Inyungu za Nefiracetam: Irashobora Kongera Intego?

Mu myaka yashize, isoko rya nootropique ryagaragaye cyane mu nyungu, hamwe n’ibintu bitandukanye bigenda byamamara kubera imitekerereze yabo yongerera ubumenyi. Muri ibyo, nefiracetam yagaragaye nkuwahatanye cyane. 

Gusobanukirwa Nefiracetam

Nefilacetam (izwi kandi nka DM-9384) ni umwe mubagize umuryango wa Piracetam, icyiciro cyimvange kizwiho kumenyekanisha ubwenge. Nefilacetam yabanje gutunganywa mu Buyapani mu myaka ya za 90 kandi yakoreshejwe cyane cyane mu kunoza kwibuka, kwiga, ndetse n'imikorere rusange yo kumenya. Nefilacetam yizera ko ikora muguhindura sisitemu ya neurotransmitter, cyane cyane acetylcholine na glutamate, nibyingenzi muburyo bwo kwibuka no kwiga.

Ifu ya Nefilacetam ikoreshwa cyane cyane mumiterere yayo ya neuronal, itezimbere kwibuka, kuba maso, kwiga, kwitondera, ndetse nibishoboka. Ubu bushakashatsi kandi bufite imiterere ya neuroprotective, bivuze ko ifasha kurinda ingirabuzimafatizo ubwonko kwangizwa na stress ya okiside.

Inyungu:

Kunoza imikorere yubwenge no gutunganya amakuru yihuta

Gukangura reseptor ya dopamine kugirango utezimbere icyerekezo, gutwara, guhanga, no gutanga umusaruro

Kunoza kwibuka kwibuka

Properties Indwara zishobora kuba neuroprotective kugirango zigumane imikorere myiza yubwonko

Ingaruka nyamukuru za Nefiracetam.

Imiyoboro ya GABAA: Nefiracetam ihindura imiyoboro ya GABAA. GABA (acide gamma-aminobutyric) ni neurotransmitter ibuza abayakira bafite uruhare runini mukugabanya umunezero wa neuronal muri sisitemu yose.

Nicotinic acetylcholine reseptors: Nefiracetam ikorana na reseptor ya nicotinic acetylcholine, igira uruhare runini mubikorwa byo kumenya. Muguhindura ibyo byakira, Nefiracetam yongera kwibuka no kwiga.

N-methyl-D-aspartate (NMDA) yakira: Nefiracetam itezimbere reseptor ya NMDA, igira uruhare mukugenzura plastike ya synaptique hamwe nibikorwa byo kwibuka. Iyi ntego yibikorwa ya Nefiracetam itera imbaraga, bityo bikazamura imyigire nibikorwa byo kwibuka.

Gufungura imiyoboro ya calcium: Nepiracetam igira ingaruka ku gufungura imiyoboro ya calcium muri neuron, ikaba ari ngombwa mu kurekura neurotransmitters no gushimisha neuronal. Ingaruka za Nefiracetam ziteza imbere imikorere yubwenge no kwibuka.

Glutamate Receptors: Mu rwego rwibikorwa byayo, Nefiracetam nayo itera glutamate. Glutamate ni neurotransmitter ishimishije cyane muri sisitemu ya nervice kandi igira uruhare runini mugukwirakwiza synaptic na plastike.

Hippocampal Neurotransmission: Imvubu nigice cyingenzi cyubwonko bwo kwibuka. Nefiracetam iterwa no kongera imbaraga za hippocampal neurotransmission intego zongerewe kwiga, gutunganya umuvuduko, no kwibuka kwibuka.

Ingaruka ku Gukura kw'Imitsi (NGF): Ingaruka za Nefiracetam kuri neurogenezi iterwa na NGF irashobora kongera cyangwa guhindura ingaruka za NGF kuri neuron. Ibi bivuze ko Nefiracetam ishobora guteza imbere gukura kwa neurite no gushinga amashami, ifasha muburyo bwo guhuza imitsi, neuroprotection, na plastike.

