Mugihe tugenda dusaza, imibiri yacu isanzwe inyura mumahinduka atandukanye ashobora kugira ingaruka kumagara yacu no kumererwa neza muri rusange. Kimwe mu bimenyetso bigaragara cyane byo gusaza ni iterambere ryiminkanyari, imirongo myiza, hamwe nuruhu runyeganyega. Mugihe nta buryo bwo guhagarika gusaza, abashakashatsi bagiye bakora badatezuka kugirango bashakishe ibice bishobora gutinda cyangwa guhindura zimwe mu ngaruka zo gusaza. Urolithin A nimwe mubintu byerekana amasezerano akomeye muriki kibazo. Ubushakashatsi buherutse gukorwa bwerekana ko urolithine A ishobora kunoza imikorere yimitsi no kwihangana, kongera imikorere ya mito-iyambere, ndetse igateza imbere kuvanaho ibice byangiritse byangiritse binyuze mubikorwa byitwa autophagy. Izi ngaruka zituma urolithin Umukandida utanga ikizere cyo guteza imbere imiti igabanya ubukana. Usibye ingaruka zayo zo kurwanya gusaza, urolithin A yizwe kubera uruhare rwayo mu guteza imbere kuramba.
Mbere yo gucukumbura ingaruka zishobora kurwanya anti-gusaza za urolithin A, reka tubanze dusobanukirwe gusaza icyo aricyo. Gusaza ni inzira igoye irimo kugabanuka gahoro gahoro imikorere ya selile no kwegeranya ibyangiritse mugihe runaka. Iyi nzira iterwa nimpamvu zitandukanye zirimo genetiki, imibereho, hamwe n’ibidukikije. Gushakisha uburyo bwo gutinda cyangwa guhindura iyi nzira byabaye intego ndende mubushakashatsi bwo gusaza.
Urolithin A yerekanwe gukora inzira ya selile yitwa mitophagy, ishinzwe gukuraho no gutunganya mitochondriya yangiritse (ingufu za selile). Mitochondria igira uruhare runini mu kubyara ingufu kandi ni isoko nyamukuru y’ubwoko bwa ogisijeni ikora (ROS), ishobora kwangiza ibice bigize selile kandi byihuta gusaza. Mugutezimbere mitofagy, urolithin A ifasha kugumana imikorere myiza ya mitochondial no kugabanya stress ya okiside, ikekwa ko igira uruhare mu gusaza.
Ubushakashatsi bwinshi bwatanze ibisubizo bitanga umusaruro kubyerekeye ingaruka za urolithine A ku gusaza. Ubushakashatsi bumwe kuri nematode bwerekanye ko urolithin A yongereye igihe cya nematode kugera kuri 45%. Ibisubizo nkibi byagaragaye mubushakashatsi bwakozwe ku mbeba, aho kongeramo urolithine A byongereye igihe cyo kubaho no kuzamura ubuzima bwabo muri rusange. Ubu bushakashatsi bwerekana ko urolithine A ifite ubushobozi bwo kugabanya umuvuduko wo gusaza no kongera igihe cyo kubaho.
Usibye ingaruka zabyo mubuzima, urolithin A nayo igira ingaruka zitangaje kubuzima bwimitsi. Gusaza akenshi bifitanye isano no gutakaza imitsi no kugabanuka kwingufu, indwara izwi nka sarcopenia. Abashakashatsi basanze urolithine A ishobora guteza imbere imikurire no kongera imitsi. Mu igeragezwa ryamavuriro ririmo abantu bakuze, urolithin Inyongera yongereye cyane imitsi yimitsi kandi inoze imikorere yumubiri. Ubu bushakashatsi bwerekana ko urolithin A idafite ingaruka zo kurwanya gusaza gusa ahubwo ifite inyungu zishobora kugira ku buzima bwimitsi, cyane cyane ku bageze mu zabukuru.
Byongeye kandi, birakwiye ko tuvuga ko urolithine A ikomoka ku makomamanga, ariko ingano ya urolithine A mu bicuruzwa by'amakomamanga irashobora gutandukana cyane. Kubwibyo, ibihimbano byubukorikori bihinduka uburyo bwiza kandi birushijeho kuba byiza kandi byoroshye kubibona.
