Salidroside: Guhishura ibanga ry'imiterere y'uturemangingo twa Rhodiola rosea mu kurwanya imisemburo mibi

Salidroside ni antioxydant karemano irinda uturemangingo tw’imitsi binyuze mu gukuraho ROS no kubuza apoptosis y’uturemangingo.

Kurenza urugero rwa kalisiyumu mu turemangingo ni imwe mu mpamvu zikomeye zitera apoptosis y’imitsi y’ubwonko. Isosi ya Rhodiola rosea na salidroside bishobora kugabanya ubwiyongere bw’urugero rwa kalisiyumu yigenga mu turemangingo ruterwa n’ihungabana rya ogisijeni no kurinda uturemangingo tw’umubiri w’umuntu glutamate. Salidroside ishobora kubuza gukora kwa mikoroglia iterwa na lipopolysaccharide, ikabuza ikorwa rya NO, ikabuza imikorere ya nitric oxide synthase (iNOS), kandi ikagabanya urugero rwa TNF-α na IL-1β, IL-6.

Salidroside ibuza NADPH oxidase 2/ROS/mitogen-activated protein kinase (MAPK) hamwe n’umugenzuzi w’iterambere n’iyangirika rya ADN 1 (REDD1)/intego ya mammalian ya rapamycin (mTOR)/p70 ribosome. Inzira yo gutanga ibimenyetso bya poroteyine S6 kinase ikora ku muyobozi wa poroteyine kinase/amakuru adacecetse 1, RAS homologous gene family member A/MAPK na PI3K/Akt signaling pathways.

1. Salidroside irwanya kwangiza uturemangingo tw’ubuntu kandi ikarinda umubiri

Umubiri ushobora gukora ingano runaka ya radicals free endogenous mu gihe cy’imikorere isanzwe ya physiological, kandi ingano runaka ya radicals free irakenewe kugira ngo ibikorwa by’umubiri bikomeze. Hariho kandi uburyo bwo gukusanya radicals free mu mubiri kugira ngo ukureho radicals free irenze urugero rwa physiological kugira ngo bitabangamira ubuzima bw’umubiri.

Ariko, bitewe n’ibintu bimwe na bimwe bidasanzwe bidukikije, ibintu bikomoka ku isanzure mu mubiri bizaba byinshi cyane kandi birengeje igipimo cyo gukusanya ibintu bikomoka ku isanzure mu mubiri, bigatera ubusumbane mu mikorere y’umubiri ikomoka ku isanzure mu mubiri, bigatuma ibintu bikomoka ku ruhu mu mubiri byiyongera, bityo bigatera kwangirika k’uturemangingo tw’umubiri.

Ubushakashatsi bwerekana ko ibidukikije bifite ubushyuhe bwinshi mu gihe cy’isuku bishobora gutera ubusumbane mu mikorere y’uturemangingo tudafite ogisijeni, bigatuma habaho ubwiyongere bw’uturemangingo tw’umubiri mu turemangingo no kongera umusaruro w’uturemangingo tw’amavuta. Ubushakashatsi bwerekanye ko salidroside ishobora kurinda uturemangingo tw’umubiri binyuze mu gukuraho uturemangingo tw’umubiri mu mubiri.

2. Salidroside irwanya hypoxia kugira ngo ikomeze gukora neza kwa mitochondrial

Hafi 80-90% bya ogisijeni yo mu ngirabuzimafatizo ikoreshwa mu gukora ogisijeni y’ibinyabuzima muri mitochondria kugira ngo ikore ATP kandi ikore ubwoko bwa ogisijeni bukora ROS kugira ngo ikomeze gukora ibikorwa bisanzwe by’uturemangingo. 10-20% gusa bya ogisijeni ni byo bidafite ubuzima hanze ya mitochondria kugira ngo bikore biosynthesis, kwangirika, guhinduka kwa biosoxide (gukuraho uburozi), nibindi. Imikorere y’ubuhumekero bwa Mitochondria irushaho kwiyongera iyo umuntu adafite ogisijeni yoroheje cyangwa mu ntangiriro ya hypoxia, ibi bikaba bigaragazwa nk'igisubizo cy’uburyo umubiri uhumeka.

