Ibikoresho fatizo bya mitophagy byuzuye umutekano n'ibikoresho bishya birwanya gusaza - Urolithin A

Amateka yaurolithine A (UA)ishobora gukurikirwa no mu 2005. Ni igikoresho cy’udukoko two mu mara kandi ntigishobora kongerwamo mu buryo butaziguye binyuze mu mirire. Ariko, icya mbere cyayo ellagitannins gikungahaye ku mbuto zitandukanye nka pomegranate na strawberry.

Uruhare rwa urolithine A

Ku ya 25 Werurwe 2016, ubushakashatsi bukomeye bwakozwe mu kinyamakuru "Nature Medicine" bwakuruye abari aho ku isano iri hagati yabwo n’igabanuka ry’ubusaza bw’abantu. Kuva aho bivumburiwe mu 2016 ko UA ishobora kongera igihe cy’ubuzima bwa C. elegans, UA yakoreshejwe ku nzego zose (uturemangingo tw’amaraso, ingirabuzimafatizo z’uruhu, ubwonko (ingingo), ubudahangarwa bw’umubiri, igihe cy’ubuzima bw’umuntu ku giti cye) no mu moko atandukanye (C. elegans, melanogaster Ingaruka zo kurwanya gusaza zagaragaye cyane ku mpungenge z’imbuto, imbeba, n’abantu.

(1) Kurwanya gusaza no kongera imikorere y'imitsi
Igerageza ryakozwe ku buryo butaziguye ryasohotse muri JAMA Network Open, ikinyamakuru ishamikiye kuri Journal of the American Medical Association, ryagaragaje ko ku bageze mu za bukuru cyangwa abantu bafite ikibazo cyo kwimuka bitewe n’uburwayi, inyongeramusaruro za UA zishobora gufasha kunoza ubuzima bw’imitsi no gukora imyitozo ngororamubiri ikenewe.

(2) Gufasha mu kongera ubushobozi bwo kurwanya kanseri bw'ubudahangarwa bw'umubiri
Mu 2022, itsinda ry’abashakashatsi rya Florian R. Greten wo mu Kigo cya Georg-Speyer-Haus cy’Ubushakashatsi ku Binyabuzima bya Kamonyi n’Ubuvuzi bw’Ibizamini mu Budage ryavumbuye ko UA ishobora gutera imitofagi mu turemangingo twa T, igatuma PGAM5 irekurwa, igatuma inzira ya Wnt signaling pathway, kandi igateza imbere ishingwa rya T memory stem cells., bityo igateza imbere ubudahangarwa bw’umubiri bwo kurwanya kamonyi.

(3) Gusubiza inyuma gusaza kw'uturemangingo tw'amaraso n'ubudahangarwa bw'umubiri
Mu bushakashatsi bwakozwe mu 2023, Kaminuza ya Lausanne mu Busuwisi yize ku ngaruka zayo ku mikorere y'amaraso, yemerera imbeba z'amezi 18 kurya ibiryo bikungahaye kuri urolithin A mu gihe cy'amezi 4 no gukurikirana impinduka mu turemangingo tw'amaraso yazo buri kwezi.
Ibisubizo byagaragaje ko indyo ya UA yongereye umubare w'uturemangingo tw'amaraso n'uturemangingo tw'amaraso, kandi ikagabanya umubare w'uturemangingo tw'amaraso. Ibi bigaragaza ko iyi ndyo ishobora guhindura zimwe mu mpinduka mu mikorere y'amaraso zijyanye no gusaza.

(4) Ingaruka zo kurwanya ububyimbirwe
Imikorere ya UA irwanya ububyimbirwe irakomeye cyane kandi ishobora gukumira ibintu bitandukanye bisanzwe bitera ububyimbirwe nka TNF-α. Niyo mpamvu UA igira uruhare mu kuvura ububyimbirwe butandukanye harimo ubwonko, ibinure, umutima, amara n'umwijima. Ishobora kugabanya ububyimbirwe mu ngingo zitandukanye.

