Alpha GPC Irashobora Kunoza Icyerekezo cyawe? Dore Ibyo Ukeneye Kumenya

Ku bijyanye no kunoza kwibuka no kwiga, ubushakashatsi buherutse kwerekana ko alpha GPC ishobora kuba ingirakamaro cyane. Ni ukubera ko A-GPC itwara choline mu bwonko, itera neurotransmitter ikomeye iteza imbere ubuzima bwubwenge.

Ubushakashatsi bwerekana alpha GPC nimwe mubintu byiza byongera ubwonko bwa nootropic ku isoko. Ni molekile itera ubwonko yerekanwe ko ifite umutekano kandi yihanganirwa neza n’abarwayi bakuze bashaka kunoza ibimenyetso by’indwara yo guta umutwe, ndetse n’abakinnyi bato bakiri bato bashaka kuzamura imbaraga zabo n’imbaraga zabo.
Kimwe ningaruka zongera ubwonko bwa fosifatidylserine, a-GPC irashobora kuba ubuvuzi busanzwe bwindwara ya Alzheimer kandi irashobora kugabanya umuvuduko ukabije wubwenge.

Alpha GPC ni iki?

Alpha GPC cyangwa alpha glycerylphosphorylcholine ni molekile ikora nk'isoko ya choline. Ni aside irike iboneka muri soya lecithine no mubindi bimera kandi ikoreshwa mubyongera ubuzima bwubwenge no kubaka imbaraga zimitsi.
Alpha GPC, izwi kandi nka choline alfoscerate, ihabwa agaciro kubera ubushobozi ifite bwo gutwara choline mu bwonko no gufasha umubiri gukora neurotransmitter acetylcholine, ishinzwe inyungu nyinshi za choline. Acetylcholine ifitanye isano no kwiga no kwibuka, kandi ni imwe mu mitsi ikomeye ya neurotransmitter yo kugabanya imitsi.
Bitandukanye na choline bitartrate, ikindi cyongewe cya choline ku isoko, A-GPC irashobora kurenga inzitizi yubwonko bwamaraso. Niyo mpamvu igira ingaruka zitanga ubwonko n'impamvu ikoreshwa mu kuvura indwara yo guta umutwe, harimo n'indwara ya Alzheimer.

Alpha GPC yunguka kandi ikoresha

1. Kunoza ubumuga bwo kwibuka

Alpha GPC ikoreshwa mugutezimbere kwibuka, kwiga no gutekereza. Irabikora mukongera acetylcholine mubwonko, imiti igira uruhare runini mukwibuka no kwiga. Abashakashatsi bavuze ko alpha GPC ifite ubushobozi bwo kunoza ibimenyetso byubwenge bifitanye isano n'indwara ya Alzheimer n'indwara yo guta umutwe.
Ikigeragezo-gihumye, giteganijwe, kigenzurwa na platbo cyasohowe muri Clinical Therapeutics mu 2003 cyasuzumye imikorere n’ubworoherane bwa alpha GPC mu kuvura ubumuga bwo mu mutwe buterwa n'indwara ya Alzheimer yoroheje kandi yoroheje.
Abarwayi bafashe 400 mg a-GPC capsules cyangwa capsules inshuro eshatu kumunsi iminsi 180. Abarwayi bose basuzumwe mu ntangiriro yikizamini, nyuma yiminsi 90 yo kwivuza, n’ikizamini kirangiye nyuma yiminsi 180.
Mu itsinda rya alpha GPC, ibipimo byose byasuzumwe, harimo igipimo cy’imyumvire y’imyitwarire ya Alzheimer hamwe n’ikizamini cya Leta ya Mini-Mental, cyakomeje gutera imbere nyuma y’iminsi 90 na 180 yo kwivuza, mu gihe mu itsinda rya placebo batigeze bahinduka. guhinduka cyangwa gukomera.
Abashakashatsi banzuye ko a-GPC ari ingirakamaro mu buvuzi kandi yihanganirwa mu kuvura ibimenyetso byerekana ubwenge bwo guta umutwe kandi ifite ubushobozi bwo kuvura indwara ya Alzheimer.

