Urashaka isoko nziza ya Oleoylethanolamide (OEA) itanga ifu? Hamwe ninyungu zishobora guterwa no gucunga ibiro nubuzima muri rusange, ntabwo bitangaje kuba abantu benshi bashishikajwe nuru ruganda. Ariko, mugihe uguze ifu ya OEA, nibyingenzi kugirango umenye neza ko ubona ibicuruzwa byujuje ubuziranenge bihuye nibyo ukeneye. Kugura ifu nziza ya oleoylethanolamide bisaba gutekereza neza kubitanga, ubuziranenge, imbaraga, imiterere, nigiciro. Urebye ibi bintu no gushaka inama zumwuga, urashobora gufata icyemezo kiboneye ugahitamo gutera inkunga ubucuruzi bwawe hamwe nifu ya OEA nziza.
Mubyubuvuzi, hariho amagambo ahinnye atabarika namagambo ashobora kwitiranya abatamenyereye umurima. Abantu benshi barashobora kutamenyera ijambo:Oleylethanolamide (OEA). Niki mubyukuri OEA mubijyanye n'ubuvuzi? Kuki ari ngombwa kubyumva?
Reka twumve muri make imiterere nimiterere ya OEA!
Imiterere
Oleic aside Ethanolamide, cyangwa Oleoylethanolamide (OEA), ni umunyamuryango wa urumogi rwa endogenous. Nibintu bya kabiri bya amide igizwe na acide lipophilique oleic na hydrophilique ethanolamine. OEA nayo isanzwe ya molekile ya lipide mubindi bice byinyamanswa nibimera. Iraboneka cyane mubice byinyamanswa n’ibimera nka paka ya kakao, soya, nimbuto, ariko ibiyirimo ni bike cyane. Gusa iyo ibidukikije byo hanze bihindutse cyangwa ibiryo bikanguwe, ingirangingo z'umubiri z'umubiri Gusa noneho hazakorwa byinshi muribi bintu.
Kamere
Ku bushyuhe bwicyumba, OEA nikintu cyera gifite aho gishonga kingana na 50 ° C. Irashobora gushonga byoroshye mumashanyarazi ya alcool nka methanol na Ethanol, byoroshye gushonga mumashanyarazi adafite inkingi nka n-hexane na ether, no kudashonga mumazi. OEA ni molekile ya amphifilike isanzwe ikoreshwa nka surfactant na detergent mu nganda zikora imiti. Nyamara, ubushakashatsi bwakozwe bwerekanye ko OEA ishobora gukora nka lipide yerekana molekile mu mara-ubwonko no kwerekana urukurikirane rwibikorwa byibinyabuzima mu mubiri, harimo: kugenzura ubushake bwo kurya, kunoza metabolisme ya lipide, kongera kwibuka no kumenya ndetse nindi mirimo. Muri byo, imikorere ya OEA yo kugenzura ubushake bwo kurya no kunoza metabolisme ya lipide yitabiriwe cyane.
Oleylethanolamide (OEA) ikomoka kuri aside irike ikomoka mu mara mato. Ni mubyiciro byimvange bizwi nka endocannabinoide. Endogenously yakozwe na Oleoylethanolamide (OEA) ni molekile isanzwe iboneka ya lipide igira uruhare runini mubikorwa bitandukanye byumubiri. Yashyizwe mu rwego rwa bioactive lipid kandi iri muri sisitemu ya endocannabinoid, urusobe rugizwe na molekile yerekana ibimenyetso hamwe na reseptors bigira uruhare mu kugenzura imikorere myinshi yumubiri, harimo ubushake bwo kurya, Metabolism, ububabare, no gutwika.
OEA irashobora kugena ibiryo hamwe ningufu homeostasis ikora peroxisome prolifator-ikora reseptor-α. Byongeye kandi, OEA yerekana ibindi bikorwa bijyanye nubuzima, harimo guhindura ibikorwa bihindura inzira ya lysosomal-to-nuclear inzira yerekana ibimenyetso biramba no kurinda imitsi igenzura imyitwarire yo kwiheba.
