Mwisi yinyongera yimirire, ifu ya magnesium alpha-ketoglutarate yitabiriwe cyane ninyungu zishobora guteza ubuzima. Uru ruganda ruzwiho uruhare mu kubyara ingufu, kugarura imitsi, hamwe nubuzima rusange. Niba ushaka gushyira iyi nyongera mubikorwa byawe bya buri munsi, ni ngombwa kumenya aho wagura ifu nziza ya magnesium alpha ketoglutarate kumurongo.
Alpha-ketoglutarate (AKG) kuva kera ni siporo izwi cyane ikunzwe gukoreshwa mumuryango wa fitness, ariko inyungu muri iyi molekile ubu yinjiye mubushakashatsi bwubusaza kubera uruhare runini muri metabolism. AKG ni ibisanzwe bisanzwe endogenous intermediate intermediate metabolite igizwe na cycle ya Krebs, bivuze ko imibiri yacu itanga umusaruro.
AKG ni molekile igira uruhare munzira nyinshi za metabolike na selile. Ikora nk'umuterankunga w'ingufu, ibanziriza umusaruro wa aside amine na selile yerekana selile, kandi ikagenga imikorere ya epigenetike. Ni molekile yingenzi muri cycle ya Krebs, igenga umuvuduko rusange wikizunguruka cya citric aside yibinyabuzima. Ikora munzira zitandukanye mumubiri kugirango ifashe kubaka imitsi no gufasha gukiza ibikomere, nimwe mumpamvu ikunzwe kwisi yimyororokere. Rimwe na rimwe, abashinzwe ubuzima batanga alpha-ketoglutarate mu mitsi kugira ngo birinde kwangirika k'umutima guterwa n'ibibazo by'amaraso mu gihe cyo kubaga umutima no kwirinda gutakaza imitsi nyuma yo kubagwa cyangwa guhahamuka.
AKG ikora kandi nka azote yogosha, ikarinda azote kurenza urugero kandi ikarinda kwirundanya kwa amoniya irenze. Nisoko nyamukuru ya glutamate na glutamine, itera intungamubiri za poroteyine kandi ikabuza kwangirika kwa poroteyine mu mitsi. Byongeye kandi, igenga imisemburo cumi nimwe (TET) igira uruhare muri demethylation ya ADN hamwe na Jumonji C irimo lysine demethylase, Enzymes nkuru ya histone demethylase. Muri ubu buryo, ni umukinnyi w'ingenzi mugutunganya gene no kwerekana.
AKG irashobora gutinza gusaza? 】
Hariho ibimenyetso byerekana ko AKG ishobora kugira ingaruka ku gusaza, kandi ubushakashatsi bwinshi bwerekana ko bubikora. Ubushakashatsi bumwe bwerekanye ko AKG yongereye igihe cyabantu bakuze C. elegans hafi 50% muguhagarika synthase ya ATP nintego ya rapamycine (TOR). Muri ubu bushakashatsi, AKG yasanze itongerera igihe cyo kubaho gusa ahubwo inadindiza fenotipike zimwe na zimwe zijyanye n’imyaka, nko gutakaza umuvuduko ukabije w’umubiri ukunze kugaragara mu nzoka za C. elegans zishaje.
Synt synthase ya ATP】
Mitochondrial ATP synthase ni enzyme iboneka hose igira uruhare mungufu zingirabuzimafatizo muri selile nyinshi. ATP ni enzyme ihujwe na membrane ikora nk'ingufu zitwara ingufu za metabolism. Ubushakashatsi bwakozwe muri 2014 bwerekanye ko kugirango wongere igihe cya C. elegans, AKG isaba ATP synthase subunit beta kandi yishingikiriza kuri TOR yo hepfo. Abashakashatsi basanze ATP synthase subunit β ari poroteyine ihuza AKG. Basanze AKG ibuza synthase ya ATP, bigatuma igabanuka rya ATP ihari, kugabanuka kwa ogisijeni, ndetse no kwiyongera kwa autofagy muri selile nematode n’inyamabere.