2. Guteza imbere kwiga no kwibanda

Hariho ubushakashatsi bwinshi bushyigikira inyungu za alpha GPC kubantu bafite ubumuga bwo kutamenya, ariko ni kangahe kubantu badafite ikibazo cyo guta umutwe? Ubushakashatsi bwerekana ko Alpha GPC ishobora kandi kunoza ibitekerezo, kwibuka hamwe nubushobozi bwo kwiga mubakuze bafite ubuzima bwiza.
Ikinyamakuru cyo muri Amerika cyita ku mirire y’amavuriro cyasohoye ubushakashatsi bwakozwe ku bitabiriye amahugurwa nta guta umutwe kandi basanga gufata choline nyinshi bifitanye isano n’imikorere myiza yo kumenya. Indangagaciro zimenyekanisha zasuzumwe zirimo kwibuka mu magambo, kwibuka amashusho, kwiga mu magambo, n'imikorere nyobozi.
Ubushakashatsi bwasohotse mu kinyamakuru cy’umuryango mpuzamahanga w’imirire ya siporo bwerekanye ko iyo abakiri bato bakoresheje inyongera ya alpha GPC, byagize akamaro ku mirimo imwe n'imwe yo gukora ku mubiri no mu mutwe. Abahawe mg 400 za a-GPC batsinze 18% byihuse mu kizamini cyo gukuramo serial kurusha abahawe mg 200 za cafeyine. Byongeye kandi, itsinda rikoresha kafeyine ryatsinze amanota menshi kuri neuroticism ugereranije nitsinda rya alpha GPC.

3. Kunoza imikorere ya siporo

Ubushakashatsi bushigikira imikoranire ya alpha GPC. Kubera iyo mpamvu, abakinnyi barushijeho gushishikazwa na-GPC bitewe nubushobozi bwayo bwo kuzamura kwihangana, ingufu, nimbaraga zimitsi. Kwiyongera hamwe na-GPC bizwiho gufasha kongera imbaraga zumubiri, guteza imbere kubaka imitsi itagabanije, no kugabanya igihe cyo gukira nyuma yimyitozo.
Ubushakashatsi bwerekana ko alpha GPC yongera imisemburo ikura yumuntu, igira uruhare mukuvugurura ingirabuzimafatizo, gukura no gufata neza ingirabuzima fatizo zabantu. Gukura imisemburo izwiho ubushobozi bwo kongera ubushobozi bwumubiri no gukora siporo.
Habayeho ubushakashatsi bwinshi busuzuma imikorere ya alpha GPC kwihangana kumubiri n'imbaraga. Ubushakashatsi bwakozwe mu mwaka wa 2008, bugenzurwa na plato, bwambukiranya abagabo barindwi bafite uburambe bwo guhugura bwerekanye ko a-GPC igira ingaruka ku misemburo ikura. Abitabiriye itsinda ryubushakashatsi bahawe mg 600 ya alpha GPC iminota 90 mbere yimyitozo yo guhangana.
Abashakashatsi basanze ugereranije n’ibanze, imisemburo ikura y’imisemburo ikura inshuro 44 hamwe na alpha GPC na 2,6 inshuro hamwe na placebo. Imikoreshereze ya A-GPC nayo yongereye imbaraga zumubiri, hamwe nimbaraga zo hejuru zintebe ziyongera 14% ugereranije na placebo.
Usibye kongera imbaraga z'imitsi no gukomera, imisemburo yo gukura irashobora guteza imbere kugabanya ibiro, gushimangira amagufa, kunoza umwuka, no kunoza ibitotsi.