Ubushakashatsi buherutse gukorwa bwerekana kandi ko OEA ishobora kugira ingaruka za neuroprotective. Mu ngero z’inyamaswa, byagaragaye ko bigabanya ibyangiritse biturutse ku bwonko no gukomeretsa ubwonko.
Ingaruka ngengamikorere ya OEA iterwa no guhuza PPARα, igabanya na reseptor ya retinoide X (RXR) ikanayikora nk'impamvu ikomeye yo kwandukura igira uruhare mu guhuza ingufu homeostasis, metabolisme ya lipide, autophagy, no gutwika. intego zo hasi.
Nyamara, ibirimo OEA biri hasi cyane kandi biragoye kubibona biturutse kubiribwa, bityo andi masoko ya OEA agomba gutezwa imbere. Muri byo, synthesis ya chimique hamwe na biologiya ihinduka ni isoko yubu yo kubona OEA. Muri byo, Suzhou Mailun Biotechnology itanga ubuziranenge-bwiza, bwiza bwa OEA binyuze muri synthesis.
Gahunda ya synthesis ya OEA ikubiyemo inzira ebyiri: synthesis ya fosifolipide ikomoka kuri N-oleoylphosphatidylethanolamine (NOPE) hamwe no guhindura NOPE muri OEA. Shunt ya NAS cyangwa NAT igira uruhare mugushinga NOPE, mugihe OEA ishobora kubyara binyuze munzira nyinshi, muri zo fosifolipase D (PLD) ninzira itaziguye.
PEA, ngufi kuriPalmitoylethanolamide (PEA), ni aside irike amide isanzwe ikorwa numubiri mugusubiza umuriro nububabare. Iboneka kandi mu biribwa bimwe na bimwe, cyane cyane bikungahaye ku binure bizima nk'amagi, soya, n'ibishyimbo. PEA yakozweho ubushakashatsi ku ngaruka zishobora kurwanya anti-inflammatory na analgesic, bituma iba inyongera ikunzwe kubantu bahura nububabare budakira, arthrite, nizindi ndwara zifata umuriro.
OEA (cyangwa oleoylethanolamide), kurundi ruhande, ni molekile ya lipide ikorwa mu mara mato. Uruhare rwarwo nyamukuru ni ukugenzura ubushake nuburemere bwumubiri muguhuza na sisitemu ya endocannabinoid. Azwiho ubushobozi bwo guteza imbere guhaga no kugabanya ibiryo, Oleoylethanolamide (OEA) ni amahitamo meza kubashaka gushyigikira gucunga ibiro hamwe nuburyo bwiza bwo kurya.
Imwe muntandukanyirizo nyamukuru hagati ya PEA na Oleoylethanolamide(OEA) nuburyo bwabo bwibikorwa na sisitemu mumubiri bagamije. PEA ikora cyane cyane munzira zo gutwika no kumva ububabare, mugihe OEA yibanda kubushake bwo kurya no kuringaniza ingufu. Iri tandukaniro ni ngombwa mugihe harebwa inyungu zishobora guterwa na buri kigo nuburyo byakoreshwa mugukemura ibibazo byubuzima byihariye.
Ku bijyanye n’inyungu zishobora kubaho ku buzima, PEA yakozweho ubushakashatsi ku ruhare rwayo mu kuvura ububabare budakira nka fibromyalgia, neuropathie, na sciatica. Imiti irwanya inflammatory ituma ihitamo ryagaciro kubantu bashaka ubundi buryo busanzwe bwo gufata ingamba zo kubabara. Byongeye kandi, PEA yerekana amasezerano yo gushyigikira ubuzima bwuruhu nibikorwa byubudahangarwa, kurushaho kwagura ibikorwa byayo mugutezimbere ubuzima rusange.