Guhuza mu buryo butaziguye na ATP-2 na AKG, kubuza enzyme bifitanye isano, kugabanya urwego rwa ATP, kugabanya ikoreshwa rya ogisijeni no kongera igihe cyo kubaho birasa nkaho iyo ATP synthase 2 (ATP-2) yakuweho genetike. Hashingiwe kuri ubwo bushakashatsi, abashakashatsi banzuye ko AKG ishobora kongera igihe cyo kwibasira ATP-2. Mu byingenzi, ibibera hano nuko imikorere ya mitochondial hari aho ihagarikwa, cyane cyane urunigi rwo gutwara ibintu bya elegitoronike, kandi ni uku kubuza igice kuganisha ku kuramba kwa C. elegans. Icyangombwa ni ukugabanya imikorere ya mitochondrial bihagije utiriwe ujya kure cyangwa biba bibi. Kubwibyo, imvugo ngo "ubeho vuba, upfe ukiri muto" nukuri rwose, gusa muriki gihe, kubera kubuza ATP, inyo irashobora kubaho gahoro kandi igapfa ishaje.
[Alpha-ketoglutarate n'intego ya rapamycin (TOR)]
Ubushakashatsi butandukanye bwerekanye ko kubuza TOR bishobora kugira ingaruka ku gusaza mu moko atandukanye, harimo gutinda gusaza mu musemburo, kugabanya gusaza muri elegans ya Caenorhabditis, gutinda gusaza muri Drosophila, no kugena igihe cyo kubaho ku mbeba. AKG ntabwo ikorana neza na TOR, nubwo igira ingaruka kuri TOR, cyane cyane mukubuza synthase ya ATP. AKG yishingikiriza byibuze igice, kuri protein kinase ikora (AMPK) hamwe nagasanduku ka forode "izindi" (FoxO) za poroteyine kugirango bigire ingaruka mubuzima. AMPK ni sensor ya selile yabitswe iboneka mumoko menshi, harimo n'abantu. Iyo igipimo cya AMP / ATP kiri hejuru cyane, AMPK irakora, ibuza ibimenyetso bya TOR ikora fosifora ya TOR inhibitor TSC2. Ubu buryo butuma ingirabuzimafatizo zigenzura neza metabolisme no guhuza imbaraga zazo. FoxOs, itsinda ryumuryango wimyandikire ya forkhead, bigira uruhare runini muguhuza ingaruka za insuline nibintu bikura kumirimo myinshi, harimo gukwirakwiza selile, metabolism selile, na apoptose. Ubushakashatsi bumwe bwerekana ko kwongerera igihe cyo kugabanya ibimenyetso bya TOR, birakenewe ko impapuro za transcript za FoxO PHA-4 zisabwa.
【Α-ketoglutarate na autophagy】
Hanyuma, autophagy yakoreshwaga no kubuza caloric no kubuza TOR kwiyongera cyane muri C. elegans yahawe AKG yinyongera. Ibi bivuze ko kubuza AKG na TOR byongera igihe cyo kubaho binyuze munzira imwe cyangwa binyuze munzira zigenga / zibangikanye ninzira nuburyo amaherezo bihurira kumurongo umwe wo hasi. Ibi kandi bishimangirwa nubushakashatsi bwakozwe ku musemburo na bagiteri bishwe n'inzara, ndetse n'abantu nyuma y'imyitozo ngororamubiri, byagaragaje ko AKG yiyongereye. Uku kwiyongera gutekerezwa nkigisubizo cyinzara, muriki gihe indishyi gluconeogenez, ikora transaminase ifitanye isano na glutamate mu mwijima kugirango ikore karubone ituruka kuri catabolism ya amino.
Magnesium ni kane mu myunyu ngugu myinshi mu mubiri w'umuntu kandi igira uruhare mu myitwarire irenga 300. Ni ngombwa mu gutanga ingufu, synthesis ya protein, kugabanuka kw'imitsi, n'imikorere y'imitsi. Magnesium kandi ikomeza injyana yumutima isanzwe kandi igenga umuvuduko wamaraso.
