Impamvu Alpha Ketoglutarate Magnesium ningirakamaro kubuzima bwawe

Kalisiyumu Alpha ketoglutarate (AKG) ni metabolite hagati ya acide ya tricarboxylic kandi ikagira uruhare muguhuza aside amine, vitamine na acide organic na metabolism. Irashobora gukoreshwa nkinyongera yimirire kandi ifite ibyifuzo byinshi. Usibye imikorere y’ibinyabuzima mu mubiri w’umuntu, calcium alpha-ketoglutarate ikoreshwa cyane mu rwego rwa farumasi kandi yabaye ikintu cyingenzi mubicuruzwa byinshi byubuzima nibisubizo byubuvuzi.

Alpha-ketoglutarate ni iki?

AKG ni ibisanzwe bisanzwe endogenous intermediate intermediate metabolite igizwe na cycle ya Krebs, bivuze ko imibiri yacu itanga umusaruro. Inganda ziyongera kandi zitanga verisiyo yubukorikori ihwanye na AKG isanzwe ikorwa.

AKG ikora iki?

AKG ni molekile igira uruhare munzira nyinshi za metabolike na selile. Ikora nk'umuterankunga w'ingufu, ibanziriza umusaruro wa aside amine na molekile yerekana selile, kandi ni modulator yimikorere ya epigenetike. Ni molekile yingenzi muri cycle ya Krebs, igenga umuvuduko rusange wikizunguruka cya citric aside yibinyabuzima. Ikora munzira zitandukanye mumubiri kugirango ifashe kubaka imitsi no gufasha gukira ibikomere, nimwe mumpamvu ikunzwe kwisi yubaka umubiri.

AKG ikora kandi nka azote yogosha, irinda azote kurenza urugero kandi ikarinda kwiyongera kwa amoniya irenze. Nisoko ikomeye ya glutamate na glutamine, itera intungamubiri za poroteyine mumitsi kandi ikabuza kwangirika kwa poroteyine.

Byongeye kandi, igenga imisemburo ya 10-11 (TET) enzyme igira uruhare muri demethylation ya ADN hamwe na Jumonji C irimo domeni irimo lysine demethylase, akaba ari na demethylase nkuru. Muri ubu buryo, ni umukinnyi w'ingenzi mugutunganya gene no kwerekana.

AKG irashobora gutinza gusaza?

Hariho ibimenyetso byerekana ko AKG ishobora kugira ingaruka ku gusaza, kandi ubushakashatsi bwinshi bwerekana ko aribyo. Ubushakashatsi bwakozwe mu 2014 bwerekanye ko AKG yongereye igihe cy’abakuze C. elegans ku kigero cya 50% mu guhagarika synthase ya ATP hamwe n’intego ya rapamycine (TOR).

Muri ubu bushakashatsi, twasanze AKG itongerera igihe cyo kubaho gusa ahubwo inadindiza fenotipike zimwe na zimwe zijyanye n'imyaka, nko gutakaza umuvuduko ukabije wimibiri ikunze kugaragara muri C. elegans. Kugira ngo twumve uburyo AKG igira ingaruka ku gusaza, tuzasobanura uburyo AKG ibuza synthase ya ATP na TOR kugirango yongere igihe muri C. elegans ndetse nibindi binyabuzima.

Uburyo calcium alpha-ketoglutarate ikora

Ubwa mbere, calcium alpha-ketoglutarate igira uruhare runini muri metabolism yingufu. Nkibicuruzwa bigereranijwe bya tricarboxylic acide cycle (TCA cycle), calcium α-ketoglutarate igira uruhare mubikorwa byo kubyara ingufu zidasanzwe. Binyuze mu ruzinduko rwa TCA, intungamubiri nka karubone, amavuta, na poroteyine ziba oxyde kandi zangirika kugira ngo zitange ATP (adenosine triphosphate) kugira ngo itange ingufu za selile. Nkumuhuza wingenzi muri cycle ya TCA, calcium α-ketoglutarate irashobora guteza imbere imbaraga zingirabuzimafatizo, kongera ingufu zumubiri, gufasha kongera imbaraga kumubiri no kwihangana, no kunaniza umunaniro wumubiri.

Icya kabiri, calcium α-ketoglutarate igira uruhare runini muri metabolism aside amine. Amino acide ni ibice byibanze bya poroteyine, na calcium α-ketoglutarate igira uruhare mu guhindura no guhinduranya metabolike ya aside amine. Muburyo bwo guhindura aside amine mubindi metabolite, calcium α-ketoglutarate yanduza aside amine kugirango itange aside amine nshya cyangwa α-keto acide, bityo bigabanye kuringaniza no gukoresha aside amine. Byongeye kandi, calcium α-ketoglutarate irashobora kandi kuba insimburangingo ya okiside ya aside amine, ikagira uruhare mu guhinduranya metaboliside ya aside amine, ikanatanga ingufu na dioxyde de carbone. Kubwibyo, calcium α-ketoglutarate ifite akamaro kanini mugukomeza homeostasis ya acide amino na protein metabolism mumubiri.

Byongeye kandi, calcium alpha-ketoglutarate ikora nka antioxydeant ikuraho radicals yubuntu kandi ikarinda selile kwangirika kwa okiside. Muri icyo gihe, calcium α-ketoglutarate irashobora kandi kugenga imikorere yimikorere yubudahangarwa bw'umubiri, guteza imbere gukora no gukwirakwiza ingirabuzimafatizo z'umubiri, kandi bikongerera umubiri kurwanya indwara n'indwara. Kubwibyo, calcium α-ketoglutarate ifite akamaro kanini mukubungabunga ubudahangarwa bw'umubiri no kurwanya indwara.

Ubushakashatsi ku ngaruka za calcium α-ketoglutarate ku gusaza

Gusaza biratureba twese kandi ni ibintu bishobora gutera indwara nyinshi, kandi ukurikije imibare y’inganda za Medicare, imibare yo kurwara yiyongera uko imyaka igenda ishira.

Kalisiyumu alpha-ketoglutarate ni metabolite y'ingenzi mu mubiri wacu, izwiho uruhare rw'utugingo ngengabuzima ya Krebs, uruziga rukenewe mu gukwirakwiza aside irike na aside amine, bigatuma mitochondriya itanga ATP (ATP ni isoko y'ingirabuzimafatizo).

Bikubiyemo kwipakurura calcium alpha-ketoglutarate, bityo calcium alpha-ketoglutarate nayo ishobora guhinduka glutamate hanyuma igahinduka glutamine, ishobora gufasha gutera intungamubiri za poroteyine na kolagen (kolagen ni poroteyine ya fibrous igizwe na 1/3 za poroteyine zose mu mubiri kandi zifasha gushyigikira amagufwa, uruhu n imitsi).

Kalisiyumu α-ketoglutarate, nk'inyongera y'imirire myinshi, ifite ibyifuzo byinshi mubicuruzwa byubuzima. Imikorere yayo itandukanye yibinyabuzima nka antioxydeant, kurwanya gusaza, kugenzura ubudahangarwa ndetse na metabolism aside amine bituma iba igikoresho gikomeye cyo kuzamura ubuzima bwabantu. Hamwe n’ubukangurambaga bwita ku buzima ndetse n’ubushakashatsi bwimbitse bwimbitse, abantu bemeza ko ikoreshwa rya calcium α-ketoglutarate mu rwego rw’ibicuruzwa byita ku buzima bizitabwaho cyane n’iterambere.