NAD + nayo yitwa coenzyme, kandi izina ryayo ryuzuye ni nicotinamide adenine dinucleotide. Ni coenzyme yingenzi muri cycle ya tricarboxylic. Itera metabolisme yisukari, ibinure, na aside amine, igira uruhare muguhuza ingufu, kandi ikagira uruhare mubihumbi n'ibihumbi muri buri selile. Umubare munini wamakuru yubushakashatsi yerekana ko NAD + igira uruhare runini mubikorwa bitandukanye byibanze byumubiri mubinyabuzima, bityo ikagira uruhare mubikorwa byingenzi bya selile nka metabolism yingufu, gusana ADN, guhindura genetike, gutwika, injyana ya biologiya, no kurwanya imihangayiko.
Nk’ubushakashatsi bufite akamaro, urwego rwa NAD + mu mubiri wumuntu ruzagabanuka uko imyaka igenda ishira. Kugabanuka kurwego rwa NAD + bishobora gutera kugabanuka kwimitsi, kubura iyerekwa, umubyibuho ukabije, imikorere yumutima kugabanuka nibindi bikorwa bigabanuka. Kubwibyo, uburyo bwo kongera urwego rwa NAD + mumubiri wumuntu byahoze ari ikibazo. Ingingo yubushakashatsi bushyushye mumuryango wibinyabuzima.
Kuberako, uko dusaza, ADN ibyangiritse biriyongera. Mugihe cyo gusana ADN, ibyifuzo bya PARP1 biriyongera, ibikorwa bya SIRT ni bike, ikoreshwa rya NAD + ryiyongera, kandi umubare wa NAD + uragabanuka bisanzwe.
Umubiri wacu ugizwe na selile zigera kuri tiriyoni 37. Ingirabuzimafatizo zigomba kuzuza byinshi "akazi" cyangwa reaction ya selile - kugirango bikomeze. Buri selile yawe miriyoni 37 yishingikiriza kuri NAD + kugirango ikore akazi kayo.
Uko abatuye isi basaza, indwara ziterwa no gusaza nk'indwara ya Alzheimer, indwara z'umutima, ibibazo bihuriweho, ibitotsi, n'ibibazo by'umutima n'imitsi byahindutse indwara zikomeye zibangamira ubuzima bw'abantu.
NAD + urwego rugabanuka uko imyaka igenda ishira, hashingiwe ku bipimo bivuye ku ngero z'uruhu rw'umuntu:
Ibisubizo byo gupima byerekana ko uko imyaka igenda yiyongera, NAD + mu mubiri w'umuntu izagenda igabanuka buhoro buhoro. None niki gitera kugabanuka kwa NAD +?
Impamvu nyamukuru zitera NAD + kugabanuka ni: gusaza no kwiyongera kwa NAD +, ibyo bigatuma igabanuka rya NAD + mubice byinshi, harimo umwijima, imitsi ya skeletale, n'ubwonko. Ingaruka zo kugabanuka, imikorere mibi ya mitochondrial, stress oxydeide na inflammation batekereza ko bigira uruhare mubibazo byubuzima bijyanye nimyaka, bigatera uruziga rukabije.
1. Gusaza hamwe nimirire ya calorie nyinshi bigabanya urugero rwa NAD + mumubiri.
Ubushakashatsi bwerekanye ko mu mbeba zishaje, gufata inyongera za NAD + byagabanije imirire- cyangwa imyaka ijyanye no kongera ibiro no kongera ubushobozi bwimyitozo ngororamubiri. Byongeye kandi, ubushakashatsi bwanahinduye ingaruka za diyabete ku mbeba z’abagore, byerekana ingamba nshya zo kurwanya indwara ziterwa n’umubyibuho ukabije.
NAD + ihuza imisemburo kandi ikohereza electron hagati ya molekile. Electron ni ishingiro ryingufu za selile. NAD + ikora kuri selile nko kwishyuza bateri. Iyo electron zimaze gukoreshwa, bateri irapfa. Muri selile, NAD + irashobora guteza imbere ihererekanyabubasha rya elegitoronike kandi igatanga ingufu muri selile. Muri ubu buryo, NAD + irashobora kugabanya cyangwa kongera ibikorwa bya enzyme, iteza imbere imvugo ya gene na signal ya selile.