Ku rundi ruhande, uruhare rwa Oleoylethanolamide (OEA) mu kugabanya ubushake bwo kurya no gucunga ibiro rwashimishije abantu mu gukemura umubyibuho ukabije ndetse n’indwara ziterwa na metabolike. Ubushakashatsi bwerekana ko Oleoylethanolamide (OEA) ishobora gufasha kugenzura irari ry'ibiribwa, kugabanya kurya cyane, no gushyigikira metabolisme nziza, bikaba igikoresho cyagaciro kubantu bashaka kugera no kugumana ibiro byiza. Byongeye kandi, imikoranire ya OEA na sisitemu ya endocannabinoid yerekana ingaruka zishobora gutera kumyitwarire no kurya amarangamutima.
Nubwo Palmitoylethanolamide (PEA) na Oleoylethanolamide (OEA) bifite ingaruka zitandukanye ninyungu zishobora kubaho, ni ngombwa kumenya ko bidatandukanye. Mubyukuri, abantu bamwe bashobora kubona agaciro mukwinjiza ibyo bintu byombi mubuzima bwabo kugirango bakemure ibintu byinshi byubuzima bwabo. Kurugero, abantu bafite ububabare budashira nibibazo byo gucunga ibiro barashobora kungukirwa nimiterere ya PEA yo kurwanya inflammatory kimwe ningaruka za OEA.
Kugenzura ubushake bwo kurya no gucunga ibiro
Mu myaka yashize, oleoylethanolamide yamenyekanye cyane nkinyongera yimirire yo kugabanya ibiro. Ubushakashatsi bwerekana ko OEA ishobora gufasha kugabanya ubushake bwo kurya, bigatuma ibiryo bigabanuka ndetse no kugabanuka nyuma.
OEA ni ingirakamaro yibiryo byokurya ibikorwa byingenzi ni ugufasha kugabanya umubyibuho ukabije. Gutera intraperitoneal ya OEA birashobora kugabanya neza gufata ibiryo no kongera ibiro ku mbeba. Ingaruka nyamukuru yo kugabanya ibiro bya OEA nuko ishobora gutera ibyiyumvo byo guhaga, bityo bikagenzura ibiryo bikabije. Ongeraho ubunini bwa OEA kugaburira imbeba zisanzwe cyangwa zifite umubyibuho ukabije birashobora kugabanya ubushake bwimbeba nuburemere.
OEA ntishobora kubuza kwinjiza amara gusa, ariko kandi yihutisha okiside ya beta ya aside irike mu guteza imbere hydrolysis ya triglyceride mu ngingo za peripheri (umwijima n’ibinure), amaherezo bikagabanya kwegeranya amavuta no kugera ku kugenzura ibiro.
Byongeye kandi, OEA ikora kuri reseptor ya PPAR mu mara mato, ifasha kugabanya ubushake bwo kurya no kongera ibinure mu mubiri. Izi ngaruka za metabolike ya OEA zituma ingufu zikoreshwa cyane, ningirakamaro mu kugabanya ibiro.
Usibye kugenzura ubushake bwo kurya, ifu ya OEA ishyigikira metabolism nziza. Ubushakashatsi bwerekana ko OEA ishobora gufasha kongera imbaraga z'umubiri zikoreshwa, bishobora kongera umuvuduko wa metabolike. Mugutezimbere lipolysis no kunoza imikoreshereze yingufu, ifu ya OEA irashobora gufasha abashaka kugumana ibiro byiza na metabolism.
Amarangamutima no gucunga ibibazo
Oleoylethanolamide (OEA) byagaragaye ko ari ingirakamaro mu kugabanya imihangayiko no guhangayika mu mubiri. OEA ifasha kugenzura imisemburo ya hormone nka cortisol, bityo bikagabanya amaganya no guhangayika.
Ubushakashatsi bwerekana ko OEA ifasha gukora reseptor ya PPAR muri amygdala, igice cyubwonko gishinzwe kugenzura amaganya no guhangayika. Uku gukora kuganisha kumaganya no guhangayika. Ifasha kugabanya amaganya kandi iteza imbere kumva umerewe neza.
