Inyongeramusaruro mu mirire - Ikintu gishya cyo kuramba no kurwanya gusaza: Calcium Alpha-ketoglutarate

Kalisiyumu Alpha ketoglutarate (AKG) ni metabolite iri hagati y’uruhererekane rw’aside tricarboxylic kandi igira uruhare mu gukora aside amine, vitamine, aside organic na metabolisme y’ingufu. Ishobora gukoreshwa nk'inyongera mu mirire kandi ifite amahirwe menshi yo gukoreshwa. Uretse imirimo yayo mu mubiri w’umuntu, kalisiyumu alpha-ketoglutarate inakoreshwa cyane mu rwego rw’imiti kandi yabaye igice cy’ingenzi cy’ibicuruzwa byinshi by’ubuzima n’ibisubizo by’ubuvuzi.

Uburyo kalisiyumu alpha-ketoglutarate ikora

Ubwa mbere,calcium alpha-ketoglutarateIgira uruhare runini mu mikorere y’ingufu. Nk’umusaruro w’igice cy’ingenzi cya aside tricarboxylic (TCA cycle), kalisiyumu α-ketoglutarate igira uruhare mu ikorwa ry’ingufu mu ngirabuzima fatizo. Binyuze muri TCA cycle, intungamubiri nka karubohidrati, ibinure, na poroteyine zirahinduka oxidation zikanabora kugira ngo habeho ATP (adenosine triphosphate) kugira ngo itange ingufu ku turemangingo. Nk’igice cy’ingenzi cya TCA cycle, kalisiyumu α-ketoglutarate ishobora guteza imbere imikorere y’ingufu mu turemangingo, kongera ingufu z’umubiri, gufasha kongera imbaraga z’umubiri no kwihangana, no kunoza umunaniro w’umubiri.

Icya kabiri, kalisiyumu α-ketoglutarate igira uruhare runini mu mikorere y’aside amine. Aside amine ni ingenzi muri poroteyine, naho kalisiyumu α-ketoglutarate igira uruhare mu guhindura no gutunganya aside amine. Mu gihe cyo guhindura aside amine mo izindi metabolites, kalisiyumu α-ketoglutarate ihinduranya aside amine kugira ngo ikore aside amine nshya cyangwa aside α-keto, bityo ikagenzura uburinganire n’ikoreshwa rya aside amine. Byongeye kandi, kalisiyumu α-ketoglutarate ishobora kandi gukora nk'ishingiro rya okiside kuri aside amine, ikagira uruhare mu mikorere y’aside amine, kandi igatanga ingufu na dioxyde de carbone. Kubwibyo, kalisiyumu α-ketoglutarate ifite akamaro kanini mu kubungabunga homeostasis ya aside amine na metabolite de poroteyine mu mubiri.

Byongeye kandi, kalisiyumu alpha-ketoglutarate ikora nk'umusemburo urwanya udukoko twinshi kandi ukarinda uturemangingo kwangirika kwa ogisijeni. Muri icyo gihe, kalisiyumu α-ketoglutarate ishobora kandi kugenzura imikorere y'ubudahangarwa bw'umubiri, igatuma uturemangingo tw'ubudahangarwa bw'umubiri dukora neza, kandi ikarushaho kurwanya indwara n'ubwandu. Kubwibyo, kalisiyumu α-ketoglutarate ifite akamaro kanini mu kubungabunga ubudahangarwa bw'umubiri no kurwanya indwara.

Ubushakashatsi ku ngaruka zo gusaza

Gusaza bitugiraho ingaruka twese kandi ni ikintu gitera indwara nyinshi, kandi dukurikije imiterere y’inganda za Medicare, amahirwe yo kurwara indwara ariyongera uko umuntu akura. Kugira ngo bigabanye gusaza no kugabanya neza ibyago byo kurwara, ubushakashatsi bwavumbuye ikintu cyizewe kandi gikora ku mubiri gishobora kugira ingaruka ku busaza - calcium alpha-ketoglutarate.

Kalisiyumu alpha-ketoglutarate ni metabolite y'ingenzi mu mubiri wacu, izwiho uruhare rw'uturemangingo mu mizunguruko ya Krebs, uruziga rw'ingenzi mu gutuma aside irike na aside amine bihinduka, bigatuma mitochondria ikora ATP (ATP ni isoko y'ingufu z'uturemangingo).

Ibi bikubiyemo gukoresha uburyo bwa calcium alpha-ketoglutarate, bityo calcium alpha-ketoglutarate ishobora no guhinduka glutamate hanyuma ikavamo glutamine, ishobora gufasha mu gutera imbaraga poroteyine na kolajeni (collagen ni poroteyine ifite uturemangingo igize 1/3 cya poroteyine zose mu mubiri kandi igafasha mu kubungabunga ubuzima bw'amagufwa, uruhu n'imitsi).

Ponce De Leon Health, Inc., ikigo cy’ubushakashatsi ku kuntu umuntu aramba, cyakoze ubushakashatsi bw’imyaka myinshi ku mbeba zo mu kigero cy’imyaka yo hagati bwakozwe ku ngirabuzimafatizo, maze basanga igihe cyo kubaho cy’imbeba zo mu itsinda ry’igerageza cyiyongereyeho 12%. Ikindi kandi, intege nke zagabanutseho 46% naho igihe cyo kubaho cy’ubuzima bwiza kiyongeraho 41%. Ibimenyetso bigaragaza ko kongera alpha-ketoglutarate bishobora kongera igihe cyo kubaho gusa, ahubwo binatuma ubuzima burushaho kuba bwiza.

Kalisiyumu α-ketoglutarate, nk'inyongeramusaruro y'intungamubiri nyinshi, ifite amahirwe menshi yo gukoreshwa mu bicuruzwa by'ubuvuzi. Imirimo yayo itandukanye ya biyolojiya nko kurwanya antioxidant, kurwanya gusaza, kugenzura ubudahangarwa bw'umubiri no gutunganya aside amine ituma iba igikoresho gikomeye cyo kunoza ubuzima bw'abantu. Bitewe n'uko ubushakashatsi bwa siyansi bukomeje kwiyongera, bikekwa ko ikoreshwa rya kalisiyumu α-ketoglutarate mu rwego rw'ibicuruzwa by'ubuvuzi bizitabwaho cyane kandi bigatera imbere.