Ese Alpha GPC ishobora kunoza icyerekezo cyawe? Dore ibyo ukeneye kumenya

Ku bijyanye no kunoza kwibuka no kwiga, ubushakashatsi buherutse bwerekana ko alpha GPC ishobora kugira akamaro kanini. Ibi biterwa nuko A-GPC ijyana choline mu bwonko, igatera imbaraga urwego rw'ingenzi rw'imitsi ituma ubwenge bugira ubuzima bwiza.

Ubushakashatsi bwerekana ko alpha GPC ari imwe mu nyongeramusaruro nziza zo mu bwonko ziboneka ku isoko. Ni molekile yongera ubwonko yagaragaye ko ifite umutekano kandi yihanganirwa n'abarwayi bakuze bashaka kunoza ibimenyetso bya dementia, ndetse n'abakinnyi bakiri bato bashaka kunoza ubushobozi bwabo bwo kwihangana no gukomera.
Kimwe n'ingaruka za phosphatidylserine zongerera ubwonko, a-GPC ishobora kuba umuti usanzwe w'indwara ya Alzheimer kandi ishobora kugabanya igabanuka ry'ubushobozi bwo gutekereza riterwa no gusaza.

Alpha GPC ni iki?

Alpha GPC cyangwa alpha glycerylphosphorylcholine ni molekile ikora nk'isoko ya choline. Ni aside irike iboneka muri soya lecithin n'ibindi bimera kandi ikoreshwa mu nyongeramusaruro z'ubuzima bw'ubwenge no kubaka imbaraga z'imitsi.
Alpha GPC, izwi kandi nka choline alfoscerate, ihabwa agaciro kubera ubushobozi bwayo bwo gutwara choline mu bwonko no gufasha umubiri gukora acetylcholine, ifite uruhare mu byiza byinshi bya choline ku buzima. Acetylcholine ifitanye isano no kwiga no kwibuka, kandi ni imwe mu ngirabuzimafatizo z’ingenzi mu gutuma imitsi irushaho kumererwa neza.
Bitandukanye na choline bitartrate, indi nyongeramusaruro izwi cyane ya choline iri ku isoko, A-GPC irashobora kwambuka umupaka w'amaraso n'ubwonko. Niyo mpamvu igira ingaruka nziza ku bwonko kandi ikoreshwa mu kuvura indwara yo kwibagirwa, harimo n'indwara ya Alzheimer.

Akamaro n'ikoreshwa rya Alpha GPC

1. Kongera ubushobozi bwo kwibuka nabi

Alpha GPC ikoreshwa mu kunoza ubushobozi bwo kwibuka, kwiga no gutekereza. Ibi ibikora yongera acetylcholine mu bwonko, ikinyabutabire gikora cyane mu kwibuka no mu mikorere yo kwiga. Abashakashatsi bagaragaje ko alpha GPC ifite ubushobozi bwo kunoza ibimenyetso byo mu mutwe bifitanye isano n'indwara ya Alzheimer na dementia.
Igerageza ryakozwe hifashishijwe ikoranabuhanga rya "double-blind", ryakozwe hifashishijwe placebo ryasohotse muri Clinical Therapeutics mu 2003 ryasuzumye akamaro n'ubushobozi bwa alpha GPC mu kuvura indwara zo mu mutwe ziterwa n'indwara ya Alzheimer yoroheje kugeza ku iringaniye.
Abarwayi bafashe capsule za a-GPC 400 mg cyangwa capsule za placebo gatatu ku munsi mu gihe cy'iminsi 180. Abarwayi bose basuzumwe mu ntangiriro z'igerageza, nyuma y'iminsi 90 y'ubuvuzi, ndetse no mu mpera z'igerageza nyuma y'iminsi 180.
Mu itsinda rya alpha GPC, ibipimo byose byapimwe, harimo igipimo cyo gusuzuma indwara ya Alzheimer mu buryo bwo gutekereza no mu myitwarire ndetse n’ikizamini cya Mini-Mental State, byakomeje kuba byiza nyuma y’iminsi 90 na 180 by’ubuvuzi, mu gihe mu itsinda rya placebo byakomeje guhinduka cyangwa bikarushaho kuba bibi.
Abashakashatsi basanze a-GPC ari ingirakamaro mu buvuzi kandi yihanganirwa mu kuvura ibimenyetso by’indwara yo kwibagirwa mu mutwe kandi ko ishobora kuba umuti usanzwe w’indwara ya Alzheimer.