Byongeye kandi, OEA yahujwe no kugenzura urugero rwa dopamine mu bwonko, rushobora kugira uruhare mu kugena imiterere n’ubuzima bwo mu mutwe muri rusange.
Gutwika no gukingira indwara
Indwara idakira ifitanye isano nibibazo bitandukanye byubuzima, harimo umubyibuho ukabije, diyabete n'indwara z'umutima. Oleoylethanolamide (OEA) yerekanwe gufasha kugabanya umuriro mu mubiri.
Ubushakashatsi bwerekana ko OEA ifasha kugabanya umusaruro wa cytokine, ibyo bikaba ari ibimenyetso byerekana umuriro mu mubiri. OEA ifasha kandi kugabanya stress ya okiside, impamvu nyamukuru itera umuriro mumubiri.
Oleoylethanolamide (OEA) yerekana amasezerano muguhindura ibisubizo byumuriro mumubiri, bishobora kugira ingaruka kumikorere rusange yubudahangarwa no kwirinda indwara. Ifu ya Oleoylethanolamide (OEA) irashobora gutanga inyungu zubuzima bwigihe kirekire mugushyigikira igisubizo cyiza.
Hasi ya lipide yamaraso kandi urwanye aterosklerose
Peroxisome prolifator-ikora reseptor-α (PPAR-α) ni ubwoko bwa reseptor bufitanye isano rya hafi n'imikorere ya metabolike y'umubiri. PPAR-α igira uruhare muri metabolisme ya lipide ihuza na peroxisome prolifator igisubizo. Ubwikorezi bwa metabolike, kugenzura ubudahangarwa, kurwanya indwara, kurwanya ikwirakwizwa n’ibindi bikorwa bifitanye isano nabyo bigira uruhare mu kugenzura lipide yamaraso na anti-aterosklerose.
Oleoylethanolamide (OEA) ni ikigereranyo cya endocannabinoid ikorwa mugihe ingirangingo z'umubiri zishutswe. Ubushakashatsi bwerekanye ko OEA ikora PPAR-M, igabanya irekurwa rya endothelin-1, ikabuza vasoconstriction no gukwirakwiza imitsi ingirabuzimafatizo, igatera vasodilasiya, kandi icyarimwe ikongera synthèse ya synthase ya nitric okiside ya endoteliyale kandi bigatuma habaho umusaruro mwinshi wa aside nitide; synthase. azote, bityo bigabanye umusaruro wa molekile zifata ingirabuzimafatizo, kugera ku ngaruka zo kurwanya inflammatory, no kugira ingaruka zo kugabanya lipide yamaraso na anti-atherosclerose.
Ubuzima bwubwonko nibikorwa byubwenge
Ubushakashatsi bwerekana ko ifu ya OEA ishobora no kugira ingaruka kubuzima bwubwonko no mumikorere yubwenge. Oleoylethanolamide (OEA) yerekanwe kurenga inzitizi yubwonko bwamaraso no gukorana nabakira mu bwonko, bikavamo ingaruka zishobora guterwa mumikorere yubwenge na neuroprotection.
Birakwiye kuvuga ko OEA ishobora kugira ingaruka kuri AD. Indwara ya amyloide-beta (Aβ) y’indwara ya Alzheimer (AD) iherekejwe n’impinduka zikomeye mu ngirabuzimafatizo zo mu bwonko. Ubushakashatsi bwakozwe na genome bugaragaza ko microglia n'inzira zijyanye nayo, nka fagocytose, metabolisme ya lipide, hamwe n’ubudahangarwa bw'umubiri, bigira uruhare runini muri etiologiya ya nyuma ya AD.
Oleylethanolamine (OEA) ni molekile ya endogenous lipide ya molekile yerekanwe mu bwihindurize byagaragaye ko yongerera igihe ubuzima n'ubuzima muri C. elegans. Mu nyamaswa z’inyamabere, OEA ikorerwa mu ngingo za periferique na sisitemu yo hagati yo hagati, kandi ubushakashatsi bwakozwe na lipidomics bwerekanye ko OEA hamwe n’andi mavuta acide etanolamine yagabanutse cyane mu mazi y’ubwonko na plasma y’abarwayi ba AD, bivuze ko molekile nka OEA zishobora kugira uruhare mu iterambere rya AD. .