4. Kunoza gukira indwara yimitsi

Ubushakashatsi bwambere bwerekana ko a-GPC ishobora kugirira akamaro abarwayi bagize ikibazo cyubwonko cyangwa igitero cyigihe gito, kizwi nka "mini-stroke." Ibi biterwa na alpha GPC ubushobozi bwo gukora nka neuroprotectant no gushyigikira neuroplastique binyuze mumyakire yimitsi ikura.
Mu bushakashatsi bwakozwe mu 1994, abashakashatsi bo mu Butaliyani basanze alpha GPC yarushijeho gukira ubwenge ku barwayi bafite ubwonko bukabije cyangwa bworoheje. Nyuma yubwonko, abarwayi bahawe mg 1.000 ya alpha GPC batewe inshinge muminsi 28, bakurikirwa na mg 400 kumunwa inshuro eshatu kumunsi mumezi 5 ari imbere.
Abashakashatsi batangaje ko igeragezwa rirangiye, 71% by’abarwayi bagaragaje ko nta bwenge bwagabanutse cyangwa amnesia. Byongeye kandi, amanota y'abarwayi ku kizamini cya Leta Mini-Mental yateye imbere ku buryo bugaragara. Usibye ubu bushakashatsi, ijanisha ryibintu bibi byakurikiye ikoreshwa rya alpha GPC ryari rito kandi abashakashatsi bemeje ko ryihanganirwa cyane.

5. Birashobora kugirira akamaro abantu barwaye igicuri

Ubushakashatsi bw’inyamaswa bwasohotse mu bushakashatsi bw’ubwonko mu 2017 bugamije gusuzuma ingaruka zo kuvura alpha GPC ku bumuga bwo kutamenya nyuma yo gufatwa na epileptic. Abashakashatsi basanze iyo imbeba zatewe inshinge-GPC nyuma y'ibyumweru bitatu nyuma yo gufatwa, uruganda rwatezimbere imikorere yubwenge kandi rwongera neurogenezi, imikurire yumubiri.
Ubu bushakashatsi bwerekana ko alpha GPC ishobora kuba ingirakamaro ku barwayi b'igicuri kubera ingaruka zayo zifata ubwonko kandi bikaba bishobora gukiza igicuri cyatewe no kutamenya kwangirika no kwangirika kw'imitsi.

Alpha GPC na Choline

Choline ni micronutrient ya ngombwa isabwa mubikorwa byinshi byumubiri, cyane cyane imikorere yubwonko. Irakenewe kugirango imikorere ikwiye yingenzi ya neurotransmitter acetylcholine, ikora nka anti-gusaza neurotransmitter kandi ifasha imitsi yacu kuvugana.
Nubwo umubiri ukora choline nkeya wenyine, tugomba kubona intungamubiri ziva mubiryo. Ibiryo bimwe birimo choline harimo umwijima w'inka, salmon, inkeri, amagi, n'amabere y'inkoko. Nyamara, raporo zimwe zerekana ko choline ikomoka ku biribwa idakirwa neza n'umubiri, niyo mpamvu abantu bamwe barwara kubura choline. Ni ukubera ko choline itunganyirizwa igice mu mwijima, kandi abantu bafite ubumuga bwumwijima ntibazashobora kuyakira.
Aha niho inyongera za alpha GPC ziza. Abahanga bamwe basaba gukoresha inyongeramusaruro za choline, nka a-GPC, kugirango zongere imikorere yubwonko no gufasha kubika kwibuka. Alpha GPC na CDP choline bibwira ko bifitiye akamaro umubiri umubiri cyane kuko bisa cyane nuburyo choline ibaho mubisanzwe mubiryo. Kimwe na choline isanzwe yinjira mu biryo turya, alpha GPC izwiho ubushobozi bwo kurenga inzitizi y'amaraso n'ubwonko iyo yinjiye, ifasha umubiri guhindura choline muri acetilcholine ya neurotransmitter ya ngombwa.
Alpha GPC nuburyo bukomeye bwa choline. Igipimo cya mg 1.000 ya a-GPC gihwanye na mg 400 za choline y'ibiryo. Cyangwa, muyandi magambo, alpha GPC igera kuri 40% choline kuburemere.

