Ubumenyi Inyuma ya Urolithin A: Ibyo Ukeneye Kumenya

Urolithin A (UA)ni uruvange rwakozwe na metabolism ya flora yo munda mu biribwa bikungahaye kuri ellagitannine (nk'amakomamanga, inkeri, n'ibindi). Bifatwa nko kurwanya inflammatory, kurwanya gusaza, antioxydeant, kwinjiza mitofagy, nibindi, kandi birashobora kurenga inzitizi yubwonko bwamaraso. Ubushakashatsi bwinshi bwemeje ko urolithine A ishobora gutinza gusaza, kandi ubushakashatsi ku mavuriro nabwo bwerekanye ibisubizo byiza.

Urolithin A ni iki?

Urolithin A (Uro-A) ni ellagitannin (ET) -ubwoko bw'amara flora metabolite. Yavumbuwe ku mugaragaro kandi yitirirwa mu 2005. Ifumbire ya molekile ni C13H8O4, naho misile yayo ni 228.2. Nka metabolike ibanziriza Uro-A, isoko nyamukuru y'ibiribwa ya ET ni amakomamanga, strawberry, raspberries, walnuts na vino itukura. UA ni umusaruro wa ETs metabolised na mikorobe yo munda. UA ifite ibyifuzo byinshi byo gukumira no kuvura indwara nyinshi. Muri icyo gihe, UA ifite amasoko menshi y'ibiribwa.

Ubushakashatsi ku ngaruka za antioxydeant ya urolithine bwakozwe. Urolithin-A ntabwo ibaho muburyo busanzwe, ariko ikorwa nuruhererekane rwo guhindura ET na flora yo munda. UA ni umusaruro wa ETs metabolised na mikorobe yo munda. Ibiribwa bikungahaye kuri ET binyura mu gifu no mu mara mato mu mubiri w'umuntu, kandi amaherezo bigahinduka cyane cyane muri Uro-A mu mara. Umubare muto wa Uro-A urashobora kandi kuboneka mumara yo hepfo.

Nkibintu bisanzwe bya polifenolike, ET yakunze kwitabwaho cyane kubera ibikorwa byibinyabuzima nka antioxydeant, anti-inflammatory, anti-allergic na anti-virusi. Usibye gukomoka ku biribwa nk'amakomamanga, strawberry, walnuts, raspberries na almonde, ET iboneka no muri gallnuts, ibishishwa by'ikomamanga, myrobalan, Dimininus, geranium, imbuto za beteli, amababi y'ibihuru byo mu nyanja, Phyllanthus, Uncaria, Sanguisorba, Mu Bushinwa. imiti nka Phyllanthus emblica na Agrimony.

Itsinda rya hydroxyl mumiterere ya molekuline ya ET irasa na polar, ntabwo ifasha kwinjizwa nurukuta rwamara, kandi bioavailable yayo ni mike cyane. Ubushakashatsi bwinshi bwerekanye ko ET imaze kwinjizwa numubiri wumuntu, ihindurwamo na flora yo munda yo munda hanyuma igahinduka urolithine mbere yo kuyinjiramo. ETs hydrolyzed muri acide ellagic (EA) mumitsi yo hejuru ya gastrointestinal, kandi EA inyura mumara. Indwara ya bagiteri itera kandi ikabura impeta ya lactone kandi ikagira reaction ya dehydroxylation ikomeza kubyara urolithine. Hari amakuru avuga ko urolithine ishobora kuba ishingiro ryibintu byangiza ibinyabuzima bya ET mu mubiri.

Niki bioavailable ya urolithin ifitanye isano?

Kubona ibi, niba ufite ubwenge, ushobora kuba usanzwe uzi icyo bioavailability ya UA ifitanye isano.

Ikintu cyingenzi cyane ni uguhimba mikorobe, kuko amoko yose ya mikorobe ntashobora kubyara. Ibikoresho fatizo bya UA ni ellagitannine iboneka mu biryo. Ibi bibanziriza kuboneka byoroshye kandi hafi ya hose muri kamere.

Ellagitannine ihindurwamo amara kugirango irekure aside ellagic, ikaba itunganijwe na flora yo munda muri urolithine A.

Nk’uko ubushakashatsi bwakorewe mu kinyamakuru Cell bubitangaza, abantu 40% bonyine ni bo bonyine bashobora guhindura urolithine A uhereye kuwayibanjirije ikayihindura urolithine A.