2. Guteza imbere imyigire no kwibanda ku byo umuntu yiga

Hari ubushakashatsi bwinshi bushyigikira ibyiza bya alpha GPC ku bantu bafite ubumuga bwo mu mutwe, ariko se ni ingirakamaro ki ku bantu badafite indwara yo kwibagirwa? Ubushakashatsi bwerekana ko Alpha GPC ishobora no kunoza ubushobozi bwo kwita ku bintu, kwibuka no kwiga mu rubyiruko rufite ubuzima bwiza.
Ikinyamakuru cy’Abanyamerika cyitwa “American Journal of Clinical Nutrition” cyasohoye ubushakashatsi bwakozwe n’abantu benshi badafite indwara yo kwibagirwa, maze gisanga ko gufata choline nyinshi bifitanye isano no kugira ubushobozi bwo gutekereza neza. Ibice by’imitekerereze byasuzumwe birimo kwibuka mu magambo, kwibuka mu maso, kwiga mu magambo, n’imikorere y’umubiri.
Ubushakashatsi bwasohotse mu kinyamakuru Journal of the International Society of Sports Nutrition bwagaragaje ko iyo urubyiruko rukoreshaga inyongeramusaruro za alpha GPC, byari ingirakamaro ku mirimo imwe n'imwe yo mu mubiri no mu mutwe. Abahawe 400 mg ya a-GPC babonye vuba 18% mu kizamini cyo gukuramo inshuro nyinshi kurusha abahawe 200 mg ya kafeyine. Byongeye kandi, itsinda ryakoreshaga kafeyine ryabonye amanota menshi cyane ku ndwara y'ubwonko ugereranije n'itsinda rya alpha GPC.

3. Kunoza imikorere ya siporo

Ubushakashatsi bushyigikira imiterere ya alpha GPC mu guhuza imikorere. Kubera iyo mpamvu, abakinnyi barushaho gushishikazwa na a-GPC bitewe n'ubushobozi bwayo bwo kunoza kwihangana, imbaraga zisohoka, n'imbaraga z'imitsi. Inyongera ya a-GPC izwiho gufasha kongera imbaraga z'umubiri, guteza imbere kubaka imitsi yoroshye, no kugabanya igihe cyo gukira nyuma yo gukora imyitozo ngororamubiri.
Ubushakashatsi bwerekana ko alpha GPC yongera imisemburo ikura mu mubiri w’umuntu, igira uruhare mu kuvugurura uturemangingo, gukura no kubungabunga ingirabuzima fatizo z’umubiri w’umuntu. Imisemburo ikura izwiho ubushobozi bwo kongera ubushobozi bw’umubiri n’imikorere myiza mu mikino.
Hari ubushakashatsi bwinshi bwakozwe busuzuma akamaro ka alpha GPC ku kwihangana no gukomera kw'umubiri. Inyigo yo mu 2008 yakozwe ku buryo bwa "randomized", igenzurwa na placebo, yakozwe ku bagabo barindwi bafite uburambe mu myitozo yo kwirinda indwara, yagaragaje ko a-GPC igira ingaruka ku rugero rw'imisemburo yo gukura. Abitabiriye itsinda ry'igerageza bahawe 600 mg ya alpha GPC iminota 90 mbere y'imyitozo yo kwirinda indwara.
Abashakashatsi basanze ugereranije n’ingero z’ibanze, urugero rw’imisemburo yo gukura ku rugero rwo hejuru rwiyongereyeho inshuro 44 ukoresheje alpha GPC n’inshuro 2.6 ukoresheje placebo. Gukoresha A-GPC nabyo byongera imbaraga z’umubiri, aho imbaraga zo gukanda ku rugero rwo hejuru ziyongereyeho 14% ugereranije n’ingero za placebo.
Uretse kongera imbaraga z'imitsi no gukomera, imisemburo itera imbere ishobora gutuma umuntu agabanya ibiro, igakomeza amagufwa, ikongera ibyiyumvo bye, kandi ikongera ubuziranenge bw'ibitotsi.

