Ibimera karemano birakenewe cyane mubushakashatsi bwubumenyi ninganda zimiti. 7,8-Dihydroxyflavone (7,8-Dihydroxyflavone), nkurwego rukomeye rukomoka ku bimera, rwashimishije abantu benshi kubera ibikorwa by’ibinyabuzima bikomeye. Ku bashakashatsi mu bya siyansi n’inganda, ni ngombwa kubona abatanga isoko yizewe ya 7.8-Dihydroxyflavone Powder. Ifu ya 7,8-Dihydroxyflavone itangwa na Suzhou Myland ifiteCAS numero 38183-03-8 nubuziranenge bugera kuri 98%, kuguha amahitamo yizewe.
7,8-Dihydroxyflavone(bizwi kandi nka 7,8-DHF cyangwa proflavonoid) ni molekile isanzwe iba mubyiciro bya flavonoid yibintu. Biboneka mumababi ya Godmania aesculifolia, Tridax procumbens na primula.
7,8-DHF ni ifumbire mvaruganda hamwe na molekuline ya C15H10O4. Irashobora gushonga mumashanyarazi kandi ifite ibara, impumuro nuburyohe bujyanye nibintu bya flavonoide.
7,8-DHF yagaragaye nkikintu cyiza cya nootropic. Yerekanye ingaruka zitandukanye za neurofarmacologique mubushakashatsi bwibanze, harimo kunoza kwibuka, guteza imbere neurogenezi no kwirinda neurodegeneration.
Nka molekile ntoya kandi itoranya agonist ya tropomyosine reseptor kinase B (TrkB), proflavin yerekanye imbaraga mubyitegererezo byinyamaswa kurwanya indwara zitandukanye, harimo n'indwara ya Alzheimer.
Flavonoide ni urwego rwibintu byinshi bya polifenolike biboneka mu mbuto zitandukanye, imboga, n’andi masoko y’ibimera. Mu myaka yashize, bagiye bitabwaho cyane kubera antioxydants, anti-inflammatory, na neuroprotective.
Ibi bikoresho byagaragaye ko bifite ingaruka nziza mubwonko, harimo kongera imikorere yubwenge no kwirinda indwara zifata ubwonko. 7,8-DHF nimwe mubintu bizwi cyane bya polifenolike byitabirwa cyane nka nootropic. Yakozweho ingaruka zishobora kuba kumyumvire, kwibuka, kwiga, guhangayika, nibindi bikorwa byubwenge.
Ingaruka zifata ubwonko bwa 7,8-DHF zitekereza ko zahujwe n’imikoranire yazo na reseptor zihariye. Byagaragaye ko ari TrkA, reseptor igira uruhare mu mikurire yikura ryerekana ibimenyetso kandi bifite akamaro mubuzima bwa neuronal na plastike.
7,8-DHF ikora muguhuza imvugo ya reseptors zitandukanye, harimo glutamate reseptor subunits na BDNF. Iragira kandi ingaruka kumikorere ya synaps, metabolism yingufu, no kurekura acetyloline mubice bimwe byubwonko.
Ubushakashatsi bwakozwe kuri 7,8-dihydroxyflavone bwagutse mu ngaruka zabwo ku buzima bw’umuntu, cyane cyane urebye uburyo bwigana ibikorwa by’ubwonko bukomoka mu bwonko (BDNF), poroteyine ikenewe mu mibereho no mu mikorere. ya poroteyine.
Ku bijyanye n’imikoreshereze yacyo, 7,8-DHF yashakishijwe mu buryo bushobora gukoreshwa mu kuvura indwara zifata ubwonko bitewe n'ubushobozi bwayo bwo kwinjira mu nzitizi y'amaraso n'ubwonko.
7,8-Dihydroxyflavone iboneka mubisanzwe mubiribwa bitandukanye byibimera, harimo:
Imbuto: pome, imbuto, inzabibu n'imbuto za citrusi
● Imboga: igitunguru, kale, broccoli na epinari
Ibimera: Parsley, thime na oregano
Usibye ayo masoko karemano, 7,8-DHF iraboneka kandi muburyo bwinyongera kugirango bikoreshwe kandi byateganijwe.
