5-Amino-1-methylquinolinium chloride No. CAS No.:42464-96-0 98.0% ubuziranenge buri munsi | uruganda rukora ibikoresho by'inyongera
Ibipimo by'ibicuruzwa
| Izina ry'igicuruzwa | 5-Amino-1-methylquinolinium chloride (5-amino-1MQ) |
| Irindi zina | 5-amino-1MQ5-Amino-1-mq kloride 5-Amino-1-methylquinolinium chloride 5-Amino-1-methylquinoline-1-iyumu kloride 5-AMINO-1-METHYLQUINOLIN-1-IUM CHLOEIDE 5-Amino-1-methyl-1-quinolinium chloride |
| Nimero ya CAS | 42464-96-0 |
| Ifishi y'ingirabuzimafatizo | C₁₀H₁₁ClN₂ |
| Uburemere bwa molekile | 194.6 |
| Ubwiza | 98% |
| Isura | Igiti cy'umukara utukura kugeza ku ibara ry'umutuku |
| Gupakira | 1kg/umufuka, 25kg/umufuka |
| Porogaramu | Inyongeramusaruro ku biribwa |
Intangiriro y'ibicuruzwa
5-Amino-1-methylquinolinium chloride ni enzyme ikoreshwa cyane mu gihe imitsi y'amagufwa isaza kandi ifitanye isano no gusana ibyangiritse bya NAD+ mu nzira, gukora nabi kwa sirtuin1, no kwiyongera kw'uturemangingo tw'imitsi. 5-Amino-1-methylquinolinium chloride itera ihinduka rya myoblast muri vitro kandi yongera ihuriro n'ivugururwa ry'uturemangingo tw'imitsi mu mbeba zishaje. 5-Amino-1-methylquinolinium chloride nayo ni umuti ukomeye wa nicotinamide N-methyltransferase (NNMT), ifata neza ibisigazwa by'aho NNMT ifata. 5-Amino-1-methylquinolinium chloride itera ihinduka rya myoblast muri vitro kandi yongera ihuriro n'ivugururwa ry'uturemangingo tw'imitsi mu mbeba zishaje. Muri byo, enzyme ya cytosolic nicotinamide N-methyltransferase (NNMT) yavumbuwe vuba aha kugira ngo igenzure urwego rwa nicotinamide isabwa kugira ngo NAD+ ikore neza, bityo ikaba igira uruhare runini mu kugenzura inzira yo gukiza NAD+ n'imikorere y'uturemangingo.
5-Amino-1-Methylquinolinium Chloride ikora muri mikorobe yawe kugira ngo igabanye ibinure (uturemangingo) kandi igufashe kugabanya ibiro. Iyo uturemangingo tw’ibinure twinshi twirundanyije, umubiri wawe ukora enzyme izwi nka NNMT (nicotinamide N-methyltransferase). Uko NNMT irushaho kuba nyinshi, ni ko umubiri wawe wongera ububyimbirwe kandi ukabibika. 5-Amino-1-Methylquinolinium Chloride ibuza NNMT, bigatuma umubiri wawe ugabanya ibiro bikabije.
Ikiranga
(1) Ubuziranenge bwinshi: 5-Amino-1-methylquinolinium chloride ishobora kubona umusaruro mwiza binyuze mu buryo bwo gutunganya neza. Ubuziranenge bwinshi busobanura ko biyoroheye kuboneka neza.
(2) Kwibanda ku bintu: 5-Amino-1-methylquinolinium chloride yibasira by’umwihariko enzyme ya NNMT kandi ishobora kubuza imikorere yayo neza, bityo ikagira ingaruka ku nzira ya metabolism ya nicotinamide.
(3) Gutuza: 5-Amino-1-methylquinolinium chloride ifite gutuza neza kandi ishobora gukomeza imikorere n'ingaruka zayo mu bidukikije bitandukanye no mu buryo butandukanye bwo kubika.
(4) Ibyiza by'iterambere: Bitewe n'imiterere itandukanye ya 5-Amino-1-methylquinolinium chloride, iterambere ryayo ryakunzwe cyane kandi rifite ubushakashatsi bwagutse n'ibyiza by'ikoreshwa.
Porogaramu
5-Amino-1-methylquinolinium chloride ni umuti ubuza nicotinamide N-methyltransferase (NNMT) gutuma habaho ihinduka rya myoblast. 5-Amino-1-methylquinolinium chloride ishobora kandi gukoreshwa nk'inyongera mu gufasha kugabanya ibiro n'ibinure no kunoza ibinure mu mwijima.