1. Menya inkomoko nubuziranenge
Mugihe uguze ifu ya Oleoylethanolamide (OEA), ugomba gutekereza inkomoko nubuziranenge bwibicuruzwa. Shakisha abatanga isoko bazwi bakoresha ibikoresho byiza kandi bakurikiza amahame akomeye yo gukora. Byaba byiza, ifu ya OEA igomba gukomoka kumasoko karemano kandi yera cyane kugirango ikore neza numutekano.
2. Reba ibizamini byabandi
Kugirango hamenyekane ubuziranenge nubuziranenge bwifu ya Oleoylethanolamide (OEA), ni ngombwa guhitamo ibicuruzwa byageragejwe na laboratoire zabandi. Igeragezwa ryagatatu ryemeza ko ifu ya OEA idafite umwanda kandi yujuje imbaraga nubuziranenge bwihariye. Shakisha ibicuruzwa bitanga ibisubizo byikizamini bisobanutse kandi byemewe, biguha amahoro yo mumutima kubijyanye nubwiza bwifu ya OEA ugura.
3. Reba uburyo
Ifu ya Oleoylethanolamide (OEA) iraboneka muburyo butandukanye, harimo capsules nifu. Mugihe uhisemo formula ikubereye, tekereza kubyo ukunda nubuzima bwawe. Capsules itanga urugero rwiza kandi rusobanutse, mugihe ifu namazi bishobora kuvangwa byoroshye mubinyobwa cyangwa ibiryo.
4. Suzuma izina ryabatanga
Mugihe ugura ifu ya OEA, nibyingenzi kugura kubatanga bazwi kandi bizewe. Kora ubushakashatsi kubatanga isoko, isuzuma ryabakiriya, hamwe nimpamyabumenyi kugirango umenye neza ibicuruzwa byizewe kandi byiza. Umuntu utanga isoko azwiho gukorera mu mucyo kubyerekeye amasoko yabo, uburyo bwo gukora, nubwiza bwibicuruzwa, biguha ikizere mubyo waguze.
5. Suzuma igiciro n'agaciro
Mugihe igiciro kitagomba kuba ikintu cyonyine gifata umwanzuro, ni ngombwa gusuzuma agaciro ka poro ya OEA ugura. Gereranya ibiciro nabatanga ibicuruzwa bitandukanye, urebye inkomoko yibicuruzwa, ubuziranenge, imiterere nicyubahiro. Wibuke ko ifu yo mu rwego rwohejuru ya OEA ishobora kuba ihenze cyane, ariko agaciro itanga muburyo bwiza numutekano bikwiye gushorwa.
6. Baza inzobere mu by'ubuzima
Mbere yo kongeramo ifu ya OEA muburyo bwawe bwinyongera, birasabwa kugisha inama inzobere mubuzima, cyane cyane niba ufite ubuzima bwihishe inyuma cyangwa ufata imiti. Inzobere mu buvuzi irashobora gutanga ubuyobozi bwihariye kandi ikemeza ko OEA ikwiranye nubuzima bwawe bwa buri munsi.
Igihe cyashize utari uzi aho wagura Oleoylethanolamide (OEA). Urusaku rwinshi icyo gihe byari ukuri. Ugomba kuva mububiko ukajya mububiko, muri supermarket, mumaduka, hanyuma ukabaza kubyerekeye inyongera ukunda. Ikintu kibi cyane gishobora kubaho nukuzenguruka umunsi wose nturangire kubona icyo ushaka. Ikibabaje kurushaho, nubona iki gicuruzwa, uzumva uhatirwa kugura ibicuruzwa.