Wige ibijyanye na flavonoide
Flavonoide ni ibice bya polifenolike bigira uruhare runini muguhindura ibimera, kuyungurura UV, no kurwanya indwara. Bagabanijwemo ibyiciro byinshi, birimo flavonol, flavone, isoflavone, flavanone, na anthocyanine. Buri cyiciro gifite imiterere itandukanye yimiti nibikorwa byibinyabuzima, bivamo inyungu zitandukanye mubuzima.
7,8-dihydroxyflavone ni iki?
7,8-Dihydroxyflavone nubwoko bwihariye bwa flavonoide iri muri flavonoid subclass. Imiterere yimiti ifite amatsinda abiri ya hydroxyl kumwanya wa 7 na 8 wumugongo wa flavonoid, ishinzwe imiterere yihariye. Uru ruganda ruboneka cyane cyane mubihingwa nka dioscorea (yam) kandi byakozweho ubushakashatsi ku ngaruka zishobora guterwa na neuroprotective, imiti irwanya inflammatory, hamwe no kongera ubwenge.
Itandukaniro ryibanze hagati ya 7,8-DHF nizindi Flavonoide
1. Imiterere yimiti
Itandukaniro rigaragara cyane hagati ya 7,8-DHF nizindi flavonoide nuburyo bwimiti. Nubwo flavonoide nyinshi isangiye umugongo umwe, kuba amatsinda ya hydroxyl kumwanya runaka birashobora kugira ingaruka zikomeye kubikorwa byabo. Kurugero, quercetin, izwi cyane ya flavonol, ifite gahunda itandukanye yitsinda rya hydroxyl, bigira ingaruka kumikorere no gukorana nintego yibinyabuzima.
2. Ibikorwa byibinyabuzima
7,8-DHF byagaragaye ko ifite ibikorwa byibinyabuzima bidasanzwe ugereranije nizindi flavonoide. Ubushakashatsi bwerekana ko bukora ubwonko bukomoka mu bwonko bukomoka ku bwonko (BDNF) bwerekana inzira, ari ingenzi cyane ku kubaho kwa neuron, gukura no gutandukana. Ubu buryo ni ingenzi cyane mu rwego rwindwara zifata ubwonko no kugabanuka kwubwenge.
Ibinyuranye na byo, izindi flavonoide nka catechine (iboneka mu cyayi kibisi) na anthocyanine (iboneka mu mbuto) zikora cyane cyane binyuze mu bikorwa bya antioxydeant, gusiba radicals z'ubuntu no kugabanya stress ya okiside. Nubwo iyi mitungo ari ingirakamaro, ntishobora kugira ingaruka ku buryo butaziguye ibintu bya neurotrophique nkuko 7,8-DHF ibikora.
3. Bioavailable
Bioavailability bivuga urugero nigipimo aho ibintu bikora cyangwa ibikorwa bikora byinjira kandi bikaboneka kurubuga rwibikorwa. 7,8-DHF yerekanye bioavailable nziza mubushakashatsi bwinyamaswa, byerekana ko ishobora kurenga neza inzitizi yubwonko bwamaraso, ifite akamaro kanini mu ngaruka zayo.
Ibinyuranye, bioavailable yizindi flavonoide irashobora gutandukana cyane. Kurugero, nubwo quercetin ikoreshwa cyane, iyinjizwa ryayo akenshi iba mike kubera metabolism yihuse. Iri tandukaniro muri bioavailability rigira ingaruka kumikorere yibi bikoresho mugushikira ubuzima bwiza bwifuzwa.
7,8-DHF uburyo bwibikorwa: amabwiriza ya BDNF no gukora reseptor ya Trkb
Kubijyanye nuburyo bwibikorwa, 7,8-DHF izwiho guteza imbere umusaruro wa BDNF (ubwonko bukomoka mu bwonko bukomoka ku bwonko) mu guhuza no gukora reseptor yayo TrkB. Utabonye tekiniki cyane, ibi nabyo biganisha kuri casade yibikorwa bya selile bifite akamaro mukubungabunga imikorere myiza ya neuronal no guteza imbere neurogenezi.
7,8-DHF uburyo bukuru bwibikorwa:
(1) Ubwonko bukomoka mu bwonko (BDNF) n'uruhare rwayo muri neuroplastique
Hamwe no kuvumbura ko imvugo ikomoka mu bwonko ikomoka mu bwonko (BDNF) igabanuka mu ndwara zifata ubwonko, cyane cyane indwara ya Alzheimer (AD), akamaro kayo mu kubungabunga no kuzamura ubuzima bw’ubwonko buragenda bugaragara.
