NAD+ (Beta-Nicotinamide Adenine Dinucleotide) ni coenzyme iboneka mu turemangingo twose tw’ibinyabuzima kandi ni ingenzi mu mikorere itandukanye ya biyoloji, harimo no gukora ingufu no gusana ADN. Uko tugenda dusaza, urugero rwa NAD+ rwacu ruragabanuka, bigatera ibibazo bitandukanye by’ubuzima. Kugira ngo turwanye iki kibazo, abantu benshi bahitamo inyongeramusaruro za NAD+ mu buryo bw’ifu. Ariko, kubera amahitamo menshi, kumenya ifu ya NAD+ ikubereye bishobora kugorana. Guhitamo ifu nziza ya NAD+ bisaba gusuzuma witonze ubuziranenge, kuba iboneka mu mubiri, ingano, ubusobanuro, n’ibitekerezo by’abakiriya. Ushyize imbere ibi bintu, ushobora gufata icyemezo gisobanutse neza no guhitamo ifu nziza ya NAD+ ishyigikira ubuzima bwawe n’imibereho myiza.
NAD ibaho mu buryo busanzwe mu turemangingo twacu,Cyane cyane muri cytoplasme na mitochondria, ariko, urugero rusanzwe rwa NAD rugabanuka uko tugenda dusaza (buri myaka 20, mu by'ukuri), bigatera ingaruka zisanzwe zo gusaza, nko kugabanuka kw'ingufu no kwiyongera k'ububabare n'ububabare. Ikindi kandi, kugabanuka kw'ingufu za NAD bitewe no gusaza bifitanye isano n'izindi ndwara ziterwa no gusaza, nka kanseri, kugabanuka k'ubushobozi bwo gutekereza, n'intege nke.
NAD+ si imisemburo, ni coenzyme. NAD+ ishobora kunoza ubushobozi bwa ADN bwo kwisana, kongera igihe cyo kubaho binyuze mu gusubiza inyuma igabanuka rya mitochondria, no kurinda ADN n'ibyangiritse bya mitochondria. Kandi ishobora kunoza uburyo chromosome zihamye. NAD+ izwi kandi nka "molecule y'igitangaza" igarura kandi ikabungabunga ubuzima bw'uturemangingo. Mu bushakashatsi ku nyamaswa, byemejwe ko ifite ubushobozi bukomeye bwo kuvura indwara zitandukanye nk'indwara z'umutima, diyabete, indwara ya Alzheimer, n'umubyibuho ukabije.
NAD+ igira uruhare mu bikorwa bitandukanye bya shimi mu turemangingo, nko muri glycolysis, oxidation ya aside irike, cycle ya aside tricarboxylic, respiratory chain, nibindi. Muri izi nzira, NAD+ ikora nk'umuyoboro wa hydrogen, yakira electrons na hydrogen bivuye muri substrates hanyuma ikabyimurira mu zindi molekile, nka NADH na FAD, kugira ngo igumane uburinganire bwa redox mu turemangingo. NAD+ igira uruhare runini mu gukora ingufu z'uturemangingo, kurinda radicals yigenga, gusana ADN, no gutanga ibimenyetso.
Byongeye kandi, NAD+ nayo ifitanye isano rya hafi no gusaza, kandi urugero rwayo rugabanuka uko imyaka igenda ishira. Kubwibyo, kubungabunga urugero rwa NAD+ bigira uruhare runini mu gutinda gusaza, kongera ingufu, guteza imbere gusana uturemangingo, kunoza imikorere y'ubwonko, no kugenzura imikorere y'ingirabuzimafatizo.
Igishimishije ni uko gusaza bijyana no kugabanuka gukomeye kw'urugero rwa NAD+ mu turemangingo no mu turemangingo mu turemangingo dutandukanye, harimo imbeba n'abantu.
Kubwibyo, kuzuza ku gihe ibikubiye muri NAD+ mu mubiri bishobora gutinda gusaza no gutuma ubuzima bukomeza kuba bwiza. Niba ushaka ko imyaka iba umubare gusa, ongeramo NAD+ hakiri kare kugira ngo ugaragare ukiri muto uhereye imbere ugana inyuma.