Mugihe Nefiracetam isa na racetam izwi cyane nka piracetam, ntabwo igira ingaruka muburyo bwa dopamine cyangwa inzira ya dopamine, kandi ingaruka zayo ntago ari nka dopamine reuptake inhibitor.

Inyungu za Nootropic za Nefiracetam

Nkumunyamuryango wumuryango wa racetam wa nootropics, Nefiracetam afite inyungu zinyuranye zo kumenya-kuzamura. Dore incamake y'inyungu za Nefiracetam.

1. Kongera Kwibuka

Nefiracetam izwiho kunoza imikorere yibuka. Ibi birimo ubushobozi bwigihe gito nigihe kirekire cyo kwibuka, bigatuma bishobora kuba ingirakamaro mukwiga no kubika amakuru.

2. Kunoza umuvuduko wo gutunganya

Nefiracetam itezimbere uburyo bwo kwiga. Mugukora sisitemu ya neurotransmitter hamwe na plastike ya synaptique, Nefiracetam yorohereza inzira yo kubona no gutunganya amakuru mashya.

3. Ingaruka za Neurotrophique

Mu kwanduza neurogenezi iterwa na NGF, Nefiracetam irashobora kwerekana ingaruka za neurotrophique, zifasha gukura kwa neuronal nubuzima. Iyi myitwarire irashobora kugira uruhare mubitekerezo byayo byongera ubwenge, cyane cyane mubijyanye no kwibuka no kwiga.

4. Neuroprotection

Nefiracetam irashobora kugira ingaruka za neuroprotective, ifasha kurinda neurone kwangirika. Iyi ngingo ni ingirakamaro cyane cyane kubungabunga ubuzima bwubwonko mugihe cyangwa murwego rwindwara zifata ubwonko nkindwara ya Alzheimer.

5. Kunonosora ibitekerezo no kwibanda

Abakoresha Nepiracetam bakunze kuvuga ubushobozi bunoze bwo kwibanda no kwibanda kubikorwa. Ibi birashobora kugirira akamaro cyane abantu bakora ibikorwa cyangwa imyuga isaba ubwenge.

6. Kuzamura imyifatire

Nubwo atari umurimo wibanze wacyo, nepiracetam isa nkaho igira ingaruka nziza kandi igabanya ubukana, ishobora kugabanya ibimenyetso byo guhangayika no kwiheba no gufasha imibereho myiza muri rusange.

7. Kunoza imikorere ya Neurotransmitter

Nepiracetam ihuza kandi igahindura ibintu byinshi byingenzi bya neurotransmitter bigira uruhare mubikorwa byubwenge, harimo acetylcholine na GABA, bishobora kunoza imitekerereze no gutunganya ubwenge.

Umusaruro wa Nefiracetam: Uruganda

Umusaruro wa nefiracetam urimo uburyo bwo guhuza imiti ikenera ibikoresho byihariye. Uruganda rwa Nefiracetam rufite tekinoroji igezweho kandi rwubahiriza amahame akomeye agenga ubuziranenge n’ibicuruzwa byanyuma. Ibikorwa byo gukora mubisanzwe birimo ibyiciro byinshi:

Isoko ry'ibikoresho bito: Umusaruro utangirana no kugura ibikoresho byiza byo mu rwego rwo hejuru, bikenewe mu guhuza nefiracetam. Ibi bikoresho bigomba kuba byujuje ingamba zikomeye zo kugenzura ubuziranenge kugirango hamenyekane umusaruro wibicuruzwa byanyuma.

Synthesis: Synthesis ya nefiracetam ikubiyemo imiti myinshi yimiti. Abahanga mu bya shimi bakoresha ubuhanga butandukanye kugirango bahindure ibikoresho bibisi murwego rwifuzwa. Iki cyiciro kirakomeye, kuko gutandukana kwose kuri protocole yashyizweho bishobora kuvamo umwanda cyangwa ibicuruzwa bitujuje ubuziranenge.