4. Kunoza gukira indwara yo mu bwonko (stroke)

Ubushakashatsi bwa mbere bwerekana ko a-GPC ishobora gufasha abarwayi bahuye n’indwara yo mu bwonko cyangwa indwara y’imitsi iterwa n’indwara y’imitsi, izwi nka "mini-stroke." Ibi biterwa n’ubushobozi bwa alpha GPC bwo gukora nk’umuti urinda ubwonko no gushyigikira uburyo bwo kuvura ubwonko binyuze mu gusana imitsi.
Mu bushakashatsi bwakozwe mu 1994, abashakashatsi b'Abataliyani basanze alpha GPC yoroshya gukira kw'imitsi mu barwayi bafite stroke ikabije cyangwa nto. Nyuma yo gucika intege mu mutwe, abarwayi bahawe 1.000 mg ya alpha GPC binyuze mu gutera inshinge mu minsi 28, hanyuma bahabwa 400 mg mu kanwa gatatu ku munsi mu mezi 5 yakurikiyeho.
Abashakashatsi bavuze ko mu mpera z'igerageza, 71% by'abarwayi bagaragaje ko nta kibazo cyo mu mutwe cyangwa kwibagirwa, nk'uko byatangajwe n'abarwayi. Byongeye kandi, amanota y'abarwayi mu kizamini cya Mini-Mental State yazamutse cyane. Uretse ibi byavumbuwe, igipimo cy'ingaruka mbi nyuma yo gukoresha alpha GPC cyari gito kandi abashakashatsi bemeza ko yihanganirwa neza.

5. Bishobora gufasha abantu barwaye igicuri

Ubushakashatsi ku nyamaswa bwasohotse mu bushakashatsi bw’ubwonko mu 2017 bwari bugamije gusuzuma ingaruka z’ubuvuzi bwa alpha GPC ku kugabanuka k’ubushobozi bwo gutekereza nyuma yo gukubita igicuri. Abashakashatsi basanze iyo imbeba zaterwaga inshinge ya a-GPC nyuma y’ibyumweru bitatu nyuma yo gukubita igicuri, icyo gikoresho cyarushijeho kunoza imikorere y’ubwonko no kongera uburyo bwo gutekereza, ndetse no gukura kw’imitsi.
Ubu bushakashatsi bwerekana ko alpha GPC ishobora kuba ingirakamaro ku barwayi b'igicuri kubera ingaruka zayo zo kurinda ubwonko kandi ishobora no koroshya ubumuga bwo mu mutwe buterwa n'igicuri ndetse no kwangirika kw'imitsi.

Alpha GPC na Choline

Choline ni intungamubiri y'ingenzi ikenewe mu mikorere myinshi y'umubiri, cyane cyane imikorere y'ubwonko. Irakenewe kugira ngo neurotransmitter acetylcholine ikore neza, ikora nk'umuti urwanya gusaza kandi igafasha imitsi yacu kuvugana.
Nubwo umubiri ukora ingano nto ya choline ukwayo, tugomba kubona intungamubiri mu biribwa. Bimwe mu biribwa birimo umwijima w'inka, salmon, chickpeas, amagi, n'amabere y'inkoko. Ariko, raporo zimwe na zimwe zivuga ko choline ikomoka ku biribwa idakwirakwizwa neza n'umubiri, ari nayo mpamvu hari abantu bahura n'ikibazo cyo kubura choline. Ibi biterwa nuko choline itunganywa igice mu mwijima, kandi abantu bafite ubumuga bw'umwijima ntibashobora kuyikuramo.
Aha niho inyongeramusaruro za alpha GPC zikoreshwa. Impuguke zimwe zitanga inama yo gukoresha inyongeramusaruro za choline, nka a-GPC, kugira ngo zongere imikorere y'ubwonko kandi zifashe mu kubika amakuru. Alpha GPC na CDP choline bifatwa nk'ingirakamaro cyane ku mubiri kuko bisa cyane n'uburyo choline iboneka mu biryo bisanzwe. Kimwe na choline isanzwe yinjizwa mu biribwa turya, alpha GPC izwiho ubushobozi bwo kwambuka umupaka w'amaraso n'ubwonko iyo inyowe, bigafasha umubiri guhindura choline ikaba acetylcholine y'ingenzi cyane.
Alpha GPC ni ubwoko bukomeye bwa choline. Igipimo cya 1.000 mg cya a-GPC kingana na 400 mg ya choline yo mu mirire. Cyangwa, mu yandi magambo, alpha GPC ni hafi 40% bya choline ukurikije uburemere.

