Niki N-Boc-O-Benzyl-D-Serine kandi ni ukubera iki bifite akamaro?

Mu nganda z’imiti n’imiti, N-Boc-O-benzyl-D-serine ni inkomoko ikomeye ya aside amine bitewe n’ikoreshwa ryayo mu guhuza molekile ya bioaktike n’ibiyobyabwenge. Yashimishije cyane kubikorwa byayo mugutezimbere. "N-Boc" bivuga itsinda ririnda tert-butoxycarbonyl (Boc), rikoreshwa cyane mukurinda aminide ya aminide acide muri synthesis ya peptide. "O-Benzyl" bivuze ko itsinda rya benzyl rifatanije na hydroxyl groupe ya serine, bityo bikazamura ituze no gukomera.

N-Boc-O-benzyl-D-serine Intangiriro

N-Boc-O-benzyl-D-serine (CAS: 47173-80-8), igaragara nkifu yera kugeza yera, N- Boc-O-Benzyl-D-serine ikomoka kuri aside amine D-serine. Bitewe nimiterere yihariye yimiterere, igira uruhare runini muri synthesis ya chimique na chimie peptide. Ibikurikira nubusobanuro burambuye bwibigize: aho N-Boc yerekeza kuri tert-butoxycarbonyl (Boc) irinda itsinda.

Kurinda amatsinda akoreshwa muri synthesis ngengabihe kugirango akingire by'agateganyo amatsinda akora, yemerera ibisubizo byatoranijwe bitabangamiye izindi mbuga. O-benzyl yerekana ko itsinda rya benzyl ryometse kuri ogisijeni ya hydroxyl groupe ya serine. Benzyl ni ikintu gisanzwe gihumura neza gishobora kugira ingaruka kumyuka no kongera imbaraga. D-serine ni umwe mubantu babiri ba serine kandi ni uwumuryango wa methionine. Serine ni aside amine yingenzi kuri biosynthesis, kubyara ingufu no kugabanya ingirabuzimafatizo. Izi nzira ningirakamaro mu mikurire no gukwirakwira kwa kanseri.

N-Boc-O-benzyl-D-serine Imikorere Intangiriro

1. D-serine irashobora kugabanya ibimenyetso byo kugabanuka kwubwenge.

Ibimenyetso bya Glutaminergique bizwiho kongera imbaraga zo kwibuka kuko gukora kwa reseptor ya NMDA bitera kwinjiza calcium no gukangurira poroteyine iterwa na calmoduline (CaMK) na CREB-ihuza poroteyine, bigira uruhare mu gutuma imbaraga z'igihe kirekire (LTP), ari zo shingiro ry’ibanze uburyo buzwi nka memoire, kandi bivamo kwiyongera mubimenyetso bya NMDA (cyane cyane binyuze muri NR2B subunit) bitera kwiyongera mububiko na LTP. Ubu kandi ni uburyo bwo kongera ubushobozi bwo kwibuka bwagaragaye hamwe na magnesium L-threonate. Kubera ko D-serine ishobora kongera ibimenyetso binyuze muri reseptor ya NMDA, igahuzwa nigikorwa cya D-serine muriki gikorwa hamwe nubukangurambaga buzwi bwa selile hippocampal to D-serine, byizerwa ko kuzuza D-serine bishobora guteza imbere kwibuka no kwiga.

2.Ubushakashatsi bwerekanye ko gutakaza poroteyine ya Menin muri hypothalamus ari ikintu gikomeye kiganisha ku gusaza, kandi kuzuza D-serine bishobora guteza imbere ubumuga bwo kutamenya ku mbeba zishaje.

Ubushakashatsi bwerekanye ko hypothalamus nayo igira uruhare runini mubumuga bwo kutamenya buterwa no gusaza. Mugihe cyo gusaza, poroteyine ya Menin muri hypothalamus (nyuma yiswe Menin) izagenda igabanuka buhoro buhoro hamwe no gusaza, bigira ingaruka kuri synthesis ya D-serine, bikarushaho kwihutisha gusaza no kudakora neza. Byongeye kandi, D-serine yiyongera irashobora kunoza cyane fenotipa yubusaza no kugabanya ubumuga bwubwenge bwimbeba zashaje.