A-GPC na CDP Choline

CDP Choline, izwi kandi nka cytidine diphosphate choline na citicoline, ni uruganda rugizwe na choline na cytidine. CDP Choline izwiho ubushobozi bwo gufasha gutwara dopamine mu bwonko. Kimwe na alpha GPC, Citicoline ihabwa agaciro kubushobozi bwayo bwo kurenga inzitizi yubwonko bwamaraso iyo yinjiye, ikayiha imbaraga zo kongera kwibuka no kongera ubwenge.
Mugihe alpha GPC irimo choline igera kuri 40% kuburemere, choline ya CDP irimo choline hafi 18%. Ariko CDP choline irimo na cytidine, ibanziriza uridine nucleotide. Azwiho ubushobozi bwo kongera ingirabuzimafatizo ya selile, uridine nayo ifite ubwenge-bwongera ubwenge.
Byombi a-GPC na CDP choline bizwiho inyungu zubwenge, harimo uruhare rwabo mugushyigikira kwibuka, imikorere yo mumutwe, hamwe no kwibanda.

Aho wasanga nuburyo bwo gukoresha

A-GPC inyongera zikoreshwa cyane mugutezimbere ubushobozi nubushobozi bwo kumenya. Irashobora kandi gukoreshwa mugutezimbere kwihangana kumubiri no gukora. Alpha GPC irahari nkinyongera yimirire. Alpha GPC inyongera iroroshye kubona kumurongo cyangwa kubatanga. Uzabisanga muburyo bwa capsule na powder. Ibicuruzwa byinshi birimo a-GPC birasaba gufata inyongera hamwe nibiryo kugirango bikore neza.
Suzhou Myland Pharm & Nutrition Inc. ni uruganda rwanditswe na FDA rutanga ifu nziza ya alpha GPC nziza.

Muri Pharm ya Suzhou Myland twiyemeje gutanga ibicuruzwa byiza cyane kubiciro byiza. Ifu ya alpha GPC irageragezwa cyane kugirango isukure nimbaraga, ikwemeza kubona inyongera nziza ushobora kwizera. Waba ushaka gushyigikira ubuzima bwimikorere, kuzamura sisitemu yumubiri cyangwa kuzamura ubuzima muri rusange, ifu ya alpha GPC niyo ihitamo neza.

Hamwe nuburambe bwimyaka 30 kandi itwarwa nubuhanga buhanitse hamwe nuburyo bunoze bwa R&D, Pharm ya Suzhou Myland Pharm yateje imbere ibicuruzwa bitandukanye byapiganiwe kandi ihinduka ubuzima bushya bwa siyanse yubuzima, synthèse progaramu na sosiyete ikora serivise.

Mubyongeyeho, Suzhou Myland Pharm nayo ikora FDA yemewe. Ibikoresho bya sosiyete R&D, ibikoresho byo kubyaza umusaruro, nibikoresho byisesengura nibigezweho kandi byinshi, kandi birashobora gukora imiti kuva kuri miligarama kugeza kuri toni mubipimo, kandi ikubahiriza ibipimo bya ISO 9001 nibisobanuro bya GMP.
A-GPC izwiho kuba hygroscopique, bivuze ko ikurura ubuhehere buturuka mu kirere gikikije. Kubera iyo mpamvu, inyongera zigomba kubikwa mubikoresho byumuyaga kandi ntibigomba guhura numwuka mugihe kinini.

Ibitekerezo byanyuma

Alpha GPC ikoreshwa mugutanga choline mubwonko hakurya ya barrière yamaraso. Nibibanziriza acetylcholine, neurotransmitter iteza imbere ubuzima bwubwenge. Alpha GPC inyongera zirashobora gukoreshwa kugirango bigirire akamaro ubuzima bwawe bwubwenge mugutezimbere kwibuka, kwiga, no kwibanda. Ubushakashatsi bwerekana kandi ko a-GPC ifasha kongera imbaraga zumubiri nimbaraga zimitsi.