Nibihe bikorwa bya urolithin A?

Kurwanya gusaza

Igitekerezo gikabije cyo gusaza cyizera ko ubwoko bwa ogisijeni ikora muri metabolisme ya mitochondial itera imbaraga za okiside mu mubiri kandi biganisha ku gusaza, kandi mitofagy igira uruhare runini mu kubungabunga ubuzima bw’imiterere n’uburinganire. Byavuzwe ko UA ishobora kugenga mitofagy bityo ikagaragaza ubushobozi bwo gutinda gusaza. Ryu n'abandi. yasanze UA yagabanije imikorere mibi ya mitochondrial no kuramba muri Caenorhabditis elegans itera mitofagy; imbeba, UA irashobora guhindura imikorere yimitsi ijyanye nimyaka igabanuka, byerekana ko UA itezimbere imikorere ya mitochondial mukuzamura imitsi no kwagura ubuzima bwumubiri. Liu n'abandi. yakoresheje UA kugira ngo yivange mu gusaza fibroblast. Ibisubizo byerekanaga ko UA yongereye cyane imvugo yubwoko I kolagen kandi igabanya imvugo ya matrix metalloproteinase-1 (MMP-1). Yatangije kandi ingufu za kirimbuzi E2 zifitanye isano na 2 (ibintu bya kirimbuzi erythroide 2 ifitanye isano na 2, Nrf2) -bisubizo bya antioxydeant bigabanya ROS yo mu nda, bityo bikerekana imbaraga zikomeye zo kurwanya gusaza

Ingaruka ya Antioxydeant

Kugeza ubu, ubushakashatsi bwinshi bwakozwe ku ngaruka za antioxydeant ya urolithine. Muri metabolite zose za urolithin, Uro-A ifite ibikorwa bikomeye bya antioxydeant, ikurikirwa na oligomers ya proanthocyanidin, catechine, epicatechin na aside 3,4-dihydroxyphenylacetic. Ikizamini cya ogisijeni ikabije (ORAC) yipimishije plasma yabakorerabushake bafite ubuzima bwiza yasanze ubushobozi bwa antioxydeant bwiyongereyeho 32% nyuma ya 0.5 h yo gufata umutobe w'amakomamanga, ariko urwego rw'ubwoko bwa ogisijeni ikora ntirwahindutse ku buryo bugaragara, mu gihe muri Neuro- Muri ubushakashatsi bwa vitro kuri selile 2a bwerekanye ko Uro-A ishobora kugabanya urwego rwubwoko bwa ogisijeni ikora mu ngirabuzimafatizo. Ibisubizo byerekana ko Uro-A ifite ingaruka zikomeye za antioxydeant.

33. Urolithin A n'indwara z'umutima n'imitsi n'ubwonko

Kwiyongera ku isi hose indwara zifata umutima (CVD) zigenda ziyongera uko umwaka utashye, kandi impfu zikomeza kuba nyinshi. Ntabwo byongera umutwaro wimibereho nubukungu gusa, ahubwo binagira ingaruka zikomeye kumibereho yabantu. CVD n'indwara nyinshi. Gutwika birashobora kongera ibyago bya CVD. Guhangayikishwa na Oxidative bifitanye isano na virusi ya CVD. Hari amakuru avuga ko metabolite ikomoka kuri mikorobe yo mu mara ifitanye isano n'ingaruka za CVD.

UA yavuzwe ko ifite ingaruka zikomeye zo kurwanya inflammatory na antioxydeant, kandi ubushakashatsi bujyanye n’ubushakashatsi bwemeje ko UA ishobora kugira uruhare runini muri CVD. Savi n'abandi. yakoresheje urugero rwimbeba ya diyabete kugirango ikore mubushakashatsi bwa vivo kuri cardiomyopathie diabete kandi isanga UA ishobora kugabanya igisubizo cyambere cyo gutwika ingirangingo ya myocardial to hyperglycemia, kunoza ibidukikije bya myocardial, no guteza imbere isubiranamo ryumutima na calcium, byerekana ko UA ishobora irashobora gukoreshwa nk'imiti ifasha kugenzura indwara ya diabete yumutima no kwirinda ingorane zayo.

UA irashobora kunoza imikorere ya mitochondial n'imikorere y'imitsi itera mitofagy. Umutima mitochondriya ningingo zingenzi zishinzwe kubyara ingufu za ATP. Imikorere mibi ya Mitochondrial niyo ntandaro yo kunanirwa k'umutima. Imikorere mibi ya mitochondrial kuri ubu ifatwa nkintego yo kuvura. Kubwibyo, UA nayo yabaye imiti mishya yumukandida wo kuvura CVD.

