Salidroside: Kumenyekanisha ibanga rya antioxydeant ya Rhodiola rose

Salidroside ni antioxydants karemano irinda ingirangingo zogosha ROS no kubuza apoptose selile.

Indwara ya calcium irenze urugero ni imwe mu mpamvu nyamukuru zitera apoptose ya neuronal. Rhodiola rosea ikuramo na salidroside irashobora kugabanya kwiyongera kurwego rwa calcium yubusa ya calcium iterwa na stress ya okiside kandi ikarinda selile cortique yabantu glutamate. Salidroside irashobora kubuza lipopolysaccharide iterwa na microglial activation, ikabuza NTA musaruro, ikabuza ibikorwa bya nitric okiside synthase (iNOS), kandi bikagabanya urwego rwa TNF-α na IL-1β, IL-6.

Salidroside ibuza okiside ya NADPH 2 / ROS / mitogen-ikora protein kinase (MAPK) hamwe nigisubizo cyo kwiteza imbere no kwangiza ADN 1 (REDD1) / inyamaswa z’inyamabere za rapamycin (mTOR) / p70 ribosome Poroteyine S6 kinase yerekana inzira ikora AMP iterwa na AMP protein kinase / gucecekesha amakuru agenga 1, RAS homologous gene mumuryango A / MAPK na PI3K / Akt yerekana inzira.

1. Salidroside irwanya kwangirika kwubusa kandi ikingira umubiri

Umubiri urashobora kubyara umubare munini wa endogenous radicals yubusa mugihe cyimikorere isanzwe ya physiologique, kandi dose ya physiologique ya radicals yubusa irakenewe kugirango ibikorwa byumubiri bisanzwe bishoboke. Hariho na sisitemu yubusa ya radical scavenging mumubiri kugirango ikureho radicals yubusa irenze dosiye yumubiri kugirango itangiza ubuzima bwumubiri.

Nubwo bimeze bityo ariko, bitewe n’ibintu bimwe bidasanzwe by’ibidukikije, umubiri wa endogenous free radicals uzaba urenze urugero kandi urenze igipimo cy’ubusa cya sisitemu yo kwisuzumisha, bigatuma habaho ubusumbane muri ogisijeni ya ogisijeni y’umubiri itangiza umusaruro, bigatuma habaho kwirundanya kwa radicals yubusa. mu mubiri, bityo bigatera kwangirika kwa selile. ibyangiritse.

Ubushakashatsi bwerekana ko ibidukikije bya hypoxique mu bihe bya plateau bishobora gutera ubusumbane muri metabolisme idafite umwuka wa ogisijeni, kwegeranya radicals yubusa no kongera ibicuruzwa bya lipide peroxidation. Ubushakashatsi bwerekanye ko salidroside ishobora kurinda ingirabuzimafatizo zangiza umubiri mu mubiri.

2. Salidroside irwanya hypoxia kugirango igumane imikorere yimikorere ya mito-iyambere

Hafi ya 80-90% ya ogisijeni yo mu nda ikoreshwa mu okiside y’ibinyabuzima muri mitochondriya kugira ngo itange ATP kandi ikore ubwoko bwa ogisijeni ikora ROS kugira ngo ibungabunge ubuzima busanzwe bw’utugingo ngengabuzima. 10-20% byonyine bya ogisijeni ni ubuntu hanze ya mitochondriya ya biosynthesis, kwangirika, biotransformation (detoxification), nibindi. sisitemu y'ubuhumekero.

Indwara ya hypoxia ikabije izabanza kugira ingaruka kuri ogisijeni yo hanze ya mitochondriya hamwe n’imikorere mibi ya metabolike y’umubiri, igabanye umusaruro wa neurotransmitter, kandi igabanye ubushobozi bw’ibinyabuzima, bityo bikagira ingaruka ku mikorere yimitsi ningingo. Ubushakashatsi bwerekanye ko salidroside ishobora kurinda imikorere yimikorere ya mito-iyambere mugabanya ibirimo ROS muri mitochondriya, kongera ibikorwa bya SOD, no kongera mitochondriya.

3. Ingaruka zo gukingira Myocardial salidroside

Ubushakashatsi bwerekanye ko sisitemu yumutima nimiyoboro niyo sisitemu nyamukuru ihindura ibidukikije bya hypoxic. Ibidukikije bya hypoxic bizatera umubiri wa metabolisme ya aerobic umubiri kugabanuka no gutanga ingufu zidahagije, biganisha ku bimenyetso nka hypoxia, ischemia, na apoptose ya selile myocardial. Ubushakashatsi bwerekanye ko salidroside ishobora kongera imikorere yumutima no kunoza microcirculation mu kwagura imiyoboro yamaraso ya arterial na venine, kunoza amaraso ya myocardial, guhindura hemodinamike yumutima, kugabanya imitima yumutima, no kwangiza ischemic myocardial.
Muri make, salidroside irashobora gukora kuri sisitemu yumutima nimiyoboro ikoresheje uburyo bwinshi, inzira, nintego, kurinda apoptose ya myocardial selile iterwa nimpamvu nyinshi, kandi igateza ischemia yumubiri hamwe na hypoxia. Mubidukikije bya hypoxic, uruhare rwa Rhodiola rosea rufite akamaro kanini mukurinda ingirangingo n'ingingo z'umubiri no gukomeza imikorere yimikorere. Ifite uruhare runini mu gukumira no kugabanya indwara zo mu butumburuke.
Imiterere yumusaruro wa salidroside

1) Ahanini gushingira ku gukuramo ibimera

Rhodiola rosea nibikoresho fatizo byasalidroside.Nkubwoko bwibimera bimera, Rhodiola rose ikura cyane mubice bifite ubukonje bwinshi, anoxia, akuma, nubushyuhe butandukanye hagati yumunsi nijoro ku butumburuke bwa metero 1600-4000. Ni kimwe mu bimera byo mu gasozi. Ubushinwa ni kamwe mu turere tw’ibanze twa Rhodiola roza ku isi, ariko ingeso zo kubaho za Rhodiola roza zirihariye. Ntabwo bigoye guhinga gusa, ariko umusaruro wubwoko bwishyamba ni muto cyane. Icyuho gisabwa buri mwaka kuri Rhodiola rosea kiri hejuru ya toni 2200.

2) Synthesis ya chimique na fermentation ya biologiya

Bitewe nibirimo bike hamwe nigiciro kinini cyumusaruro mubihingwa, usibye uburyo bwo kuvoma bisanzwe, uburyo bwo gukora salidroside burimo nuburyo bwo guhuza imiti, uburyo bwo gusembura ibinyabuzima, nibindi. Muri byo, uko ikoranabuhanga rikomeje gukura, fermentation yibinyabuzima yabaye inzira nyamukuru inzira ya tekiniki yo guteza imbere ubushakashatsi no gukora salidroside. Kugeza ubu, Suzhou Mailun yageze ku bushakashatsi n’iterambere kandi yageze ku nganda.