Ubumenyi bw'Urolithine A: Icyo Ugomba Kumenya

Urolithine A (UA)ni ikintu kivangwa n’imikorere y’ibimera byo mu mara mu biribwa bikungahaye kuri ellagitannins (nk’amakomamanga, raspberries, nibindi). Bifatwa nk’ibirwanya ubushyuhe, birwanya gusaza, antioxydants, bitera mitophagy, nibindi, kandi bishobora kwambuka umupaka w’amaraso n’ubwonko. Ubushakashatsi bwinshi bwemeje ko urolithin A ishobora gutinza gusaza, kandi ubushakashatsi bwa muganga nabwo bwagaragaje umusaruro mwiza.

Urolithine A ni iki?

Urolithin A (Uro-A) ni metabolite y’ibimera byo mu mara yo mu bwoko bwa ellagitannin (ET). Yavumbuwe ku mugaragaro inahabwa izina mu 2005. Formula yayo ya molekile ni C13H8O4, kandi uburemere bwayo bwa molekile ni 228.2. Nk’umusozo w’imikorere ya Uro-A, amasoko y’ibanze y’ibiribwa bya ET ni amakomamanga, inkeri, iraberi, inyo na divayi itukura. UA ni umusaruro wa ET zikorwa na mikorobe zo mu mara. UA ifite amahirwe menshi yo gukoreshwa mu gukumira no kuvura indwara nyinshi. Muri icyo gihe, UA ifite amasoko menshi y’ibiribwa.

Ubushakashatsi ku ngaruka za urolithine ku kurwanya antioxydants bwakozwe. Urolithin-A ntabwo ibaho mu buryo karemano, ahubwo ikorwa n'impinduka nyinshi za ET ziterwa n'ibimera byo mu mara. UA ni umusaruro wa ET ziterwa na mikorobe zo mu mara. Ibiryo bikungahaye kuri ET binyura mu gifu no mu mara mato mu mubiri w'umuntu, amaherezo bigashyirwa mu mara mato cyane cyane muri Uro-A mu mara. Uro-A nkeya ishobora no kugaragara mu mara mato yo hasi.

Nk’ibinyabutabire karemano bya polyphenolic, ET zakuruye abantu benshi bitewe n’ibikorwa byazo bya kinyabuzima nko kurwanya imisemburo, kurwanya ubushyuhe, kurwanya allergie no kurwanya virusi. Uretse kuba zikomoka ku biribwa nka pomegranate, strawberries, walnuts, raspberries na almonds, ETs ziboneka no mu bimera bya gallnuts, impumuro za pomegranate, myrobalan, Dimininus, geranium, betel nut, amababi ya sea buckthorn, Phyllanthus, Uncaria, Sanguisorba, Mu miti y’Abashinwa nka Phyllanthus emblica na Agrimony.

Itsinda rya hydroxyl riri mu miterere ya molekile ya ETs riri mu gice cy’imbere cy’urukuta rw’amara, ritabasha kwinjiza neza mu mara, kandi ubushobozi bwaryo bwo kubaho buri hasi cyane. Ubushakashatsi bwinshi bwagaragaje ko nyuma y’uko ETs zinyowe n’umubiri w’umuntu, zihindukamo ibimera byo mu mara mu mara hanyuma zigahinduka urolithine mbere yo kwinjiza. ETs zishyirwamo aside ellagique (EA) mu gice cyo hejuru cy’amara, maze EA inyuzwa mu mara. Ibimera bya bagiteri bikomeza gukora no gutakaza impeta ya lactone kandi bigahora bihura n’ingaruka zo kudakoresha urolithine mu mubiri. Hari raporo zivuga ko urolithine ishobora kuba ishingiro ry’ingaruka za ETs mu mubiri ku binyabuzima.

Ni iki kijyanye no kuba urolithine iboneka mu mubiri?

