Ibiryo byuzuye-Ibintu bishya byo kuramba no kurwanya gusaza: Kalisiyumu Alpha-ketoglutarate

Kalisiyumu Alpha ketoglutarate . Irashobora gukoreshwa nkinyongera yimirire kandi ifite ibyifuzo byinshi. Usibye imikorere y’ibinyabuzima mu mubiri w’umuntu, calcium alpha-ketoglutarate ikoreshwa cyane mu rwego rwa farumasi kandi yabaye ikintu cyingenzi mubicuruzwa byinshi byubuzima nibisubizo byubuvuzi.

Uburyo calcium alpha-ketoglutarate ikora

Icya mbere,calcium alpha-ketoglutarateigira uruhare runini muri metabolism yingufu. Nkibicuruzwa bigereranijwe bya tricarboxylic acide cycle (TCA cycle), calcium α-ketoglutarate igira uruhare mubikorwa byo kubyara ingufu zidasanzwe. Binyuze mu ruzinduko rwa TCA, intungamubiri nka karubone, amavuta, na poroteyine ziba oxyde kandi zangirika kugira ngo zitange ATP (adenosine triphosphate) kugira ngo itange ingufu za selile. Nkumuhuza wingenzi muri cycle ya TCA, calcium α-ketoglutarate irashobora guteza imbere imbaraga zingirabuzimafatizo, kongera ingufu zumubiri, gufasha kongera imbaraga kumubiri no kwihangana, no kunaniza umunaniro wumubiri.

Icya kabiri, calcium α-ketoglutarate igira uruhare runini muri metabolism aside amine. Amino acide ni ibice byibanze bya poroteyine, na calcium α-ketoglutarate igira uruhare mu guhindura no guhinduranya metabolike ya aside amine. Muburyo bwo guhindura aside amine mubindi metabolite, calcium α-ketoglutarate yanduza aside amine kugirango itange aside amine nshya cyangwa α-keto acide, bityo bigabanye kuringaniza no gukoresha aside amine. Byongeye kandi, calcium α-ketoglutarate irashobora kandi kuba insimburangingo ya okiside ya aside amine, ikagira uruhare mu guhinduranya metaboliside ya aside amine, ikanatanga ingufu na dioxyde de carbone. Kubwibyo, calcium α-ketoglutarate ifite akamaro kanini mugukomeza homeostasis ya acide amino na protein metabolism mumubiri.

Byongeye kandi, calcium alpha-ketoglutarate ikora nka antioxydeant ikuraho radicals yubuntu kandi ikarinda selile kwangirika kwa okiside. Muri icyo gihe, calcium α-ketoglutarate irashobora kandi kugenga imikorere yimikorere yubudahangarwa bw'umubiri, guteza imbere gukora no gukwirakwiza ingirabuzimafatizo z'umubiri, kandi bikongerera umubiri kurwanya indwara n'indwara. Kubwibyo, calcium α-ketoglutarate ifite akamaro kanini mukubungabunga ubudahangarwa bw'umubiri no kurwanya indwara.

Ubushakashatsi ku ngaruka zo gusaza

Gusaza biratureba twese kandi ni ibintu bishobora gutera indwara nyinshi, kandi ukurikije imibare y’inganda z’ubuvuzi, imibare y’indwara yiyongera uko imyaka igenda ishira. Mu rwego rwo kugabanya gusaza no kugabanya neza ibyago by’indwara, ubushakashatsi bwavumbuye ikintu cyizewe kandi kinyabuzima gishobora kugira ingaruka ku gusaza - calcium alpha-ketoglutarate.

Kalisiyumu alpha-ketoglutarate ni metabolite y'ingenzi mu mubiri wacu, izwiho uruhare rw'akagari muri cycle ya Krebs, uruziga rukenewe mu okiside ya aside irike na aside amine, bigatuma mitochondriya itanga ATP (ATP ni isoko y'ingirabuzimafatizo).

Ibi birimo gupakira calcium alpha-ketoglutarate, bityo calcium alpha-ketoglutarate nayo ishobora guhinduka glutamate hanyuma igahinduka glutamine, ishobora gufasha gutera intungamubiri za poroteyine na kolagen (kolagen ni poroteyine ya fibrous igizwe na 1/3 cya poroteyine zose mu mubiri kandi zifasha gushyigikira amagufwa, uruhu n'imitsi).

Ponce De Leon Health, Inc., isosiyete ikora ubushakashatsi buramba yibanda ku guhindura gusaza kwa geneti, yakoze ubushakashatsi bwimyaka myinshi igenzurwa na calcium alpha-ketoglutarate ku mbeba zimaze imyaka yo hagati maze isanga ubuzima bwimbeba bwimbeba mumatsinda yubushakashatsi bwiyongereyeho 12%. Icy'ingenzi cyane, Ikirenzeho, intege nke zagabanutseho 46% naho ubuzima buzira umuze bwiyongereyeho 41%. Ibimenyetso byerekana ko inyongera ya alpha-ketoglutarate idashobora kongera igihe cyo kubaho gusa ahubwo ishobora no kwagura ubuzima mugihe kinini.

Kalisiyumu α-ketoglutarate, nk'inyongera y'imirire myinshi, ifite ibyifuzo byinshi mubicuruzwa byubuzima. Imikorere yayo itandukanye yibinyabuzima nka antioxydeant, kurwanya gusaza, kugenzura ubudahangarwa ndetse na metabolism aside amine bituma iba igikoresho gikomeye cyo kuzamura ubuzima bwabantu. Hamwe n’ubukangurambaga bwita ku buzima ndetse n’ubushakashatsi bwimbitse bwimbitse, abantu bemeza ko ikoreshwa rya calcium α-ketoglutarate mu rwego rw’ibicuruzwa byita ku buzima bizitabwaho cyane n’iterambere.