BAM15A CAS No.:210302-02-6 Kubaka imitsi no kugabanya ibinure.
Ibipimo by'ibicuruzwa
| Izina ry'igicuruzwa | BAM15A |
| Irindi zina | N5,N6-Bis(2-Chlorophenyl)-[1,2,5]oxadiazolo[3,4-b]pyrazine-5,6-diamine |
| Nimero ya CAS | 210302-02-6 |
| Ifishi y'ingirabuzimafatizo | C16H10Cl2N6O |
| Uburemere bwa molekile | 373.2 |
| Ubwiza | 98% |
| Isura | Ifu y'umuhondo woroshye kuva ku cyera kugeza ku ifu y'umuhondo woroshye |
| Gupakira | 1kg/umufuka, 25kg/umufuka |
| Porogaramu | Inyongeramusaruro ku biribwa |
Intangiriro y'ibicuruzwa
BAM15A ni modulator ya mitochondrial yo mu gisekuru gishya. Nk'umuyoboro mwiza wa proton ya mitochondrial uncoupler, igenzura buhoro buhoro imiterere ya proton mu gice cy'imbere cya mitochondrial, yongera ubushobozi bw'umubiri mu gutunganya ingufu kandi yihutisha igabanuka ry'ibinure mu buryo busanzwe, idahinduye imitsi cyangwa ubushake busanzwe bwo kurya.
Ubushakashatsi bwakozwe mbere y’uko ubuvuzi butangira bwerekanye ko iki kintu gifasha mu kongera kubyimba umubiri, kongera ubushobozi bwo kumva insuline, kugabanya ibinure mu mwijima no kugabanya ingaruka zo kubyimba umubiri. Gifite ubushobozi bwo kunywa kugeza kuri 67% kandi gifite imiterere yoroheje kandi gifite umutekano mwinshi. Bitandukanye n’ibindi bintu bisanzwe bisa, ntabwo gitera ubushyuhe budasanzwe bw’umubiri cyangwa kwangirika kw’uturemangingo, bigatuma kiba igikoresho cy’ingenzi mu ntungamubiri mu kugabanya ibiro no kugenzura imikorere y’umubiri.
Ikiranga
(1) Ubuziranenge buhanitse: BAM15Aishobora gukora ibicuruzwa bifite isuku nyinshi binyuze mu buryo bwo gukora bunoze. Isuku nyinshi bivuze ko binyabuzima biboneka neza.
(2) Uburyo bwo gukurura neza: Nk'umutwaro wa protoni ya mitochondrial, ibangamira imiterere ya protoni y'urukiramende rw'imbere rwa mitochondrial, igatuma ingufu za oxidative ziva mu ntungamubiri zihinduka ingufu z'ubushyuhe aho kuba ATP, bigatuma ingufu zikoreshwa cyane.
(3) Gutakaza ibinure neza no kunoza imikorere y’umubiri: Mu igerageza ry’inyamaswa, uburyo umubiri uboneka mu kanwa bwageze kuri 67%, bigabanya ibinure byo mu mubiri ho ibirenze 20% bitagabanyije imitsi, bigira ingaruka ku gushaka kurya cyangwa ubushyuhe bw’umubiri, ariko bikongera ubushobozi bwo kumva insuline, bikagabanya ibinure mu mwijima no kubyimba.
(4) Akamaro k'uburozi gake: Ugereranyije n'ibintu bisanzwe bifasha mu gukurura, nta ngaruka zo kugira umuriro mwinshi cyangwa uburozi bukabije. Nta kwangirika kw'ingingo cyangwa ingaruka mbi ku mitsi..
Porogaramu
1. Kugabanya ibinure no kunoza imikorere y'umubiri: Binyuze mu gukuramo imitochondrial, bigabanya cyane ibinure mu mubiri (mu nyamaswa, ibinure mu mubiri bigabanukaho ibirenze 20%), bigabanya icyarimwe isukari mu maraso, ubudahangarwa bwa insuline, n'ubwiyongere bw'ibinure mu mwijima, bitagize ingaruka ku byifuzo cyangwa ku mitsi;
2. Kurwanya gusaza: Kongera imitsi (ku kigero cya 8%) n'imbaraga (ku kigero cya 40%) mu matungo ashaje, kugabanya ibinure no gukumira ububyimbirwe budakira, no kurwanya umubyibuho ukabije wa myogenic.
3. Kurwanya ubushyuhe: Bigabanya ibyago byo kwangirika kw'impyiko biturutse ku gushyuha kw'amaraso (AKI), kandi bigabanya ingaruka z'ubushyuhe mu mubiri binyuze mu kubuza ikorwa rya ROS ya mitochondrial no kurekurwa kwa mtDNA.
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