Ubibonye, ​​niba uri umunyabwenge, ushobora kuba uzi neza isano iri hagati ya bioavailability ya UA n'ibindi.

Ikintu cy'ingenzi cyane ni imiterere ya mikorobe, kuko si ubwoko bwose bwa mikorobe bushobora gutanga. Ibikoresho fatizo bya UA ni ellagitannins biva mu biribwa. Iyi ngaruka iboneka byoroshye kandi hafi ya hose mu miterere.

Ellagitannins zishyirwa mu mara kugira ngo zikuremo aside ellagique, ikomeza gutunganywa n'ibimera byo mu mara ikajyamo urolithine A.

Nk’uko ubushakashatsi bwakozwe mu kinyamakuru Cell bubivuga, abantu 40% gusa ni bo bashobora guhindura urolithin A mu buryo busanzwe bayikuye mu yindi miterere yayo ikaba urolithin A ikoreshwa.

Ni iyihe mirimo ya urolithine A?

Kurwanya gusaza

Inyigisho y’ubusaza bw’ibintu birwanya gusaza yizera ko ubwoko bwa ogisijeni bukora mu mitochondrial butera stress ya oxidative mu mubiri kandi bigatera gusaza, kandi mitophagy igira uruhare runini mu kubungabunga ubuzima n’ubusugire bwa mitochondrial. Byatangajwe ko UA ishobora kugenzura mitophagy bityo ikagaragaza ubushobozi bwo gutinza gusaza. Ryu n'abandi basanze UA yagabanyije imikorere mibi ya mitochondrial no kongera igihe cyo kubaho mu mitophagy ya Caenorhabditis; mu mbeba, UA ishobora gusubiza inyuma igabanuka ry’imikorere y’imitsi ifitanye isano n’izabukuru, bigaragaza ko UA yongera imikorere ya mitochondrial binyuze mu kongera imitsi no kongera ubuzima bw’umubiri. Liu n'abandi bakoresheje UA kugira ngo bivange fibroblasts z’uruhu zishaje. Ibisubizo byagaragaje ko UA yongereye cyane imiterere ya collagen yo mu bwoko bwa I kandi ikagabanya imiterere ya matrix metalloproteinase-1 (MMP-1). Yanakoresheje uburyo bwo kurwanya antioxidant buterwa na nuclear Factor E2-related factor 2 (nuclear factor erythroid 2-related factor 2, Nrf2)-igabanya ROS yo mu ngirabuzima fatizo, bityo ikagaragaza ubushobozi bukomeye bwo kurwanya gusaza.

Ingaruka zo kurwanya ogisijeni

Kugeza ubu, ubushakashatsi bwinshi bwakozwe ku ngaruka za urolithin ku kurwanya imisemburo ya antioxydant. Muri metabolites zose za urolithin, Uro-A ifite imikorere ikomeye ya antioxydant, ikaba iya kabiri nyuma ya proanthocyanidin oligomers, catechins, epicatechin na aside 3,4-dihydroxyphenylacetic. Ikizamini cya ORAC ku plasma y'abakorerabushake bazima cyagaragaje ko ubushobozi bwa antioxydant bwiyongereyeho 32% nyuma y'amasaha 0.5 yo kunywa umutobe w'ipomegranate, ariko urwego rw'ubwoko bwa oxydant bwa reactive ntirwahindutse cyane, mu gihe mu bushakashatsi bwa Neuro-In vitro ku turemangingo twa 2a bwagaragaje ko Uro-A ishobora kugabanya urwego rw'ubwoko bwa oxydant bwa reactive mu turemangingo. Ibi byavuye mu bushakashatsi bigaragaza ko Uro-A ifite ingaruka zikomeye za antioxydant.