Nubwo magnesium ari ngombwa, abantu benshi ntibayikoresha bihagije, bikaviramo kubura magnesium bigira ingaruka kubuzima muri rusange. Imirire isanzwe ya magnesium irimo imboga rwatsi rwatsi, imbuto, imbuto, ibinyampeke n'ibinyamisogwe.
Imikoranire hagati ya magnesium na alpha-ketoglutarate
1. Igisubizo cya Enzymatique
Iyoni ya Magnesium ningirakamaro mubikorwa byimisemburo itandukanye igira uruhare mukuzenguruka kwa Krebs, harimo na enzyme ihindura alpha-ketoglutarate na succinyl-CoA. Ihinduka ningirakamaro mugukomeza ukwezi kwa Krebs no kubyara ATP, ifaranga ryingufu.
Hatariho magnesium ihagije, iyi reaction ya enzymatique irashobora kwangirika, bigatuma kugabanuka kwingufu ndetse no gukora nabi metabolike. Ibi birerekana akamaro ko gukomeza urugero rwa magnesium ihagije kugirango imikorere myiza ya selile ikoreshwe neza.
2. Kugena inzira ya metabolike
Magnesium nayo igira uruhare mukugenzura inzira ya metabolike irimo alpha-ketoglutarate. Kurugero, magnesium igira ingaruka kumikorere ya enzymes ya amino acide metabolism ifitanye isano rya hafi na AKG. Guhindura aside amine zimwe na zimwe muri α-ketoglutarate ni intambwe yingenzi mu kubyara ingufu na metabolism ya azote. Byongeye kandi, magnesium yerekanwe kugenzura ibikorwa byinzira zingenzi zerekana inzira, nkinzira ya mTOR igira uruhare mu mikurire ya selile na metabolism. Muguhindura iyi nzira, magnesium irashobora kugira uruhare rutaziguye urwego no gukoresha alpha-ketoglutarate mumubiri.
3. Imiti igabanya ubukana
Alpha-ketoglutarate izwiho kurwanya antioxydeant, ifasha kugabanya imbaraga za okiside mu ngirabuzimafatizo. Magnesium nayo yagaragaye ko ifite ingaruka za antioxydeant. Iyo magnesium ihari muburyo buhagije, byongera ubushobozi bwa antioxydeant ya alpha-ketoglutarate, itanga ubundi burinzi bwo kwirinda kwangirika kwa okiside. Guhangayikishwa na Oxidative bifitanye isano nibibazo bitandukanye byubuzima, harimo indwara zidakira no gusaza. Mugushyigikira imikorere ya antioxydeant ya alpha-ketoglutarate, magnesium irashobora kugira uruhare mubuzima bwingirabuzimafatizo no kuramba.
Magnesium alpha-ketoglutarate nuruvange ruhuza magnesium na alpha-ketoglutarate, urufunguzo rwingenzi hagati yizunguruka ya Krebs (ruzwi kandi nka citric acide cycle), rukenewe kugirango ingirabuzimafatizo zitangwe ningirakamaro. Akenshi ikoreshwa mubyokurya byinyongera bitewe ninyungu zishobora gutera mukuzamura imikorere ya siporo, gukira nubuzima rusange bwimikorere.
1. Kongera umusaruro w'ingufu
Imwe mu nyungu zingenzi za Magnesium Alpha KetoglutarateIfu nubushobozi bwayo bwo kongera urwego rwingufu. AKG igira uruhare runini muri cycle ya Krebs, ishinzwe guhindura intungamubiri mu mbaraga. Wongeyeho AKG, ushyigikiye uburyo umubiri wawe ukora. Byongeye kandi, magnesium ni ngombwa mu gukora ATP (adenosine triphosphate), ifaranga ry’ingirabuzimafatizo.
