziza kubuzima bwubwenge. Ubushakashatsi bwerekana ko bushobora gufasha kwirinda indwara zifata ubwonko nka Alzheimer mu kugabanya iyubaka rya poroteyine zangiza mu bwonko. Ibi birerekana inyungu zishobora kubaho kubuzima bwubwonko nibikorwa byubwenge.
Nimbuto za ruby-umutuku hamwe nuburyohe bwa tart, amakomamanga arahabwa agaciro kubwinyungu nyinshi zubuzima. Kuva kuri antioxydants nyinshi kugeza kubintu bishobora kurwanya anti-inflammatory, iyi mbuto imaze igihe kinini ifatwa nk'imbaraga mu isi yintungamubiri. Kimwe mu bintu bishimishije biboneka mu makomamanga ni urolithine, metabolite yagiye ikorerwa ubushakashatsi bwinshi ku ngaruka zishobora guteza ubuzima.
Kugira ngo wumve igisubizo cyiki kibazo, birakenewe gucengera cyane mubumenyi bwa urolithine nuburyo byakozwe. Iyo turya ibiryo bikungahaye kuri ellagitannine, nk'amakomamanga, ibyo bikoresho bivamo mo urolithine na microbiota yo mu nda. Nyamara, ntabwo abantu bose bafite ibice bimwe bya microbiota yo mu nda, biganisha ku gutandukanya umusaruro wa urolithin hagati yabantu.
Nubwo amakomamanga ari isoko ikungahaye kuri ellagitannine, ingano ya urolithine iba mu mubiri irashobora gutandukana. Ihindagurika ryatumye habaho iterambere ryinyongera ya urolithin ikomoka kumikomamanga yamakomamanga, ikomeza gufata iyi metabolite yingirakamaro. Izi nyongera zirimo kwitabwaho kubushobozi bwazo bwo gushyigikira ubuzima bwimitsi, kunoza imikorere ya mito-iyambere, no kuzamura ubuzima muri rusange.
Kugaragara kw'inyongeramusaruro za urolithin byakuruye inyungu mubushobozi bwabo bwo gukoresha inyungu zubuzima bw'amakomamanga badashingiye ku itandukaniro ryihariye ku musaruro wa urolithine. Kubadashobora kurya amakomamanga buri gihe cyangwa ntibashobora kungukirwa byuzuye nibirimo urolithin bitewe na mikorobe yabo yo mu nda.
Ikibazo niba ikomamanga yikomamanga irimo urolithine irashobora gusubizwa mubyemeza. Nubwo urolithine ari umusaruro usanzwe wo kurya amakomamanga, guhinduka mu musaruro wacyo mu mubiri byatumye habaho iterambere ry’inyongera ya urolithine kugira ngo ukomeze gufata iyi metabolite ifite akamaro.
Mugihe ubushakashatsi bukomeje kwerekana ingaruka ziteza imbere ubuzima bwa urolithine, ukoresheje ibimera by'amakomamanga nkisoko yuru ruganda bifite amahirwe menshi. Haba binyuze mu kurya amakomamanga ubwabo cyangwa gukoresha inyongeramusaruro za urolithine, gukoresha imbaraga za urolithine ni inzira itanga icyizere cyo gushyigikira ubuzima rusange n'imibereho myiza.
Iyo uhisemo urolithin Inyongera, hari ibintu byinshi byingenzi ugomba gusuzuma. Mbere na mbere, ni ngombwa gushaka uruganda ruzwi rukoresha ibikoresho byujuje ubuziranenge kandi rukurikiza amahame akomeye yo kugenzura ubuziranenge. Shakisha inyongeramusaruro zindi-zipimishije kubwera nimbaraga kugirango umenye neza ibicuruzwa byiza kandi byiza.
Byongeye kandi, tekereza kumiterere ya urolithin A ikoreshwa mubyongeweho. Urolithin A ikunze guhuzwa nibindi bikoresho, nka urolithin B cyangwa aside ellagic, ishobora kongera ingaruka zayo. Shakisha inyongera zikoresha bioavailable ya urolithin A kugirango igabanye neza kandi ikore neza mumubiri.