Igipimo cya NAD+ kigabanuka uko imyaka igenda ishira, ahanini bitewe n'uko umusaruro wayo udashobora kugendana n'umubare w'ikoreshwa ryayo.
Ubushakashatsi bwinshi bwagaragaje ko kugabanuka k'urugero rwa NAD+ bifitanye isano n'indwara nyinshi ziterwa no gusaza, harimo kugabanuka k'ubushobozi bwo gutekereza, kubyimba, kanseri, indwara za metabolism, sarcopenia, indwara zo kwangirika kw'ubwonko, n'ibindi.
Iyi niyo mpamvu dukeneye inyongeramusaruro za NAD+. Kimwe na kolajeni yacu yo mu bwoko bwa 3, ihora itakara.
NAD+ ishobora kurwanya gusaza. Ni iyihe ngingo ishingiyeho?
nad+ ikora enzyme yo gusana gene ya parp1
Ifasha mu gusana ADN Imwe mu mpamvu zitera gusaza ni ukwangirika kwa ADN. Umusatsi wawe wera, intanga ngabo n'izindi ngingo zigabanuka, byose bifitanye isano no kwangirika kwa ADN. Kurara usinziriye no kugira stress bizongera kwangirika kwa ADN.
Ubushakashatsi bwagaragaje ko NAD+ ifasha mu gukora gene ya PARP1 (ikora nk'umukozi wa mbere usubiza mu gupima ibyangiritse bya ADN hanyuma igatera imbere mu guhitamo inzira zo gusana. PARP1 ituma habaho gukuraho imiterere ya chromatin binyuze muri ADP ribosylation ya histones, kandi igira uruhare mu bintu bitandukanye byo gusana ADN bikorana kandi bikayihindura, bityo bikanoza imikorere yo gusana), bityo bigasana ibyangiritse bya ADN kandi bigatera imbaraga impinduka mu mikorere y'umubiri.
Muri make, NAD+ ishobora kugira ingaruka ku mikorere myinshi y’ingenzi y’uturemangingo, harimo inzira z’imikorere y’uturemangingo, gusana ADN, kuvugurura chromatin, gusaza kw’uturemangingo, imikorere y’uturemangingo tw’ubudahangarwa bw’umubiri, nibindi, bityo bigatinza gusaza kw’abantu.
NAD+ Ni incamake y'Icyongereza ya Nicotinamide adenine dinucleotide. Izina ryayo ryuzuye mu Gishinwa ni nicotinamide adenine dinucleotide, cyangwa Coenzyme I mu magambo ahinnye. Nk'inyongeramusaruro ikwirakwiza iyoni za hydrogen, NAD+ igira uruhare mu bintu byinshi bigize imikorere y'umubiri w'umuntu, harimo glycolysis, Gluconeogenesis, tricarboxylic acid cycle, nibindi. Hari ubushakashatsi bwagaragaje ko kugabanuka kwa NAD+ bifitanye isano n'imyaka, kandi uburyo umubiri uterwa na NAD+ bufitanye isano no gusaza, indwara za metabolic, neuropathy na kanseri, harimo no kugenzura homeostasis y'uturemangingo, sirtuins izwi nka "genes longevity", gusana ADN, poroteyine zo mu muryango wa PARP zijyanye na necroptosis na CD38 ifasha mu gutanga ibimenyetso bya calcium.
Kurwanya gusaza
Gusaza bivuga inzira aho uturemangingo tureka kwigabanyamo ibice burundu. Kwangirika kwa ADN kudakosowe cyangwa stress y'uturemangingo bishobora gutera gusaza. Gusaza muri rusange bisobanurwa nk'inzira yo kwangirika buhoro buhoro kw'imikorere y'umubiri uko umuntu agenda asaza; ibimenyetso byo hanze ni impinduka z'umubiri ziterwa no gutakaza imitsi n'amagufwa, naho ibimenyetso by'imbere ni ukugabanuka k'imikorere y'umubiri n'imikorere y'ubudahangarwa bw'umubiri.