NAD + ifasha kugenzura ibyangiritse kuri ADN
Mugihe ibinyabuzima bisaza, ibintu bibi bidukikije nkimirasire, umwanda, no kwigana ADN bidakwiye birashobora kwangiza ADN. Iyi ni imwe mu nyigisho zo gusaza. Ingirabuzimafatizo hafi ya zose zirimo "imashini ya molekile" kugirango isane ibyangiritse.
Uku gusana bisaba NAD + ningufu, bityo kwangirika kwa ADN birenze urugero bitwara umutungo wa selile. Imikorere ya PARP, proteine ikomeye yo gusana ADN, nayo biterwa na NAD +. Gusaza bisanzwe bitera ADN kwangirika mu mubiri, RARP iriyongera, bityo NAD + igabanuka. ADN ya Mitochondrial yangiritse ku ntambwe iyo ari yo yose izongera ubukana.
2. NAD + igira ingaruka kumikorere ya gen kuramba Sirtuins kandi ikabuza gusaza.
Indwara ya sirtuins irambye yavumbuwe, izwi kandi ku izina rya "abarinzi ba gen", igira uruhare runini mu kubungabunga ubuzima bw'utugari. Sirtuins ni umuryango wimisemburo igira uruhare mugukemura ibibazo bya selile no gusana ibyangiritse. Bagira uruhare kandi mu gusohora insuline, gusaza, hamwe n’ubuzima bujyanye n’ubusaza nkindwara zifata ubwonko na diyabete.
NAD + ni lisansi ifasha sirtuins gukomeza uburinganire bwa genome no guteza imbere gusana ADN. Nkuko imodoka idashobora kubaho idafite lisansi, Sirtuins isaba NAD + kugirango ikore. Ibisubizo bivuye mu bushakashatsi bw’inyamaswa byerekana ko kongera urwego rwa NAD + mu mubiri bikora poroteyine za sirtuin kandi bikongerera igihe cyo kubaho mu musemburo n'imbeba.
3.Imikorere yumutima
Kuzamura urwego rwa NAD + birinda umutima kandi bigateza imbere imikorere yumutima. Umuvuduko ukabije wamaraso urashobora gutera umutima munini hamwe nimiyoboro ifunze, bishobora gutera ubwonko. Nyuma yo kuzuza urwego rwa NAD + mumutima ukoresheje inyongera ya NAD +, ibyangiritse kumutima biterwa na reperfusion birabujijwe. Ubundi bushakashatsi bwerekanye ko inyongera za NAD + nazo zirinda imbeba kwaguka k'umutima bidasanzwe.
4. Neurodegeneration
Imbeba zifite uburwayi bwa Alzheimer, kongera urwego rwa NAD + byongera imikorere yubwenge mugabanya iyubaka rya poroteyine zibangamira itumanaho ryubwonko. Kuzamura urwego rwa NAD + birinda kandi ingirabuzimafatizo zo mu bwonko gupfa igihe nta maraso ahagije yinjira mu bwonko. NAD + isa nkaho ifite amasezerano mashya mukurinda neurodegeneration no kunoza kwibuka.
5. Sisitemu yo kwirinda
Mugihe tugenda dusaza, sisitemu z'umubiri ziragabanuka kandi dushobora kwibasirwa n'indwara. Ubushakashatsi buherutse gukorwa bwerekana ko urwego rwa NAD + rufite uruhare runini mugutunganya ubudahangarwa bw'umubiri no gutwika no kubaho kwa selile mugihe cyo gusaza. Ubushakashatsi bwerekana ubushobozi bwo kuvura NAD + bwo kudakora neza.
