Ni ubuhe bwoko bwa aside amine ihinduka intanga? Ni ubuhe butumwa bukora?

Intangani ingirakamaro ya polyamine igaragara cyane mubinyabuzima, cyane cyane igira uruhare runini mu gukwirakwiza selile no gukura. Intanga zahinduwe ziva muri amino acide arginine na ornithine. Iyi ngingo izasesengura inkomoko, imikorere n'akamaro k'intanga ngabo.

Inkomoko yintanga

Synthesis ya spermine ahanini biterwa na metabolism ya acide amine. Ubwa mbere, ornithine niyo ibanziriza synthesis ya spermine, ishobora gukorwa na decarboxylation reaction ya arginine. Inzira yihariye niyi ikurikira:

Arginine ihindurwamo ornithine: Munsi ya catalizike ya enzymes, arginine ni decarboxylated kugirango itange ornithine.
Guhindura ornithine kuri spermine: Ornithine irushijeho guhuzwa na aside amine (mubisanzwe aside amine aside alineine) kandi, binyuze murukurikirane rwimikorere ya enzymatique, amaherezo ikora intanga.
Iyi nzira yo guhindura ntabwo ikubiyemo metabolism ya acide amine gusa, ahubwo ifitanye isano rya hafi no gukura kwingirabuzimafatizo, kugabana no gusana.

Ingaruka zibinyabuzima zintanga

Intanga ngabo zifite ibikorwa byinshi byingenzi byibinyabuzima mubinyabuzima, cyane cyane harimo ibi bikurikira:

Ikwirakwizwa ry'uturemangingo no gukura: Intanga ngabo zigira uruhare runini mugutunganya ingirabuzimafatizo. Ubushakashatsi bwerekanye ko intanga ngabo zishobora guteza imbere ikwirakwizwa ry'uturemangingo, cyane cyane mu gihe cyo gusana ingirabuzima fatizo. Itera amacakubiri no gukura muguhindura imvugo ya proteine ​​zijyanye na selile.

Ingaruka ya Antioxydants: Intanga ngabo ifite antioxydeant, ishobora gukuraho radicals yubusa mumubiri no kugabanya kwangirika kwingirabuzimafatizo ziterwa na stress ya okiside. Uyu mutungo utuma intanga ngabo zifite agaciro gakoreshwa mugutinda gusaza no kwirinda indwara ziterwa nimyaka.

Kugenga imvugo ya gene: Intanga ngabo irashobora kugenga imvugo ya gene ihuza ADN na RNA. Izi ngaruka zingirakamaro ni ingenzi kumikorere ya selile na physiologique, cyane cyane mugusubiza ibibazo bituruka hanze.

Itera apoptose: Mu bihe bimwe na bimwe, intanga ngabo zirashobora kandi guteza apoptose (progaramu ya progaramu ya selile), ikaba ari ngombwa mu kubungabunga homeostasis selile nubuzima bwimitsi.

Immunomodulation: Spermine nayo igira uruhare runini mumikorere yumubiri. Irashobora kongera imikorere yingirabuzimafatizo kandi igahindura umubiri kurwanya indwara n'indwara.

Intanga n'ubuzima

Mugihe ubushakashatsi kuri spermine bwimbitse, ibimenyetso byinshi kandi byinshi byerekana ko intanga ngabo zifitanye isano rya bugufi nibibazo bitandukanye byubuzima. Kurugero, urugero rwintanga zifitanye isano rya bugufi no kubaho kwiterambere ryindwara zitandukanye nko gusaza, indwara zifata umutima, na kanseri.

Gusaza: Ubushakashatsi bwerekanye ko intanga ngabo zigabanuka buhoro buhoro mugihe cyo gusaza, kandi inyongera zintanga zishobora gufasha gutinda gusaza no kuzamura ubuzima bwabantu bakuru.

Ubuzima bwumutima: Spermine igira uruhare mukurinda sisitemu yumutima nimiyoboro, kunoza imikorere ya endoteliyale no kugabanya ibyago byindwara zifata umutima.

mu gusoza

Nka molekile yingenzi yibinyabuzima, intanga ngabo zikomoka cyane cyane kuri metabolism ya acide amine, cyane cyane ihinduka rya arginine na ornithine. Intanga ngabo zigira uruhare runini mu gukwirakwiza ingirabuzimafatizo, kurwanya okiside, kugenzura imiterere ya gene, n'ibindi, kandi ni ngombwa mu kubungabunga ubuzima n'imikorere y'ibinyabuzima. Hamwe nubushakashatsi bwimbitse bwintanga ngabo, amakuru menshi yerekeye uruhare rwayo mubuzima nindwara arashobora kuvumburwa mugihe kizaza, agatanga ibitekerezo nuburyo bushya bwo gukumira no kuvura indwara zifitanye isano.

Mugusobanukirwa inkomoko n'imikorere yintanga, dushobora kumva neza akamaro kayo mubikorwa byubuzima kandi tugatanga ishingiro ryubumenyi ryo guteza imbere ubuzima no gutinda gusaza. Twizera ko ubushakashatsi buzaza buzagaragaza kurushaho gukoresha intanga ngabo kandi bikagira uruhare runini mubuzima bwabantu.

Inshingano: Uru rubuga rutangaza cyangwa rusubiramo iyi ngingo hagamijwe gusa gutanga no gusangira amakuru menshi, kandi ntibisobanura ko yemera ibitekerezo byayo cyangwa yemeza ibisobanuro byayo. Niba hari ikosa ryerekana inkomoko cyangwa rihungabanya uburenganzira bwawe bwemewe, nyamuneka hamagara kururu rubuga ufite icyemezo cya nyirubwite, kandi tuzakosora cyangwa dusibe mugihe gikwiye. Murakoze.