2. Kunoza imikorere yimitsi no gukira
Magnesium izwiho uruhare mu kugabanya imitsi no kuruhuka, bikaba ngombwa mu mikorere myiza. AKG irashobora kandi gufasha kugabanya ububabare bwimitsi no kugabanya igihe cyo gukira nyuma yimyitozo ikomeye. Mugushira iyi nyongera mubikorwa byawe bya buri munsi, urashobora guhura no kwihangana, kugabanya umunaniro, no gukira byihuse, bikwemerera gusunika imipaka.
3. Inkunga yo kumenya
Ubuzima bwubwenge nibibazo byiyongera kubantu benshi, cyane cyane uko dusaza. Ubushakashatsi bwerekana ko AKG ishobora kuba ifite imitekerereze ya neuroprotective ishobora gufasha ubuzima bwubwonko nibikorwa byubwenge. Magnesium nayo igira uruhare mugutunganya neurotransmitter, ningirakamaro kumyumvire no mumikorere. Muguhuza ibyo bintu byombi, ifu ya magnesium alpha ketoglutarate ifasha irashobora kunoza intumbero, kwibuka, hamwe nibitekerezo rusange.
4. Shigikira gusaza neza
Mugihe dusaza, imibiri yacu igira impinduka zitandukanye zishobora kugira ingaruka kubuzima bwacu. Kuzuza ifu ya magnesium alpha ketoglutarate ifasha kugabanya zimwe murizo ngaruka. Ubushakashatsi bw’inyamaswa bwahujije AKG no kuramba, kandi ubushobozi bwayo bwo gufasha ubuzima bwimikorere irashobora kugira uruhare mugusaza neza. Ku rundi ruhande, Magnesium ni ngombwa mu gukomeza ubwinshi bw'amagufwa no kwirinda indwara ziterwa n'imyaka. Hamwe na hamwe, barashobora guteza imbere ubuzima buzira umuze, imbaraga nyinshi uko dusaza.
5. Kongera imikorere yumubiri
Sisitemu ikomeye yumubiri ningirakamaro kubuzima muri rusange, cyane cyane kwisi. Magnesium igira uruhare runini mu mikorere y’ubudahangarwa, ifasha kugabanya gucana no gushyigikira uburyo bwo kwirinda umubiri. AKG irashobora kandi kuba ifite imbaraga zo kongera ubudahangarwa bw'umubiri, bigatuma iyi mikoranire ifatanya imbaraga mukubungabunga ubudahangarwa bw'umubiri.
Mugihe ibintu byibanze bya alfa-ketoglutarate na magnesium bishobora kuba bisa mubyongeweho bitandukanye, ibintu byinshi birashobora kugira ingaruka kubikorwa byabo no mubwiza. Dore bimwe mubyingenzi byingenzi:
1.Impapuro zikoreshwa na dosiye
Ntabwo inyongera za AKG magnesium zose zakozwe zingana. Ibisobanuro birashobora gutandukana cyane mubirango. Bimwe bishobora kuba birimo ibindi bintu, nka vitamine, imyunyu ngugu, cyangwa ibimera bivamo ibyatsi, bishobora kongera cyangwa guhindura ingaruka zingenzi.
2. Bioavailable
Bioavailability bivuga urugero nigipimo ibintu byinjira mumaraso. Ubwoko bumwebumwe bwa magnesium, nka magnesium citrate cyangwa magnesium glycinate, burashobora kuboneka cyane kuruta ubundi buryo bwa magnesium, nka oxyde ya magnesium. Imiterere ya magnesium ikoreshwa mubyongeweho irashobora guhindura cyane uburyo umubiri wawe uyikoresha neza.
Mu buryo nk'ubwo, uburyo bwa alpha-ketoglutarate bugira ingaruka ku iyinjira ryayo. Reba inyongera zikoresha ubuziranenge, bioavailable form zombi zombi kugirango urebe ko ubona inyungu nini.