6. Tunganya metabolism
Kurwanya ibyangiritse
NAD + irashobora gufasha gutinda gusaza mukurinda ingaruka ziterwa no gutwika, kugenga redox homeostasis yumubiri, kurinda selile kwangirika, gukomeza ibikorwa bisanzwe bya metabolike
7. Fasha mukurwanya ibibyimba
NAD + irashobora kandi gukumira no kuvura leukopenia iterwa na radiotherapi na chimiotherapie, kunoza imiti iterwa no gukoresha igihe kirekire antibodiyite ya PD-1 / PD-L1, ikanatezimbere imikorere ya selile T hamwe nubushobozi bwo kwica ibibyimba.
8. Kunoza imikorere yintanga
Urwego rwa NAD + mu ntanga ngore zigabanuka muburyo bushingiye ku myaka. Kongera NAD + ibirimo birashoborakunoza imikorere yintanga ngore,gabanya ubwoko bwubwoko bwa ogisijeni ikora muri oocytes ishaje, kandi utinde gusaza kwintanga.
9. Kunoza ireme ryibitotsi
NAD + irashobora kunonosora injyana ya sikadiyani, kunoza ibitotsi, no guteza imbere ibitotsi muguhuza isaha yibinyabuzima.
Ibice bitandukanye byumubiri ntibibaho byigenga. Isano n'imikoranire hagati yabo biregeranye cyane kuruta uko tubitekereza. Ibintu byasohowe na selile birashobora kujyanwa ahantu hose mumubiri mukanya; amakuru ya neurotransmitter yoherezwa byihuse nkumurabyo. Uruhu rwacu, nkinzitizi yumubiri wose, numurongo wambere wurugamba kandi rushobora kwibasirwa nibikomere bitandukanye. Iyo izo nkomere zidashobora gusanwa, ibibazo bitandukanye nko gusaza bizakurikiraho.
Ubwa mbere, gusaza kwuruhu ruherekezwa nuruhererekane rwimpinduka kurwego rwa selile na molekile, zishobora kwanduza izindi ngingo cyangwa ingingo zinyuze munzira zitandukanye.
Kurugero, inshuro zingirabuzimafatizo za p16 (ikimenyetso cyo gusaza) muruhu zifitanye isano neza nibimenyetso byo gusaza kwingirabuzimafatizo, bivuze ko imyaka yibinyabuzima yuruhu ishobora guhanura gusaza kwumubiri kurwego runaka. Byongeye kandi, ubushakashatsi bwerekanye ko microbiota yuruhu ishobora guhanura neza imyaka ikurikirana, bikomeza kwemeza isano iri hagati yuruhu no gusaza kwa sisitemu.
Ubuvanganzo bwabanje bwatangaje ko inzira yo gusaza mu ngingo zitandukanye mu mubiri zidahuye, kandi uruhu rushobora kuba urugingo rwa mbere rugaragaza ibimenyetso byo gusaza. Ukurikije isano ya hafi hagati yo gusaza kwuruhu nizindi ngingo zumubiri, abantu bafite impamvu zo gushidikanya bashize amanga ko gusaza kwuruhu bishobora gutera gusaza umubiri wose.
Gusaza k'uruhu birashobora kugira ingaruka ku bwonko binyuze muri sisitemu ya endocrine
Gusaza k'uruhu birashobora kugira ingaruka kumubiri wose binyuze muri hypothalamic-pituitar-adrenal (HPA). Uruhu ntabwo ari inzitizi gusa, rufite kandi imikorere ya neuroendocrine kandi rushobora kwitabira ibidukikije no gusohora imisemburo, neuropeptide nibindi bintu.
Kurugero, imirasire ya ultraviolet irashobora gutuma selile zuruhu zirekura imisemburo itandukanye hamwe nabunzi ba inflammatory, nka cortisol na cytokine. Ibi bintu birashobora gukora sisitemu ya HPA muruhu. Gukora kwa HPA bitera hypothalamus kurekura imisemburo ya corticotropine (CRH). Ibi na byo bitera glande ya pitoito imbere gusohora imisemburo ya adrenocorticotropique (ACTH), amaherezo igatera glande ya adrenal gusohora imisemburo ya stress nka cortisol. Cortisol irashobora kugira ingaruka mubice byinshi byubwonko, harimo na hippocampus. Indwara ya cortisol idakira cyangwa ikabije irashobora kugira ingaruka mbi kumikorere ya neuronal na plastike muri hippocampus. Ibi na byo bigira ingaruka ku mikorere ya hippocampus no gukemura ibibazo byubwonko.
