Gusaza ni inzira buri kinyabuzima kinyuramo.Umuntu ku giti cye ntashobora gukumira gusaza, ariko barashobora gufata ingamba zimwe kugirango bagabanye gahunda yo gusaza no kubaho kwindwara ziterwa nimyaka.Urusobe rumwe rwitabiriwe cyane-nicotinamide riboside, izwi kandi nka NR.Nka NAD + ibanziriza, nicotinamide riboside itekereza ko ifite ingaruka zidasanzwe zo kurwanya gusaza.Mu kongera urwego rwa NAD +, nicotinamide riboside yongera ibikorwa bya sirtuin, itezimbere imikorere ya mito-iyambere, kandi ikora inzira zinyuranye zigira uruhare mubikorwa byo kurwanya gusaza。
Nikotinamide riboside (NR) ni ubwoko bwa vitamine B3, izwi kandi nka acide nicotinike cyangwa aside nicotinike.Nibintu bisanzwe biboneka biboneka muke mubiribwa bimwe na bimwe, nk'amata, umusemburo, n'imboga zimwe.
NR niyo ibanziriza nicotinamide adenine dinucleotide (NAD +), coenzyme igaragara muri selile zose nzima.NAD + igira uruhare runini muburyo butandukanye bwibinyabuzima, harimo kubyara ingufu, gusana ADN, no kugenzura metabolism selile.Mugihe tugenda dusaza, urwego rwacu rwa NAD + rukunda kugabanuka, rushobora guhindura iyi mirimo ikomeye.Inyongera za NR zasabwe nkuburyo bwo kongera urwego rwa NAD + kandi birashoboka ko bidindiza gusaza.
Imwe mu nyungu zingenzi ziyongera kuri NR nubushobozi bwayo bwo kongera imikorere ya mito-iyambere.Mitochondria ni imbaraga zingirabuzimafatizo, ishinzwe kubyara ingufu nyinshi zingirabuzimafatizo muburyo bwa adenosine triphosphate (ATP).NR yerekanwe guteza imbere umusaruro wa ATP yongera urwego rwa NAD +, bityo iteza imbere ingufu zingirakamaro hamwe na metabolism selile.Uku kwiyongera k'umusaruro w'ingufu gushobora kugirira akamaro ingirangingo n'ingingo zitandukanye, harimo ubwonko, umutima, n'imitsi.
●Kongera ingufu za selile
Nikosinamide riboside igira uruhare runini mugutanga ingufu mumashanyarazi, mitochondria.Uru ruganda ni intangiriro ya nicotinamide adenine dinucleotide (NAD +), coenzyme ikomeye igira uruhare mubikorwa byinshi bya selile, cyane cyane metabolism yingufu.Ubushakashatsi bwerekana ko kuzuza NR bishobora kongera urwego rwa NAD + kandi bigateza imbere guhumeka neza ningirabuzimafatizo.
Urwego rwa NAD + rukunda kugabanuka uko tugenda dusaza, biganisha ku mikorere ya mitochondial igabanuka no kugabanuka kurwego rusange.Ariko, hiyongereyeho nicotinamide riboside, birashoboka guhindura uku kugabanuka no kugarura urwego rwingufu.NR kandi yabonetse kugirango yongere imbaraga zo kwihangana kumubiri no kunoza imikorere yimikino, bituma iba ikibuga cyiza kubakinnyi nabantu bashaka ubuzima bwiza.
●Kongera gusana selile no kurwanya gusaza
Ikindi kintu gishimishije cya nicotinamide riboside nubushobozi bwayo bwo guteza imbere gusana ADN no kurwanya ibyangizwa nimyaka.NAD + nikintu cyingenzi mubikorwa byo gusana ADN.Mu kuzuza NR kugirango twongere urwego rwa NAD +, dushobora kongera ubushobozi bwakagari ko gusana ADN, bityo tukarinda neza gusaza.
Byongeye kandi, NR yagize uruhare mugutunganya inzira zingenzi zo kuramba, nka sirtuins, bigira uruhare runini mukubungabunga imikorere myiza ya selile.Izi genes ziramba zifasha guhindura uburyo bwo kwirwanaho bwingirabuzimafatizo zirwanya imihangayiko no guteza imbere kuramba muri rusange.Mugukoresha sirtuins, nicotinamide riboside irashobora gufasha gutinza indwara ziterwa nimyaka kandi birashobora kwagura ubuzima bwacu.
●Irinde indwara zifata ubwonko
Indwara zifata ubwonko nka Alzheimer na Parkinson ziragenda ziyongera muri sosiyete yacu.Ubushakashatsi bwerekana ko nicotinamide riboside ishobora kuba ifite amasezerano yo gukumira izo ndwara zica intege.Ubushakashatsi bwerekanye ko ubuyobozi bwa NR bwongera imikorere ya mitochondial, bugabanya imihangayiko ya okiside, kandi bukanonosora imitsi, ibyo byose bigira uruhare mu bwonko bwiza.