A-GPC na CDP Choline

CDP Choline, izwi kandi nka cytidine diphosphate choline na citicoline, ni ikintu kigizwe na choline na cytidine. CDP Choline izwiho ubushobozi bwo gufasha gutwara dopamine mu bwonko. Kimwe na alpha GPC, Citicoline ihabwa agaciro kubera ubushobozi bwayo bwo kwambuka umupaka w'amaraso n'ubwonko iyo inyoye, ibi bikaba biyiha ubushobozi bwo kwibuka no kongera ubushobozi bwo gutekereza.
Nubwo alpha GPC irimo hafi 40% bya choline ukurikije uburemere, CDP choline irimo hafi 18% bya choline. Ariko CDP choline irimo kandi cytidine, ibanziriza uridine ya nucleotide. Uridine izwiho ubushobozi bwo kongera imikorere y’uturemangingo, ifite n’ubushobozi bwo kongera ubushobozi bwo gutekereza.
Choline ya a-GPC na CDP byombi bizwiho inyungu zabyo mu bwenge, harimo n'uruhare rwabyo mu gushyigikira kwibuka, imikorere y'ubwonko, no kwibanda ku bintu.

Aho wasanga n'uko wakoresha

Inyongeramusaruro za A-GPC zikoreshwa cyane mu kunoza ubushobozi bwo kwibuka no gutekereza. Zishobora kandi gukoreshwa mu kunoza ubushobozi bwo kwihangana no gukora neza kw'umubiri. Alpha GPC iraboneka nk'inyongeramusaruro mu mirire. Inyongeramusaruro za Alpha GPC zoroshye kuzibona kuri interineti cyangwa ku batanga serivisi. Uzazibona mu bwoko bwa capsule na puderi. Ibikoresho byinshi birimo a-GPC bitanga inama yo gufata inyongeramusaruro hamwe n'ibiryo kugira ngo bigire akamaro kanini.
Suzhou Myland Pharm & Nutrition Inc. ni uruganda rwemewe na FDA rutanga ifu ya alpha GPC nziza kandi isukuye cyane.

Muri Suzhou Myland Pharm twiyemeje gutanga ibicuruzwa byiza cyane ku giciro cyiza. Ifu yacu ya alpha GPC irapimwa neza kugira ngo imenyekane ko ari nziza kandi ifite imbaraga, bityo ukaba ubona inyongeramusaruro nziza ushobora kwizera. Waba ushaka gufasha ubuzima bw'uturemangingo, kongera ubudahangarwa bw'umubiri wawe cyangwa kongera ubuzima bwiza muri rusange, ifu yacu ya alpha GPC ni yo mahitamo meza.

Suzhou Myland Pharm ifite uburambe bw'imyaka 30 kandi iyobowe n'ikoranabuhanga rigezweho hamwe n'ingamba zo gukora ubushakashatsi n'iterambere zinoze cyane, yateje imbere ibicuruzwa bitandukanye kandi iba ikigo gishya gitanga serivisi z'inyongera ku buzima, gukora ibintu bitandukanye no gukora ibikoresho bitandukanye.

Byongeye kandi, Suzhou Myland Pharm ni uruganda rwanditswe na FDA. Imbuga z’ubushakashatsi n’iterambere by’iyi sosiyete, ibikoresho byayo byo gukora, n’ibikoresho byo gusesengura ni ibintu bigezweho kandi bifite imikorere myinshi, kandi bishobora gukora imiti kuva kuri miligarama kugeza kuri toni, kandi bikurikiza amahame ya ISO 9001 n’ibipimo bya GMP mu gukora.
A-GPC izwiho kuba ifite ubushobozi bwo gukurura ubushuhe buva mu kirere gikikije. Kubera iyo mpamvu, inyongeramusaruro zigomba kubikwa mu bikoresho bitagira umwuka kandi ntizigomba gushyirwa mu mwuka igihe kirekire.

Ibitekerezo bya nyuma

Alpha GPC ikoreshwa mu kugeza choline mu bwonko inyuze mu ruzitiro rw'amaraso n'ubwonko. Ni ikintu cya mbere cya acetylcholine, umusemburo w'ubwonko utuma ubwenge burushaho kugira ubuzima bwiza. Inyongeramusaruro za Alpha GPC zishobora gukoreshwa mu kugirira akamaro ubuzima bwawe bwo gutekereza binyuze mu kunoza kwibuka, kwiga no kwibanda ku bintu. Ubushakashatsi bwerekana kandi ko a-GPC ifasha kongera imbaraga z'umubiri n'imbaraga z'imitsi.