5-amino-1-methylquinolinium iyode CAS No.:42464-96-0 98.0% isuku min. | inyongera yinganda
Ibipimo byibicuruzwa
| Izina ryibicuruzwa | 5-amino-1-methylquinolinium iyode |
| Irindi zina | NNMTi5-Amino-1-mq iyode 5-amino-1-methylquinolinium iyode 5-AMINO-1-METHYLQUINOLIN-1-IUM IODIDE 5-Amino-1-methylquinolin-1-iumiodide 1-methylquinolin-1-ium-5-amine; iyode 5-Amino-1-methyl-1-quinolinium Iodide |
| URUBANZA No. | 42464-96-0 |
| Inzira ya molekulari | C10H11IN2 |
| Uburemere bwa molekile | 286.11 |
| Isuku | 98% |
| Kugaragara | Umuhondo kugeza umutuku wijimye |
| Gupakira | 1kg / igikapu, 25kg / ingunguru |
| Gusaba | Ibyokurya byongera ibiryo |
Kumenyekanisha ibicuruzwa
NNMTi ni enzyme ikabije cyane mugihe cyo gusaza kwimitsi ya skeletale kandi ifitanye isano no gusana ibyangiritse bya NAD + inzira, ibikorwa bya sirtuin1 itagengwa, hamwe no kwiyongera kwimitsi yimitsi. NNMTi iteza myoblast itandukanya muri vitro kandi ikongerera guhuza no kuvugurura ingirabuzimafatizo z'imitsi mu mbeba zashaje. NNMTi kandi ni inhibitori ikomeye ya nikotinamide N-methyltransferase (NNMT) (IC50 = 1.2 μM), ihitamo guhuza NNMT substrate ihuza ibisigazwa bya site. NNMTi iteza myoblast itandukanya muri vitro kandi ikongerera guhuza no kuvugurura ingirabuzimafatizo z'imitsi mu mbeba zashaje. Muri byo, enzyme ya cytosoliki nicotinamide N-methyltransferase (NNMT) yavumbuwe vuba kugirango igenzure urwego rwibanze rwa nicotinamide rusabwa kuri NAD + biosynthesis, bityo rukaba rufite uruhare runini mugutunganya inzira ya NAD + salvage na metabolism selile.
Ikiranga
(1) Isuku ryinshi: NNMTi irashobora kubona ibicuruzwa byera cyane binyuze mubikorwa bitunganijwe neza. Isuku ryinshi risobanura bioavailable nziza.
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Porogaramu
NNMTi ni nikotinamide N-methyltransferase (NNMT) inhibitor itera myoblast itandukanye. NNMTi irashobora kandi gukoreshwa nk'inyongera ifasha kugabanya ibiro n'ibinure no kunoza amavuta y'umwijima.