Byongeye kandi, inyongera ya NR yahujwe no kongera imikorere yubwenge, kugumana kwibuka, no kunoza kwibanda no kwitabwaho.Mugihe hakenewe ubundi bushakashatsi, ubushakashatsi bwibanze bwerekana ko nicotinamide riboside ishobora kwerekana ko ari ingamba zishobora gukumira cyangwa gutera inkunga abantu bafite ibyago byo kwandura indwara.
●Kongera insuline
Ubushakashatsi bwinshi bwerekanye ko NR ifite ubushobozi bwo kuzamura ubuzima bwimikorere muri rusange.Byerekanwe kongera imbaraga za insuline, ikintu cyingenzi mu gukomeza isukari nziza mu maraso no kwirinda indwara ya diyabete yo mu bwoko bwa 2.Ubushakashatsi bwerekanye kandi ko inyongera ya NR ishobora kunoza metabolisme ya lipide, bityo bikagabanya urugero rwa cholesterol na triglyceride.Izi ngaruka ni ingenzi cyane kubantu bafite ikibazo cyo guhindagurika cyangwa abafite umubyibuho ukabije cyangwa umubyibuho ukabije.
●Ifite ubushobozi bwa antioxydeant
Byongeye kandi, NR yerekanwe mu kongera imbaraga zo kwirinda selile ziterwa na okiside.Guhangayikishwa na Oxidative bibaho mugihe habaye ubusumbane hagati yumusemburo wubwoko bwa ogisijeni (ROS) nubushobozi bwumubiri bwo kubutandukanya na antioxydants.Umuvuduko ukabije wa okiside urashobora kwangiza selile kandi ukagira uruhare mu gutera imbere kwindwara zitandukanye, harimo kanseri, indwara zifata umutima, nindwara zifata ubwonko.Ubushakashatsi bwerekanye ko kuzuza NR bishobora kongera ubushobozi bwa antioxydants ya selile kandi bikagabanya ingaruka ziterwa na okiside ku mubiri.
Ubushakashatsi bwerekana ko nicotinamide riboside ifite ubushobozi bwo gutinda gusaza byongera urugero rwa molekile ya nicotinamide adenine dinucleotide (NAD +).NAD + ni molekile y'ingenzi igira uruhare runini muri metabolism selile.
Urwego rwa NAD + rusanzwe rugabanuka uko dusaza.Uku kugabanuka gufatwa nkimpamvu nyamukuru itera gusaza.Mu kongera urwego rwa NAD +, nicotinamide riboside irashobora gufasha kugabanya iri gabanuka no kugabanya ingaruka zo gusaza.
NAD + igira uruhare mubikorwa byinshi bya selile, harimo kubyara ingufu, gusana ADN, no kwerekana gene.Mugukomeza urwego rwa NAD +, nicotinamide riboside irashobora kuzamura izi nzira no kunoza imikorere ya selile.
Ubushakashatsi bwinshi bwerekanye ibisubizo bitanga umusaruro mu ngirabuzimafatizo n’inyamaswa.Mu bushakashatsi bumwe, abashakashatsi basanze inyongera ya nicotinamide riboside yongereye urugero rwa NAD + mu myanya y’imitsi, bityo imikorere ya mito-iyambere ikanakora imikorere yimbeba.
Ubundi bushakashatsi bwerekanye ko kuzuza nicotinamide riboside byongereye insuline no kwihanganira glucose mu mbeba zifite umubyibuho ukabije, prediabete.Ibi birerekana ko nicotinamide riboside ishobora no kugira inyungu kubuzima bwa metabolike.
Mu bushakashatsi bumwe bwakozwe ku bantu bakuze ndetse n'abakuru, inyongera ya nicotinamide riboside yongereye urugero rwa NAD + kandi itera umuvuduko w'amaraso no gukomera kwa arterial, ibimenyetso bibiri by'ingenzi bigize ubuzima bw'umutima.
Mu bundi bushakashatsi, abashakashatsi basanze inyongera ya nicotinamide riboside yatezimbere imikorere yimitsi kandi irinda gutakaza imitsi kubantu bakuze.Ibi byerekana ko nicotinamide riboside ishobora kugira inyungu zishobora kugabanuka kumitsi.
Birakwiye ko tumenya ko gusaza ari inzira igoye iterwa nibintu byinshi, harimo genetiki, imibereho n'ibidukikije.Nikosinamide riboside igomba gufatwa nkinyongera ishobora gufasha gutinda gusaza no gushyigikira gusaza neza aho kuba amasasu.
BenshiNAD + hamenyekanye ababanjirije, harimo nicotinamide riboside (NR), nicotinamide mononucleotide (NMN), na aside nicotinike (NA).Ibi bibanziriza byahinduwe muri NAD + rimwe imbere muri selire.
Muri ibyo bibanziriza iki, nicotinamide riboside yitabiriwe cyane kubera ituze ryayo, bioavailable, hamwe nubushobozi bwo kuzamura neza urwego rwa NAD +.NR ni uburyo busanzwe bwa vitamine B3 kandi buboneka mu bwinshi bw'amata n'ibindi biribwa.Byerekanwe kuzamura NAD + synthesis no gukangurira ibikorwa bya sirtuins, itsinda rya poroteyine zijyanye no kuramba.