Urolithin A ikomoka kuri ellagitannine, ikunze kuboneka mu mbuto zimwe na zimwe. Izi ellagitannine ziterwa na bagiteri zo munda kugirango zibyare urolithine A nizindi metabolite. Iyo urolithine A imaze kwinjizwa, igira ingaruka kumubiri kurwego rwa selile.
Imwe mu nyungu zigaragara za urolithine A nubushobozi bwayo bwo gukangura mitofagy, inzira ikomeye kubuzima bwa selile. Mitochondriya bakunze kwitwa imbaraga z'akagari kandi zigira uruhare runini mu kubyara ingufu. Ariko, uko tugenda dusaza, imikorere ya mitochondial iragabanuka, biganisha ku mikorere mibi ya selile kandi birashoboka ko habaho indwara zitandukanye ziterwa nimyaka.
Mitophagy nuburyo bwingenzi bwo gukuraho mitochondriya yangiritse kandi idakora neza, ituma mitochondriya nshya, nzima ibasimbuza. Urolithin A yerekanwe koroshya iki gikorwa, iteza imbere mitochondial no kuzamura ubuzima bwimikorere. Mugukuraho mitochondriya idakora neza, urolithin A idindiza gusaza kandi igabanya ibyago byindwara ziterwa nimyaka.
Usibye ingaruka zabyo kuri mitofagy, urolithin A ifite kandi imiti igabanya ubukana. Indurwe idakira ni moteri ikomeye yubuzima butandukanye, harimo indwara zifata umutima, umubyibuho ukabije, n'indwara zifata ubwonko. Ubushakashatsi bwerekanye ko urolithine A ihagarika ibimenyetso byerekana umuriro kandi ikabuza gukora imiti igabanya ubukana, bityo bikagabanya ibyago byo gutwika indwara zidakira n'indwara zifitanye isano nayo.
Byongeye kandi, urolithin A yerekanye ubushobozi bwayo nka antioxydeant ikomeye. Guhangayikishwa na Oxidative biterwa nubusumbane hagati yumusemburo wa radicals yubuntu nubushobozi bwumubiri bwo kubitesha agaciro, kandi bigira uruhare runini mugusaza no gutera indwara zitandukanye. Urolithin A irashobora gukuraho radicals yangiza yubusa, ikongerera umubiri imbaraga zo kwirinda antioxydeant, kurinda selile kwangirika kwa okiside, kandi bishobora gutinda gusaza.
Ubushakashatsi bugaragaza kandi inyungu zishobora guterwa na urolithin A kubuzima bwimitsi no gukora siporo. Gusaza bikunze guherekezwa no kugabanuka kwimitsi nimbaraga, biganisha ku byago byinshi byo kugwa, kuvunika, no gutakaza ubwigenge. Urolithin A yerekanwe ko yongerera imitsi ya fibre no kunoza imikorere yimitsi, bishobora kugabanya gutakaza imitsi bijyanye nimyaka.
Byongeye kandi, urolithine A yabonetse kugirango yongere imikorere y'imyitozo ngororamubiri itera imbaraga za poroteyine zigira uruhare mu mikurire no gusana. Mugushyigikira ubuzima bwimitsi nibikorwa bya siporo, urolithin A irashobora gufasha gukomeza ubuzima bukora kandi bwigenga uko dusaza.
Guteza imbere ubuzima bwo munda
Kugirango dushobore kongera umusaruro wa Urolithin A mumibiri yacu, guhindura ubuzima bwinda ni ingenzi. Microbiome itandukanye kandi itera imbere byorohereza ihinduka ryiza rya ellagitannine muri urolithine A. Kurya indyo ikungahaye kuri fibre irimo imbuto, imboga, ibinyampeke, n'ibinyamisogwe bigaburira bagiteri zifata igifu kandi bigakora ibidukikije bifasha gukora urolithine A.
R Urolithin A mu biryo
Amakomamanga ni imwe mu masoko akungahaye kuri urolithine A. Imbuto ubwazo zirimo prursor ellagitannins, zihinduka urolithine A na bagiteri zo mu nda mu gihe cyo gusya. Umutobe w'amakomamanga wasangaga urimo urolithine A nyinshi kandi ufatwa nk'uburyo bwiza bwo kubona iyi mvange bisanzwe. Kunywa ikirahuri cy'umutobe w'amakomamanga buri munsi cyangwa kongeramo amakomamanga mashya mumirire yawe birashobora kugufasha kongera urolithine yawe.