03. Urolithine A n'indwara z'umutima n'imitsi yo mu bwonko

Indwara z'umutima n'imitsi (CVD) ziyongera ku isi buri mwaka, kandi igipimo cy'impfu kiracyari hejuru. Ntabwo byongera umutwaro mu mibereho no mu bukungu gusa, ahubwo bigira ingaruka zikomeye ku mibereho y'abantu. CVD ni indwara iterwa n'ibintu byinshi. Kubyimba bishobora kongera ibyago byo kurwara CVD. Imihangayiko ya oxidative ifitanye isano n'imiterere ya CVD. Hari raporo zivuga ko metabolites zikomoka ku dukoko two mu mara zifitanye isano n'ibyago byo kurwara CVD.

Byatangajwe ko UA ifite ingaruka zikomeye zo kurwanya ububyimbirwe no kurwanya antioxydants, kandi ubushakashatsi bw'ingenzi bwemeje ko UA ishobora kugira uruhare runini muri CVD. Savi n'abandi bakoresheje icyitegererezo cy'imbeba za diyabete kugira ngo bakore ubushakashatsi ku ndwara y'umutima iterwa n'indwara ya diyabete kandi basanga UA ishobora kugabanya ingaruka z'ububyimbirwe bw'imitsi y'umutima ku ndwara ya hyperglycemia, kunoza ibidukikije by'umutima, no guteza imbere gukira kw'imitsi y'umutima n'imitsi ya kalisiyumu, bigaragaza ko UA ishobora gukoreshwa nk'umuti w'inyongera mu kugenzura indwara y'umutima iterwa n'indwara ya diyabete no gukumira ingorane zayo.

UA ishobora kunoza imikorere ya mitochondrial n'imikorere y'imitsi binyuze mu gutera mitophagy. Mitochondria y'umutima ni organelles z'ingenzi zikora ATP ikungahaye ku ngufu. Kudakora neza kwa mitochondrial ni yo mpamvu nyamukuru itera kunanirwa k'umutima. Kudakora neza kwa mitochondrial ubu bifatwa nk'ikintu gishobora kuvura. Kubwibyo, UA nayo yabaye umuti mushya ukoreshwa mu kuvura indwara ya CVD.

Urolithine A n'indwara z'imitsi

Kubyimba kw'imitsi ni ingenzi mu kugaragara no gukura kw'indwara yo kwangirika kw'imitsi (ND). Kugabanuka kw'imitsi guterwa n'ingufu za oxidative hamwe no kwibumbirana kwa poroteyine kudasanzwe akenshi bitera kubyimba kw'imitsi, hanyuma za cytokine zitera ububyimbirwe zirekurwa na neuroinflammation zigira ingaruka ku kugabanuka kw'imitsi.

Ubushakashatsi bwagaragaje ko UA ifasha mu kurwanya ububyimbirwe binyuze mu gutera autophagy no gukora uburyo bwo guhagarika acetylation butagira icyo buvuga (SIRT-1), ikabuza ububyimbirwe bw'ubwonko n'uburozi bw'ubwonko, kandi ikarinda kwangirika kw'ubwonko, bigaragaza ko UA ari umuti urinda ubwonko neza. Muri icyo gihe, hari ubushakashatsi bwagaragaje ko UA ishobora kugira ingaruka ku buvuzi bw'ubwonko binyuze mu gukuraho mu buryo butaziguye ibintu bihumanya ikirere no gukumira oxidases.

Ubushakashatsi bwagaragaje ko umutobe w'imbuto z'umurama w'imbuto z'umurama ugira uruhare mu kurinda ubwonko binyuze mu kongera imikorere ya aldehyde dehydrogenase muri mitochondrial, kubungabunga urwego rwa poroteyine irwanya apoptotike ya Bcl-xL, kugabanya ukwiyongera kwa α-synuclein no kwangirika kwa ogisijeni, kandi bigira ingaruka ku mikorere n'ituze ry'imitsi. Urolithin ni metabolites n'ibice bigize ellagitannins mu mubiri kandi bifite ibikorwa bya biyoloji nko kurwanya ububyimbirwe, kurwanya stress ya ogisijeni, no kurwanya apoptosis. Urolithin ishobora gukora ibikorwa byo kurinda ubwonko binyuze mu nzitizi y'amaraso n'ubwonko kandi ni molekile nto ishobora gukora mu gukumira indwara z'ubwonko.

