O-304 CAS No.:1261289-04-6 Kubaka imitsi no kugabanya ibinure.
Ibipimo by'ibicuruzwa
| Izina ry'igicuruzwa | O-304 |
| Irindi zina | 4-Chloro-N-[2-[(4-chlorophenyl)methyl]-2,3-dihydro-3-oxo-1,2,4-thiadiazol-5-yl]benzamide |
| Nimero ya CAS | 1261289-04-6 |
| Ifishi y'ingirabuzimafatizo | C16H11Cl2N3O2S |
| Uburemere bwa molekile | 380.25 |
| Ubwiza | 98% |
| Isura | Ifu y'umweru kuva kuri umweru kugeza kuri umweru |
| Gupakira | 1kg/umufuka, 25kg/umufuka |
| Porogaramu | Inyongeramusaruro ku biribwa |
Intangiriro y'ibicuruzwa
O-304 ni igikoresho gito cya AMPK kigabanya imikorere ya AMPK binyuze mu kubuza AMPK ya fosforilise (pAMPK) kuva kuri fosforilise, bityo kikongera urugero rwa pAMPK hatagabanyijwe urugero rwa adenosine triphosphate (ATP) mu ngirabuzimafatizo. Gifite uburyo bwinshi bwo gukora, harimo kunoza imikorere ya glucose, kugabanya ubudahangarwa bwa insuline, no kurinda uturemangingo tw’umutima n’imitsi.
Ikiranga
(1) Ubuziranenge bwinshi: O-304 ikorwa binyuze mu buryo bwo gukora bunoze, bigatuma ibicuruzwa birushaho kuba byiza. Ubuziranenge bwinshi busobanura ko binyabuzima biboneka neza.
(2) Ibikorwa by'ibinyabuzima:O-304 ni ikintu gitera imbaraga mu kanwa cya AMPK (AMP-activated protein kinase). Yongera imikorere ya AMPK mu kubuza pAMPK gukora phosphorylation.
Porogaramu
1. Gukora AMPK: O-304 yongera imikorere ya AMPK ibuza inzira yo gukuraho fosfori ya AMPK (pAMPK) ikoresheje fosfori, bityo ikagenzura uburinganire bw'ingufu mu mikorere y'umubiri.
2. Kunoza imikorere y’isukari mu maraso: Mu bushakashatsi ku nyamaswa, urugero rwa 100 mg/kg rwa O-304 rwafashije cyane mu kubungabunga urwego rw’isukari mu maraso rudahindagurika ndetse n’urugero rwa insuline mu maraso, bigabanya cyane umutwaro w’imikorere y’isukari uterwa n’indyo irimo ibinure byinshi, kandi bikarinda ihindagurika ry’isukari mu maraso no kwiyongera kwa insuline mu buryo budasanzwe biterwa n’uburyo butari bwiza mu mirire.
3. Pkurinda imitsi y'amaraso guhindagurika:O-304 ifasha mu kubungabunga umuvuduko w'amaraso ku rugero rwiza, ikagabanya imitsi itera amaraso guhangayika, kandi igatanga uburinzi bworoheje kandi bw'igihe kirekire ku mitsi y'umutima n'imitsi yo mu bwonko, igashyigikira ituze ry'amarangamutima n'ingufu zirambye.
4.Guteza imbere ubuto burambye:O-304 yibanda ku buryo bufatika ku nzira y’ibimenyetso ya AMPK-mTOR, igenzura mu buryo bw’ubwenge inzira y’ubwihindurize bw’uturemangingo, iteza imbere katabolisme ya poroteyine zishaje n’ibinure bidasanzwe, kandi igakomeza kubungabunga ibidukikije by’uturemangingo bisukuye kandi bizima, bityo bigatinda gusaza kw’uturemangingo.