Urolithin A n'indwara zifata ubwonko

Neuroinflammation ni inzira y'ingenzi mu kubaho no gutera indwara zifata ubwonko (ND). Apoptose iterwa no guhangayika kwa okiside hamwe no gukusanya poroteyine idasanzwe akenshi itera neuroinflammation, kandi cytokine pro-inflammatory yasohowe na neuroinflammation noneho ikagira ingaruka kuri neurodegeneration.

Ubushakashatsi bwerekanye ko UA ihuza ibikorwa byo kurwanya inflammatory itera autophagy no gukora uburyo bwo gucecekesha ibimenyetso byicecekeye 1 (SIRT-1) uburyo bwa deacetylation, kubuza neuroinflammation na neurotoxicity, no kwirinda neurodegeneration, byerekana ko UA ari agent ikora neza ya Neuroprotective. Muri icyo gihe, ubushakashatsi bumwe bwerekanye ko UA ishobora kugira ingaruka za neuroprotective ikoresheje radicals yubusa kandi ikabuza okiside.

Ubushakashatsi bwerekanye ko umutobe w'amakomamanga ugira uruhare mu bwonko bwa neuroprotective mu kongera ibikorwa bya mitochondrial aldehyde dehydrogenase, bikomeza urwego rwa poroteyine anti-apoptotique Bcl-xL, kugabanya igiteranyo cya α-synuclein no kwangiza okiside, kandi bigira ingaruka ku mikorere ya neuronal no gutuza. Ibikoresho bya Urolithin ni metabolite n'ingaruka za ellagitannine mu mubiri kandi bifite ibikorwa byibinyabuzima nka anti-inflammation, stress anti-okiside, na anti-apoptose. Urolithine irashobora gukora ibikorwa bya neuroprotective ikoresheje inzitizi yubwonko bwamaraso kandi ni molekile ntoya ishobora gukora kugirango yivange mu ndwara zifata ubwonko.

Urolithin A n'indwara zifata umugongo

Indwara zangirika ziterwa nimpamvu nyinshi nko gusaza, guhangayika, no guhahamuka. Indwara zikunda kwibasira ingingo zose ni osteoarthritis (OA) hamwe n'indwara y'umugongo igenda yangirika (IDD). Ibibaho birashobora gutera ububabare nibikorwa bike, bikaviramo kubura akazi kandi bikangiza ubuzima rusange. Uburyo bwa UA mukuvura indwara yumugongo IDD irashobora kuba ifitanye isano no gutinda nucleus pulposus (NP) selile apoptose. NP nikintu cyingenzi kigize disikuru. Ikomeza imikorere yibinyabuzima ya disikuru ihuza ikwirakwiza ingufu no gukomeza matrix homeostasis. Ubushakashatsi bwerekanye ko UA itera mitofagy ikora inzira yerekana ibimenyetso bya AMPK, bityo ikabuza tert-butyl hydroperoxide (t-BHP) -yatewe na apoptose ya selile osteosarcoma ya selile ya NP no kugabanya kwangirika kwa disikuru.

Urolithin A n'indwara zo guhindagurika

Umubare w'indwara ziterwa na metabolike nk'umubyibuho ukabije na diyabete uragenda wiyongera uko umwaka utashye, kandi ingaruka nziza za polifenole y'ibiryo ku buzima bwa muntu zemejwe n'amashyaka menshi kandi zigaragaza ubushobozi mu gukumira no kuvura indwara ziterwa na metabolike. Amakomamanga y'amakomamanga hamwe na metabolite yo mu mara yayo arashobora kunoza ibipimo ngenderwaho bijyanye n'indwara ziterwa na metabolike, nka lipase, α-glucosidase (α-glucosidase) na dipeptidyl peptidase-4 (dipeptidyl peptidase-4) bigira uruhare muri glucose na aside metabolisme. 4), kimwe na gen bifitanye isano nka adiponectine, PPARγ, GLUT4 na FABP4 bigira ingaruka ku gutandukanya adipocyte no kwirundanya kwa triglyceride (TG).