Kimwe mu byiza bya nicotinamide riboside nubushobozi bwayo bwo kurenga intambwe ndende isabwa kuri NAD + synthesis.Irashobora guhindurwa muri NAD + bidakenewe enzymes ziyongera.Ibinyuranye, ibindi bibanziriza nka nicotinamide mononucleotide bisaba izindi ntambwe zidasanzwe zirimo nicotinamide fosiforiibosyltransferase (NAMPT) kugirango ihindurwe NAD +.
Ubushakashatsi bwinshi bwagereranije imikorere ya nicotinamide riboside nizindi NAD + zabanjirije, kandi NR ihora isohoka hejuru.Mu bushakashatsi bwibanze ku mbeba zishaje, inyongera ya nikotinamide riboside yasanze yongera urwego rwa NAD +, kunoza imikorere ya mito-iyambere, no kongera imikorere yimitsi.
Ubushakashatsi buteganijwe, buhumye-buhumyi, bugenzurwa na placebo mubantu bakuze bafite ubuzima bwiza nabwo bwerekanye ibisubizo bitanga icyizere.Urwego rwa NAD + rwiyongereye cyane mubitabiriye gufata nicotinamide riboside ugereranije nitsinda rya placebo.Byongeye kandi, bavuze ko imikorere myiza yo kumenya no kugabanya umunaniro udasanzwe.
Mugihe abandi babanjirije NAD +, nka nicotinamide mononucleotide na niacin, bagaragaje ingaruka nziza kurwego rwa NAD + mubushakashatsi bumwe na bumwe, ntibaragaragaza urwego rwiza nka nicotinamide riboside.
Ni ngombwa kumenya ko nubwo nicotinamide riboside isa nkaho ikora neza mukongera urwego rwa NAD +, ibisubizo byabantu birashobora gutandukana.Abantu bamwe bashobora gusanga abandi babanjirije, nka nicotinamide mononucleotide cyangwa niacin, bikwiranye nibyifuzo byabo byihariye.
Nikotinamide riboside yinyongera iraboneka muri tablet, capsule, nifu yifu.Kubona ibipimo byiza bya NR biterwa ahanini nibintu bitandukanye, harimo imyaka, ubuzima, n'ingaruka zifuzwa.Kubwibyo, burigihe nibyiza kubaza inzobere mubuzima mbere yo gutangira gahunda nshya yinyongera, kuko zishobora gutanga inama yihariye ukurikije ibyo ukeneye byihariye.
Byongeye kandi, hamwe na NR izwi cyane kandi ibicuruzwa bitabarika byuzuye ku isoko, ni ngombwa guhitamo isoko yizewe kandi izwi.Hano hari ibintu by'ingenzi ugomba gusuzuma muguhitamo inyongera ya NR:
1. Isuku nubuziranenge: Shakisha ibicuruzwa byageragejwe nundi muntu wa gatatu kandi byemejwe kugirango byuzuze ubuziranenge bukomeye.Shakisha inyongera zidafite ibyuzuzo, inyongeramusaruro zangiza, nibishobora kwanduza.
2. Imyitozo yo gukora: Hitamo inyongera zakozwe mubikoresho byanditswe na FDA hanyuma ukurikize amabwiriza meza yo gukora (GMP).Ibi bituma ibicuruzwa bihoraho, umutekano kandi neza.
4. Icyubahiro no Gusubiramo Abakiriya: Reba isuzuma ryabakiriya nu amanota kugirango umenye neza imikorere yinyongera no kunyurwa kwabakiriya muri rusange.
Ikibazo: Nigute Nikotinamide Riboside (NR) ikora?
Igisubizo: Nikotinamide Riboside (NR) ikora mukongera urwego rwa NAD + mumubiri.NAD + igira uruhare mu gukora ingufu za selile, gusana ADN, no kubungabunga ubuzima n'imikorere ya mitochondria.
Ikibazo: Ni izihe ngaruka zishobora kurwanya gusaza kwa Nikotinamide Riboside (NR)?
Igisubizo: Nikotinamide Riboside (NR) yerekanye ingaruka nziza zo kurwanya gusaza binyuze mu ruhare rwayo mu kuzamura urwego rwa NAD +.Kongera urwego rwa NAD + birashobora kongera imikorere ya mitochondial, guteza imbere ingufu za selile, no guteza imbere ADN gusana, ibyo byose bishobora kugira uruhare mukurwanya kugabanuka kwimyaka no kuzamura ubuzima muri rusange.
Inshingano: Iyi ngingo ni iyamakuru rusange gusa kandi ntigomba gusobanurwa nkinama zose zubuvuzi.Amwe mumakuru yohereza amakuru aturuka kuri enterineti kandi ntabwo ari umwuga.Uru rubuga rufite inshingano zo gutondeka, gutunganya no guhindura ingingo.Intego yo gutanga amakuru menshi ntabwo bivuze ko wemera ibitekerezo byayo cyangwa kwemeza ukuri kwibirimo.Buri gihe ujye ubaza inzobere mu buzima mbere yo gukoresha inyongera cyangwa guhindura ibintu byubuzima bwawe.
Igihe cyo kohereza: Ugushyingo-10-2023
