Ibikoresho bya mitofagy byizewe & ibikoresho bishya birwanya gusaza-Urolithin A.

Amateka yaurolithin A (UA)Irashobora kuva mu 2005. Ni metabolite ya mikorobe yo mu mara kandi ntishobora kongerwaho mu buryo butaziguye binyuze mu nzira y'imirire. Nyamara, ibanziriza ellagitannine ikungahaye ku mbuto zitandukanye nk'amakomamanga na strawberry.

Uruhare rwa urolithin A.

Ku ya 25 Werurwe 2016, ubushakashatsi bukomeye mu kinyamakuru "Ubuvuzi bwa Kamere" bwashishikarije abari aho isano bifitanye no gutinda gusaza kwabantu. Kuva byavumburwa mu 2016 ko UA ishobora kongera ubuzima bwa C. elegans, UA yakoreshejwe mu nzego zose (hematopoietic stem selile, tissue tissue, ubwonko (ingingo), sisitemu yumubiri, ubuzima bwa buri muntu) no mubwoko butandukanye (C. elegans, melanogaster Ingaruka zo kurwanya gusaza zagaragaye cyane mubisazi byimbuto, imbeba, nabantu.

(1) Kurwanya gusaza no kongera imikorere yimitsi
Ikigeragezo cy’amavuriro cyateguwe cyasohotse muri JAMA Network Open, ikinyamakuru gishamikiye ku kinyamakuru cy’Abanyamerika cy’ubuvuzi, cyerekanye ko ku bageze mu za bukuru cyangwa abantu bafite ikibazo cyo kwimuka kubera uburwayi, inyongera za UA zishobora gufasha kuzamura ubuzima bw’imitsi no gukora imyitozo isabwa.

(2) Fasha mukuzamura ubushobozi bwo kurwanya ibibyimba byo gukingira indwara
Mu 2022, itsinda ry’ubushakashatsi bwa Florian R. Greten wo mu kigo cya Georg-Speyer-Haus Institute of Tumor Biology and Experimental Therapeutics mu Budage bavumbuye ko UA ishobora gutera mitofagy mu tugari T, igateza imbere irekurwa rya PGAM5, igakora inzira yerekana ibimenyetso bya Wnt, kandi kuzamura T yibuka stem selile. kwibumbira hamwe, bityo biteza imbere ubudahangarwa bw'umubiri.

(3) Hindura gusaza kwa hematopoietic stem selile na sisitemu yumubiri
Mu bushakashatsi bwakozwe mu 2023, kaminuza ya Lausanne mu Busuwisi yize ku ngaruka zayo kuri sisitemu ya hematopoietic yemerera imbeba z’amezi 18 kurya ibiryo bikungahaye kuri urolithine A mu gihe cy’amezi 4 no gukurikirana impinduka z’uturemangingo tw’amaraso buri kwezi. Ingaruka.
Ibisubizo byerekanye ko indyo ya UA yongereye umubare wuturemangingo twa hematopoietic stem selile na lymphoide progenitor, kandi bigabanya umubare wa selile progenitor. Ubu bushakashatsi bwerekana ko indyo ishobora guhindura zimwe mu mpinduka muri sisitemu ya hematopoietic ijyanye no gusaza.

(4) Ingaruka zo kurwanya inflammatory
Igikorwa cyo kurwanya inflammatory ya UA kirakomeye kandi kirashobora guhagarika cyane ibintu bitandukanye bisanzwe bitera nka TNF-α. Niyo mpamvu rwose niyo mpamvu UA igira uruhare mubuvuzi butandukanye burimo ubwonko, ibinure, umutima, amara nu mwijima. Irashobora kugabanya uburibwe mu ngingo zitandukanye.

(5) Neuroprotection
Bamwe mu bahanga bemeje ko UA ishobora kubuza inzira ya apoptose ya mitochondriya no kugenzura inzira ya p-38 MAPK yerekana inzira, bityo ikabuza guhagarika umutima biterwa na apoptose. Kurugero, UA irashobora kuzamura igipimo cyo kubaho kwa neuron iterwa na stress ya okiside kandi ifite imikorere myiza ya neuroprotective.

(6) Ingaruka zamavuta
UA irashobora kugira ingaruka kuri selile ya lipide metabolism na lipogenez. Ubushakashatsi bwerekanye ko UA ishobora gutera gukora ibinure byijimye no gukara ibinure byera, mugihe ikumira ibinure biterwa nimirire.

(7) Kunoza umubyibuho ukabije
UA irashobora kandi kugabanya ikwirakwizwa ryamavuta muri adipocytes na selile yumwijima ikura muri vitro kandi ikongera okiside yibinure. Irashobora guhindura T4 idakora cyane muri tiroxine muri T3 ikora cyane, ikongerera umuvuduko wa metabolike nubushuhe bukoresheje ibimenyetso bya thyroxine. , bityo ukagira uruhare mukurwanya umubyibuho ukabije.

(8) Rinda amaso
Mitofagy inducer UA irashobora kugabanya imbaraga za okiside muri retina ishaje; bigabanya urwego rwa cytosoliki cGAS kandi bigabanya gukora glial selile muri retina ishaje.

(9) Kwita ku ruhu
Mu bintu byose byabonetse by’inyamabere zo mu nda, UA ifite ibikorwa bikomeye bya antioxydeant, ikurikirwa na oligomers ya proanthocyanidin, catechine, epicatechin na aside 3,4-dihydroxyphenylacetic. rindira.

Urolithin Ikoreshwa rya porogaramu

Muri 2018, UA yagenwe n’ubuyobozi bw’ibiribwa n’ibiyobyabwenge muri Amerika nk’ibiribwa "bisanzwe bizwi ko bifite umutekano" kandi birashobora kongerwaho kunyeganyezwa kwa poroteyine, ibinyobwa bisimbuza ifunguro, oatmeal ako kanya, utubari twa poroteyine nintungamubiri (kugeza kuri mg 500) .

UA irashobora kandi kongerwa mubicuruzwa byita ku ruhu, harimo amavuta yo kwisiga, amavuta yo kwisiga nijoro hamwe na serumu ikomatanya, igamije kongera uruhu rwuruhu no kugabanya cyane iminkanyari, kunoza imiterere yuruhu imbere, no kurwanya neza ibimenyetso bigaragara byubusaza. , gufasha uruhu gukomeza kuba muto.

Urolithin Igikorwa cyo gukora

(1) Inzira yo gusembura
Umusaruro wubucuruzi wa UA ubanza kugerwaho hifashishijwe ikoranabuhanga rya fermentation, ikomoka cyane cyane mubishishwa by'amakomamanga kandi ifite urolithine Ibirimo birenga 10%.
(2) Uburyo bwo guhuza imiti
Hamwe no guhanga udushya no guteza imbere ubushakashatsi, synthèse chimique nuburyo bwingenzi bwo gukora inganda za urolithin A. Suzhou Myland Pharm ni inyongera yubumenyi bwubuzima bushya, synthesis gakondo hamwe na serivise zikora inganda zishobora gutanga ubuziranenge-bwinshi, urolithine nini cyane ifu y'ibikoresho fatizo.