Uyu munsi, hari ahantu henshi tugura ifu ya Oleoylethanolamide (OEA). Nkesha interineti, urashobora kugura ikintu cyose utiriwe uva murugo rwawe. Kuba kumurongo ntabwo byorohereza akazi kawe gusa, binatuma uburambe bwawe bwo guhaha bworoha. Ufite kandi amahirwe yo gusoma byinshi kuriyi nyongera itangaje mbere yo gufata icyemezo cyo kuyigura.
Hano hari abagurisha kumurongo benshi uyumunsi kandi birashobora kukugora guhitamo icyiza. Icyo ugomba kumenya nuko mugihe bose bazasezeranya zahabu, ntabwo bose bazatanga.
Niba ushaka kugura ifu ya Oleoylethanolamide (OEA) kubwinshi, urashobora kutwishingikiriza. Dutanga inyongera nziza zizatanga ibisubizo. Tegeka muri Suzhou Myland Pharm uyumunsi hanyuma utangire urugendo rwawe kubuzima bwiza.
Suzhou Myland Pharm & Nutrition Inc yatangiye gukora ubucuruzi bwongera imirire kuva mu 1992. Nisosiyete ya mbere mu Bushinwa yateje imbere kandi igacuruza imbuto zinzabibu.
Hamwe nuburambe bwimyaka 30 kandi itwarwa nubuhanga buhanitse hamwe ningamba zinoze cyane R&D, isosiyete yateje imbere ibicuruzwa bitandukanye byapiganwa kandi ihinduka ubumenyi bwa siyanse yubuzima bushya, synthesis gakondo hamwe na serivise zikora inganda.
Mubyongeyeho, Suzhou Myland Pharm & Nutrition Inc nayo ikora FDA yemewe. Ibikoresho bya sosiyete R&D, ibikoresho byububiko, nibikoresho byisesengura nibigezweho kandi bikora kandi birashobora gukora imiti kuva kuri miligarama kugeza kuri toni mubipimo, kandi ikubahiriza ibipimo bya ISO 9001 nibisobanuro byakozwe na GMP.
Ikibazo: Ifu ya Oleoylethanolamide (OEA) ni iki kandi ikora ite?
Igisubizo: Ifu ya Oleoylethanolamide (OEA) ni molekile isanzwe ya lipide ikorwa mumara mato. Ikora mugukora peroxisome prolifator-ikora reseptor alpha (PPAR-α), igira uruhare mukugenzura metabolism no guteza imbere ibyiyumvo byuzuye.
Ikibazo: Ni izihe nyungu zishobora gukoreshwa mu gukoresha ifu ya Oleoylethanolamide (OEA)?
Igisubizo: Inyungu zimwe zishoboka zo gukoresha ifu ya OEA harimo guhagarika ubushake bwo kurya, gucunga ibiro, no gushyigikira metabolism nzima. Irashobora kandi kugira imiti irwanya inflammatory na neuroprotective.
Ikibazo: Nigute nahitamo ifu nziza ya Oleoylethanolamide (OEA)?
Igisubizo: Mugihe uhitamo ifu ya OEA, nibyingenzi gushakisha isoko ryiza ritanga ibizamini byabandi-byera kububasha nimbaraga. Byongeye kandi, suzuma inkomoko yifu hanyuma uhitemo ibicuruzwa biva mubisanzwe, birambye.
Inshingano: Iyi ngingo ni iyamakuru rusange gusa kandi ntigomba gusobanurwa nkinama zose zubuvuzi. Amwe muma poste yamakuru aturuka kuri enterineti kandi ntabwo ari umwuga. Uru rubuga rufite inshingano zo gutondeka, gutunganya no guhindura ingingo. Intego yo gutanga amakuru menshi ntabwo bivuze ko wemera ibitekerezo byayo cyangwa kwemeza ukuri kwibirimo. Buri gihe ujye ubaza inzobere mu buzima mbere yo gukoresha inyongeramusaruro cyangwa guhindura ibintu byubuzima bwawe.
Igihe cyo kohereza: Kanama-23-2024