BDNF ni ingenzi kumikorere itandukanye ya neuronal kuko iteza imbere kwanduza synaptic, synaptogenez, hamwe na plastike ya synaptic binyuze mukumenyesha hamwe na reseptor ya TrkB. Ibi bituma inzira ya BDNF-TrkB yerekana inzira itanga intego yo guteza imbere ibikorwa byo kuvura bigamije kurwanya indwara zifata ubwonko.
(2) Tropomyosin reseptor kinase B (Trkb) reseptor yerekana inzira
Reseptor ya tropomyosine kinase B (TrkB) igira uruhare runini muguhuza ingaruka za BDNF kuri neuron. Nka reseptor ya tyrosine kinase reseptor, TrkB niyakirwa ryambere rya BDNF kandi itangiza caskade yibintu byerekana ibimenyetso byerekana ibimenyetso bya neurotrophique.
BDNF ikora TrkB kugirango itere inzira nyinshi zingenzi zingirangingo, harimo fosifatiidilinositol 3-kinase (PI3K) -Ibikorwa, mitogen-ikora protein kinase (MAPK) -ibimenyetso bidasanzwe bigengwa na kinase (ERK), na fosifolipase Cγ (PLCγ) -protein kinase C ( PKC) inzira. Buri nzira muriyi nzira igira uruhare muburyo butandukanye bwimikorere ya neuronal n'imibereho myiza.
Inzira ya PI3K-Akt ningirakamaro mugutezimbere ubuzima bwa neuronal no kubuza apoptose. Ibimenyetso bya BDNF-TrkB bifasha iyi nzira kugirango ubuzima bwiyongere bwingirabuzimafatizo hirindwa ibintu bitera apoptotique no gukangurira ibintu birwanya apoptotique, bityo bikabungabunga neurone nzima.
Kurundi ruhande, inzira MAPK-ERK igira uruhare runini mugutandukanya imitsi no gukwirakwira. Ibimenyetso bya BDNF-TrkB biteza imbere gukora inzira ya MAPK-ERK, nayo igashyigikira gukura kwa neuronal no gutandukana no kwinjiza mumiyoboro isanzwe ya neuronal.
Inzira ya PLCγ-PKC ningirakamaro mugutunganya plastike ya synaptique, inzira yibanze yo kwiga no kwibuka. Ibimenyetso bya BDNF-TrkB bihindura ibikorwa byiyi nzira, amaherezo biganisha kumahinduka mumbaraga za synaptic no guhuza.
Iri hindurwa riteza imbere guhuza no kuvugurura imiyoboro y’imitsi isubiza ibyabaye bishya hamwe n’ibidukikije.
Mugukora nka TrkB agonist, 7,8-DHF igira ingaruka za nootropique cyane cyane muguhuza inzira zerekana ibimenyetso bya BDNF, bityo bigatera neurogenezi no kuzamura plastike ya synaptic.
Mu kwigana ingaruka za BDNF, 7,8-DHF ifasha kurinda neurone kwangirika, iteza imbere kubaho, kandi iteza imbere no gukomeza imiyoboro mishya ya neuronal. Ubu bushobozi bwo guteza imbere ubwonko, kunoza imikorere yubwenge, no kugabanya ibimenyetso byindwara zifata ubwonko bituma 7.8-DHF umukandida utanga ikizere cyo guteza imbere ibiyobyabwenge nubushakashatsi bwimbitse.
7,8-DHF Inyungu za Nootropic: Kongera ubwenge no Kongera Neuroprotection
Kubyerekeye inyungu za nootropique, 7,8-DHF ikora binyuze muburyo 4 nyamukuru:
Guhuza kwibuka no kugarura: umurimo ushingiye kuri hippocampus
7,8-DHF yabonetse kugirango yongere imbaraga zo kwibuka no kugarura muburyo butandukanye bwo kwiga bushingiye kuri hippocampus hamwe nibikorwa byo kwibuka muburyo bwimbeba. Ubu bushakashatsi bwerekana ko 7,8-DHF ishobora kuba nootropique itanga icyizere, Irashobora gukoreshwa mugutezimbere imikorere yibuka kubantu bafite ubuzima bwiza nabafite ubumuga bwo kwibuka.