Abahanga mu bya siyansi bakoze ubushakashatsi ku bantu baramba, kandi ibyavuye mu bushakashatsi bigaragaza ko hari gene ijyanye no kuramba mu bantu baramba - "gene ya Sirtuins". Iyi gene izagira uruhare mu gusana ingufu z'umubiri no kongera ADN kugira ngo igumane ubusugire n'ituze bya gene, ikureho uturemangingo dusaza, inoze ubudahangarwa bw'umubiri binyuze mu kurwanya ububyimbirwe n'ingaruka za antioxydants, kandi itinze gusaza kw'uturemangingo dusanzwe.
Uburyo bwonyine bwo gukora gene zo kuramba "Sirtuins" bwibasiwe -NAD+
NAD+ ni ingenzi mu kubungabunga ubuzima bw'umubiri no kuringaniza. Ihinduka ry'umubiri, redox, kubungabunga no gusana ADN, guhagarara neza kw'uturemangingo, kugenzura epigenetic, n'ibindi byose bisaba ko NAD+ igira uruhare.
NAD+ ikomeza itumanaho rya shimi hagati y’ingirabuzimafatizo na mitochondria, kandi itumanaho rike ni impamvu ikomeye ituma ingirabuzimafatizo zisaza.
NAD+ ishobora gukuraho umubare ugenda wiyongera wa ADN zibeshya mu gihe cy’imikorere y’uturemangingo, igakomeza kugaragaza neza imiterere y’uturemangingo, igakomeza gukora neza kw’uturemangingo, kandi igatuma uturemangingo tw’umuntu tugabanuka.
Gusana ibyangiritse bya ADN
NAD+ ni ingenzi cyane mu gusana ADN enzyme PARP, ifite ingaruka zikomeye ku gusana ADN, imikorere y’uturemangingo, iterambere ry’uturemangingo, kubaho kw’uturemangingo, kongera kubaka chromosomes, no kudahinduka kw’uturemangingo.
Koresha poroteyine irambye
Sirtuins zikunze kwitwa umuryango wa poroteyine zo kuramba kandi zigira uruhare runini mu kugenzura imikorere y’uturemangingo, nko kubyimba, gukura kw’uturemangingo, imikorere ya circadian, imikorere y’ingufu, imikorere y’imitsi, no kudahangayika, kandi NAD+ ni enzyme y’ingenzi mu gukora poroteyine zo kuramba. Ikora poroteyine zose 7 zo kuramba mu mubiri w’umuntu, igira uruhare runini mu kudahangana n’imihangayiko y’uturemangingo, imikorere y’ingufu, gukumira impinduka mu turemangingo, apoptosis no gusaza.
Tanga ingufu
Itera imbaraga mu gukora ingufu zisaga 95% zikenewe mu bikorwa by'ubuzima. Mitochondria mu turemangingo tw'abantu ni zo ngirabuzimafatizo z'uturemangingo. NAD+ ni coenzyme y'ingenzi muri mitochondria kugira ngo ikore molekile y'ingufu ATP, igahindura intungamubiri mo ingufu zikenewe n'umubiri w'umuntu.
Guteza imbere imiyoboro y'amaraso no gukomeza ubwisanzure bw'imiyoboro y'amaraso
Imitsi y'amaraso ni ingirabuzimafatizo z'ingenzi mu bikorwa by'ubuzima. Uko tugenda dusaza, imitsi y'amaraso igenda itakaza ubushobozi bwayo bwo kwiyoroshya no gukomera, kuba minini, no kuba mito, bigatera "arteriosclerosis." NAD+ ishobora kongera imikorere ya elastine mu mitsi y'amaraso, bityo igakomeza kwiyoroshya kw'imitsi y'amaraso no kubungabunga ubuzima bw'imitsi y'amaraso.
Guteza imbere metabolism
Metabolism ni uruhurirane rw'ibikorwa bitandukanye bya shimi mu mubiri. Umubiri uzakomeza guhanahana ibintu n'ingufu. Iyo iri hagarikwa, ubuzima bw'umubiri nabwo buzarangira.