Kubura umwuka mwinshi mu mubiri bizagira ingaruka ku ishyirwa ry’umwuka mu mubiri no ku mikorere mibi y’umubiri, bigabanye ikorwa rya neurotransmitters, kandi bigabanye ubushobozi bwo guhindura imiterere y’umubiri, bityo bikagira ingaruka ku mikorere y’ingingo n’ingingo. Ubushakashatsi bwagaragaje ko salidroside ishobora kurinda imikorere ya mitochondrial binyuze mu kugabanya ROS muri mitochondria y’uturemangingo, kongera imikorere ya SOD, no kongera umubare wa mitochondrial.

3. Ingaruka zo kurinda umutima za salidroside

Ubushakashatsi bwagaragaje ko sisitemu y'umutima n'imitsi ari yo sisitemu nyamukuru ihindura ibidukikije bifite ubushyuhe bukabije. Ahantu hafite ubushyuhe bukabije bizatuma imikorere y'umubiri mu mubiri igabanuka kandi ntihagire ingufu nyinshi, bigatera ibimenyetso nko kubura umwuka uhagije, kubura amaraso, no kubura kw'uturemangingo tw'umutima. Ubushakashatsi bwagaragaje ko salidroside ishobora kongera imikorere y'umutima no kunoza imiyoboro y'amaraso binyuze mu kwagura imiyoboro y'amaraso n'imitsi, kunoza uburyo amaraso y'umutima anyuramo, guhindura uburyo umutima ugenda utera, kugabanya umutwaro w'umutima, no kugabanya kwangirika kw'imitsi y'umutima.
Muri make, salidroside ishobora gukora ku mikorere y’umutima n’imitsi binyuze mu buryo butandukanye, inzira, n’intego, ikarinda apoptosis y’uturemangingo tw’umutima iterwa n’impamvu nyinshi, kandi ikanoza imiterere y’umubiri yo kubura amaraso no kubura umwuka uhagije. Mu bidukikije bifite ubushyuhe bwinshi, uburyo bwa Rhodiola rosea bwo gukora bufite akamaro kanini mu kurinda ingingo n’ingingo z’umubiri no kubungabunga imikorere y’uturemangingo. Igira uruhare runini mu gukumira no kugabanya indwara zo mu kirere.
Uko umusaruro wa salidroside uhagaze ubu

1) Bishingira ahanini ku gukura ibimera

Rhodiola rosea ni igikoresho cy'ibanze cyauruhande rwa salidroside.Nk'ubwoko bw'igihingwa cy'ibyatsi bihoraho, Rhodiola rosea ikura cyane cyane mu turere dufite ubukonje bwinshi, anoxia, ubwumye, n'ubushyuhe bwinshi hagati y'amanywa na nijoro ku butumburuke bwa metero 1600-4000. Ni kimwe mu bimera byo mu gasozi. Ubushinwa ni kimwe mu bice by'ingenzi byera Rhodiola rosea ku isi, ariko imibereho ya Rhodiola rosea ni yihariye cyane. Ntabwo bigoye kuyihinga mu buryo bw'ubukorano gusa, ahubwo n'umusaruro w'ubwoko bw'ibimera byo mu gasozi ni muto cyane. Icyuho cy'ubukene bwa Rhodiola rosea buri mwaka ni toni 2.200.

2) Gutunganya imiti no kuyitunganya mu buryo bw'ibinyabuzima

Bitewe n'uko ibimera bifite ingano nto n'igiciro kinini cyo gukora, uretse uburyo bwo gukuramo ibinyabutabire mu buryo bw'umwimerere, uburyo bwo gukora salidroside burimo kandi uburyo bwo gukora imiti, uburyo bwo gukora fermentation mu buryo bw'ibinyabuzima, n'ibindi. Muri byo, uko ikoranabuhanga rikomeza gukura, fermentation mu buryo bw'ibinyabuzima yabaye inzira nyamukuru ya tekiniki yo guteza imbere ubushakashatsi no gukora salidroside. Kuri ubu, Suzhou Mailun yageze ku musaruro w'ubushakashatsi n'iterambere kandi yageze ku nganda.