Ifu ya Nefiracetam nimero ya CAS: 77191-36-7 Isuku ya 99% ku bikoresho by'inyongera
Videwo y'ibicuruzwa
Ibipimo by'ibicuruzwa
| Izina ry'igicuruzwa | Nefiracetam |
| Irindi zina | n-(2,6-dimethylphenyl)-2-oxo-1-pyrrolidineacetamide; NEFIRACETAM; 2-oxo-1-pyrrolidinylacetic acid, 2,6-dimethylanilide; dm9384; n-(2,6-dimethylphenyl)-2-oxo-1-pyrrolidineacetamide;DM-9384,(2-(2-Oxopyrrolidin-1-yl)-N-(2,6-dimethylphenyl)-acetamide); DMPA |
| Nimero ya CAS | 77191-36-7 |
| Ifishi y'ingirabuzimafatizo | C14H18N2O2 |
| Uburemere bwa molekile | 246.3 |
| Ubwiza | 99.0% |
| Isura | Ifu y'umweru |
| Gupakira | Ibiro 25 ku icupa |
| Porogaramu | nootropic |
Intangiriro y'ibicuruzwa
Nefiracetam iri mu muryango wa piracetam, ubwoko bw'imiti izwiho kugira ubushobozi bwo kongera ubushobozi bwo gutekereza. Nefiracetam yakozwe bwa mbere mu ntangiriro za 1980 kandi yakuruye abantu vuba bitewe n'uburyo ikora n'uburyo ishobora gukoreshwa mu kuvura. Iyi mvange y'ubwoko bwa racemic ifatwa nk'igira ingaruka ku mikorere ya neurotransmitters na receptors mu bwonko, amaherezo igateza imbere ubushobozi bwo gutekereza. Nefiracetam igira ingaruka cyane cyane ku rugero rw'ubwonko rwa acetylcholine, neurotransmitter y'ingenzi ishinzwe kwibuka, kwiga, n'imikorere y'ubwenge. Mu guhindura receptors za acetylcholine, nefiracetam itera imbere itumanaho hagati y'imitsi, bityo yongera uburyo synaptic plasticity kandi ikongera uburyo bwo kwibuka. Byongeye kandi, nefiracetam ikorana na receptors za aside gamma-aminobutyric (GABA) kugira ngo ifashe kuringaniza imiterere ya neurotransmitters. Mu kugira ingaruka nziza ku mikorere ya neurotransmitters itera imbaraga kandi ibuza, nefiracetam ifasha mu gukomeza imikorere myiza y'ubwonko, bityo ikongera ubushobozi bwo kwibanda, kwita ku bintu, n'imikorere y'ubwenge muri rusange.
Ikiranga
(1) Ubuziranenge bwinshi: Nefiracetam ishobora kubona ibicuruzwa bifite ubuziranenge bwinshi binyuze mu gutunganya ikorwa ryayo. Ubuziranenge bwinshi busobanura ko binyabuzima biboneka neza kandi ingaruka mbi zikaba nke.
(2) Umutekano: Umutekano mwinshi, ingaruka mbi nke.
(3) Gutuza: Nefiracetam ifite ubuziranenge kandi ishobora gukomeza imikorere yayo n'ingaruka zayo mu bidukikije bitandukanye no mu buryo butandukanye bwo kubika.
Porogaramu
Nefiracetam ni ikintu gikomoka kuri piracetam gikomoka kuri hydrophobic, muri rusange gifatwa nk'ikintu gishinzwe kuvumbura imiyoboro ya kalisiyumu mu mubiri no kohereza mu buryo butaziguye ibintu bitera imbaraga nk'igice cy'imiyoboro ya kalisiyumu. Aho receptor ya NDMA ihurira na Glycine. Binyuze mu ngaruka zayo ku gice cy'ubwonko, nefiracetam ishobora kongera ubushobozi bwo gutekereza no gukumira kwiga no kwibuka nabi. Ntabwo ifite imiterere ya muscarinic receptor agonist cyangwa antagonist, kandi ntibuza acetylcholinease gukora. Kubwibyo, ingaruka zayo zo kurwanya amnestic no kongera kwibuka zigerwaho binyuze mu kunoza irekurwa rya acetylcholine mu gice cy'ubwonko.