Porofeseri Anthony n'itsinda rye ry'ubushakashatsi muri Kaminuza ya California, muri Amerika, basanze NAD+ ishobora kunoza neza igabanuka ry'imikorere y'uturemangingo ijyanye no gusaza, bityo ikarushaho kunoza ubuzima bw'abantu no kongera igihe cyo kubaho.
Kurinda ubuzima bw'umutima
Umutima ni urugingo rw'ingenzi cyane mu bantu, kandi urwego rwa NAD+ mu mubiri rugira uruhare runini mu kubungabunga imikorere isanzwe y'umutima. Kugabanuka kwa NAD+ bishobora kuba bifitanye isano n'indwara nyinshi z'umutima n'imitsi, kandi ubushakashatsi bwinshi bw'ibanze bwemeje ingaruka zo kongera NAD+ ku ndwara z'umutima.
Kurinda indwara z'umutima n'imitsi yo mu bwonko
Ubushakashatsi bwagaragaje ko ubwoko bwose burindwi bwa sirtuines (SIRT1-SIRT7) bufitanye isano no kurwara indwara z'umutima n'imitsi. Sirtuines zifatwa nk'intego zo kuvura indwara z'umutima n'imitsi, cyane cyane SIRT1.
NAD+ ni yo substrate yonyine ya Sirtuins. Kongera NAD+ ku mubiri w'umuntu ku gihe bishobora gutuma buri bwoko bwa Sirtuins bukora neza, bityo bikarinda ubuzima bw'umutima n'imitsi no gukumira indwara z'umutima n'imitsi.
Guteza imbere imikurire y'umusatsi
Impamvu nyamukuru itera gutakaza umusatsi ni ukubura imbaraga z'uturemangingo tw'umusatsi, kandi kubura imbaraga z'uturemangingo tw'umusatsi ni uko urugero rwa NAD+ mu mubiri w'umuntu rugabanuka. Uturemangingo tw'umusatsi ntabwo dufite ATP ihagije yo gukora poroteyine y'umusatsi, bityo bigatuma ubura imbaraga zatwo. Kubwibyo, kongeramo NAD+ bishobora kongera uruhererekane rw'aside no gukora ATP, bityo uturemangingo tw'umusatsi tukagira ubushobozi buhagije bwo gukora poroteyine y'umusatsi, bityo bikanoza gutakaza umusatsi.
Uburyo bwo kuvura molecule za NAD+ mu turemangingo
Uko imyaka igenda yiyongera, urugero rwa NAD+ (Coenzyme I) mu mubiri ruzamanuka ku gasongero, biganisha ku mikorere y'umubiri no gusaza kw'uturemangingo! Nyuma y'imyaka yo hagati, urugero rwa NAD+ mu mubiri w'umuntu rugabanuka uko umwaka utashye. Ku myaka 50, urugero rwa NAD+ mu mubiri ni kimwe cya kabiri cy'urwo iyo umuntu afite imyaka 20. Ku myaka 80, urugero rwa NAD+ rugera kuri 1% gusa by'uko yari ameze ku myaka 20.
None se, ifu ya NAD+ itandukanye ite n'izindi nyongeramusaruro ziri ku isoko? Reka turebere hamwe ingingo z'ingenzi zo gusuzuma:
1. Kuboneka kw'ibinyabuzima:
Kimwe mu bitandukanya ifu ya NAD+ n'izindi nyongeramusaruro ni uko iboneka mu mubiri. Ifu ya NAD+ inyuzwa mu mubiri byoroshye kandi ikoresha coenzymes neza. Ku rundi ruhande, izindi nyongeramusaruro zishobora kuba ziboneka mu mubiri nke, bivuze ko umubiri ushobora kudashobora kwinjiza no gukoresha neza ibintu bikora.
2. Uburyo bw'ibikorwa:
Ifu ya NAD+ ikora mu kongera urwego rwa NAD+ mu mubiri, bityo igashyigikira imikorere itandukanye y'uturemangingo. Izindi nyongeramusaruro zishobora kugira uburyo butandukanye bwo gukora, ziganisha ku nzira cyangwa sisitemu runaka mu mubiri. Gusobanukirwa uburyo bwihariye bwo gukora kw'inyongeramusaruro zitandukanye bishobora kugufasha kumenya izikwiriye ibyo ukeneye ku giti cyawe.