Ibyavuye mu bushakashatsi byagaragaje ko nyuma yo kuzuza D-serine, urwego rwa D-serine muri hypothalamus na hippocampus y’amatsinda atatu y’imbeba yariyongereye cyane ugereranije n’ubwoko bumwe bw’imbeba butigeze bwuzuzwa na D-serine (p <0.01), kandi imiterere yabo yo kumenya yaratejwe imbere. Iterambere rikomeye (p <0.05), byerekana ko inyongera ya D-serine ishobora kuba uburyo bwo kuvura kunoza gusaza bijyanye no gusaza.

N-Boc-O-Benzyl-D-Serine na Acide Amino: Itandukaniro irihe?

1. Itandukaniro ryimiterere

Itandukaniro rigaragara cyane hagati ya N-Boc-O-benzyl-D-serine nandi acide amine ni imiterere yayo. Mugihe aside amine isanzwe ifite umugongo woroheje ugizwe nitsinda rya amino, amatsinda ya carboxyl nu munyururu wuruhande, N-Boc-O-benzyl-D-serine ifite andi matsinda yimikorere ahindura imiterere.

Kurugero, itsinda rya Boc ritanga uburinzi mugihe cya peptide synthesis, ryemerera ibisubizo byinshi bigoye gukorwa nta reaction zidakenewe. Amatsinda ya Benzyl atezimbere imikoranire ya hydrophobique, bityo bikagira ingaruka kumubyimba no gutuza kwa peptide na proteyine.

2. Ibiranga imikorere

N-Boc-O-Benzyl-D-Serine yerekana imiterere yihariye ugereranije nandi acide amine. Iboneza rya D ryemerera gukorana muburyo butandukanye na biologiya ugereranije nibisanzwe L iboneka muri poroteyine nyinshi. Ibi birashobora gutuma habaho impinduka mubikorwa byibinyabuzima, bikagira igikoresho cyagaciro mugushushanya ibiyobyabwenge no kwiteza imbere.

Ibinyuranye, byoroshye, acide nyinshi ya amino nka glycine cyangwa alanine ntabwo ifite urwego rumwe rugoye cyangwa rwihariye mubikorwa byabo. Ibi bituma N-Boc-O-Benzyl-D-Serine igira akamaro kanini mubushakashatsi bwibibazo bya neuropharmacology hamwe na reseptor.

3. Gusaba mubushakashatsi nubuvuzi

N-Boc-O-Benzyl-D-Serine yakuruye ibitekerezo mubice bitandukanye, cyane cyane mubijyanye na chimie chimique na neurobiology. Ubushobozi bwayo bwo guhindura ibikorwa bya reseptor ya NMDA bituma iba imiti yumukandida wiga indwara zifata ubwonko nka schizofrenia n'indwara ya Alzheimer. Abashakashatsi barimo gushakisha ubushobozi bwayo nkumuti wo kuvura kugirango bongere imikorere yubwenge cyangwa kugabanya imikorere ya neurodegenerative.

Ibinyuranye na byo, aside amine ikunze kugaragara nka leucine cyangwa valine yakunze kwigwa kubera uruhare rwayo mu mitsi no guhinduranya poroteyine. Mugihe ari ngombwa mubuzima rusange no kumererwa neza, intego zabo muri neuropharmacology zitandukanye na N-Boc-O-Benzyl-D-Serine.

4. Synthesis and Stabilite

Synthesis ya N-Boc-O-benzyl-D-serine ikubiyemo imiti igoye kuruta aside amine isanzwe. Intangiriro yo kurinda amatsinda no gukenera imiterere yihariye irashobora gutuma synthèse yabo igorana. Ariko, ibyo byahinduwe nabyo byongera ituze ryabyo, bigatuma bikwiranye nuburyo butandukanye bwubushakashatsi.

Ibinyuranye, aside amine isanzwe iraboneka byoroshye kandi byoroshye guhuza, ariko ntibishobora gutanga urwego rumwe rwumutekano cyangwa umwihariko ukenewe mubushakashatsi bwateye imbere.

D-Ubuzima-busanzwe Porogaramu ya N-Boc-O-Benzyl-D-Serine

Serine igira uruhare rukomeye mumubiri wumuntu, cyane cyane kugenzura no kurinda sisitemu yimitsi. N-Boc-O-benzyl-D-serine nkibikomoka kuri serine nicyiciro cyingenzi cya molekile ya bioaktike ikoreshwa cyane muri synthesis ya peptide hamwe nubundi buryo bwa chimie organique ikoreshwa cyane cyane mugutezimbere ibiyobyabwenge nibindi binyabuzima. Itsinda ririnda rishobora gukurwaho mubihe byihariye kugirango ubone aside amine yubusa cyangwa ibindi bikomoka kubushakashatsi cyangwa kubishyira mubikorwa. Byakoreshejwe cyane mubushakashatsi bwubuvuzi nibinyabuzima.