Indi mbuto irimo urolithine A ni strawberry, ikungahaye kuri aside ya ellagic. Kimwe n'amakomamanga, strawberry irimo ellagitannine, ihinduka urolithine A na bagiteri zo munda. Ongeramo strawberry kumafunguro yawe, kuyatanga nkibiryo, cyangwa kuyongerera uburyohe bwawe nuburyo bwiza buryoshye bwo kongera urwego rwa urolithine A.
Usibye imbuto, imbuto zimwe na zimwe zirimo ellagitannine, zishobora kuba isoko ya urolithine A. Walnuts, cyane cyane wasangaga irimo ellagitannine nyinshi, zishobora guhinduka urolithine A mu mara. Ongeramo intoki za ياڭ u mubyo kurya bya buri munsi ntabwo ari byiza kubuzima bwawe muri rusange, ahubwo no kubona urolithine A mubisanzwe.
Sup Inyongera zimirire hamwe na urolithine Ikuramo
Kubashaka urugero rwinshi, rwizewe rwa urolithine A, inyongeramusaruro nimirire bishobora kuba amahitamo. Iterambere mu bushakashatsi ryatumye habaho iterambere ry’inyongera zujuje ubuziranenge zikomoka ku ikomamanga ry'amakomamanga zakozwe mu buryo bwihariye kugira ngo zitange urugero rwiza rwa urolithine A. Icyakora, ni ngombwa guhitamo ikirango kizwi kandi kizwi kugira ngo ibicuruzwa n'umutekano bibe byiza.
● Igihe nibintu byihariye
Icyitonderwa, guhindura ellagitannine kuri urolithine A biratandukanye mubantu, bitewe na mikorobe yabo yo mu nda hamwe na maquillage genetique. Kubwibyo, igihe gisabwa kugirango ubone inyungu zikomeye ziva muri urolithine Ikoreshwa rishobora gutandukana. Kwihangana no gushikama nibyingenzi mugihe ushizemo urolithine A ibiryo bikungahaye cyangwa inyongera mubikorwa byawe bya buri munsi. Guha umubiri wawe umwanya wo kumenyera no kubona uburimbane bizagufasha gusarura ibihembo byuru ruganda rudasanzwe.
Myland ni ubumenyi bushya bwa siyanse yubuzima, uruganda rukora ibicuruzwa hamwe ninganda zikora inganda zitanga kandi zitanga amasoko menshi yinyongera zimirire hamwe nubwiza buhoraho hamwe niterambere rirambye kubuzima bwabantu. Urolithin Inyongera zakozwe na myland:
(1) Isuku ryinshi: Urolithin A irashobora kuba ibicuruzwa byera cyane binyuze mu kuvoma no gutunganya umusaruro. Isuku ryinshi risobanura bioavailable nziza hamwe na reaction nkeya.
(2) Umutekano: Urolithin A nigicuruzwa gisanzwe cyagaragaye ko gifite umutekano kumubiri wumuntu. Mubipimo bya dosiye, nta ngaruka mbi zifite.
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1. Kongera ubuzima bwimitsi
Urolithin A ifite imbaraga nyinshi mubijyanye nubuzima bwimitsi. Ubushakashatsi bwerekana ko ari imbaraga zikomeye za mitofagy, inzira karemano ikuraho mitochondriya idakora neza muri selile. Mugukangura mitofagy, urolithin A ifasha mukuvugurura no kuvugurura ingirangingo zimitsi, bityo bigatuma imikorere yimitsi igabanya imitsi iterwa nimyaka. Ubu bushobozi bushimishije bwa urolithin A butanga inzira yo kuvura kugirango igabanye indwara yimitsi no kuzamura imbaraga zumubiri muri rusange.
2. Kurwanya inflammatory
Gutwika bigira uruhare runini mu iterambere ry’indwara zitandukanye zidakira, nk'indwara z'umutima n'imitsi, indwara zifata ubwonko, ndetse na kanseri zimwe na zimwe. Urolithin A wasangaga ifite imbaraga zikomeye zo kurwanya inflammatory zifasha kurwanya umuriro kurwego rwa selile. Mugabanye urugero rwa molekile ziterwa na inflammatory, urolithin A ifasha kugumana igisubizo cyuzuye cyo gutwika, kikaba ari ingenzi mu gukumira no gucunga indwara zidakira.