3. Ubushakashatsi n'ibimenyetso:
Mu gihe utekereza ku nyongeramusaruro iyo ari yo yose, ni ngombwa gusuzuma ubushakashatsi n'ibimenyetso bihari bishyigikira imikorere n'umutekano wayo. Ifu ya NAD+ yagizweho ubushakashatsi bwinshi, igaragaza akamaro kayo ku buzima bw'uturemangingo no kuramba kwayo. Ku rundi ruhande, izindi nyongeramusaruro zimwe na zimwe zishobora kuba zifite ubushakashatsi buke bwo gushyigikira ibyo zivuga. Gusobanukirwa ibimenyetso bya siyansi biri inyuma y'inyongeramusaruro bishobora kugufasha gufata ibyemezo birambuye ku ikoreshwa ryayo.
4. Ibyo umuntu akeneye n'intego ze bwite:
Amaherezo, icyemezo cyo gukoresha ifu ya NAD+ cyangwa izindi nyongeramusaruro kigomba gushingira ku byo ukeneye n'intego zawe ku buzima. Tekereza kugisha inama inzobere mu by'ubuzima cyangwa inzobere mu by'imirire kugira ngo umenye inyongeramusaruro zishobora kukugirira akamaro cyane. Ibintu nk'imyaka, imibereho, n'ubuzima busanzweho byose bishobora kugira uruhare mu kugena uburyo bwiza bwo gukoresha inyongeramusaruro.
Abahanga mu bya siyansi bamaze imyaka 100 bayiga. NAD+ si ikintu gishya cyavumbuwe, ahubwo ni ikintu kimaze imyaka irenga 100 cyigwaho.
NAD+ yavumbuwe bwa mbere mu 1904 n'umuhanga mu binyabuzima witwa Sir Arthur Harden, waje kwegukana igihembo cya Nobel mu bya chimie mu 1929.
Mu 1920, Hans von Euler-Chelpin yakuyemo NAD+ anayisukura ku nshuro ya mbere maze avumbura imiterere yayo ya dinucleotide, hanyuma yegukana igihembo cya Nobel mu bya Chimie mu 1929.
Mu 1930, Otto Warburg yavumbuye bwa mbere uruhare rw'ingenzi rwa NAD+ nk'umusemburo mu mikorere y'ibintu n'ingufu, nyuma aza kwegukana igihembo cya Nobel mu buvuzi mu 1931.
Mu 1980, George Birkmayer, umwarimu mu ishami ry’ubutabire mu buvuzi muri Kaminuza ya Graz muri Otirishiya, yatangiye gukoresha imiti yagabanyije NAD+ mu kuvura indwara.
Mu 2012, itsinda ry’ubushakashatsi rya Leonard Guarente, itsinda ry’ubushakashatsi rya Stephen L. Helfand, umuhanga mu bya shimi uzwi cyane ku isi, n’itsinda ry’ubushakashatsi rya Haim Y. Cohen, bavumbuye ko NAD+ ishobora kongera uburebure bw’uduti twa Caenorhabditis elegans. Igihe cyo kubaho cy’udusimba ni hafi 50%, gishobora kongera igihe cyo kubaho cy’isazi y’imbuto ku kigero cya 10%-20%, kandi gishobora kongera igihe cyo kubaho cy’imbeba z’ingabo ku kigero kirenga 10%.
Ubushakashatsi n'ubushakashatsi bw'abahanga mu bya siyansi ku buzima byagiye bivugururwa buri gihe kandi bigasubirwamo. Mu Kuboza 2013, David Sinclair, umwarimu w'ubushakashatsi mu bijyanye n'imiterere y'umubiri muri Kaminuza ya Harvard, yasohoye igitabo cyitwa "Supplementing NAD with NAD" mu kinyamakuru gikomeye ku isi cyitwa "Cell". "Nyuma y'icyumweru kimwe cyongereye NAD hamwe n'ikintu kiyitera, igihe cyo kubaho cy'imbeba cyongereweho 30%." Ibisubizo by'ubushakashatsi byagaragaje bwa mbere ko inyongeramusaruro za NAD+ zishobora gusubiza inyuma cyane gusaza no kongera igihe cyo kubaho. Ubu bushakashatsi bwatunguye isi kandi bufungura inzira yo kwamamara kubera inyongeramusaruro za NAD nk'ibintu birwanya gusaza.