Plastike ya synaptique: imbaraga zigihe kirekire no kwiheba
7,8-DHF yerekanwe kugenga plastike ya synaptique iteza imbere LTP no kugabanya LTD muri hippocampus. Izi ngaruka zitekerezwa kuba zahujwe nubushobozi bwayo bwo gukora reseptor ya TrkB hanyuma bikazamura inzira ya BDNF yerekana inzira. Ihindurwa rya plastike ya synaptique igira uruhare mugutezimbere mumikorere yubwenge yagaragaye nyuma yubuyobozi 7,8-DHF.
Indwara ya Antioxydeant: ROS scavenging na lipid peroxidation
7,8-DHF ifite antioxydeant nkuko bigaragazwa nubushobozi bwayo bwo gusiba ubwoko bwa ogisijeni ikora (ROS) no kugabanya lipide peroxidation. Izi ngaruka zigira uruhare mu ngaruka za neuroprotective mukugabanya imbaraga za okiside iterwa na neuronal kwangirika no kudakora neza.
Ingaruka zo kurwanya inflammatory: igenga imikorere ya microglial hamwe na cytokine
Usibye imiterere ya antioxydeant, 7,8-DHF byagaragaye ko igira ingaruka zo kurwanya inflammatory ihindura imikorere ya microglial no kugabanya umusaruro wa cytokine itera inflammatory nka TNF-α na IL-1β. Ibi kandi bigira uruhare mu ngaruka zayo za neuroprotective na nootropic mukurinda kwangirika kwatewe na neuronal.
Mugihe ushakisha uwaguhaye7,8-DihydroxyflavoneIfu, urashobora gusuzuma ibintu bikurikira:
1. Icyubahiro cy'abatanga isoko
Guhitamo utanga isoko ufite izina ryiza ni ngombwa. Urashobora kumva neza izina ryabatanga ibicuruzwa mugenzura ibyasuzumwe byabakiriya, raporo zinganda, hamwe namahuriro yabigize umwuga. Suzhou Myland afite izina ryiza mu nganda, hamwe nibitekerezo byiza byabakiriya hamwe nubwiza bwibicuruzwa bizwi.
2. Ubwiza bwibicuruzwa
Menya neza ko ibicuruzwa bitangwa nababitanga byujuje ubuziranenge mpuzamahanga nibisabwa kugenzura ubuziranenge. Suzhou Myland 7,8-Dihydroxyflavone Powder yakorewe ibizamini byujuje ubuziranenge kandi ifite ubuziranenge bugera kuri 98%, bituma ibicuruzwa bikora neza n'umutekano.
3. Icyemezo no kubahiriza
Guhitamo utanga isoko hamwe na GMP (Pratique nziza yo gukora) hamwe na ISO byemeza ko umusaruro wacyo wujuje ubuziranenge mpuzamahanga. Suzhou Myland ikurikiza byimazeyo ibipimo ngenderwaho kugirango harebwe ituze kandi rihamye kuri buri cyiciro cyibicuruzwa.
4. Inkunga ya tekiniki na serivisi
Utanga isoko yizewe agomba gutanga ubufasha bwa tekiniki yumwuga na serivisi zabakiriya. Suzhou Myland ifite itsinda rya tekinike yumwuga rishobora guha abakiriya ibyifuzo byo gukoresha ibicuruzwa nubuyobozi bwa tekinike kugirango bafashe abakiriya kugera kubisubizo byiza mubushakashatsi no kubishyira mubikorwa.
5. Igiciro nigihe cyo gutanga
Igiciro nigihe cyo gutanga nacyo ni ibitekerezo byingenzi muguhitamo uwaguhaye isoko. Urashobora gusaba amagambo yatanzwe nabaguzi benshi hanyuma ukagereranya ibiciro byabo nigihe cyo gutanga kugirango ubone amahitamo meza. Suzhou Myland
itanga ibiciro byapiganwa nibihe byoroshye byo gutanga mugihe byemeza ubuziranenge bwibicuruzwa.
Nigute Wabona 7,8-Ifu ya Dihydroxyflavone
Niba ushaka ubuziranenge bwo hejuru 7,8-Dihydroxyflavone Powder, Suzhou Myland nibyo wahisemo. Urashobora kutwandikira kuri:
Urubuga rwemewe: Suraurubuga rwemewe rwa Suzhou Mylandkwiga byinshi kubyerekeye amakuru yibicuruzwa ninkunga ya tekiniki.