1. Himiki ya chimique na peptide chimie

N-Boc-O-benzyl-D-serine ikoreshwa nkibice byubaka muri synthesis yimiti yibintu bitandukanye kandi nikintu cyingenzi muri chimie peptide. Imikoreshereze yacyo muri uru rwego biterwa nubushobozi bwayo bwo kwinjizwa mumiterere minini ya molekile, ifasha iterambere ryimiti mishya na molekile ya bioactive.

Inganda zimiti

N-Boc-O-benzyl-D-serine yakoreshejwe nkibibanziriza gutegura naphthodiazolidinone yasimbuwe. Izi mvange zikora nka protein tyrosine phosphatase yangiza kandi zifite uburyo bwo kuvura mugukiza kanseri n'indwara ziterwa na metabolike. Kwangirika kwa fosifata bifasha kugenzura inzira zerekana ibimenyetso, bityo bigatanga uburyo bwo kuvura indwara.

3. Ubushakashatsi niterambere

Mubushakashatsi niterambere, N-Boc-O-benzyl-D-serine ikoreshwa muguhuza molekile nshya hamwe nibikorwa bya biologiya. Imiterere yihariye ituma abahanga bashakisha imiterere nuburyo bukoreshwa mugukora imiti nubuvuzi bushya kubuvuzi butandukanye.

Ni he Kugura N-Boc-O-benzyl-D-serine?

Nkuruganda rukora ifu ya N-Boc-O-benzyl-D-serine, Suzhou Myland yatsindiye abakiriya benshi ibicuruzwa byayo bifite isuku nyinshi no kugenzura ubuziranenge. Isosiyete yiyemeje guha abakiriya ibikoresho byiza byo mu rwego rwo hejuru no kubafasha gutsinda mu nganda zabo.

1. Ubwiza bwibicuruzwa byizewe

Ifu ya N-Boc-O-benzyl-D-serine ya Suzhou Myland ikorerwa ibizamini byinshi kugirango isuku nubuziranenge byujuje ubuziranenge bwinganda. Isosiyete ifite itsinda ryigenzura ryumwuga rikora ubugenzuzi bwibicuruzwa buri gihe kugirango harebwe ubuziranenge bwa buri cyiciro cyibicuruzwa.

2. Ubushobozi bwo gutanga ibintu byoroshye

Yaba ari agace gato cyangwa gahunda nini nini, Suzhou Mailun Biotechnology irashobora gusubiza byoroshye kugirango ibyifuzo byabakiriya byuzuzwe. Isosiyete yashyizeho uburyo bwuzuye bwo gutanga ibikoresho kugirango igere ku bicuruzwa byihuse abakiriya.

3. Inkunga yumwuga

Itsinda R&D rya Suzhou Myland rigizwe ninzobere mu nganda kandi rishobora guha abakiriya inama zubuhanga n’ubuhanga mu gufasha abakiriya gusobanukirwa neza no gushyira mu bikorwa N-Boc-O-benzyl-D-serine.

4. Igiciro cyo guhatanira

Mu rwego rwo kwemeza ubuziranenge bwibicuruzwa, Suzhou Myland itanga ibiciro byapiganwa kugirango bifashe abakiriya kugabanya ibiciro byamasoko no kuzamura isoko ryisoko.

Guhitamo neza N-Boc-O-benzyl-D-serine itanga ni urufunguzo rwo kwemeza ibicuruzwa n'umutekano. Suzhou Myland yahindutse amahitamo yizewe mu nganda n'ibicuruzwa byayo bifite isuku nyinshi, kugenzura ubuziranenge na serivisi z'umwuga. Waba uri uruganda rukora imiti cyangwa ikigo cyubushakashatsi bwa siyansi, Suzhou Myland irashobora kuguha ifu nziza ya N-Boc-O-benzyl-D-serine ifasha ubushakashatsi niterambere. Kubindi bisobanuro, nyamuneka sura urubuga rwemewe rwa Suzhou Myland.