5-Amino-1-methylquinolinium iodide（NNMTi） CAS No.:42464-96-0 98.0% ubuziranenge buri munsi | uruganda rukora ibikoresho by'inyongera
Ibipimo by'ibicuruzwa
| Izina ry'igicuruzwa | 5-Amino-1-methylquinolinium iyode（NNMTi） |
| Irindi zina | NNMTi5-AMINO-1-METHYLQUINOLIN-1-IUM IODIDE iyode ya 5-amino-1-methylquinolinium 5-Amino-1-methylquinolin-1-imiodide 1-methylquinoline-1-ium-5-amine; iyode 5-Amino-1-methyl-1-quinolinium Iyode Iyode ya 5-Amino-1-mq |
| Nimero ya CAS | 42464-96-0 |
| Ifishi y'ingirabuzimafatizo | C10H11IN2 |
| Uburemere bwa molekile | 286.11 |
| Ubwiza | 98.0% |
| Isura | Igiti cy'umukara utukura kugeza ku ibara ry'umutuku |
| Gupakira | 1kg/umufuka, 25kg/umufuka |
| Porogaramu | Inyongeramusaruro ku biribwa |
Intangiriro y'ibicuruzwa
Havumbuwe vuba aha enzyme ya cytosolic nicotinamide N-methyltransferase (NNMT) igenzura urwego rwa nicotinamide isabwa kugira ngo NAD+ ikoreshwe, bityo ikaba igira uruhare runini mu kugenzura inzira yo gukiza NAD+ n'imikorere y'uturemangingo. NNMT igaragara mu mitsi y'amagufwa, kandi imikorere yayo igenda yiyongera uko imitsi isaza. Icy'ingenzi ni uko NNMT ari igice cy'ingenzi cy'ishyirwa mu bikorwa rya gene ya sarcopenic, kandi imikorere yayo irenze urugero ishobora gutuma urugero rwa NAD+ rugabanuka cyane ndetse n'igabanuka ry'imitsi, imbaraga, n'imikorere ijyana no gusaza. Kuvura imbeba zishaje hakoreshejwe molecule nto ya NNMT ibuza (NNMTTi) byongereye ubushobozi bwo kwiyongera, guhuza no kongera ubushobozi bwa muSC, bityo bikanoza imikorere y'imitsi y'amagufwa. Ibisubizo nk'ibyo byabonetse muri vitro hakoreshejwe uturemangingo twa C2C12, dusa cyane na muSC, aho ubuvuzi bwa NNMTTi bwateje imbere ihinduka rya myoblast kandi bugashyigikira impinduka mu mikorere y'uturemangingo mu mikorere y'uturemangingo ijyanye n'inzira ya NAD + yo gukiza.
NNMT ni enzyme ikoreshwa cyane mu gihe imitsi y'amagufwa isaza kandi ifitanye isano no kwangirika kw'inzira ya NAD+, gukora nabi kwa sirtuin1, no kwiyongera kw'uturemangingo tw'imitsi. NNMT ni enzyme ikora metabolisme ikoresha methylation ya nicotinamide (NAM) ikoresheje methyl donor S-adenosylmethionine (SAM), ihuza imiterere y'ingirabuzimafatizo n'uburinganire bwa methylation n'urwego rwa NAD+ mu ngirabuzimafatizo. NNMT igaragara cyane mu mwijima no mu ngirabuzimafatizo z'amafuta, ndetse no mu bihe by'uburwayi birangwa no kwiyongera k'ibikenewe mu ngirabuzimafatizo, nk'indwara zimwe na zimwe z'umwijima w'ibinure na diyabete. NNMT igira uruhare mu buryo butandukanye bwo gutandukanya, harimo guhinduka kw'uturemangingo tw'imitsi y'umuntu ukiri mu nda kugeza ku gukura, myogenesis, no guhinduka kwa epithelial na neuromesenchymal muri kanseri zitandukanye. Imiterere ya NNMT igenzurwa mu buryo bwihariye ku ngingo no mu buryo bwihariye aho kuba mu buryo busanzwe bwo kugenzura.
Ikiranga
(1) Ubuziranenge bwinshi: NNMTi ishobora kubona ibicuruzwa bifite ubuziranenge bwinshi binyuze mu buryo bwo gukora bunoze. Ubuziranenge bwinshi busobanura ko binyabuzima biboneka neza.
(2) Kwibanda ku bintu: NNMTTi yibasira by’umwihariko enzyme ya NNMT kandi ishobora kubuza imikorere yayo neza, bityo ikagira ingaruka ku nzira ya metabolism ya nicotinamide.
(3) Gutuza: NNMTi ifite umutekano mwiza kandi ishobora gukomeza imikorere yayo n'ingaruka zayo mu bidukikije bitandukanye no mu buryo butandukanye bwo kubika.
(4) Ibyiza by'iterambere: Bitewe n'imiterere itandukanye ya NNMTi, iterambere ryayo ryakunzwe cyane kandi rifite ubushakashatsi bwagutse n'ibyiza by'ikoreshwa.
Porogaramu
NNMT (CAS 42464-96-0) ni umuti ugabanya nicotinamide N-methyltransferase (NNMT), umuti ugabanya imbaraga (IC50 = 1.2 μM) wa nicotinamide N-methyltransferase (NNMT) utuma habaho ihinduka rya myoblast. NNMTTi ifata neza ibisigazwa by’aho ifata substrate. NNMTTi itera ihinduka rya myoblast muri vitro kandi yongera ihuzwa ry’uturemangingo tw’imitsi no kongera kuvugurura mu mbeba zishaje. NNMT ni enzyme y’ibanze ya cytosolic biotransformation itera N-methylation y’uturemangingo tw’umubiri n’utw’inyuma. Ugereranije no gusimbuza indyo yoroheje gusa, ubuvuzi bwa NNMTTi buhujwe no gusimbuza indyo yoroheje byihutishije iterambere mu kubura ibinure mu mubiri, kwiyongera k’umubiri wose ugereranije n’uburemere bw’umubiri, kugabanuka k’uburemere bw’amafuta y’umwijima, kugabanuka k’ibinure mu mwijima, no kunoza umwijima. Byongeye kandi, NNMTTi ishobora kongera imbaraga no guteza imbere ubushobozi bwo kuvugurura imitsi ishaje, bishobora kuba ingirakamaro mu kuvura sarcopenia.