Binyuze muri ubu buvumbuzi butangaje, NAD+ yashyizeho isano itagereranywa no kurwanya gusaza. Mu myaka ya vuba aha, ubushakashatsi kuri NAD+ bwagiye buganza cyane mu binyamakuru bikomeye bya SCI nka Siyansi, Kamere, na Seli, buba ubuvumbuzi butangaje cyane mu rwego rw'ubuvuzi. Bivugwa ko ibi ari intambwe y'amateka yatewe n'abantu mu rugendo rwo kurwanya gusaza no kongera igihe cyo kubaho.
1. Kora ubushakashatsi ku izina ry'ikirango n'umucyo wacyo
Mu gihe utekereza ku kirango runaka cya NAD+ cy’ifu, ni ngombwa gukora ubushakashatsi ku izina ry’ikigo no ku mucyo wacyo. Shaka ibirango bishyira imbere ubwisanzure mu mikorere yabyo yo gushakisha no gukora. Ibirango by’indashyikirwa bizatanga amakuru arambuye ku bijyanye no gucuruza ifu ya NAD+, harimo n’ubwiza bw’ibikoresho fatizo n’amahame agenga uruganda bubahiriza. Byongeye kandi, shaka ibitekerezo by’abakiriya n’ubuhamya kugira ngo umenye uko abandi bakoresha banyuzwe n’ibicuruzwa by’ikirango muri rusange.
2. Suzuma ubuziranenge bw'ifu ya NAD+
Ubuziranenge ni ikintu cy'ingenzi mu guhitamo ikirango cy'ifu ya NAD+. Ifu ya NAD+ nziza cyane igomba kuba idafite umwanda n'ibindi byuzuza, bityo ukabona ibicuruzwa bisukuye kandi bifite akamaro. Shaka ibirango bikora isuzuma ry'abandi kugira ngo urebe ko ifu yabo ya NAD+ ari nziza. Isuzuma ry'abandi ritanga icyizere cy'uko ibicuruzwa byujuje ibisabwa mu buziranenge kandi ko nta bintu byangiza birimo.
3. Tekereza inzira zo gukora n'ibipimo ngenderwaho by'ubuziranenge
Uburyo bwo gukora bugira uruhare runini mu bwiza bw'ifu ya NAD+. Hitamo ibirango bikurikiza ingamba zikomeye zo kugenzura ubuziranenge kandi bikurikiza amahame meza yo gukora (GMP). Icyemezo cya GMP gihamya ko ibicuruzwa bikorerwa ahantu hasukuye kandi hagenzurwa, bigabanya ibyago byo kwandura no kwemeza ko ubuziranenge buhoraho. Byongeye kandi, baza ku byemezo by'ikirango mu kubungabunga ubuziranenge no gushaka amasoko y'ibintu, kuko ibi bintu bishobora no kugaragaza ubuziranenge rusange bw'ibicuruzwa.
4. Suzuma uburyo ifu ya NAD+ iboneka n'uburyo ishyirwa mu mubiri
Kuboneka mu mubiri bivuga ubushobozi bw'umubiri bwo kwinjiza no gukoresha ibintu bikora mu nyongeramusaruro. Mu gihe uhitamo ikirango cy'ifu ya NAD+, tekereza ku kuboneka mu mubiri kw'iki gicuruzwa. Shaka ibirango bikoresha sisitemu zigezweho zo gutanga cyangwa ikoranabuhanga kugira ngo byongere kuboneka mu mubiri kwa NAD+. Ibi bishobora kuba birimo ibintu nka micronization cyangwa encapsulation, bishobora kunoza uburyo NAD+ yinjizwa mu mubiri, amaherezo bikarushaho kugira akamaro.