Hanyuma, tekereza ku buzima bwawe bwite n'intego zawe zihariye zo gufata urolithine A. Kurugero, niba uri umukinnyi ushaka kunoza imikorere yimitsi, urashobora guhitamo inyongera yateguwe kubuzima bwimitsi no gukira.
Suzhou Myland Pharm & Nutrition Inc yatangiye gukora ubucuruzi bwongera imirire kuva mu 1992. Nisosiyete ya mbere mu Bushinwa yateje imbere kandi igacuruza imbuto zinzabibu.
Hamwe nuburambe bwimyaka 30 kandi itwarwa nubuhanga buhanitse hamwe ningamba zinoze cyane R&D, isosiyete yateje imbere ibicuruzwa bitandukanye byapiganwa kandi ihinduka ubumenyi bwa siyanse yubuzima bushya, synthesis gakondo hamwe na serivise zikora inganda.
Byongeye kandi, isosiyete kandi ni uruganda rwanditswe na FDA, rwemeza ubuzima bwabantu bafite ireme rihamye kandi ryiterambere rirambye. Isosiyete R&D umutungo n'ibikoresho byo kubyaza umusaruro nibikoresho byisesengura nibigezweho kandi byinshi, kandi birashobora gukora imiti kuri miligarama kugeza kuri toni yubahiriza ibipimo bya ISO 9001 hamwe nuburyo bwo gukora GMP.
Ikibazo: Ketone ester ni iki kandi ikora ite?
Igisubizo: Ketone ester ninyongera itanga umubiri na ketone, ikorwa muburyo bwumwijima mugihe cyo kwiyiriza ubusa cyangwa gufata karubone nkeya. Iyo yinjiye, ester ya ketone irashobora kuzamura vuba urugero rwa ketone yamaraso, igaha umubiri ubundi buryo bwa peteroli kuri glucose.
Ikibazo: Nigute nshobora kwinjiza ester ya ketone mubikorwa byanjye bya buri munsi?
Igisubizo: Ketone ester irashobora kwinjizwa mubikorwa byawe bya buri munsi uyifata mugitondo nkinyongera mbere yimyitozo ngororamubiri, uyikoresha kugirango uzamure imikorere yibitekerezo no kwibanda mugihe cyakazi cyangwa amasomo yo kwiga, cyangwa kuyikoresha nkimfashanyo yo gukira nyuma yimyitozo. Irashobora kandi gukoreshwa nkigikoresho cyo kwimukira mu ndyo ya ketogenique cyangwa kwiyiriza ubusa rimwe na rimwe.
Ikibazo: Haba hari ingaruka cyangwa ingamba zo gusuzuma mugihe ukoresheje ketone ester?
Igisubizo: Mugihe estet ester isanzwe ifatwa nkumutekano kubantu benshi, abantu bamwe bashobora guhura nibibazo byigifu mugihe batangiye kubikoresha. Ni ngombwa kandi kugisha inama inzobere mu by'ubuzima mbere yo kwinjiza ester ya ketone muri gahunda zawe, cyane cyane niba ufite ubuzima bw’ibanze cyangwa ufata imiti.
Ikibazo: Nigute nshobora kwerekana ibisubizo byo gukoresha ketone ester?
Igisubizo: Kugirango ugere ku bisubizo byo gukoresha ketone ester, ni ngombwa guhuza ibyo ukoresha nubuzima buzira umuze burimo imyitozo isanzwe, hydrated ihagije, nimirire yuzuye. Byongeye kandi, kwitondera igihe cyo gukoresha ketone ester bijyanye nibikorwa byawe n'intego zawe birashobora kugufasha guhindura ingaruka zabyo.
Inshingano: Iyi ngingo ni iyamakuru rusange gusa kandi ntigomba gusobanurwa nkinama zose zubuvuzi. Amwe muma poste yamakuru aturuka kuri enterineti kandi ntabwo ari umwuga. Uru rubuga rufite inshingano zo gutondeka, gutunganya no guhindura ingingo. Intego yo gutanga amakuru menshi ntabwo bivuze ko wemera ibitekerezo byayo cyangwa kwemeza ukuri kwibirimo. Buri gihe ujye ubaza inzobere mu buzima mbere yo gukoresha inyongeramusaruro cyangwa guhindura ibintu byubuzima bwawe.
Igihe cyo kohereza: Mutarama-15-2024