(5) Kurinda ubwonko
Hari intiti zemeza ko UA ishobora kubuza inzira ya apoptosis ifitanye isano na mitochondria no kugenzura inzira ya p-38 MAPK, bityo ikabuza apoptosis iterwa na oxidative stress. Urugero, UA ishobora kongera umuvuduko wo kubaho kwa neuron ziterwa na oxidative stress kandi ikagira imikorere myiza yo kurinda ubwonko.

(6) Ingaruka z'ibinure
UA ishobora kugira ingaruka ku mikorere y'uturemangingo tw'ibinure no ku ikorwa ry'amavuta. Ubushakashatsi bwagaragaje ko UA ishobora gutuma ibinure by'umukara bitangira gukora no guhindura ibinure byera, mu gihe ikarinda ibinure kwiyongera bitewe n'imirire.

(7) Kongera umubyibuho ukabije
UA ishobora kandi kugabanya ukwiyongera kw'ibinure mu turemangingo tw'amafuta n'umwijima byakorewe muri vitro no kongera ogisijeni y'ibinure. Ishobora guhindura T4 idakora cyane muri thyroxine ikayihindura T3 ikora cyane, yongera umuvuduko wa metabolisme n'umusaruro w'ubushyuhe binyuze mu gutanga ibimenyetso bya thyroxine. , bityo ikagira uruhare mu kugenzura umubyibuho ukabije.

(8) Rinda amaso
Iterambere rya mitophagy UA rishobora kugabanya stress ya oxidative muri retina ishaje; rigabanya urugero rwa cytosolic cGAS kandi rigagabanya gukora kwa selile za glial muri retina ishaje.

(9) Kwita ku ruhu
Mu bintu byose byabonetse mu mara y'inyamabere, UA ifite imikorere ikomeye ya antioxydant, ikaba iya kabiri nyuma ya proanthocyanidin oligomers, catechins, epicatechin na aside 3,4-dihydroxyphenylacetic.

Uburyo bwo gukoresha Urolithin A

Mu 2018, UA yagenwe n’Ikigo cy’Ibiribwa n’Imiti cya Amerika nk’ikintu kiribwa “cyemewe muri rusange ko gifite umutekano” kandi gishobora kongerwa mu binyobwa biryoshye bya poroteyine, ibinyobwa bisimbura ibiryo, oatmeal instantly, protein bar n’ibinyobwa by’amata (kugeza kuri 500 mg/ifunguro)), yawurute y’Abagereki, yawurute irimo poroteyine nyinshi n’ibinyobwa biryoshye bya poroteyine y’amata (kugeza kuri 1000 mg/ifunguro).

UA ishobora kandi kongerwa mu bikoresho byo kwita ku ruhu, harimo amavuta yo ku manywa, amavuta yo kwisiga nijoro n'amavange y'amaraso, yagenewe kongera amazi mu ruhu no kugabanya cyane iminkanyari, kunoza imiterere y'uruhu imbere no hanze, no kurwanya neza ibimenyetso bigaragara byo gusaza. , bifasha uruhu kuguma rukiri rushya.

Uburyo bwo gukora Urolithin A

(1) Uburyo bwo guhisha
Umusaruro w’ubunyobwa bwa UA uboneka bwa mbere binyuze mu ikoranabuhanga ryo gushyushya, rikunze gushyushya mu bishishwa by’amakomamanga kandi rifite urolithin A irenga 10%.
(2) Uburyo bwo guhuza imiti
Hamwe n’udushya duhoraho n’iterambere ry’ubushakashatsi, guhuza imiti ni uburyo bw’ingenzi bwo gukora urolithin A mu nganda. Suzhou Myland Pharm ni ikigo gishya gishinzwe inyongeramusaruro mu buzima, gukora ibintu byihariye no gukora ibikoresho bishobora gutanga ibikoresho fatizo bya urolithin A bifite ifu nziza kandi nini.