Kugisha inama kumurongo: Vugana neza nitsinda ryabakiriya bacu binyuze mumikorere yo kugisha inama kumurongo itangwa nurubuga kugirango ubone amakuru yibicuruzwa hamwe na cote ukeneye.
Twandikire kuri terefone: Hamagara numero yacu kugirango tuvugane nabakozi bashinzwe kugurisha babigize umwuga kandi ubone amakuru arambuye yibicuruzwa nibitekerezo byo kugura.
Kubaza imeri: Urashobora kandi kutubaza amakuru yibicuruzwa ukoresheje imeri, kandi tuzagusubiza vuba bishoboka.
Kubona ibyiringiro 7,8-Dihydroxyflavone Abatanga ifu ntabwo byoroshye, ariko nukwitondera izina ryuwabitanze, ubwiza bwibicuruzwa, ibyemezo no kubahiriza, inkunga ya tekiniki na serivisi, hamwe nigiciro nigihe cyo gutanga, urashobora gufata icyemezo cyubwenge. hitamo. Suzhou Myland numufatanyabikorwa wawe mwiza hamwe nubuziranenge bwa 7,8-Dihydroxyflavone Powder na serivisi nziza zabakiriya. Dutegereje kuzakorana nawe kugirango dushakishe byinshi mubishobora gukoreshwa 7,8-Dihydroxyflavone.
Ikibazo: Ese proflavin ishobora kuzamura ubushobozi bwo kwiga?
Igisubizo: Yego, proflavin yerekanwe kugirango yongere ubushobozi bwo kwiga mubushakashatsi bwibikoko biteza imbere neurogenezi no guhuza synaptic. Igenga sisitemu ya neurotransmitter ifite akamaro kanini muburyo bwo kwiga, cyane cyane muri hippocampus, agace kingenzi k'ubwonko bwo kwiga.
Ikibazo: Ese 7,8-DHF ifasha ubwenge bwo gukira nyuma yimvune?
Igisubizo: Yego, ubushakashatsi bwibanze bwerekana ko 7,8-DHF ishobora gufasha gukira kwubwenge nyuma yo gukomeretsa ubwonko itera neuroprotection na neuroregeneration. Igabanya urupfu rwa neuronal kandi ishyigikira imikurire ya neuron nshya, ishobora kuzamura imikorere yubwenge iterwa nihungabana cyangwa ibikomere byatewe na ischemic.
Ikibazo: Ni uruhe ruhare 7,8-dihydroxyflavone igira mu gusaza kugabanuka kwubwenge?
Igisubizo: Ubushakashatsi bumaze kuvuka bwerekana ko 7,8-DHF ishobora gutinda kugabanuka kwubwenge bujyanye no gusaza birinda impungenge za okiside ndetse n’umuriro, ibintu bisanzwe mu ndwara ziterwa n’imyaka.
Mugutezimbere urwego rwa BDNF hamwe na TrkB yakira reseptor, bifasha kugumya kwihanganira ubwenge, nubwo hakenewe ubushakashatsi bwinshi bwabantu kugirango bashakishe neza izo ngaruka.
Ikibazo: Ese 7,8-DHF irashobora kunoza ibitekerezo nibikorwa byubuyobozi?
Igisubizo: Ubushakashatsi bwibanze bwinyamanswa bwerekana ko 7,8-DHF ishobora kunoza imikorere ninshingano zogutezimbere imitegekere ya neurotransmitter hamwe n’imitsi iva mu bwonko igira uruhare muri ibyo bikorwa.
Inshingano: Iyi ngingo ni iyamakuru rusange gusa kandi ntigomba gusobanurwa nkinama zose zubuvuzi. Amwe muma poste yamakuru aturuka kuri enterineti kandi ntabwo ari umwuga. Uru rubuga rufite inshingano zo gutondeka, gutunganya no guhindura ingingo. Intego yo gutanga amakuru menshi ntabwo bivuze ko wemera ibitekerezo byayo cyangwa kwemeza ukuri kwibirimo. Buri gihe ujye ubaza inzobere mu buzima mbere yo gukoresha inyongeramusaruro cyangwa guhindura ibintu byubuzima bwawe.
Igihe cyo kohereza: Ukwakira-16-2024