Iri tumanaho ry’uruhu n'ubwonko ryerekana ko inzira yo gusaza ishobora guterwa n’ibidukikije, bikabanza gutera uruhu hanyuma bikagira ingaruka ku bwonko binyuze mu murongo wa HPA, biganisha ku bibazo bya sisitemu nko kugabanuka kwubwenge no kongera ibyago byo kurwara umutima.
Uruhu rwa senescent selile isohora SASP kandi itera uburibwe kugirango itere gusaza n'indwara
Gusaza k'uruhu birashobora no kugira ingaruka kumubiri wose mugutezimbere no gukingira indwara. Ingirabuzimafatizo zuruhu zishaje zisohora ibintu byitwa "senescence ifitanye isano n’ibanga rya fenotype" (SASP), ikubiyemo cytokine zitandukanye na matrix metalloproteinase. SASP ni physiologique itandukanye. Irashobora kurwanya ibidukikije byangiza muri selile zisanzwe. Nyamara, uko imikorere yumubiri igabanuka, ururenda runini rwa SASP rushobora gutera uburibwe mu mubiri kandi bigatera imikorere mibi yingirabuzimafatizo, harimo ingirabuzimafatizo ndetse na selile endothelia. Iyi miterere yo murwego rwo hasi yibwira ko ari umushoferi wingenzi windwara nyinshi ziterwa nimyaka.
Coenzymes igira uruhare mu guhinduranya ibintu by'ingenzi nk'isukari, ibinure, na poroteyine mu mubiri w'umuntu, kandi bigira uruhare runini mu kugenga umubiri n'ingufu z'umubiri no gukomeza imikorere isanzwe ya physiologiya.NAD ni coenzyme ikomeye mumubiri wumuntu, nanone yitwa coenzyme I. Ifite uruhare mubihumbi n'ibihumbi redox enzymatique reaction mumubiri wumuntu. Nibintu byingirakamaro kuri metabolism ya buri selile. Ifite imirimo myinshi, imirimo nyamukuru ni:
1. Guteza imbere umusaruro wa bioenergy
NAD + itanga ATP binyuze mu guhumeka kwa selile, ikuzuza mu buryo butaziguye ingufu za selile no kuzamura imikorere ya selile;
2. Gusana ingirabuzima fatizo
NAD + niyo substrate yonyine ya ADN yo gusana enzyme PARP. Ubu bwoko bwa enzyme bugira uruhare mu gusana ADN, bufasha gusana ADN na selile byangiritse, bigabanya amahirwe yo guhinduka kwa selile, kandi bikarinda kanseri;
3. Koresha poroteyine zose zo kuramba
NAD + irashobora gukora poroteyine 7 zose zo kuramba, bityo NAD + igira ingaruka zikomeye mukurwanya gusaza no kongera igihe cyo kubaho;
4. Komeza imbaraga z'umubiri
NAD + ishimangira ubudahangarwa bw'umubiri kandi itezimbere ubudahangarwa bw'umubiri muguhitamo guhindura ubuzima n'imikorere ya selile T igenga.
Ikigaragara ni uko gusaza biherekejwe no kugabanuka gahoro gahoro mubice na selile NAD + murwego rwibinyabuzima bitandukanye byicyitegererezo, harimo imbeba nabantu. Kugabanuka kurwego rwa NAD + bifitanye isano nindwara nyinshi zijyanye no gusaza, harimo kugabanuka kwubwenge, kanseri, indwara ya metabolike, sarcopenia, nintege nke.
Nta soko ridashira rya NAD + mumubiri. Ibirimo nibikorwa bya NAD + mumubiri wumuntu bizagabanuka uko imyaka igenda ishira, kandi bizagabanuka vuba nyuma yimyaka 30, bivamo gusaza kwingirabuzimafatizo, apoptose no gutakaza ubushobozi bushya. .