Urolithine A n'indwara zo kwangirika kw'ingingo n'umugongo

Indwara zo kwangirika ziterwa n'ibintu byinshi nko gusaza, gucika intege, no gukomereka. Indwara zikunze kwangirika mu ngingo ni osteoarthritis (OA) n'indwara yo kwangirika mu mugongo yo kwangirika mu mitsi yo hagati y'ingingo (IDD). Kugaragara kwazo bishobora gutera ububabare no gukora bike, bigatera kubura igihe cyo kubyara no gushyira ubuzima bw'abaturage mu kaga gakomeye. Uburyo UA ikoresha mu kuvura indwara yo kwangirika mu mugongo IDD ishobora kuba ifitanye isano no gutinda kwa apoptosis y'uturemangingo twa nucleus pulposus (NP). NP ni igice cy'ingenzi cya disiki yo hagati y'ingingo. Ikomeza imikorere y'uturemangingo two hagati y'ingingo binyuze mu gukwirakwiza igitutu no kubungabunga homeostasis ya matrix. Ubushakashatsi bwagaragaje ko UA itera mitophagy binyuze mu gukora inzira y'ibimenyetso ya AMPK, bityo ikabuza apoptosis iterwa na tert-butyl hydroperoxide (t-BHP) y'uturemangingo twa NP tw'uturemangingo twa osteosarcoma y'umuntu no kugabanya kwangirika kwa disiki yo hagati y'ingingo.

Urolithine A n'indwara z'imikorere y'umubiri

Indwara z’impinduka mu mubiri nk’umubyibuho ukabije na diyabete zigenda ziyongera uko umwaka utashye, kandi ingaruka nziza za polyphenols ku buzima bw’abantu zemejwe n’abantu benshi kandi zagaragaje ubushobozi mu gukumira no kuvura indwara z’impinduka mu mubiri. Polyphenols z’amakomamanga hamwe na metabolite yayo ya UA bishobora kunoza ibimenyetso by’ubuvuzi bijyanye n’indwara z’impinduka mu mubiri, nka lipase, α-glucosidase (α-glucosidase) na dipeptidyl peptidase-4 (dipeptidyl peptidase-4) bigira uruhare mu ihinduka rya glucose na aside irike. 4), hamwe n’uturemangingo dufitanye isano nka adiponectin, PPARγ, GLUT4 na FABP4 bigira ingaruka ku itandukana ry’amafuta n’ubwiyongere bwa triglyceride (TG).

Byongeye kandi, hari ubushakashatsi bwagaragaje ko UA ifite ubushobozi bwo kugabanya ibimenyetso by'umubyibuho ukabije. UA ni umusaruro w'imikorere y'amara ya polyphenols. Izi metabolites zifite ubushobozi bwo kugabanya ubwiyongere bwa TG mu turemangingo tw'umwijima na adipocytes. Abdulrasheed n'abandi. bagaburiye imbeba za Wistar indyo irimo ibinure byinshi kugira ngo batere umubyibuho ukabije. Ubuvuzi bwa UA ntibwongereye ibinure mu mwanda gusa, ahubwo bwanagabanije uburemere bw'ibinure byo mu nda n'uburemere bw'umubiri binyuze mu kugenzura imiterere y'uturemangingo ijyanye no gusohora lipogenesis na oxidation ya aside fatty acid. Bigabanya ubwiyongere bw'ibinure mu mwijima n'umuvuduko wa oxidation. Muri icyo gihe, UA ishobora kongera ingufu binyuze mu kongera termogenesis y'ibinure by'umukara no gutuma ibinure byera bihinduka ibara ry'umukara. Uburyo ni ukongera urugero rwa triiodothyronine (T3) mu binure by'umukara n'ibinure byo mu gifu. Byongera umusaruro w'ubushyuhe bityo bikarwanya umubyibuho ukabije.