Isuku: Nyuma ya synthesis, nefiracetam ikora inzira yo kweza kugirango ikureho ibisigazwa byose bisigaye cyangwa ibicuruzwa. Iyi ntambwe ningirakamaro kugirango ibicuruzwa byanyuma bitekanye kubikoresha kandi byujuje ibisabwa.

Kugenzura ubuziranenge: Igeragezwa rikomeye rikorwa kugirango harebwe isuku, imbaraga, n'umutekano bya nefiracetam. Ibi birimo tekinoroji yo gusesengura nka chromatografiya ikora cyane (HPLC) hamwe na sprometrike.

Gupakira no gukwirakwiza: Ibicuruzwa bimaze gutsinda igenzura ryiza, bipakirwa hubahirijwe ibipimo ngenderwaho kandi byateguwe kugirango bigabanwe kubacuruzi n’abaguzi.

Aho Kugura Nefiracetam

Kubashaka kugura nefiracetam, hariho inzira nyinshi zirahari. Ni ngombwa gushakira hamwe ibicuruzwa bitanga isoko kugirango bizere ubuziranenge n'umutekano. Hano hari amahitamo asanzwe yo kugura nefiracetam:

Abacuruzi bo kumurongo: Urubuga rwinshi rwa interineti ruzobereye muri nootropics no kuzamura ubwenge. Abacuruzi bakunze gutanga ibisobanuro birambuye kubicuruzwa, harimo urwego rwubuziranenge namakuru aturuka. Nibyiza gusoma ibyasuzumwe byabakiriya no kugenzura ibizamini byabandi kugirango barebe ubwiza bwibicuruzwa.

Amaduka yinyongera yubuzima: Amaduka amwe yubuzima bwamatafari na minisiteri arashobora gutwara nefiracetam, cyane cyane yibanda kuri nootropics nibicuruzwa byongera ubwenge. Gusura amaduka bituma abakiriya babaza ibibazo kandi bagashaka inama kubakozi babizi.

Abatanga ibicuruzwa byinshi: Kubashaka kugura ubwinshi, abatanga ibicuruzwa byinshi barashobora gutanga nefiracetam muburyo bwifu kubiciro birushanwe. Ihitamo rirakunzwe mubashakashatsi nabantu bakoresha nootropics buri gihe.

Suzhou Myland ni uruganda rwa FDA rwanditse rutanga ifu nziza, nziza cyane ya Nefiracetam.

Kuri Suzhou Myland, twiyemeje gutanga ibicuruzwa byiza byiza kubiciro byiza. Ifu yacu ya Nefiracetam ikorerwa isuku ikomeye kandi ikagerageza imbaraga kugirango umenye neza ko wongeyeho inyongera nziza ushobora kwizera. Waba ushaka gushyigikira ubuzima bwa selile, kuzamura sisitemu yumubiri, cyangwa kuzamura ubuzima bwawe muri rusange, ifu ya Nefiracetam niyo ihitamo neza kuri wewe.

Hamwe nuburambe bwimyaka 30 kandi itwarwa nubuhanga buhanitse kandi bunoze cyane ingamba za R&D, Suzhou Myland Nutraceuticals yateje imbere ibicuruzwa bitandukanye byapiganiwe kandi ibaye inyongera mubuzima bwa siyanse yubuzima, synthesis gakondo hamwe nisosiyete ikora serivise.

Mubyongeyeho, Suzhou Myland Nutraceuticals nayo ni FDA yanditse. Isosiyete R&D umutungo n’ibikorwa byo kubyaza umusaruro, ibikoresho byisesengura bigezweho kandi bitandukanye, kandi birashobora gukora imiti kuri miligarama kugeza kuri toni, kandi ikubahiriza ibipimo bya ISO 9001 nibisobanuro bya GMP.