Byongeye kandi, kugabanuka kwa NAD + bizanatera urukurikirane rwibibazo byubuzima, niba rero NAD + idashobora kuzuzwa mugihe, ingaruka zirashobora gutekerezwa.
Inyongera ziva mu biryo
Ibiribwa nka keleti, broccoli, avoka, igikoma, ibihumyo, na edamame birimo NAD + ibanziriza, ishobora guhinduka NAD * ikora mumubiri nyuma yo kuyakira.
Gabanya indyo na karori
Kugabanya kalorike mu rugero birashobora gukora inzira-yumvikanisha imbaraga mungirabuzimafatizo no kongera mu buryo butaziguye urwego rwa NAD.Ariko menya neza ko urya indyo yuzuye kugirango uhuze imirire yumubiri wawe.
Komeza kwimuka no gukora siporo
Imyitozo ngororangingo iringaniye nko kwiruka no koga irashobora kongera urwego rudasanzwe rwa NAD +, rufasha kongera umwuka wa ogisijeni mu mubiri no kuzamura imbaraga za metabolism.
Kurikiza ingeso nziza zo gusinzira
Mugihe cyo gusinzira, umubiri wumuntu ukora ibintu byinshi byingenzi byo guhinduranya no gusana, harimo na synthesis ya NAD * .Gusinzira bihagije bifasha kugumana urwego rusanzwe rwa NAD *
05Kuzuza NAD + ibintu bibanziriza
Abantu bakurikira ntibashobora kwivuza
Abantu bafite imikorere mike yimpyiko, abafite dialyse, abarwayi ba epilepsy, abagore batwite, abagore bonsa, abana, abavurwa na kanseri, abafata imiti, nabafite amateka ya allergie, nyamuneka ubaze umuganga wawe witabye.
Ikibazo: Niki NAD + inyongera zikoreshwa?
Igisubizo: NAD + inyongera ni intungamubiri zuzuza coenzyme NAD + (nicotinamide adenine dinucleotide). NAD + igira uruhare runini muguhindura ingufu no gusana ingirabuzimafatizo.
Ikibazo: Ese inyongera za NAD + zirakora koko?
Igisubizo: Ubushakashatsi bumwe bwerekana ko inyongera za NAD + zishobora gufasha kunoza ingufu za selile selile no kugabanya gusaza.
Ikibazo: Ni ubuhe buryo bukomoka ku mirire ya NAD +?
Igisubizo: Inkomoko y'ibiryo bya NAD + harimo inyama, amafi, ibikomoka ku mata, ibishyimbo, imbuto n'imboga. Ibyo biryo birimo niacinamide na niacin nyinshi, bishobora guhinduka NAD + mu mubiri.
Ikibazo: Nigute nahitamo inyongera ya NAD +?
Igisubizo: Mugihe uhisemo inyongera za NAD +, birasabwa kubanza gushaka inama kwa muganga cyangwa inzobere mu mirire kugirango wumve ibyo ukeneye byimirire nubuzima bwawe. Mubyongeyeho, hitamo ikirango kizwi, reba ibicuruzwa nibicuruzwa, hanyuma ukurikize ubuyobozi bwa dosiye kumurongo winjiza.
Inshingano: Iyi ngingo ni iyamakuru rusange gusa kandi ntigomba gusobanurwa nkinama zose zubuvuzi. Amwe muma poste yamakuru aturuka kuri enterineti kandi ntabwo ari umwuga. Uru rubuga rufite inshingano zo gutondeka, gutunganya no guhindura ingingo. Intego yo gutanga amakuru menshi ntabwo bivuze ko wemera ibitekerezo byayo cyangwa kwemeza ukuri kwibirimo. Buri gihe ujye ubaza inzobere mu buzima mbere yo gukoresha inyongeramusaruro cyangwa guhindura ibintu byubuzima bwawe.
Igihe cyo kohereza: Kanama-06-2024