Byongeye kandi, UA ifite ingaruka zo kubuza ikorwa rya melanin. Ubushakashatsi bwagaragaje ko UA ishobora kugabanya cyane ikorwa rya melanin mu turemangingo twa melanoma ya B16. Uburyo nyamukuru ni uko UA igira ingaruka ku ikorwa rya tyrosinase binyuze mu gukumira tyrosinase y’uturemangingo, bityo ikagabanya ibara. Bityo, UA ifite ubushobozi n'ubushobozi bwo kwera no kugabanya amabara. Kandi ubushakashatsi bwerekana ko urolithine A ifite ingaruka zo gusubiza inyuma gusa ubusaza bw'ubudahangarwa bw'umubiri. Ubushakashatsi buheruka bwagaragaje ko iyo urolithine A yongewemo nk'inyongera mu mirire, idakora gusa imbaraga z'agace ka lymphatic k'ubudahangarwa bw'imbeba, ahubwo inanongera imikorere y'uturemangingo tw'amaraso. Imikorere rusange igaragaza ubushobozi bwa urolithine A bwo kurwanya igabanuka ry'ubudahangarwa bw'umubiri bushingiye ku gusaza.

Muri make, UA, nk'ikintu kigize imikorere y'amara ya ETs karemano, yakuruye abantu benshi mu myaka ya vuba aha. Ubushakashatsi ku ngaruka z'imiti n'uburyo UA ikora burushaho kuba bwinshi kandi bwimbitse, UA ntabwo igira ingaruka nziza gusa ku ndwara za kanseri na CVD (indwara z'umutima). Ifite ingaruka nziza zo kwirinda no kuvura indwara nyinshi nka ND (indwara z'ubwonko) n'indwara z'imikorere y'umubiri. Igaragaza kandi ubushobozi bukomeye mu bijyanye n'ubwiza n'ubuvuzi nko gutinda gusaza k'uruhu, kugabanya ibiro by'umubiri no kubuza melanin gukorwa.

Suzhou Myland Pharm & Nutrition Inc. ni uruganda rwemewe na FDA rutanga ifu ya Urolithin A nziza kandi isukuye cyane.

Muri Suzhou Myland Pharm twiyemeje gutanga ibicuruzwa byiza cyane ku giciro cyiza. Ifu yacu ya Urolithin A irageragezwa cyane kugira ngo imenyekane ko ari nziza kandi ifite imbaraga, bityo ukaba wabona inyongeramusaruro nziza ushobora kwizera. Waba ushaka gufasha ubuzima bw'uturemangingo, kongera ubudahangarwa bw'umubiri wawe cyangwa kongera ubuzima bwiza muri rusange, ifu yacu ya Urolithin A ni yo mahitamo meza.

Suzhou Myland Pharm ifite uburambe bw'imyaka 30 kandi iyobowe n'ikoranabuhanga rigezweho hamwe n'ingamba zo gukora ubushakashatsi n'iterambere zinoze cyane, yateje imbere ibicuruzwa bitandukanye kandi iba ikigo gishya gitanga serivisi z'inyongera ku buzima, gukora ibintu bitandukanye no gukora ibikoresho bitandukanye.

Byongeye kandi, Suzhou Myland Pharm ni uruganda rwanditswe na FDA. Imbuga z’ubushakashatsi n’iterambere by’iyi sosiyete, ibikoresho byayo byo gukora, n’ibikoresho byo gusesengura ni ibintu bigezweho kandi bifite imikorere myinshi, kandi bishobora gukora imiti kuva kuri miligarama kugeza kuri toni, kandi bikurikiza amahame ya ISO 9001 n’ibipimo bya GMP mu gukora.