3. Ubuziranenge nubuziranenge
Ubuziranenge nubwiza bwibigize bikoreshwa mu nyongera ni ingenzi ku mikorere n’umutekano. Ibicuruzwa bimwe bishobora kuba birimo ibyuzuza, inyongeramusaruro, cyangwa ibyanduye bishobora kugabanya imikorere yabyo cyangwa bigatera ingaruka kubuzima. Mugihe uhisemo inyongera ya magnesium ya AKG, shakisha ibicuruzwa byageragejwe mugice cya gatatu kugirango bisukure kandi byiza. Icyemezo cy’imiryango nka NSF International cyangwa Pharmacopeia yo muri Amerika yemeza ko ibicuruzwa byujuje ubuziranenge.
4. Icyamamare
Icyamamare kiranga kandi uruhare runini mubwiza bwinyongera. Ibirangantego bizwi bifite amateka yo gukora ibicuruzwa byujuje ubuziranenge akenshi byizewe kuruta ibigo bishya cyangwa bitamenyekanye cyane. Kora ubushakashatsi kubakiriya no gusuzuma kugirango umenye neza ibicuruzwa byawe.
5. Gukoresha umugambi
Mugihe uhisemo inyongera ya AKG magnesium, suzuma intego zawe zubuzima. Urashaka kuzamura imikorere ya siporo, gushyigikira imitsi cyangwa kuzamura ubuzima muri rusange? Ibice bitandukanye birashobora kuba byiza kubwintego zitandukanye.
Mu mirire igezweho nubushakashatsi bwibinyabuzima, ifu ya α-ketoglutarate ya magnesium yakuruye abantu benshi nkibintu byingenzi byongera ibiryo byingenzi. Ntabwo igira uruhare runini gusa muburyo bwo guhinduranya ingufu, biranatekerezwa ko bigira ingaruka nziza kumikurire, gusana no kurwanya gusaza. Kugirango uhuze ibyifuzo byubushakashatsi nubumenyi bwamasoko yubuzima, ni ngombwa cyane guhitamo ifu nziza ya Alpha Ketoglutarate Magnesium Powder.
Suzhou Myland ni uruganda ruzobereye mu bushakashatsi, guteza imbere no gutanga umusaruro wibiryo byongera ibiryo. Yiyemeje guha abakiriya isuku ryinshi α-ketoglutarate ifu ya magnesium. Umubare CAS wibicuruzwa ni 42083-41-0, kandi ubuziranenge bwabwo buri hejuru ya 98%, byemeza ko bwizewe kandi bukora neza mubushakashatsi butandukanye no mubikorwa.
Ibiranga
Isuku ryinshi: Ubuziranenge bwa Suzhou Myland α-ketoglutarate ifu ya magnesium igera kuri 98%, bivuze ko abayikoresha bashobora kubona ibisubizo byubushakashatsi bwuzuye kandi buhoraho mugihe cyo gukoresha. Ibicuruzwa bifite isuku nyinshi birashobora kugabanya neza kwivanga kwanduye kubushakashatsi no kwemeza ubushakashatsi.
Ubwishingizi bufite ireme: Nka sosiyete ikora ibijyanye n’ibinyabuzima ifite uburambe bukomeye, Suzhou Myland ikurikiza byimazeyo amahame mpuzamahanga agenga umusaruro no kugenzura ubuziranenge. Buri cyiciro cyibicuruzwa bikorerwa ibizamini bikomeye kugirango byemeze ko byujuje ubuziranenge bijyanye. Abakiriya barashobora kuyikoresha bafite ikizere kandi bakagabanya ingaruka ziterwa nibibazo byubuziranenge bwibicuruzwa.
Imikorere myinshi: Ifu ya Magnesium α-ketoglutarate ntabwo igira uruhare runini muburyo bwo guhinduranya ingufu, ahubwo ikoreshwa cyane mumirire ya siporo, kurwanya gusaza, kurinda selile nizindi nzego. Ubushakashatsi bwerekana ko AKG ishobora guteza imbere synthesis ya aminide acide, ikongerera ubushobozi imitsi, kandi igatinda gusaza kurwego runaka.