3. Igikorwa gikomeye cya antioxydeant
Guhangayikishwa na Oxidative, biterwa nubusumbane hagati ya radicals yubusa na antioxydants mu mibiri yacu, birashobora kwangiza ingirabuzimafatizo kandi bikagira uruhare mu iterambere ry’indwara zitandukanye, harimo n’izisaza. Urolithin A ni antioxydants ikomeye ikomeye itesha agaciro radicals yubusa kandi ikingira selile kwangirika kwa okiside. Mugushira urolithine A mumirire yacu cyangwa gahunda yinyongera, turashobora kongera imbaraga zo kwirinda umubiri wa antioxydeant kandi tugatera imbere gusaza neza.
4. Gutera Ubuzima bwiza
Mu myaka yashize, microbiome yo mu nda yitabiriwe cyane ningaruka zayo kubuzima bwacu muri rusange no kumererwa neza. Urolithin A igira uruhare rwihariye mubuzima bwigifu muguhitamo guhitamo amoko yihariye ya bagiteri munda. Ihindurwa muburyo bukora na bagiteri, bityo igatera imbere inzitizi zo munda hamwe nubuzima rusange. Byongeye kandi, ubushakashatsi buherutse gukorwa bwerekana ko urolithine A ishobora kongera umusaruro wa acide fatty acide acide, itanga imbaraga zingirakamaro ku ngirabuzimafatizo ziri mu mara kandi igafasha ibidukikije neza.
5. Ingaruka zo gusaza za urolithine A.
(1) Kongera ubuzima bwa mitochondrial: Mitochondria nisoko yingufu zingirabuzimafatizo zacu kandi ishinzwe kubyara ingufu. Mugihe tugenda dusaza, imikorere ya mitochondial iragabanuka. Urolithin A yerekanwe gukora inzira yihariye ya mitochondial yitwa mitophagy, ikuraho mitochondriya yangiritse kandi igateza imbere mitochondriya nshya, nzima. Kugarura ubuzima bwa mitochondial birashobora guteza imbere umusaruro nubuzima muri rusange.
. Mu ngirabuzimafatizo zishaje, iyi nzira iba gahoro, biganisha ku kwegeranya imyanda yangiza. Ubushakashatsi bwerekanye ko urolithine A ishobora kongera autofagy, bityo igasukura neza selile kandi igatera kuramba.
Ikibazo: Ese inyongera zo kurwanya gusaza zifite umutekano?
Igisubizo: Mubisanzwe, inyongera zirwanya gusaza zifatwa nkumutekano iyo zifashwe mumabwiriza yatanzwe. Icyakora, ni ngombwa kugisha inama inzobere mu buvuzi mbere yo kwinjiza ibintu byose bishya muri gahunda zawe, cyane cyane niba ufite ubuvuzi bwihariye cyangwa ukaba ufata imiti yandikiwe.
Ikibazo: Bitwara igihe kingana iki kugirango inyongera zirwanya ubusaza zerekana ibisubizo?
Igisubizo: Igihe ntarengwa cyibisubizo bigaragara kirashobora gutandukana bitewe numuntu kugiti cye hamwe ninyongera ikoreshwa. Mugihe abantu bamwe bashobora gutangira kubona iterambere mugihe cyibyumweru bike, abandi barashobora gusaba igihe kirekire cyo gukoresha mbere yo kugira impinduka zikomeye mubuzima bwabo no mumiterere yabo.
Inshingano: Iyi ngingo ni iyamakuru rusange gusa kandi ntigomba gusobanurwa nkinama zose zubuvuzi. Amwe muma poste yamakuru aturuka kuri enterineti kandi ntabwo ari umwuga. Uru rubuga rufite inshingano zo gutondeka, gutunganya no guhindura ingingo. Intego yo gutanga amakuru menshi ntabwo bivuze ko wemera ibitekerezo byayo cyangwa kwemeza ukuri kwibirimo. Buri gihe ujye ubaza inzobere mu buzima mbere yo gukoresha inyongeramusaruro cyangwa guhindura ibintu byubuzima bwawe.
Igihe cyo kohereza: Ukuboza-04-2023