5. Shakisha ubushakashatsi bwa siyansi n'ubushakashatsi mu by'ubuvuzi
Ibirango by’ifu ya NAD+ bizwiho gukora ubusanzwe bitanga inyigo za siyansi n’iz’ubuvuzi kugira ngo bishyigikire imikorere n’umutekano w’ibicuruzwa byabo. Shaka ibirango bishora imari mu bushakashatsi no mu iterambere, kuko ibi bigaragaza ubwitange mu gukora ibicuruzwa bifite ireme kandi bishingiye ku bimenyetso. Kwemeza siyansi byemeza ko ifu ya NAD+ yapimwe cyane kandi igasuzumwa, byongera kwemeza ubwiza n’ubuziranenge bwayo.
Suzhou Myland Pharm & Nutrition Inc. yatangiye gukora ubucuruzi bw'inyongeramusaruro z'imirire kuva mu 1992. Ni yo sosiyete ya mbere mu Bushinwa ikora kandi igacuruza imbuto z'imizabibu.
Ifite uburambe bw'imyaka 30 kandi iyobowe n'ikoranabuhanga rigezweho hamwe n'ingamba zo gukora ubushakashatsi n'iterambere zinoze cyane, iyi sosiyete yateguye ibicuruzwa bitandukanye kandi iba ikigo gishya mu bijyanye n'ubuzima, gukora ibintu bitandukanye no gukora ibikoresho bitandukanye.
Byongeye kandi, Suzhou Myland Pharm & Nutrition Inc. ni uruganda rwanditswe na FDA. Imbuga z’ubushakashatsi n’iterambere, ibikoresho byo gukora, n’ibikoresho byo gusesengura by’iyi sosiyete ni ibigezweho kandi bifite imikorere myinshi kandi bishobora gukora imiti kuva kuri miligarama kugeza kuri toni, kandi bikurikiza amahame ya ISO 9001 n’ibipimo bya GMP mu gukora.
Q: Inyongeramusaruro za NAD+ zikoreshwa mu ki?
Inyongeramusaruro ya A: NAD+ ni inyongeramusaruro y’imirire ikungahaye kuri coenzyme NAD+ (nicotinamide adenine dinucleotide). NAD+ igira uruhare runini mu mikorere y’ingufu no gusana uturemangingo mu turemangingo.
Q: Ese koko inyongeramusaruro za NAD+ zirakora?
A: Ubushakashatsi bumwe bwerekana ko inyongeramusaruro za NAD+ zishobora gufasha kunoza imikorere y’ingufu z’uturemangingo no kugabanya igihe cyo gusaza.
Q: Ni izihe mbogamizi zikomoka ku mirire ya NAD+?
A: Inkomoko y'imirire ya NAD+ irimo inyama, amafi, ibikomoka ku mata, ibishyimbo, imbuto z'ubunyobwa n'imboga. Ibi biribwa birimo niacinamide na niacin nyinshi, zishobora guhinduka NAD+ mu mubiri.
Q: Nigute nahitamo inyongeramusaruro ya NAD+?
A: Mu gihe uhitamo inyongeramusaruro za NAD+, ni byiza kubanza gushaka inama kwa muganga cyangwa inzobere mu by'imirire kugira ngo usobanukirwe ibyo ukeneye mu mirire n'uko ubuzima bwawe buhagaze. Byongeye kandi, hitamo ikirango cyemewe, urebe ibikoresho by'umuti n'ingano yawo, kandi ukurikize amabwiriza y'ingano iri ku gice cy'umuti.
Icyitonderwa: Iyi nkuru ni iy'amakuru rusange gusa kandi ntigomba gufatwa nk'inama iyo ari yo yose y'ubuvuzi. Amwe mu makuru yo kuri blog aturuka kuri interineti kandi si ay'umwuga. Uru rubuga rufite inshingano zo gutondeka, gutunganya no gutunganya ingingo gusa. Intego yo gutanga amakuru menshi ntibivuze ko wemera ibitekerezo byarwo cyangwa ngo wemeze ukuri kw'ibikubiye muri rwo. Buri gihe gisha inama umuhanga mu by'ubuzima mbere yo gukoresha inyongeramusaruro cyangwa guhindura uburyo bwawe bwo kwita ku buzima.
Igihe cyo kohereza: Kanama-05-2024