Byoroshye kubyakira: Nka minerval yingenzi, magnesium ningirakamaro kubikorwa byinshi byumubiri byumubiri wumuntu. Iyo uhujwe na alpha-ketoglutarate, bioavailable ya magnesium iriyongera, bigatuma abayikoresha bongera magnesium mugihe banabona inyungu nyinshi za AKG.
Kugura imiyoboro
Suzhou Myland itanga uburyo bworoshye bwo kugura kumurongo. Abakiriya barashobora kubona ibisobanuro birambuye binyuze kurubuga rwemewe. Byongeye kandi, itsinda ryumwuga ryikigo rizaha abakiriya inkunga yubuhanga na serivisi zubujyanama kugirango bafashe abakiriya kumva neza no gukoresha ibicuruzwa.
Iyo ushakisha ifu nziza ya magnesium alpha-ketoglutarate ifu, Suzhou Myland ntagushidikanya ni amahitamo yizewe. Hamwe nubuziranenge bwacyo, kugenzura ubuziranenge bukomeye hamwe nuburyo bugaragara bwo gukoresha, ibicuruzwa bya Suzhou Myland birashobora guhaza ibyifuzo bitandukanye byabashakashatsi mubumenyi ninganda. Waba ukora ubushakashatsi bwibanze cyangwa guteza imbere ibicuruzwa bishya, urashobora kubona uburinzi bwiza ninkunga uhitamo ifu ya Suzhou Myland magnesium alpha-ketoglutarate.
Ikibazo: Ifu ya Magnesium Alpha-Ketoglutarate ni iki?
Igisubizo: Magnesium Alpha-Ketoglutarate Ifu ninyongera yimirire ihuza magnesium na alpha-ketoglutarate, uruganda rugira uruhare mukuzenguruka kwa Krebs, rukaba rukenewe mukubyara ingufu mumubiri. Iyi nyongera ikoreshwa kenshi mugushigikira ubuzima bwimikorere, kuzamura imikorere yimikino, no guteza imbere imibereho myiza muri rusange.
Ikibazo: Ni izihe nyungu zo gufata ifu ya Magnesium Alpha-Ketoglutarate?
Igisubizo: Inyungu zimwe zishoboka za Magnesium Alpha-Ketoglutarate Ifu irimo:
Umusaruro wongerewe ingufu: Gushyigikira ukwezi kwa Krebs, gufasha mu guhindura intungamubiri mu mbaraga.
Recovery Kugarura imitsi: Birashobora gufasha kugabanya ububabare bwimitsi no kunoza igihe cyo gukira nyuma yimyitozo.
Health Ubuzima bw'amagufa: Magnesium ni ngombwa mu kubungabunga amagufwa meza kandi irashobora gufasha kwirinda ostéoporose.
Imikorere yo kumenya: Ubushakashatsi bumwe bwerekana ko bushobora gushyigikira ubuzima bwubwonko nibikorwa byubwenge.
Support Inkunga ya Metabolic: Irashobora gufasha mugutunganya inzira ya metabolike kandi irashobora gufasha mugucunga ibiro.
Inshingano: Iyi ngingo ni iyamakuru rusange gusa kandi ntigomba gusobanurwa nkinama zose zubuvuzi. Amwe muma poste yamakuru aturuka kuri enterineti kandi ntabwo ari umwuga. Uru rubuga rufite inshingano zo gutondeka, gutunganya no guhindura ingingo. Intego yo gutanga amakuru menshi ntabwo bivuze ko wemera ibitekerezo byayo cyangwa kwemeza ukuri kwibirimo. Buri gihe ujye ubaza inzobere mu buzima mbere yo gukoresha inyongeramusaruro cyangwa guhindura ibintu byubuzima bwawe.
Igihe cyo kohereza: Ukwakira-12-2024