Byongeye kandi, ubushakashatsi bumwe na bumwe bwerekanye ko UA ifite ubushobozi bwo kugabanya ibimenyetso by’umubyibuho ukabije. UA ni umusaruro wa metabolism yo munda ya polifenol. Izi metabolite zifite ubushobozi bwo kugabanya kwirundanya kwa TG muri selile yumwijima na adipocytes. Abdulrasheed n'abandi. kugaburira indyo yuzuye imbeba za Wistar kugirango zibyibushye. Ubuvuzi bwa UA ntabwo bwongereye amavuta mu mwanda gusa, ahubwo bwanagabanije ubwinshi bwimitsi ya adipose ya tipusi hamwe nuburemere bwumubiri muguhindura genes zijyanye na lipogenezi na okiside ya aside irike. Kugabanya ibinure byumwijima hamwe na stress ya okiside. Muri icyo gihe, UA irashobora kongera ingufu mu kongera ingufu za termogenezi ya tissue adipose yumukara no gutera ibinure byamavuta yera. Uburyo ni ukongera urugero rwa triiodothyronine (T3) mu binure byijimye no kubitsa amavuta ya inguinal. Yongera ubushyuhe bityo bikarwanya umubyibuho ukabije.

Byongeye kandi, UA nayo ifite ingaruka zo guhagarika umusaruro wa melanin. Ubushakashatsi bwerekanye ko UA ishobora kugabanya cyane umusaruro wa melanine muri selile B16 melanoma. Uburyo nyamukuru nuko UA igira uruhare mubikorwa bya catalitiki ya tyrosinase binyuze mukurwanya guhatanira tirozine selile, bityo bikagabanya pigmentation. Kubwibyo, UA ifite ubushobozi nibikorwa byo kwera no koroshya ibibanza. Kandi ubushakashatsi bwerekana ko urolithin A ifite ingaruka zo guhindura gusaza kwa sisitemu yumubiri. Ubushakashatsi buheruka gukorwa bwerekanye ko iyo urolithine A yongewemo nk'inyongera y'ibiryo, ntabwo ikora gusa imbaraga z'akarere ka lymphatike k'umubiri w’umubiri w’imbeba, ahubwo inongera ibikorwa bya selile hematopoietic stem selile. Imikorere muri rusange yerekana ubushobozi bwa urolithin A kugirango irwanye imyaka igabanuka ryumubiri.

Muri make, UA, nka metabolite yo munda ya phytochemicals ETs, yakunze kwitabwaho cyane mumyaka yashize. Hamwe nubushakashatsi ku ngaruka za farumasi nuburyo bwa UA bigenda byiyongera kandi byimbitse, UA ntabwo ikora neza muri kanseri na CVD (indwara zifata umutima). Ifite ingaruka nziza zo gukumira no kuvura indwara nyinshi zamavuriro nka ND (indwara ya neurodegenerative) n'indwara za metabolike. Irerekana kandi imbaraga zikomeye zo gukoresha mubijyanye nubwiza nubuvuzi nko gutinda gusaza kwuruhu, kugabanya ibiro byumubiri no kubuza umusaruro wa melanin.

Suzhou Myland Pharm & Nutrition Inc ni uruganda rwanditswe na FDA rutanga ifu ya Urolithin nziza kandi nziza.

Muri Pharm ya Suzhou Myland twiyemeje gutanga ibicuruzwa byiza cyane kubiciro byiza. Urolithin Yacu Ifu irageragezwa cyane kugirango isukure nimbaraga, ikwemeza ko ubona inyongera nziza-nziza ushobora kwizera. Waba ushaka gushyigikira ubuzima bwimikorere, kuzamura sisitemu yumubiri cyangwa kuzamura ubuzima muri rusange, ifu ya Urolithin Ifu niyo ihitamo neza.

Hamwe nuburambe bwimyaka 30 kandi itwarwa nubuhanga buhanitse hamwe nuburyo bunoze bwa R&D, Pharm ya Suzhou Myland Pharm yateje imbere ibicuruzwa bitandukanye byapiganiwe kandi ihinduka ubuzima bushya bwa siyanse yubuzima, synthèse progaramu na sosiyete ikora serivise.

Mubyongeyeho, Suzhou Myland Pharm nayo ikora FDA yemewe. Ibikoresho bya sosiyete R&D, ibikoresho byo kubyaza umusaruro, nibikoresho byisesengura nibigezweho kandi byinshi, kandi birashobora gukora imiti kuva kuri miligarama kugeza kuri toni mubipimo, kandi ikubahiriza ibipimo bya ISO 9001 nibisobanuro bya GMP.